CN104738078A - Bactericidal composition containing zoxamide and silthiopham - Google Patents
Bactericidal composition containing zoxamide and silthiopham Download PDFInfo
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- CN104738078A CN104738078A CN201510136263.XA CN201510136263A CN104738078A CN 104738078 A CN104738078 A CN 104738078A CN 201510136263 A CN201510136263 A CN 201510136263A CN 104738078 A CN104738078 A CN 104738078A
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- silthiopham
- zoxamide
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Abstract
The invention discloses a bactericidal composition containing zoxamide and silthiopham, wherein the mass ratio of zoxamide to silthiopham, which are taken as active components, is 15:1 to 1:15. The bactericidal composition disclosed by the invention is remarkable in the effects of preventing and treating crop fungal diseases such as wheat sharp eyespot disease, and the two chemicals of zoxamide and silthiopham are co-used, so that a dosage can be reduced, ecological damages and environmental pollution can be effectively reduced, and crop yield and quality can be improved; zoxamide and silthiopham in the bactericidal composition disclosed by the invention are both low in toxicity, and safe to people and livestock as well as beneficial organisms; the drug resistance of germs to a single chemical can be delayed. Zoxamide and silthiopham have different structure types and action mechanisms with a difference, and by combining zoxamide and silthiopham in a certain ratio, the bactericidal composition is high in bactericidal activity in actual use, is capable of avoiding the selective pressure caused on pathogens when zoxamide and silthiopham are independently used to a higher extent, delaying the generation and development of the drug resistance of the pathogens, and reducing a total dosage in unit area, and is economic, efficient, and environmentally friendly.
Description
Technical field
The invention belongs to disinfectant use in agriculture field, be specifically related to the bactericidal composition of a kind of zoxamide and Silthiopham.
Background technology
Zoxamide (English name: ZOXAMIDE molecular formula is C
13h
22nO
5pS, structural formula is as follows:
Chemical name: (RS)-3,5-bis-chloro-N-(the chloro-1-ethyl of 3--1-methyl-2-oxopropyl) to methyl benzamide; The mechanism of action of zoxamide is very unique in Oomycete bactericide, and it suppresses sclerotium to divide by the combination of tubulin-subunit and breaking of microtubule cytoskeleton.Zoxamide do not affect travelling spore in travelling, sporangiocyst formed or sprout.Along with caryocinetic first circulation of bacterium, the elongation of germ tube is suppressed, thus stops disease mattress to penetrate host plant.Controlling object is mainly used in control ovum mattress guiding principle disease as potato and tomato late blight, cucumber downy mildew and downy mildew of garpe etc.; Special efficacy is had to downy mildew of garpe.Infer grey mould of sweet potato, lettuce dish stalk is mould, and the cercospora brown spot of peanut, powdery mildew etc. have certain activity.
Silthiopham (English common name: silthiopham), molecular formula is C
13h
21nOSSi, structural formula is as follows:
Chemical common name is N-pi-allyl-4,5-dimethyl-2-(TMS) thiophene-3-formamide, and research shows that it is inhibitor of energy: may be ATP inhibitor.Have good prolection, the longevity of residure is long.Suitable for crop and to the safety wheat of crop, to crop, mammal, Environmental security.Controlling object take-all.Using method mainly makes seed treatment, seed dressing strong inhibition take-all.
Summary of the invention
The object of the present invention is to provide a kind of new type bactericide composition containing zoxamide and Silthiopham, for preventing and treating the various crop diseases such as wheat sharp eyespot.Zoxamide and Silthiopham possess different structure types and discrepant mechanism of action, the two is combined by a certain percentage, there is bactericidal activity in actual use high, simultaneously can when avoiding zoxamide to a greater extent and Silthiopham single dose is used alone to the selection pressure that pathogen causes, delay pathogen pesticide resistance emergence and development, and dosage total in unit are is declined, economic, efficient, environmental protection.
A kind of bactericidal composition containing zoxamide and Silthiopham of the present invention, includes active component zoxamide and Silthiopham that mass ratio is 15:1 ~ 1:15.
Preferably, the mass ratio of described zoxamide and Silthiopham is 10:1 ~ 1:5, more preferably 5:1 ~ 1:10, is more preferably 1:1 ~ 1:10.
Composition of the present invention makes agriculturally conventional bactericidal composition formulation being added with conventional agricultural bactericidal agent aid.
Described bactericidal composition formulation can be aqueous suspension agent, wetting powder, water-dispersible granules.The agricultural bactericidal agent aid adopted comprises each analog assistants such as wetting agent, dispersant, thickener, defoamer, filler, the wetting agent adopted, dispersant can be sodium lignin sulfonate, calcium lignosulfonate, naphthalenesulfonic acid-formaldehyde condensate, nekal formaldehyde condensation products, oleic acid methylaminoethyl sodium sulfonate, one or more in alkylphenol-polyethenoxy base ether, alkylphenol-polyethenoxy base phosphate, castor oil polyoxyethylene ether etc.; The thickener adopted can be xanthans, polyvinyl alcohol etc.; The defoamer adopted to can be in phosphoric acid ester defoamer and silicone defoaming agent one or more; The filler adopted can be in white carbon, kaolin, attapulgite etc. one or more;
The active ingredient of preferred described zoxamide and Silthiopham element composition accounts for 10% ~ 60% of bactericidal composition gross mass.
Bactericidal composition of the present invention can be used for the fungal disease preventing and treating the crops such as wheat sharp eyespot.
By the careful analysis to zoxamide and the Silthiopham mechanism of action and sterilization idiocratic, Wadley method is used to carry out experimental scheme and result treatment.First the EC of zoxamide and Silthiopham two single compound (hereinafter referred to as medicament) is measured
50, according to the EC of two single medicaments
50set the portfolio ratio of two medicaments by Wadley method, and according to Wadley synergy index SR value, determine suitable composition ratio, then verified by the abundant method of Sun Yun.
Test objective thing is wheat sharp eyespot.Test adopts colony diameter method.Get zoxamide, Silthiopham mother liquor, be configured to need liquid dull and stereotyped, every ware is about 14ml, arranges without medicine flat board contrast (CK) simultaneously, often processes repetition 3 ware, namely repeat 3 times.Produce the mycelia block of 5mm diameter at the card punch of preculture colony edge sterilizing, move on on different culture media flat board respectively, cultivate 4d, measure colony diameter (mm), by following formulae discovery growth inhibition ratio for 28 DEG C:
Mycelial growth inhibition rate is converted into and suppresses probit value (Y), drug concentration is converted into log concentration (X), by log concentration be abscissa, probit value is that ordinate makes toxicity regression straight line, try to achieve zoxamide and Silthiopham single dose and mixture thereof to the virulence regression equation of rhizoctonia cerealis, and calculate EC
50, EC
90value and correlation coefficient r value.
According to the interaction of Wadley method evaluation mixture, computing formula is as follows:
EC
50 (theoretical values)=(a+b)/(a/EC
50a+ b/EC
50b), SR=EC
50 (theoretical values)/ EC
50 (real values).
Wherein a, b are each component content ratio in mixture, analyze the effect of mixture with SR value.SR≤0.5, then two kinds of medicament mixtures have antagonism; SR=0.5 ~ 1.5, then two kinds of medicament mixtures have addition; SR >=1.5, then two kinds of medicament mixtures have synergistic effect.
Table 1 zoxamide and Silthiopham single dose and mixture thereof are to wheat sharp eyespot toxicity test result
From table 1, data can be analyzed and obtain, and zoxamide and Silthiopham, can suppress the growth of wheat sharp eyespot mycelia during 15:1 ~ 1:15 ratio mixture, with 1:5 ratio mixture, compared with the growth of high inhibition wheat sharp eyespot mycelia, can show synergistic effect.
The present invention has good control efficiency to crop fungal diseases such as wheat sharp eyespots, and two medicament couplings can reduce dosage, effectively reduces ecological disruption and environmental pollution, and can improve crop yield and quality; In the present invention, zoxamide and Silthiopham all belong to the toxicity such as low, to people and animals, beneficial organism safety; The pesticide resistance of germ to single medicament can be delayed.
Embodiment
Following embodiment further illustrates using as the explaination to the technology of the present invention content for content of the present invention; but flesh and blood of the present invention is not limited in described in following embodiment, those of ordinary skill in the art can and should know any simple change based on connotation of the present invention or replace all should belong to protection domain of the presently claimed invention.
Embodiment 1
The preparation method of 30% zoxamide Silthiopham suspending agent: by mass percentage.
Preparation method: according to formula, weighs in proportion by above component, adds ball mill ball milling 30 minutes, filter, suction dispersion tank high speed shear was fully ground through sand mill after 3 minutes, controlled solid constituent particle diameter within 2 microns, stir after grinding terminates, obtain suspending agent product.Every mu of 60-80g can reach more than 88% for preventing and treating wheat sharp eyespot effect.
Embodiment 2
The preparation method of 30% zoxamide Silthiopham suspending agent: by mass percentage.
Preparation method, with embodiment 1.Every mu of 60-80g can reach 90% for preventing and treating wheat sharp eyespot effect.
Embodiment 3
The preparation method of 33% zoxamide Silthiopham suspending agent: by mass percentage.
Preparation method, with embodiment 1.Every mu of 60-80g can reach 80% for preventing and treating wheat sharp eyespot effect.
Embodiment 4
The preparation method of 50% zoxamide Silthiopham wetting powder: by mass percentage.
Preparation method: above component is added mixer by formula rate and mixes laggard row air-flow crushing, stir after having pulverized, wetting powder product.Every mu of 60-80g can reach 86% for preventing and treating wheat sharp eyespot effect.
Embodiment 5
The preparation method of 30% zoxamide Silthiopham wetting powder: by mass percentage.
Preparation method, with embodiment 4.Every mu of 60-80g is about 80% for preventing and treating wheat sharp eyespot effect.
Embodiment 6
The preparation method of 12% zoxamide Silthiopham water dispersible granules: by mass percentage.
Preparation method: above component is added mixer by formula rate and mixes laggard row air-flow crushing, add a small amount of purified water after having pulverized and stir, extruder grain, after oven dry water dispersible granules product.Every mu of 80-100g can reach 80% for preventing and treating wheat sharp eyespot effect.
Claims (7)
1. contain a bactericidal composition for zoxamide and Silthiopham, it is characterized in that: include active component zoxamide and Silthiopham that mass ratio is 15:1 ~ 1:15.
2. bactericidal composition according to claim 1, is characterized in that: the mass ratio of described zoxamide and Silthiopham is 5:1 ~ 1:10.
3. bactericidal composition according to claim 2, is characterized in that: the mass ratio of described zoxamide and Silthiopham is 1:1 ~ 1:10.
4. the bactericidal composition according to any one of claim 1-3, is characterized in that: be added with conventional agricultural bactericidal agent aid and make agriculturally conventional bactericidal composition formulation.
5. bactericidal composition according to claim 4, is characterized in that: described bactericidal composition formulation is aqueous suspension agent, wetting powder, water-dispersible granules.
6. bactericidal composition according to claim 4, is characterized in that: the active ingredient of described zoxamide and Silthiopham composition accounts for 10% ~ 60% of bactericidal composition gross mass.
7. the bactericidal composition described in any one of claim 1-6 is for preventing and treating the crop fungal disease of wheat sharp eyespot.
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|---|---|---|---|
| CN201510136263.XA CN104738078B (en) | 2015-03-25 | 2015-03-25 | A kind of containing zoxamide with the bactericidal composition of Silthiopham |
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|---|---|---|---|
| CN201510136263.XA CN104738078B (en) | 2015-03-25 | 2015-03-25 | A kind of containing zoxamide with the bactericidal composition of Silthiopham |
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| CN104738078B CN104738078B (en) | 2016-09-14 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647435A (en) * | 2009-07-21 | 2010-02-17 | 深圳诺普信农化股份有限公司 | Synthetical sterilization composition |
| CN103210907A (en) * | 2013-03-24 | 2013-07-24 | 广东中迅农科股份有限公司 | Zoxamide water suspension and preparation method thereof |
| CN104247716A (en) * | 2013-06-29 | 2014-12-31 | 深圳诺普信农化股份有限公司 | Silthiopham-containing composition |
| CN104381293A (en) * | 2014-11-03 | 2015-03-04 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Fungicidal composition containing silthiopham and validamycin |
-
2015
- 2015-03-25 CN CN201510136263.XA patent/CN104738078B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647435A (en) * | 2009-07-21 | 2010-02-17 | 深圳诺普信农化股份有限公司 | Synthetical sterilization composition |
| CN103210907A (en) * | 2013-03-24 | 2013-07-24 | 广东中迅农科股份有限公司 | Zoxamide water suspension and preparation method thereof |
| CN104247716A (en) * | 2013-06-29 | 2014-12-31 | 深圳诺普信农化股份有限公司 | Silthiopham-containing composition |
| CN104381293A (en) * | 2014-11-03 | 2015-03-04 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Fungicidal composition containing silthiopham and validamycin |
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