CN105008352B - 用作溴区结构域抑制剂的咔唑化合物 - Google Patents

用作溴区结构域抑制剂的咔唑化合物 Download PDF

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CN105008352B
CN105008352B CN201480010613.1A CN201480010613A CN105008352B CN 105008352 B CN105008352 B CN 105008352B CN 201480010613 A CN201480010613 A CN 201480010613A CN 105008352 B CN105008352 B CN 105008352B
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carbazole
dimethyl
carboxamide
oxazol
carbonyl
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CN105008352A (zh
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M·A·波斯
D·R·托尔托拉尼
D·S·多德
C·P·穆萨里
J·S·托卡尔斯基
A·V·加瓦伊
赵玉芬
G·V·德卢卡
D·奥马利
D·J·诺里斯
P·吉尔
C·A·魁斯内尔
韩文景
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Bristol Myers Squibb Co
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/42—Oxazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
CN201480010613.1A 2013-02-27 2014-02-27 用作溴区结构域抑制剂的咔唑化合物 Active CN105008352B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361769996P 2013-02-27 2013-02-27
US61/769,996 2013-02-27
US14/190,477 2014-02-26
US14/190,477 US9492460B2 (en) 2013-02-27 2014-02-26 Carbazole compounds useful as bromodomain inhibitors
PCT/US2014/018820 WO2014134232A1 (en) 2013-02-27 2014-02-27 Carbazole compounds useful as bromodomain inhibitors

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CN105008352A CN105008352A (zh) 2015-10-28
CN105008352B true CN105008352B (zh) 2018-12-07

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US (1) US9492460B2 (cg-RX-API-DMAC10.html)
EP (1) EP2961748B1 (cg-RX-API-DMAC10.html)
JP (1) JP6395731B2 (cg-RX-API-DMAC10.html)
CN (1) CN105008352B (cg-RX-API-DMAC10.html)
BR (1) BR112015020389A8 (cg-RX-API-DMAC10.html)
CA (1) CA2902737A1 (cg-RX-API-DMAC10.html)
EA (1) EA027345B1 (cg-RX-API-DMAC10.html)
ES (1) ES2669189T3 (cg-RX-API-DMAC10.html)
MX (1) MX2015010921A (cg-RX-API-DMAC10.html)
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