CN104957149B - A kind of bactericidal composition containing zoxamide and tiadinil - Google Patents
A kind of bactericidal composition containing zoxamide and tiadinil Download PDFInfo
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- CN104957149B CN104957149B CN201510361397.1A CN201510361397A CN104957149B CN 104957149 B CN104957149 B CN 104957149B CN 201510361397 A CN201510361397 A CN 201510361397A CN 104957149 B CN104957149 B CN 104957149B
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- Prior art keywords
- tiadinil
- zoxamide
- action
- preparation
- bactericidal composition
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- SOUGWDPPRBKJEX-UHFFFAOYSA-N 3,5-dichloro-N-(1-chloro-3-methyl-2-oxopentan-3-yl)-4-methylbenzamide Chemical compound ClCC(=O)C(C)(CC)NC(=O)C1=CC(Cl)=C(C)C(Cl)=C1 SOUGWDPPRBKJEX-UHFFFAOYSA-N 0.000 title claims abstract description 52
- 239000005863 Zoxamide Substances 0.000 title claims abstract description 52
- VJQYLJSMBWXGDV-UHFFFAOYSA-N tiadinil Chemical compound N1=NSC(C(=O)NC=2C=C(Cl)C(C)=CC=2)=C1C VJQYLJSMBWXGDV-UHFFFAOYSA-N 0.000 title claims abstract description 49
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 16
- 201000010099 disease Diseases 0.000 claims abstract description 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 25
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 23
- 235000009566 rice Nutrition 0.000 claims abstract description 23
- 208000031888 Mycoses Diseases 0.000 claims abstract description 4
- 240000007594 Oryza sativa Species 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 abstract description 19
- 239000003814 drug Substances 0.000 abstract description 18
- 229940079593 drug Drugs 0.000 abstract description 7
- 230000003111 delayed effect Effects 0.000 abstract description 3
- 230000010534 mechanism of action Effects 0.000 abstract description 3
- 241001465754 Metazoa Species 0.000 abstract description 2
- 206010034133 Pathogen resistance Diseases 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 230000007423 decrease Effects 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract description 2
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- 231100000053 low toxicity Toxicity 0.000 abstract description 2
- 244000052769 pathogen Species 0.000 abstract description 2
- 230000001717 pathogenic effect Effects 0.000 abstract description 2
- 230000006806 disease prevention Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 24
- 241000209094 Oryza Species 0.000 description 21
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
- 239000013530 defoamer Substances 0.000 description 9
- 239000004563 wettable powder Substances 0.000 description 9
- 229910019142 PO4 Inorganic materials 0.000 description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 8
- 239000010452 phosphate Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000000047 product Substances 0.000 description 7
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 7
- 239000000375 suspending agent Substances 0.000 description 7
- LWEAHXKXKDCSIE-UHFFFAOYSA-M 2,3-di(propan-2-yl)naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S([O-])(=O)=O)=C(C(C)C)C(C(C)C)=CC2=C1 LWEAHXKXKDCSIE-UHFFFAOYSA-M 0.000 description 6
- 239000005995 Aluminium silicate Substances 0.000 description 6
- 235000012211 aluminium silicate Nutrition 0.000 description 6
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 description 5
- 239000007859 condensation product Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 description 5
- 239000004562 water dispersible granule Substances 0.000 description 5
- 239000003899 bactericide agent Substances 0.000 description 4
- 229920005551 calcium lignosulfonate Polymers 0.000 description 4
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 4
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- QOYXIHSMOOWKSF-XXAVUKJNSA-N CNCC[Na].C(CCCCCCC\C=C/CCCCCCCC)(=O)O Chemical compound CNCC[Na].C(CCCCCCC\C=C/CCCCCCCC)(=O)O QOYXIHSMOOWKSF-XXAVUKJNSA-N 0.000 description 3
- 241000233679 Peronosporaceae Species 0.000 description 3
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241001558929 Sclerotium <basidiomycota> Species 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 229960000892 attapulgite Drugs 0.000 description 2
- 238000000498 ball milling Methods 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 229910052625 palygorskite Inorganic materials 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241001157813 Cercospora Species 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000221785 Erysiphales Species 0.000 description 1
- 244000017020 Ipomoea batatas Species 0.000 description 1
- 235000002678 Ipomoea batatas Nutrition 0.000 description 1
- 240000008415 Lactuca sativa Species 0.000 description 1
- 235000003228 Lactuca sativa Nutrition 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 241000813090 Rhizoctonia solani Species 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- -1 toluyl Amine Chemical class 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing zoxamide and tiadinil, the mass ratio of active component zoxamide and tiadinil is 15：1~1：15.The present invention is notable to the crop fungal disease prevention effect such as rice sheath blight disease, the combination of two medicaments, can reduce dosage, effectively reduce ecological disruption and environmental pollution, and can improve crop yield and quality；Zoxamide and tiadinil belong to low toxicity in the present invention, to people and animals, beneficial organism safety；The resistance to the action of a drug of the germ to single medicament can be delayed.Zoxamide possesses different structure types and discrepant mechanism of action from tiadinil, the two is combined by a certain percentage, have bactericidal activity high in actual use, pressure is selected to caused by pathogen when zoxamide and tiadinil single dose can be avoided to be used alone to a greater extent simultaneously, the pathogen resistance to the action of a drug is delayed to produce and develop, and decline dosage total in unit area, economic, efficient, environmental protection.
Description
Technical field
The invention belongs to disinfectant use in agriculture field, and in particular to a kind of Bactericidal composite containing zoxamide and tiadinil
Thing.
Background technology
Zoxamide（English name：ZOXAMIDE molecular formula are C13H22NO5PS, structural formula are as follows：
Chemical name：(RS) -3,5-, bis- chloro- N- (the chloro- 1- ethyls -1- methyl -2- oxopropyls of 3-) are to toluyl
Amine;The mechanism of action of zoxamide be in Oomycete bactericide it is very unique, it by the combination of tubulin-subunit and
The rupture of microtubule cytoskeleton is divided to suppress sclerotium.Zoxamide do not influence travelling spore in travelling, sporangiocyst formed or sprout.
Along with first circulation of sclerotium division, the elongation of germ tube is suppressed, so as to prevent disease mattress from penetrating host plant.Preventing and treating pair
As being mainly used in preventing and treating ovum mattress guiding principle disease such as potato and tomato late blight, cucumber downy mildew and downy mildew of garpe etc.；To grape
Downy mildew has special efficacy.Speculate has certain activity to grey mould of sweet potato, lettuce disk stalk mould, the cercospora brown spot of peanut, powdery mildew etc..
Tiadinil（English common name：Tiadinil Standard）, molecular formula C11H10ClN3OS, structural formula is such as
Under：
Chemical common name is chloro- 4, the 4'- dimethyl -1,2 of 3'-, 3- thiadiazoles -5- formailides, novel absorbability
Bactericide, it is transmitted to other positions rapidly by root absorption.This medicament itself is poor to the inhibitory activity of germ, passes through prevention
The neighbouring healthy cell of germ mycelia intrusion, and can induce and produce disease-resistant gene.Suitable water reason uses, lasting period length, to leaf blast
Disease and fringe rice blast have preferable prevention effect, especially suitable for seedling cultivation of rice case.In sick medication effect at hair initial stage it is further preferred that.
The content of the invention
It is an object of the invention to provide a kind of new type bactericide composition containing zoxamide and tiadinil, for preventing
Harness the river the various crop disease such as sheath and culm blight of rice.Zoxamide possesses different structure types and discrepant effect from tiadinil
Mechanism, the two is combined by a certain percentage, it is high with bactericidal activity in actual use, while can avoid to a greater extent
Zoxamide and tiadinil single dose select pressure when being used alone to caused by pathogen, delay the pathogen resistance to the action of a drug produce and
Development, and decline dosage total in unit area, economic, efficient, environmental protection.
A kind of bactericidal composition containing zoxamide and tiadinil of the present invention, include mass ratio for 15：1~1：15
Active component zoxamide and tiadinil.
Preferably, the mass ratio of the zoxamide and tiadinil is 10：1~1：10, more preferably 1：1~1：10,
Most preferably 1:5.
Agriculturally conventional bactericidal composition is being made added with conventional agricultural bactericidal agent aid for the composition of the present invention
Formulation.
Described bactericidal composition formulation can be aqueous suspension agent, wettable powder, water-dispersible granules.What is used is agricultural
Sterilizing agent aid includes each analog assistants such as wetting agent, dispersant, thickener, defoamer, filler, wetting agent, the dispersant of use
Can be alkylnaphthalene sulfonate formaldehyde condensation products, nekal formaldehyde condensation products, oleic acid methylaminoethyl sodium sulfonate,
Sodium lignin sulfonate, calcium lignosulfonate, alkylphenol-polyethenoxy base ether, alkylphenol-polyethenoxy base phosphate, castor oil gather
One or more in oxygen vinethene etc.；The thickener used can be xanthans, polyvinyl alcohol etc.；The defoamer used can be for
It is one or more in phosphoric acid ester defoamer and organic silicon defoamer；Used filler can be white carbon, kaolin, concave convex rod
One or more in soil etc.；
It is preferred that the active ingredient of the zoxamide and tiadinil composition accounts for the 2%~60% of bactericidal composition gross mass.
Bactericidal composition of the present invention can be used for the fungal disease of the crops such as preventing and treating rice sheath blight disease.
By to zoxamide and the tiadinil mechanism of action and the careful analysis of sterilization idiocratic, entering with Wadley methods
Row experimental design and result treatment.Zoxamide and the single compound of tiadinil two are determined first（Hereinafter referred to as medicament）'s
EC50, according to the EC of two single medicaments50The portfolio ratio of two medicaments is set by Wadley methods, and according to Wadley synergy indexes
SR values, it is determined that suitable composition ratio, is then verified by the abundant methods of Sun Yun.
Test objective thing is rice sheath blight disease.Experiment uses colony diameter method.Zoxamide, tiadinil mother liquor are taken, is matched somebody with somebody
Being set to needs decoction flat board, per ware about 14ml, while sets and is compareed without medicine flat board（CK）, 3 wares of often processing repetition, that is, it is repeated 3 times.
The mycelia block of 5mm diameters is produced with the card punch of sterilizing in preculture colony edge, is moved on to respectively on different culture media flat board, 28
DEG C culture 4d, measure colony diameter（mm）, growth inhibition ratio is calculated by following equation：
Mycelial growth inhibition rate is converted into suppression probit value（Y）, drug concentration is converted into log concentration（X）, by concentration
Logarithm is abscissa, probit value is that ordinate makees toxicity regression straight line, tries to achieve zoxamide and tiadinil single dose and its mixture
To the virulence regression equation of Rhizoctonia solani Kuhn, and calculate EC50、EC90Value and correlation coefficient r value.
The interaction of mixture is evaluated according to Wadley methods, calculation formula is as follows：
EC50 (theoretical values) = (a+b)/(a/EC50a+ b/EC50b), SR=EC50 (theoretical values)/EC50 (actual values) 。
Wherein a, b are each component content ratios in mixture, and the effect of mixture is analyzed with SR values.SR≤0.5, then two kinds of medicines
Agent mixture has antagonism；SR=0.5~1.5, then two kinds of medicament mixtures have addition；SR >=1.5, then two kinds of medicaments mix
Equipped with synergistic effect.
The zoxamide of table 1 is with tiadinil single dose and its mixture to rice sheath blight disease toxicity test result
Data can be analyzed to obtain from table 1, and zoxamide is with tiadinil with 15：1~1：It can press down during 15 ratio mixture
The growth of rice sheath blight disease mycelia processed, with 1:1~1:10 ratio mixtures, can compared with the growth of high inhibition rice sheath blight disease mycelia,
Synergistic effect is showed, wherein with 1:5 synergy performance is most obvious.
The present invention has preferable prevention effect to the crop fungal disease such as rice sheath blight disease, the combination of two medicaments, can reduce
Dosage, ecological disruption and environmental pollution are effectively reduced, and crop yield and quality can be improved；Zoxamide and thiophene in the present invention
Acyl bacterium amine belongs to low toxicity, to people and animals, beneficial organism safety；The resistance to the action of a drug of the germ to single medicament can be delayed.
Embodiment
Following embodiments are further explanations for present invention using as the explaination to the technology of the present invention content, but
The present invention substantive content be not limited in described in following embodiments, one of ordinary skill in the art can with and should know appoint
What simple change or replacement based on true spirit all should belong to protection domain of the presently claimed invention.
Embodiment 1
The preparation method of 60% zoxamide tiadinil suspending agent：By mass percentage.
Zoxamide 10%；
Tiadinil 50%；
Alkylnaphthalene sulfonate formaldehyde condensation products 4%；
Alkylphenol-polyethenoxy base phosphate 3%；
Xanthans 0.2%；
Organic silicon defoamer 0.4%；
Water surplus.
Preparation method：According to formula, above component is weighed in proportion, adds ball mill ball milling 30 minutes, filters, is pumped into
Dispersion tank high speed shear is fully ground after 3 minutes through sand mill, and control solid constituent particle diameter is within 2 microns, grinding knot
Stirred after beam, produce suspending agent product.Every mu of 60-80g is used to prevent and treat rice sheath blight disease effect up to more than 88%.
Embodiment 2
The preparation method of 30% zoxamide tiadinil suspending agent：By mass percentage.
Zoxamide 5%；
Tiadinil 25%；
Sodium lignin sulfonate 4%；
Alkylphenol-polyethenoxy base phosphate 3%；
Xanthans 0.2%；
Phosphate defoamer 0.3%；
Water surplus.
Preparation method, with embodiment 1.Every mu of 60-80g is used to prevent and treat rice sheath blight disease effect up to 80%.
Embodiment 3
The preparation method of 2% zoxamide tiadinil suspending agent：By mass percentage.
Zoxamide 0.33%；
Tiadinil 1.67%；
Nekal 2%；
Castor oil polyoxyethylene ether 2%；
Polyvinyl alcohol 0.2%；
Phosphate defoamer 0.4%；
Water surplus.
Preparation method, with embodiment 1.Every mu of 60-80g is used to prevent and treat rice sheath blight disease effect up to 80%.
Embodiment 4
The preparation method of 40% zoxamide tiadinil wettable powder：By mass percentage.
Zoxamide 6.67%；
Tiadinil 33.33%；
Calcium dodecyl benzene sulfonate 3%
Nekal 4%；
White carbon 10%；
Kaolin surplus；
Preparation method：Above component is added after mixer is well mixed by formula rate and carries out air-flow crushing, has been crushed
Stirred after, you can obtain wettable powder product.Every mu of 60-80g is reachable for preventing and treating rice sheath blight disease effect
86%。
Embodiment 5
The preparation method of 30% zoxamide tiadinil wettable powder：By mass percentage.
Zoxamide 5%；
Tiadinil 25%；
Alkylnaphthalene sulfonate formaldehyde condensation products 4%
Sodium lignin sulfonate 4%；
White carbon 10%；
Attapulgite surplus
Preparation method, with embodiment 4.It is about 80% that every mu of 60-80g, which is used to prevent and treat rice sheath blight disease effect,.
Embodiment 6
The preparation method of 10% zoxamide tiadinil water dispersible granules：By mass percentage.
Zoxamide 1.67%；
Tiadinil 8.33%；
Oleic acid methylaminoethyl sodium sulfonate 5%；
Calcium lignosulfonate 2%；
Polyvinyl alcohol 4%
Ammonium sulfate 8%
White carbon 10%；
Kaolin surplus；
Preparation method：Above component is added after mixer is well mixed by formula rate and carries out air-flow crushing, has been crushed
Stirred into the rear a small amount of purified water of addition, extruder grain, water dispersible granules product can be obtained after drying.Every mu of 60-80g
For preventing and treating rice sheath blight disease effect up to 82%.
Embodiment 7
The preparation method of 40% zoxamide tiadinil wettable powder：By mass percentage.
Zoxamide 20%；
Tiadinil 20%；
Calcium dodecyl benzene sulfonate 3%
Nekal 4%；
White carbon 10%；
Kaolin surplus；
Preparation method：Above component is added after mixer is well mixed by formula rate and carries out air-flow crushing, has been crushed
Stirred after, you can obtain wettable powder product.Every mu of 100-120g is reachable for preventing and treating rice sheath blight disease effect
76%。
Embodiment 8
The preparation method of 30% zoxamide tiadinil wettable powder：By mass percentage.
Zoxamide 25%；
Tiadinil 5%；
Alkylnaphthalene sulfonate formaldehyde condensation products 4%
Calcium lignosulfonate 4%；
White carbon 10%；
Attapulgite surplus
Preparation method, with embodiment 7.It is about 74% that every mu of 60-80g, which is used to prevent and treat rice sheath blight disease effect,.
Embodiment 9
The preparation method of 55% zoxamide tiadinil water dispersible granules：By mass percentage.
Zoxamide 5%；
Tiadinil 50%；
Oleic acid methylaminoethyl sodium sulfonate 5%；
Calcium lignosulfonate 2%；
Polyvinyl alcohol 4%
Ammonium sulfate 3%
Kaolin surplus；
Preparation method：Above component is added after mixer is well mixed by formula rate and carries out air-flow crushing, has been crushed
Stirred into the rear a small amount of purified water of addition, extruder grain, water dispersible granules product can be obtained after drying.Every mu of 60-80g
For preventing and treating rice sheath blight disease effect up to 82%.
Embodiment 10
The preparation method of 22% zoxamide tiadinil suspending agent：By mass percentage.
Zoxamide 2%；
Tiadinil 20%；
Nekal 2%；
Castor oil polyoxyethylene ether 3%；
Polyvinyl alcohol 0.5%；
Phosphate defoamer 0.5%；
Water surplus.
Preparation method：According to formula, above component is weighed in proportion, adds ball mill ball milling 30 minutes, filters, is pumped into
Dispersion tank high speed shear is fully ground after 3 minutes through sand mill, and control solid constituent particle diameter is within 2 microns, grinding knot
Stirred after beam, produce suspending agent product.Every mu of 60-80g is used to prevent and treat rice sheath blight disease effect up to 75%.
Embodiment 11
The preparation method of 32% zoxamide tiadinil suspending agent：By mass percentage.
Zoxamide 2%；
Tiadinil 30%；
Sodium lignin sulfonate 5%；
Alkylphenol-polyethenoxy base phosphate 4%；
Xanthans 0.5%；
Phosphate defoamer 0.4%；
Water surplus.
Preparation method, with embodiment 10.Every mu of 60-80g is used to prevent and treat rice sheath blight disease effect up to 74%.
Embodiment 12
The preparation method of 48% zoxamide tiadinil wettable powder：By mass percentage.
Zoxamide 45%；
Tiadinil 3%；
Calcium dodecyl benzene sulfonate 5%
Nekal 3%；
White carbon 6%；
Kaolin surplus；
Preparation method：Above component is added after mixer is well mixed by formula rate and carries out air-flow crushing, has been crushed
Stirred after, you can obtain wettable powder product.Every mu of 100-120g is reachable for preventing and treating rice sheath blight disease effect
75%。
Claims (1)
1. a kind of bactericidal composition containing zoxamide and tiadinil is used for the crop fungal disease for preventing and treating rice sheath blight disease, institute
State bactericidal composition and include mass ratio for 1：5 active component zoxamide and tiadinil.
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| CN103098801A (en) * | 2013-01-17 | 2013-05-15 | 海南正业中农高科股份有限公司 | Sterilization composition containing tiadinil |
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| GAVEL 75%水分散粒剂防治黄瓜霜霉病药效试验研究;郑鹭飞等;《农药科学与管理》;20031225(第12期);全文 * |
| 新型稻田杀菌剂噻酰菌胺;赵卫光等;《农药》;20031025(第10期);全文 * |
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