CN105002109B - 乳酸菌、包含该乳酸菌的组合物以及其用途 - Google Patents
乳酸菌、包含该乳酸菌的组合物以及其用途 Download PDFInfo
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
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| US14/259,442 US10967013B2 (en) | 2014-04-23 | 2014-04-23 | Lactic acid bacterium for prophylaxis or treatment of a stress-induced disorder and a composition containing the same |
| US14/259,442 | 2014-04-23 | ||
| US14/690,502 | 2015-04-20 | ||
| US14/690,502 US10188684B2 (en) | 2015-04-20 | 2015-04-20 | Method for preventing or treating functional gastrointestinal disorder by lactic acid bacterium |
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| CN105002109A CN105002109A (zh) | 2015-10-28 |
| CN105002109B true CN105002109B (zh) | 2018-09-14 |
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| JP (1) | JP6035578B2 (enExample) |
| CN (1) | CN105002109B (enExample) |
| ES (1) | ES2624673T3 (enExample) |
| PL (1) | PL2937424T3 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2020156417A1 (en) * | 2019-01-28 | 2020-08-06 | Bened Biomedical Co., Ltd. | Method for protecting a subject for exercise |
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| JP6933358B2 (ja) * | 2016-04-06 | 2021-09-08 | 東海漬物株式会社 | 美肌促進剤 |
| EP3487985B1 (en) * | 2016-07-19 | 2023-11-08 | Bened Biomedical Co., Ltd. | Method for preventing or treating movement disorders with lactic acid bacterium |
| KR20180019474A (ko) * | 2016-08-16 | 2018-02-26 | 주식회사 엠디헬스케어 | 락토바실러스 플란타룸 유래 소포를 포함하는 정신질환 예방 또는 치료용 조성물 |
| CN107050062A (zh) * | 2016-11-08 | 2017-08-18 | 江西益盟科技有限公司 | 治疗便秘的乳酸菌组合物及其制备方法 |
| MY199866A (en) * | 2017-01-13 | 2023-11-26 | Bened Biomedical Co Ltd | A novel lactic acid bacteria and its applications |
| KR102089836B1 (ko) * | 2017-03-15 | 2020-03-16 | (주)바이오일레븐 | 트립토판분해효소 음성균과 인터페론 감마 형성을 유도하는 균주를 이용한 염증성 질환 예방 및 치료용 약학적 조성물 또는 이를 이용한 치료방법 |
| CN106906165B (zh) * | 2017-04-25 | 2020-07-24 | 重庆第二师范学院 | 一种植物乳杆菌及其在制备预防便秘的食品中的应用 |
| CN107267416A (zh) * | 2017-07-05 | 2017-10-20 | 重庆第二师范学院 | 植物乳杆菌ys2及其在制备预防便秘的食品中的应用 |
| WO2019119261A1 (en) * | 2017-12-19 | 2019-06-27 | Dupont Nutrition Biosciences Aps | Probiotics for cognitive and mental health |
| KR102741244B1 (ko) * | 2017-12-19 | 2024-12-11 | 인터내셔널 엔＆에이치 덴마크 에이피에스 | 인지 및 정신 건강을 위한 프로바이오틱스 |
| KR102265538B1 (ko) | 2018-02-02 | 2021-06-16 | 주식회사 고바이오랩 | 락토바실러스 플란타럼 kbl396 균주 및 그 용도 |
| CN111035661A (zh) * | 2018-10-15 | 2020-04-21 | 深圳市华大农业应用研究院 | 植物乳杆菌的用途 |
| TWI731279B (zh) | 2018-11-21 | 2021-06-21 | 葡萄王生技股份有限公司 | 發酵乳桿菌gkf3、含其之組合物及改善精神失調之用途 |
| ES2763350B2 (es) * | 2018-11-28 | 2020-10-13 | Consejo Superior Investigacion | Cepa de christensenella minuta y uso de la misma |
| WO2020115206A1 (en) * | 2018-12-06 | 2020-06-11 | Dupont Nutrition Biosciences Aps | Probiotics for cognitive and mental health |
| BR112021014935A2 (pt) * | 2019-02-01 | 2021-09-28 | Bened Biomedical Co., Ltd. | Método para prevenir ou tratar uma emoção ou comportamento anormal em um animal não humano por meio de bactéria ácido-láctica |
| CA3127726A1 (en) * | 2019-02-01 | 2020-08-06 | Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement | Lactococcus lactis strains for the prevention and/or the treatment of visceral pain |
| KR102148707B1 (ko) * | 2019-02-22 | 2020-08-31 | 한국식품연구원 | 우울증 및 불안장애의 예방, 개선 또는 치료 효능을 갖는 김치 유산균 락토바실러스 사케아이 |
| WO2021155543A1 (en) * | 2020-02-06 | 2021-08-12 | Lee Wang Tso | Composition of lactic acid bacterium for use in preventing or treating rett syndrome |
| EP4106780A4 (en) * | 2020-03-25 | 2023-08-23 | Bened Biomedical Co., Ltd. | PROCEDURES FOR REDUCING BEHAVIORAL ANOMALIES |
| TWI826851B (zh) * | 2020-10-22 | 2023-12-21 | 國立臺灣大學 | 植物乳酸桿菌植物亞種ｐｓ１２８於製備治療芳香族l-胺基酸脫羧基酶缺乏症的藥物的用途 |
| TW202241477A (zh) * | 2020-12-16 | 2022-11-01 | 日商明治股份有限公司 | 腦組織之發炎改善用組成物 |
| CN113215018A (zh) * | 2021-02-04 | 2021-08-06 | 郑州大学 | 一株植物乳杆菌植物亚种及其在豆粕和北艾混合发酵中的应用 |
| CN113564084A (zh) * | 2021-08-13 | 2021-10-29 | 华东理工大学 | 植物乳杆菌x7022在预防和治疗便秘上的应用 |
| TWI810645B (zh) * | 2021-09-06 | 2023-08-01 | 景岳生物科技股份有限公司 | 乳桿菌組合物及其改善抗生素造成之焦慮症的用途 |
| KR20250095634A (ko) * | 2022-10-28 | 2025-06-26 | 시에이치알. 한센 에이/에스 | 과민성 대장 증후군 증상 해결에 사용되기 위한 락티플란티바실러스 플란타룸 |
| CN117143760B (zh) * | 2023-07-12 | 2024-09-20 | 西南大学 | 一株能促进5-htp分泌及缓解抑郁的鼠李糖乳酪杆菌ky16及其应用 |
| KR102741129B1 (ko) * | 2023-11-07 | 2024-12-11 | 농업회사법인 고려홍삼원 주식회사 | 락토바실러스 플란타룸 ckh-01 균주를 포함하는 스트레스 완화 및 수면개선용 프로바이오틱스 조성물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5725853A (en) * | 1994-10-18 | 1998-03-10 | Pioneer Hi-Bred International, Inc. | 4 strain direct-fed microbial |
| US20050158294A1 (en) * | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
| EP2332539A4 (en) * | 2008-08-21 | 2012-05-09 | Suntory Holdings Ltd | PHARMACEUTICAL PREPARATION, FOOD OR BEVERAGE WITH ANTICIPATIVE EFFECT ON THE SEROTONINE TRANSPORTER |
-
2015
- 2015-04-23 EP EP15164896.1A patent/EP2937424B1/en active Active
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- 2015-04-23 JP JP2015088066A patent/JP6035578B2/ja active Active
Non-Patent Citations (5)
| Title |
|---|
| Diversity of lactic acid bacteria in suan-tsai and fu-tsai,traditional fermented mustard products of Taiwan;Shiou-Huei Chao等;《International Journal of Food Microbiology》;20091231;第135卷;203-210 * |
| Genome architecture of Lactobacillus plantarum PS128,a probiotic strain with potential immunomodulatory activity;Wei-Hsien Liu等;《Gut Pathog》;20150815;第7卷;1-7 * |
| Oral administration of Lactobacillus plantarum K68 ameliorates DSS-induced ulcerative colitis in BALB/c mice via the anti-inflammatory and immunomodulatory activites;Yen-Wenn Liu等;《International Immunopharmacology》;20111231;第11卷(第12期);2159-2166 * |
| γ-氨基丁酸发酵乳的研制;薛玉清等;《食品与发酵工业》;20131231;第39卷(第11期);85-90 * |
| 植物乳杆菌的生理功能及应用;王水泉等;《中国农业科技导报》;20101231;第12卷(第4期);49-55 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020156417A1 (en) * | 2019-01-28 | 2020-08-06 | Bened Biomedical Co., Ltd. | Method for protecting a subject for exercise |
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| JP2015213501A (ja) | 2015-12-03 |
| PL2937424T3 (pl) | 2017-09-29 |
| JP6035578B2 (ja) | 2016-11-30 |
| CN105002109A (zh) | 2015-10-28 |
| EP2937424A1 (en) | 2015-10-28 |
| ES2624673T3 (es) | 2017-07-17 |
| EP2937424B1 (en) | 2017-03-29 |
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