CN104738078B - A kind of containing zoxamide with the bactericidal composition of Silthiopham - Google Patents
A kind of containing zoxamide with the bactericidal composition of Silthiopham Download PDFInfo
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- CN104738078B CN104738078B CN201510136263.XA CN201510136263A CN104738078B CN 104738078 B CN104738078 B CN 104738078B CN 201510136263 A CN201510136263 A CN 201510136263A CN 104738078 B CN104738078 B CN 104738078B
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- silthiopham
- zoxamide
- bactericidal composition
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Abstract
The invention discloses a kind of containing zoxamide with the bactericidal composition of Silthiopham, the mass ratio of active component zoxamide and Silthiopham is 15:1～1:15.The present invention is notable to crop fungal disease prevention effects such as wheat sharp eyespots, two medicament combinations, can reduce dosage, effectively reduce ecological disruption and environmental pollution, and can improve crop yield and quality；In the present invention, zoxamide and Silthiopham all belong to the toxicity such as low, to people and animals, beneficial organism safety；The pathogenic bacteria Drug resistance to single medicament can be delayed.Zoxamide possesses different structure types and discrepant mechanism of action from Silthiopham, the two is combined by a certain percentage, there is bactericidal activity in actual use high, the selection pressure that pathogen is caused when being used alone by zoxamide and Silthiopham single dose can be avoided to a greater extent simultaneously, pathogen Drug resistance is delayed to produce and development, and make dosage total in unit are decline, economic, efficient, environmental protection.
Description
Technical field
The invention belongs to disinfectant use in agriculture field, be specifically related to the Bactericidal composite of a kind of zoxamide and Silthiopham
Thing.
Background technology
Zoxamide (English name: ZOXAMIDE molecular formula is C13H22NO5PS, structural formula is as follows:
Chemical name: (RS)-3, the chloro-N-of 5-bis-(3-chloro-1-ethyl-1-methyl-2-oxopropyl) is to methyl benzamide；
The mechanism of action of zoxamide is unique in Oomycete antibacterial, it by the combination of tubulin-subunit and
Rupturing of microtubule cytoskeleton suppresses sclerotium to divide.Zoxamide do not affect travelling spore in travelling, sporangiocyst formed
Or sprout.Along with caryocinetic first circulation of bacterium, the elongation of germ tube is suppressed, thus stops disease mattress to penetrate
Host plant.Controlling object is mainly used in preventing and treating ovum mattress guiding principle disease such as Rhizoma Solani tuber osi and tomato late blight, cucumber downy mildew
With downy mildew of garpe etc.；Downy mildew of garpe there is specially good effect.Speculate that Caulis et Folium Lactucae sativae dish stalk is mould, and Semen arachidis hypogaeae is brown to grey mould of sweet potato
Pinta, powdery mildew etc. has certain activity.
Silthiopham (English common name: silthiopham), molecular formula is C13H21NOSSi, structural formula is as follows:
Chemical common name is N-pi-allyl-4,5-dimethyl-2-(TMS) thiophene-3-Methanamide, research
Show that it is inhibitor of energy: be probably ATP inhibitor.Having good protection activity, the longevity of residure is long.Suitably
Crop and to the safety Semen Tritici aestivi of crop, to crop, mammal, Environmental security.Controlling object Semen Tritici aestivi total eclipse
Sick.Using method mainly makees seed treatment, strong inhibition take-all of dressing seed.
Summary of the invention
It is an object of the invention to provide a kind of new type bactericide compositions containing zoxamide and Silthiopham, use
In various crop diseases such as preventing and treating wheat sharp eyespots.Zoxamide possess from Silthiopham different structure types and
Discrepant mechanism of action, combines by a certain percentage by the two, has bactericidal activity in actual use high, simultaneously
The selection pressure that pathogen is caused when being used alone by zoxamide and Silthiopham single dose can be avoided to a greater extent
Power, delays pathogen Drug resistance to produce and development, and makes dosage total in unit are decline, economical, efficient,
Environmental protection.
The present invention a kind of is containing zoxamide with the bactericidal composition of Silthiopham, and including mass ratio is 15:1～1:
The active component zoxamide of 15 and Silthiopham.
Preferably, the mass ratio of described zoxamide and Silthiopham is 10:1～1:5, more preferably 5:
1～1:10, more preferably 1:1～1:10.
The compositions of the present invention makes agriculturally conventional bactericidal composition being added with conventional agricultural bactericidal agent aid
Dosage form.
Described bactericidal composition dosage form can be aqueous suspension agent, wettable powder, water-dispersible granules.Use
Agricultural bactericidal agent aid includes each analog assistants such as wetting agent, dispersant, thickening agent, defoamer, filler, employing
Wetting agent, dispersant can be sodium lignin sulfonate, calcium lignosulfonate, naphthalenesulfonic acid-formaldehyde condensate, two fourths
Base naphthalenesulfonic acid-formaldehyde condensate, oleic acid methylaminoethyl sodium sulfonate, alkylphenol-polyethenoxy base ether, alkyl phenol
One or more in polyoxyethylene groups phosphate ester, castor oil polyoxyethylene ether etc.；The thickening agent used can be yellow
Virgin rubber, polyvinyl alcohol etc.；The defoamer used can be a kind of or many in phosphoric acid ester defoamer and organic silicon defoamer
Kind；The filler used can be one or more in white carbon, Kaolin, attapulgite etc.；
The effective ingredient of the most described zoxamide and Silthiopham element composition accounts for bactericidal composition gross mass
10%～60%.
Bactericidal composition of the present invention can be used for preventing and treating the fungal disease of the crops such as wheat sharp eyespot.
By to zoxamide and the Silthiopham mechanism of action and the careful analysis of sterilization idiocratic, use Wadley side
Method carries out EXPERIMENTAL DESIGN and result treatment.First measure zoxamide and Silthiopham two single compound is (following
Be called for short medicament) EC50, according to the EC of two single medicaments50The portfolio ratio of two medicaments is set by Wadley method, and
According to Wadley potentiation index SR value, determine suitable compositions ratio, then verified by the abundant method of Sun Yun.
Test objective thing is wheat sharp eyespot.Test uses colony diameter method.Take zoxamide, Silthiopham mother
Liquid, is configured to need medicinal liquid flat board, every ware about 14ml, arranges simultaneously and compares (CK) without medicine flat board, often processes repetition 3
Ware, is i.e. repeated 3 times.The mycelia block of 5mm diameter produced by card punch in preculture colony edge sterilizing, respectively
Move on on different culture media flat board, cultivate 4d, measure colony diameter (mm) for 28 DEG C, following equation calculate growth
Suppression ratio:
Mycelial growth inhibition rate is converted into suppression probit value (Y), and drug concentration is converted into log concentration (X), presses
Log concentration be abscissa, probit value be that vertical coordinate makees toxicity regression straight line, try to achieve zoxamide and Silthiopham list
Agent and the mixture virulence regression equation to rhizoctonia cerealis thereof, and calculate EC50、EC90Value and correlation coefficient r value.
Evaluate the interaction of mixture according to Wadley method, computing formula is as follows:
EC50 (theoretical values)=(a+b)/(a/EC50a+b/EC50b), SR=EC50 (theoretical values)/EC50 (actual values)。
Wherein a, b are each component content ratio in mixture, analyze the effect of mixture with SR value.SR≤0.5, then
Two kinds of medicament mixtures have antagonism；SR=0.5～1.5, then two kinds of medicament mixtures have addition；SR >=1.5,
Then two kinds of medicament mixtures have potentiation.
Table 1 zoxamide and Silthiopham single dose and mixture thereof are to wheat sharp eyespot toxicity test result
From table 1, data can be analyzed and obtain, when zoxamide and Silthiopham are with 15:1～1:15 ratio mixture
The growth of wheat sharp eyespot mycelia can be suppressed, with 1:5 ratio mixture, it is possible to relatively high inhibition wheat sharp eyespot mycelia
Growth, shows potentiation.
The present invention has preferable prevention effect to crop fungal diseases such as wheat sharp eyespots, and two medicament combinations can reduce
Dosage, effectively reduces ecological disruption and environmental pollution, and can improve crop yield and quality；Benzoyl in the present invention
Bacterium amine and Silthiopham all belong to the toxicity such as low, to people and animals, beneficial organism safety；Pathogenic bacteria can be delayed single medicament
Drug resistance.
Detailed description of the invention
Following embodiment is to further illustrate using as the explaination to the technology of the present invention content for present invention,
But the flesh and blood of the present invention is not limited in described in following embodiment, those of ordinary skill in the art can and should
When know any simple change based on true spirit or replace all should belong to protection model of the presently claimed invention
Enclose.
Embodiment 1
The preparation method of 30% zoxamide Silthiopham suspending agent: by mass percentage.
Preparation method: according to formula, above component weighed in proportion, adds ball mill ball milling 30 minutes, filters, takes out
Be fully ground through sand mill after entering dispersion tank high speed shear 3 minutes, control solid constituent particle diameter 2 microns with
In, grind and stir after terminating, obtain suspending agent product.Every mu of 60-80g is used for preventing and treating wheat sharp eyespot effect
Up to more than 88%.
Embodiment 2
The preparation method of 30% zoxamide Silthiopham suspending agent: by mass percentage.
Preparation method, with embodiment 1.Every mu of 60-80g is used for preventing and treating wheat sharp eyespot effect up to 90%.
Embodiment 3
The preparation method of 33% zoxamide Silthiopham suspending agent: by mass percentage.
Preparation method, with embodiment 1.Every mu of 60-80g is used for preventing and treating wheat sharp eyespot effect up to 80%.
Embodiment 4
The preparation method of 50% zoxamide Silthiopham wettable powder: by mass percentage.
Preparation method: above component being pressed formula proportion and adds mixer mix homogeneously laggard row comminution by gas stream, pulverizing completes
After stir, wettable powder product.Every mu of 60-80g is used for preventing and treating wheat sharp eyespot effect can
Reach 86%.
Embodiment 5
The preparation method of 30% zoxamide Silthiopham wettable powder: by mass percentage.
Preparation method, with embodiment 4.Every mu of 60-80g is used for preventing and treating wheat sharp eyespot effect and is about 80%.
Embodiment 6
The preparation method of 12% zoxamide Silthiopham water dispersible granules: by mass percentage.
Preparation method: above component being pressed formula proportion and adds mixer mix homogeneously laggard row comminution by gas stream, pulverizing completes
The a small amount of purified water of rear addition stirs, extruder grain, after drying water dispersible granules product.Every mu
80-100g is used for preventing and treating wheat sharp eyespot effect up to 80%.
Claims (5)
1. one kind contains zoxamide and the bactericidal composition of Silthiopham, it is characterised in that: include active component zoxamide and Silthiopham that mass ratio is 1:5.
Bactericidal composition the most according to claim 1, it is characterised in that: it is added with conventional agricultural bactericidal agent aid and makes agriculturally conventional bactericidal composition dosage form.
Bactericidal composition the most according to claim 2, it is characterised in that: described bactericidal composition dosage form is aqueous suspension agent, wettable powder, water-dispersible granules.
Bactericidal composition the most according to claim 2, it is characterised in that: the effective ingredient of described zoxamide and Silthiopham composition accounts for the 10%～60% of bactericidal composition gross mass.
5. the bactericidal composition described in any one of claim 1-4 is for preventing and treating the crop fungal disease of wheat sharp eyespot.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510136263.XA CN104738078B (en) | 2015-03-25 | 2015-03-25 | A kind of containing zoxamide with the bactericidal composition of Silthiopham |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510136263.XA CN104738078B (en) | 2015-03-25 | 2015-03-25 | A kind of containing zoxamide with the bactericidal composition of Silthiopham |
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| Publication Number | Publication Date |
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| CN104738078A CN104738078A (en) | 2015-07-01 |
| CN104738078B true CN104738078B (en) | 2016-09-14 |
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| CN201510136263.XA Expired - Fee Related CN104738078B (en) | 2015-03-25 | 2015-03-25 | A kind of containing zoxamide with the bactericidal composition of Silthiopham |
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Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647435A (en) * | 2009-07-21 | 2010-02-17 | 深圳诺普信农化股份有限公司 | Synthetical sterilization composition |
| CN103210907A (en) * | 2013-03-24 | 2013-07-24 | 广东中迅农科股份有限公司 | Zoxamide water suspension and preparation method thereof |
| CN104247716B (en) * | 2013-06-29 | 2016-02-24 | 深圳诺普信农化股份有限公司 | A kind of composition containing Silthiopham |
| CN104381293B (en) * | 2014-11-03 | 2016-05-25 | 安徽省农业科学院植物保护与农产品质量安全研究所 | A kind of bactericidal composition containing Silthiopham and jinggangmeisu |
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