CN104996436B - A kind of bactericidal composition of containing fluazinam and tiadinil - Google Patents
A kind of bactericidal composition of containing fluazinam and tiadinil Download PDFInfo
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- CN104996436B CN104996436B CN201510361391.4A CN201510361391A CN104996436B CN 104996436 B CN104996436 B CN 104996436B CN 201510361391 A CN201510361391 A CN 201510361391A CN 104996436 B CN104996436 B CN 104996436B
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- tiadinil
- fluazinam
- bactericidal composition
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Abstract
The invention discloses a kind of containing fluazinam and the bactericidal composition of tiadinil, the mass ratio of active component fluazinam and tiadinil is 15：1~1：15.The present invention is notable to the crop fungal disease prevention effect such as rice sheath blight disease, the combination of two medicaments, can reduce dosage, effectively reduce ecological disruption and environmental pollution, and can improve crop yield and quality；Fluazinam and tiadinil belong to low toxicity in the present invention, to people and animals, beneficial organism safety；The resistance to the action of a drug of the germ to single medicament can be delayed.Fluazinam possesses different structure types and discrepant mechanism of action from tiadinil, the two is combined by a certain percentage, have bactericidal activity high in actual use, pressure is selected to caused by pathogen when fluazinam and tiadinil single dose can be avoided to be used alone to a greater extent simultaneously, the pathogen resistance to the action of a drug is delayed to produce and develop, and decline dosage total in unit area, economic, efficient, environmental protection.
Description
Technical field
The invention belongs to disinfectant use in agriculture field, and in particular to a kind of bactericidal composition of containing fluazinam and tiadinil.
Background technology
Fluazinam（English common name：Fluazinam）, molecular formula C13H4Cl2F6N4O4, structural formula is as follows：
Chemical common name is the chloro- N- of 3- (the chloro- 5- trifluoromethyls -2- pyridine radicals of 3-)-a, a, the fluoro- 2,6- dinitros of a- tri-
Base-p-toluidine, pyridine amine derivative, dinitroaniline series bactericidal agent.It is broad-spectrum high efficacy without therapeutic effect and systemic activity
Protective fungicide.It is highly effective to interlink spore genus, Phytophthora, Plasmopara, Sclerotinia and Venturia.For anti-benzene
And the Botrytis cinerea of imidazoles and dicarboximide series bactericidal agent also has good effect, to the rice samping off as caused by rhizopus
Also there is good effect.This grade resistance of rainwater washing against, longevity of residure length.In addition the effect of control phytophagous mites is had concurrently.Due to β-
Trifluoromethyl Fampridine part plays conveying compound to the unique effect of the active site of pathogenic bacteria, can suppress sick in course of infection
Sprouting, infiltration, the growth of mycelia and the formation of spore of substance spore.
Tiadinil（English common name：Tiadinil Standard）, molecular formula C11H10ClN3OS, structural formula are as follows：
Chemical common name is chloro- 4, the 4'- dimethyl -1,2 of 3'-, 3- thiadiazoles -5- formailides, novel absorbability
Bactericide, it is transmitted to other positions rapidly by root absorption.This medicament itself is poor to the inhibitory activity of germ, passes through prevention
The neighbouring healthy cell of germ mycelia intrusion, and can induce and produce disease-resistant gene.Suitable water reason uses, lasting period length, to leaf blast
Disease and fringe rice blast have preferable prevention effect, especially suitable for seedling cultivation of rice case.In sick medication effect at hair initial stage it is further preferred that.
The content of the invention
It is an object of the invention to provide a kind of containing fluazinam and the new type bactericide composition of tiadinil, for preventing and treating
The various crop disease such as rice sheath blight disease.Fluazinam possesses different structure types and discrepant effect machine from tiadinil
System, the two is combined by a certain percentage, high with bactericidal activity in actual use, while can avoid fluorine to a greater extent
Pyridine amine and tiadinil single dose select pressure when being used alone to caused by pathogen, delay the pathogen resistance to the action of a drug to produce and send out
Exhibition, and decline dosage total in unit area, economic, efficient, environmental protection.
The bactericidal composition of a kind of containing fluazinam and tiadinil of the present invention, include mass ratio for 15：1~1：15
Active component fluazinam and tiadinil.
Preferably, the mass ratio of the fluazinam and tiadinil is 10：1~1：10, more preferably 5：1~1：5, it is optimal
Elect 1 as:1.
Agriculturally conventional bactericidal composition formulation is being made added with conventional agricultural bactericidal agent aid for the composition of the present invention.
Described bactericidal composition formulation can be aqueous suspension agent, wettable powder, water-dispersible granules.What is used is agricultural
Sterilizing agent aid includes each analog assistants such as wetting agent, dispersant, thickener, defoamer, filler, wetting agent, the dispersant of use
Can be alkylnaphthalene sulfonate formaldehyde condensation products, nekal formaldehyde condensation products, oleic acid methylaminoethyl sodium sulfonate,
Sodium lignin sulfonate, calcium lignosulfonate, alkylphenol-polyethenoxy base ether, alkylphenol-polyethenoxy base phosphate, castor oil gather
One or more in oxygen vinethene etc.；The thickener used can be xanthans, polyvinyl alcohol etc.；The defoamer used can be for
It is one or more in phosphoric acid ester defoamer and organic silicon defoamer；Used filler can be white carbon, kaolin, concave convex rod
One or more in soil etc.；
It is preferred that the active ingredient of the fluazinam and tiadinil composition accounts for the 10%~60% of bactericidal composition gross mass.
Bactericidal composition of the present invention can be used for the fungal disease of the crops such as preventing and treating rice sheath blight disease.
By to fluazinam and the tiadinil mechanism of action and the careful analysis of sterilization idiocratic, being carried out with Wadley methods
Experimental design and result treatment.Fluazinam and the single compound of tiadinil two are determined first（Hereinafter referred to as medicament）EC50,
According to the EC of two single medicaments50The portfolio ratio of two medicaments is set by Wadley methods, and according to Wadley synergy index SR values, really
Fixed suitable composition ratio, is then verified by the abundant methods of Sun Yun.
Test objective thing is rice sheath blight disease.Experiment uses colony diameter method.Fluazinam, tiadinil mother liquor are taken, is configured
Into decoction flat board is needed, per ware about 14ml, while set and compareed without medicine flat board（CK）, 3 wares of often processing repetition, that is, it is repeated 3 times.
Preculture colony edge produces the mycelia block of 5mm diameters with the card punch of sterilizing, moves on to respectively on different culture media flat board, 28 DEG C
4d is cultivated, measures colony diameter（mm）, growth inhibition ratio is calculated by following equation：
Mycelial growth inhibition rate is converted into suppression probit value（Y）, drug concentration is converted into log concentration（X）, by concentration
Logarithm is abscissa, probit value is that ordinate makees toxicity regression straight line, tries to achieve fluazinam and tiadinil single dose and its mixture pair
The virulence regression equation of Rhizoctonia solani Kuhn, and calculate EC50、EC90Value and correlation coefficient r value.
The interaction of mixture is evaluated according to Wadley methods, calculation formula is as follows：
EC50 (theoretical values) = (a+b)/(a/EC50a+ b/EC50b), SR=EC50 (theoretical values)/EC50 (actual values) 。
Wherein a, b are each component content ratios in mixture, and the effect of mixture is analyzed with SR values.SR≤0.5, then two kinds of medicines
Agent mixture has antagonism；SR=0.5~1.5, then two kinds of medicament mixtures have addition；SR >=1.5, then two kinds of medicaments mix
Equipped with synergistic effect.
The fluazinam of table 1 is with tiadinil single dose and its mixture to rice sheath blight disease toxicity test result
Data can be analyzed to obtain from table 1, and fluazinam is with tiadinil with 15：1~1：It can suppress during 15 ratio mixture
The growth of rice sheath blight disease mycelia, can be compared with the growth of high inhibition rice sheath blight disease mycelia, wherein fluazinam and tiadinil 5：1
~1:5 performance synergistic effects.Fluazinam is with tiadinil with 1:1 mixture suppresses rice sheath blight disease mycelia best results.
The present invention has preferable prevention effect to the crop fungal disease such as rice sheath blight disease, the combination of two medicaments, can reduce
Dosage, ecological disruption and environmental pollution are effectively reduced, and crop yield and quality can be improved；Fluazinam and thiophene acyl in the present invention
Bacterium amine belongs to low toxicity, to people and animals, beneficial organism safety；The resistance to the action of a drug of the germ to single medicament can be delayed.
Embodiment
Following embodiments are further explanations for present invention using as the explaination to the technology of the present invention content, but
The present invention substantive content be not limited in described in following embodiments, one of ordinary skill in the art can with and should know appoint
What simple change or replacement based on true spirit all should belong to protection domain of the presently claimed invention.
Embodiment 1
The preparation method of 60% fluazinam tiadinil suspending agent：By mass percentage.
Fluazinam 30%；
Tiadinil 30%；
Alkylnaphthalene sulfonate formaldehyde condensation products 4%；
Alkylphenol-polyethenoxy base phosphate 3%；
Xanthans 0.2%；
Organic silicon defoamer 0.4%；
Water surplus.
Preparation method：According to formula, above component is weighed in proportion, adds ball mill ball milling 30 minutes, filters, is pumped into
Dispersion tank high speed shear is fully ground after 3 minutes through sand mill, and control solid constituent particle diameter is within 2 microns, grinding knot
Stirred after beam, produce suspending agent product.Every mu of 60-80g is used to prevent and treat rice sheath blight disease effect up to more than 88%.
Embodiment 2
The preparation method of 30% fluazinam tiadinil suspending agent：By mass percentage.
Fluazinam 15%；
Tiadinil 15%；
Sodium lignin sulfonate 4%；
Alkylphenol-polyethenoxy base phosphate 3%；
Xanthans 0.2%；
Phosphate defoamer 0.3%；
Water surplus.
Preparation method, with embodiment 1.Every mu of 60-80g is used to prevent and treat rice sheath blight disease effect up to 86%.
Embodiment 3
The preparation method of 20% fluazinam tiadinil suspending agent：By mass percentage.
Fluazinam 10%；
Tiadinil 10%；
Nekal 5%；
Castor oil polyoxyethylene ether 4%；
Polyvinyl alcohol 0.2%；
Phosphate defoamer 0.4%；
Water surplus.
Preparation method, with embodiment 1.Every mu of 60-80g is used to prevent and treat rice sheath blight disease effect up to 83%.
Embodiment 4
The preparation method of 40% fluazinam tiadinil wettable powder：By mass percentage.
Fluazinam 20%；
Tiadinil 20%；
Calcium dodecyl benzene sulfonate 3%
Nekal 4%；
White carbon 10%；
Kaolin surplus；
Preparation method：Above component is added after mixer is well mixed by formula rate and carries out air-flow crushing, has been crushed
Stirred after, you can obtain wettable powder product.Every mu of 60-80g is reachable for preventing and treating rice sheath blight disease effect
86%。
Embodiment 5
The preparation method of 30% fluazinam tiadinil wettable powder：By mass percentage.
Fluazinam 15%；
Tiadinil 15%；
Alkylnaphthalene sulfonate formaldehyde condensation products 4%
Sodium lignin sulfonate 4%；
White carbon 10%；
Attapulgite surplus
Preparation method, with embodiment 4.It is about 84% that every mu of 60-80g, which is used to prevent and treat rice sheath blight disease effect,.
Embodiment 6
The preparation method of 10% fluazinam tiadinil water dispersible granules：By mass percentage.
Fluazinam 5%；
Tiadinil 5%；
Oleic acid methylaminoethyl sodium sulfonate 5%；
Calcium lignosulfonate 2%；
Polyvinyl alcohol 4%
Ammonium sulfate 8%
White carbon 10%；
Kaolin surplus；
Preparation method：Above component is added after mixer is well mixed by formula rate and carries out air-flow crushing, has been crushed
Stirred into the rear a small amount of purified water of addition, extruder grain, wettable powder product can be obtained after drying.Every mu of 60-80g
For preventing and treating rice sheath blight disease effect up to 82%.
Embodiment 7
The preparation method of 55% fluazinam tiadinil water dispersible granules：By mass percentage.
Fluazinam 5%；
Tiadinil 50%；
Oleic acid methylaminoethyl sodium sulfonate 5%；
Calcium lignosulfonate 2%；
Polyvinyl alcohol 4%
Ammonium sulfate 3%
Kaolin surplus；
Preparation method：Above component is added after mixer is well mixed by formula rate and carries out air-flow crushing, has been crushed
Stirred into the rear a small amount of purified water of addition, extruder grain, water dispersible granules product can be obtained after drying.Every mu of 60-80g
For preventing and treating rice sheath blight disease effect up to 75%.
Embodiment 8
The preparation method of 48% fluazinam tiadinil wettable powder：By mass percentage.
Fluazinam 45%；
Tiadinil 3%；
Calcium dodecyl benzene sulfonate 5%
Nekal 3%；
White carbon 6%；
Kaolin surplus；
Preparation method：Above component is added after mixer is well mixed by formula rate and carries out air-flow crushing, crushes and completes
After stir, you can wettable powder product.Every mu of 100-120g is used to prevent and treat rice sheath blight disease effect up to 73%.
Embodiment 9
The preparation method of 22% fluazinam tiadinil suspending agent：By mass percentage.
Fluazinam 2%；
Tiadinil 20%；
Nekal 2%；
Castor oil polyoxyethylene ether 3%；
Polyvinyl alcohol 0.5%；
Phosphate defoamer 0.5%；
Water surplus.
Preparation method：According to formula, above component is weighed in proportion, adds ball mill ball milling 30 minutes, filters, is pumped into
Dispersion tank high speed shear is fully ground after 3 minutes through sand mill, and control solid constituent particle diameter is within 2 microns, grinding knot
Stirred after beam, produce suspending agent product.Every mu of 60-80g is used to prevent and treat rice sheath blight disease effect up to 75%.
Embodiment 10
The preparation method of 30% fluazinam tiadinil wettable powder：By mass percentage.
Fluazinam 25%；
Tiadinil 5%；
Alkylnaphthalene sulfonate formaldehyde condensation products 4%
Calcium lignosulfonate 4%；
White carbon 10%；
Attapulgite surplus
Preparation method：Above component is added after mixer is well mixed by formula rate and carries out air-flow crushing, crushes and completes
After stir, you can wettable powder product.It is about 76% that every mu of 60-80g, which is used to prevent and treat rice sheath blight disease effect,.
Embodiment 11
The preparation method of 32% fluazinam tiadinil suspending agent：By mass percentage.
Fluazinam 2%；
Tiadinil 30%；
Sodium lignin sulfonate 5%；
Alkylphenol-polyethenoxy base phosphate 4%；
Xanthans 0.5%；
Phosphate defoamer 0.4%；
Water surplus.
Preparation method：According to formula, above component is weighed in proportion, adds ball mill ball milling 30 minutes, filters, is pumped into
Dispersion tank high speed shear is fully ground after 3 minutes through sand mill, and control solid constituent particle diameter is within 2 microns, grinding knot
Stirred after beam, produce suspending agent product.Every mu of 60-80g is used to prevent and treat rice sheath blight disease effect up to 74%.
Embodiment 12
The preparation method of 24% fluazinam tiadinil wettable powder：By mass percentage.
Fluazinam 4%；
Tiadinil 20%；
Calcium dodecyl benzene sulfonate 2%
Nekal 2%；
White carbon 4%；
Kaolin surplus；
Preparation method：Above component is added after mixer is well mixed by formula rate and carries out air-flow crushing, has been crushed
Stirred after, you can obtain wettable powder product.Every mu of 100-120g is reachable for preventing and treating rice sheath blight disease effect
78%。
Claims (5)
- A kind of 1. bactericidal composition of containing fluazinam and tiadinil, it is characterised in that：Include mass ratio for 5：1~1：5 Active component fluazinam and tiadinil.
- 2. bactericidal composition according to claim 1, it is characterised in that：It is made added with conventional agricultural bactericidal agent aid Agriculturally conventional bactericidal composition formulation.
- 3. bactericidal composition according to claim 2, it is characterised in that：Described bactericidal composition formulation is aqueous suspension Agent, wettable powder or water-dispersible granules.
- 4. bactericidal composition according to claim 2, it is characterised in that：The fluazinam and tiadinil form effective Composition accounts for the 10%~60% of bactericidal composition gross mass.
- 5. the bactericidal composition described in claim any one of 1-4 is used for the crop fungal disease for preventing and treating rice sheath blight disease.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| PL340334A1 (en) * | 1997-10-31 | 2001-01-29 | Nihon Nohyaku Co Ltd | Derivative of thiadiazolcarboxamide as an agent for fighting against plant diseases and application of that agent |
| ATE238661T1 (en) * | 1998-07-30 | 2003-05-15 | Nihon Nohyaku Co Ltd | FUNGICIDE COMPOSITION CONTAINING A 1,2,3-THIADIAZOLE DERIVATIVE AND USE THEREOF |
| CN100581362C (en) * | 2003-10-31 | 2010-01-20 | 石原产业株式会社 | Bactericide composition and method for controlling plant disease |
| CN103081924A (en) * | 2013-02-27 | 2013-05-08 | 海利尔药业集团股份有限公司 | Sterilizing composition containing enestroburin and tiadinil |
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Inventor after: Zhou Fengyan Inventor after: Sun Mingna Inventor after: Zhang Yong Inventor after: Shen Yan Inventor after: Zheng Fen Inventor after: Duan Jinsheng Inventor after: Gao Tongchun Inventor before: Zhang Yong Inventor before: Zhou Fengyan Inventor before: Shen Yan Inventor before: Zheng Fen Inventor before: Sun Mingna Inventor before: Duan Jinsheng Inventor before: Gao Tongchun |
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