CN104719307A - Fungicidal composition containing probenazole and 2-cyano-3-amino-3-ethyl phenylacrylate - Google Patents
Fungicidal composition containing probenazole and 2-cyano-3-amino-3-ethyl phenylacrylate Download PDFInfo
- Publication number
- CN104719307A CN104719307A CN201510135057.7A CN201510135057A CN104719307A CN 104719307 A CN104719307 A CN 104719307A CN 201510135057 A CN201510135057 A CN 201510135057A CN 104719307 A CN104719307 A CN 104719307A
- Authority
- CN
- China
- Prior art keywords
- cyano
- amino
- probenazole
- bactericidal composition
- ethyl phenylacrylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a fungicidal composition containing probenazole and 2-cyano-3-amino-3-ethyl phenylacrylate, which is characterized in that probenazole and 2-cyano-3-amino-3-ethyl phenylacrylate are the active constituents, and a mass ratio of probenazole to 2-cyano-3-amino-3-ethyl phenylacrylate is (15:1)-(1:15). According to the fungicidal composition, probenazole and 2-cyano-3-amino-3-ethyl phenylacrylate are combined for use, so that the dosage can be reduced; ecological damages and environmental pollution can be reduced effectively; the crop yield and the quality can be increased and improved; probenazole and 2-cyano-3-amino-3-ethyl phenylacrylate in the fungicidal composition have low toxicity, and are safe to people, livestock and beneficial organisms; the drug resistance of a germ to a single drug can be delayed; probenazole and 2-cyano-3-amino-3-ethyl phenylacrylate have different mechanisms of action, and are combined according to certain ratio, so that the fungicidal activity is high; the generation and development of the drug resistance of a pathogen can be delayed; the fungicidal composition has high fungicidal activity during actual use; in addition, the selection pressure on the pathogen due to single-dose exclusive use of probenazole or 2-cyano-3-amino-3-ethyl phenylacrylate can be avoided to a greater degree; the total dosage in a unit area can be reduced; and the fungicidal composition is economical, efficient and environmentally friendly.
Description
Technical field
The invention belongs to disinfectant use in agriculture field, be specifically related to the bactericidal composition of a kind of probenazole and 2-cyano-3-amino-3-phenylancryic acetate.
Background technology
Probenazole has another name called allyl isothiazole (English name: probenazole molecular formula is C
10h
9nO
3s, structural formula is as follows:
Chemical name: allyl isothiazole; 3-(2-acrylic oxygen base)-1,2-benzisothiazole 1,1-dioxide; This medicine is different from normal sterile agent mechanism, can not directly act on pathogen, but the activity of inducing plant resistance enzyme improves after plant absorption, lignin synthesis strengthens, to stop the intrusion of pathogen, the growth of mycelia and the formation of spore, thus reach the effect of diseases prevention.Controlling object is mainly used in preventing and treating wheat diseases, as rice blast and white wheat leaf blight.
(molecular formula is C to 2-cyano-3-amino-3-phenylancryic acetate
12h
12n
2o
2), structural formula is as follows:
Chemical name: 2-cyano group-3-amino-3-phenyl cinnamic acid ethyl ester; Belong to original creativity invention.This compound belongs to cyanoacrylate; efficiently, micro-poison, low-residual, environmentally friendly; to being had protection and therapeutic action by the microbial all kinds of plant disease of reaping hook, can be applicable to the microbial wheat scab of control reaping hook, cotton wilt, banana Panama disease, wheat bakanae disease, watermelon blight etc.
Summary of the invention
The present invention proposes a kind of new type bactericide composition containing probenazole and 2-cyano-3-amino-3-phenylancryic acetate, for preventing and treating the various crop diseases such as wheat scab.Probenazole and 2-cyano-3-amino-3-phenylancryic acetate possess different structure types and discrepant mechanism of action, the two are combined by a certain percentage, can delay pathogen pesticide resistance emergence and development, and dosage total in unit are is declined, economic, efficient, environmental protection.
A kind of bactericidal composition containing probenazole and 2-cyano-3-amino-3-phenylancryic acetate of the present invention, it includes active component probenazole and 2-cyano-3-amino-3-phenylancryic acetate that mass ratio is 15:1 ~ 1:15, and preferred mass, than being 5:1 ~ 1:10, is more preferably 1:1 ~ 1:10.
Be added with conventional agricultural bactericidal agent aid in described composition and make agriculturally conventional bactericidal composition formulation.
Described bactericidal composition formulation is aqueous suspension agent, wetting powder, water-dispersible granules.The agricultural bactericidal agent aid adopted comprises each analog assistants such as wetting agent, dispersant, surfactant, thickener, defoamer, filler, the wetting agent adopted, dispersant can be alkylnaphthalene sulfonate formaldehyde condensation products, nekal formaldehyde condensation products, oleic acid methylaminoethyl sodium sulfonate, one or more in sodium lignin sulfonate, calcium lignosulfonate, alkylphenol-polyethenoxy base ether, alkylphenol-polyethenoxy base phosphate, castor oil polyoxyethylene ether etc.; The thickener adopted can be xanthans, polyvinyl alcohol etc.; The defoamer adopted to can be in phosphoric acid ester defoamer and silicone defoaming agent one or more; The filler adopted can be in white carbon, kaolin, attapulgite etc. one or more;
Preferably, the active ingredient of described probenazole and 2-cyano-3-amino-3-phenylancryic acetate composition accounts for 10% ~ 60% of bactericidal composition gross mass.
Bactericidal composition of the present invention can be used for the crop fungal disease preventing and treating wheat scab.
By the careful analysis to probenazole and the 2-cyano-3-amino-3-phenylancryic acetate mechanism of action and sterilization idiocratic, Wadley method is used to carry out experimental scheme and result treatment.First the EC of probenazole and 2-cyano-3-amino-3-phenylancryic acetate two single compound (hereinafter referred to as medicament) is measured
50, according to the EC of two single medicaments
50set the portfolio ratio of two medicaments by Wadley method, and according to Wadley synergy index SR value, determine suitable composition ratio, then verified by the abundant method of Sun Yun.
Test objective thing is wheat scab.Test adopts colony diameter method.Get probenazole, 2-cyano-3-amino-3-phenylancryic acetate mother liquor, be configured to need liquid dull and stereotyped, every ware is about 14ml, arranges without medicine flat board contrast (CK) simultaneously, often processes repetition 3 ware, namely repeat 3 times.Produce the mycelia block of 5mm diameter at the card punch of preculture colony edge sterilizing, move on on different culture media flat board respectively, cultivate 4d, measure colony diameter (mm), by following formulae discovery growth inhibition ratio for 28 DEG C:
Mycelial growth inhibition rate is converted into and suppresses probit value (Y), drug concentration is converted into log concentration (X), by log concentration be abscissa, probit value is that ordinate makes toxicity regression straight line, try to achieve probenazole and 2-cyano-3-amino-3-phenylancryic acetate single dose and mixture thereof to the virulence regression equation of fusarium graminearum, and calculate EC
50, EC
90value and correlation coefficient r value.
According to the interaction of Wadley method evaluation mixture, computing formula is as follows:
EC
50 (theoretical values)=(a+b)/(a/EC
50a+ b/EC
50b), SR=EC
50 (theoretical values)/ EC
50 (real values).
Wherein a, b are each component content ratio in mixture, analyze the effect of mixture with SR value.SR≤0.5, then two kinds of medicament mixtures have antagonism; SR=0.5 ~ 1.5, then two kinds of medicament mixtures have addition; SR >=1.5, then two kinds of medicament mixtures have synergistic effect.
Table 1 probenazole and 2-cyano-3-amino-3-phenylancryic acetate single dose and mixture thereof are to wheat scab toxicity test result
From table 1, data can be analyzed and obtain, and probenazole and 2-cyano-3-amino-3-phenylancryic acetate, can suppress the growth of wheat scab mycelia during 15:1 ~ 1:15 ratio mixture, with 1:10 ratio mixture, compared with the growth of high inhibition wheat scab mycelia, can show synergistic effect.
The present invention has good control efficiency to crop fungal diseases such as wheat scabs, and two medicament couplings can reduce dosage, effectively reduces ecological disruption and environmental pollution, and can improve crop yield and quality; In the present invention, probenazole and 2-cyano-3-amino-3-phenylancryic acetate all belong to the toxicity such as low, to people and animals, beneficial organism safety; The pesticide resistance of germ to single medicament can be delayed.
Embodiment
Following embodiment further illustrates using as the explaination to the technology of the present invention content for content of the present invention; but flesh and blood of the present invention is not limited in described in following embodiment, those of ordinary skill in the art can and should know any simple change based on connotation of the present invention or replace all should belong to protection domain of the presently claimed invention.
Embodiment 1
The preparation method of 30% probenazole 2-cyano-3-amino-3-phenylancryic acetate suspending agent: by mass percentage.
Preparation method: according to formula, weighs in proportion by above component, adds ball mill ball milling 30 minutes, filter, suction dispersion tank high speed shear was fully ground through sand mill after 3 minutes, controlled solid constituent particle diameter within 2 microns, stir after grinding terminates, obtain suspending agent product.Every mu of 60-80g is used for preventing and treating wheat scab effect and can reaches more than 88%.
Embodiment 2
The preparation method of 33% probenazole 2-cyano-3-amino-3-phenylancryic acetate suspending agent: by mass percentage.
Preparation method, with embodiment 1.Every mu of 60-80g is used for preventing and treating wheat scab effect and can reaches 85%.
Embodiment 3
The preparation method of 20% probenazole 2-cyano-3-amino-3-phenylancryic acetate suspending agent: by mass percentage.
Preparation method, with embodiment 1.Every mu of 60-80g is used for preventing and treating wheat scab effect and can reaches 80%.
Embodiment 4
The preparation method of 30% probenazole 2-cyano-3-amino-3-phenylancryic acetate wetting powder: by mass percentage.
Preparation method: above component is added mixer by formula rate and mixes laggard row air-flow crushing, stir after having pulverized, wetting powder product.Every mu of 60-80g is used for preventing and treating wheat scab effect and can reaches 86%.
Embodiment 5
The preparation method of 50% probenazole 2-cyano-3-amino-3-phenylancryic acetate wetting powder: by mass percentage.
Preparation method, with embodiment 4.Every mu of 60-80g is used for preventing and treating wheat scab effect and is about 80%.
Embodiment 6
The preparation method of 6% probenazole 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules: by mass percentage.
Preparation method: above component is added mixer by formula rate and mixes laggard row air-flow crushing, add a small amount of purified water after having pulverized and stir, extruder grain, after oven dry water dispersible granules product.Every mu of 100-120g is used for preventing and treating wheat scab effect and can reaches 80%.
Claims (7)
1. contain a bactericidal composition for probenazole and 2-cyano-3-amino-3-phenylancryic acetate, it is characterized in that: include active component probenazole and 2-cyano-3-amino-3-phenylancryic acetate that mass ratio is 15:1 ~ 1:15.
2. bactericidal composition according to claim 1, is characterized in that: the mass ratio of described probenazole and 2-cyano-3-amino-3-phenylancryic acetate is 5:1 ~ 1:10.
3. bactericidal composition according to claim 2, is characterized in that: the mass ratio of described probenazole and 2-cyano-3-amino-3-phenylancryic acetate is 1:1 ~ 1:10.
4. the bactericidal composition according to any one of claim 1-3, is characterized in that: be added with conventional agricultural bactericidal agent aid and make agriculturally conventional bactericidal composition formulation.
5. bactericidal composition according to claim 4, is characterized in that: described bactericidal composition formulation is aqueous suspension agent, wetting powder, water-dispersible granules.
6. bactericidal composition according to claim 4, is characterized in that: the active ingredient of described probenazole and 2-cyano-3-amino-3-phenylancryic acetate composition accounts for 10% ~ 60% of bactericidal composition gross mass.
7. the bactericidal composition described in any one of claim 1-6 is for preventing and treating the crop fungal disease of wheat scab.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510135057.7A CN104719307A (en) | 2015-03-25 | 2015-03-25 | Fungicidal composition containing probenazole and 2-cyano-3-amino-3-ethyl phenylacrylate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510135057.7A CN104719307A (en) | 2015-03-25 | 2015-03-25 | Fungicidal composition containing probenazole and 2-cyano-3-amino-3-ethyl phenylacrylate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104719307A true CN104719307A (en) | 2015-06-24 |
Family
ID=53444181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510135057.7A Pending CN104719307A (en) | 2015-03-25 | 2015-03-25 | Fungicidal composition containing probenazole and 2-cyano-3-amino-3-ethyl phenylacrylate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104719307A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1623390A (en) * | 2004-10-27 | 2005-06-08 | 江苏省农药研究所有限公司 | Application of 2-cydno-3-amino-3-phenylethyl acrylate for preventing and treating patty rice bakanae disease |
| CN103636615A (en) * | 2013-01-17 | 2014-03-19 | 海南正业中农高科股份有限公司 | Sterilizing composition containing tiadinil and application thereof |
| CN103749479A (en) * | 2012-07-30 | 2014-04-30 | 陕西上格之路生物科学有限公司 | Sterilization composition containing 2-cyan-3-amino-3-phenylacrylate and amide bactericides |
-
2015
- 2015-03-25 CN CN201510135057.7A patent/CN104719307A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1623390A (en) * | 2004-10-27 | 2005-06-08 | 江苏省农药研究所有限公司 | Application of 2-cydno-3-amino-3-phenylethyl acrylate for preventing and treating patty rice bakanae disease |
| CN103749479A (en) * | 2012-07-30 | 2014-04-30 | 陕西上格之路生物科学有限公司 | Sterilization composition containing 2-cyan-3-amino-3-phenylacrylate and amide bactericides |
| CN103636615A (en) * | 2013-01-17 | 2014-03-19 | 海南正业中农高科股份有限公司 | Sterilizing composition containing tiadinil and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 毛武涛: "具有诱导抗病活性的农药先导优化及生物活性", 《天津大学博士毕业论文》, 15 July 2014 (2014-07-15), pages 6 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104106575B (en) | A kind of bactericidal composition containing pungent bacterium amine and olefin conversion | |
| CN103329905B (en) | Sterilization composition containing penflufen and validamycin | |
| CN103518724A (en) | Bactericidal composition containing fluopyram and methoxyacrylate | |
| CN103329903A (en) | Sterilization composition containing JS399-19 and fluopyram | |
| CN104430361B (en) | A kind of bactericidal composition of 2-cyano-3-amino-3-phenylancryic acetate-containing and fluazinam | |
| CN104957152A (en) | Sterilization composition and use thereof | |
| CN102090400B (en) | Sterilization composition containing cyprodinil and thifluzamide | |
| CN102084861A (en) | Bactericidal composition containing cyprodinil and jinggangmycin | |
| CN104957149B (en) | A kind of bactericidal composition containing zoxamide and tiadinil | |
| CN104381293B (en) | A kind of bactericidal composition containing Silthiopham and jinggangmeisu | |
| CN103141482B (en) | Sterilization compound containing JS399-19 and mepanipyrim | |
| CN103141483B (en) | Sterilization compound containing mepanipyrim and validamycin | |
| CN106818797A (en) | A kind of bactericidal composition containing Difenoconazole and folpet and application thereof | |
| CN104719307A (en) | Fungicidal composition containing probenazole and 2-cyano-3-amino-3-ethyl phenylacrylate | |
| CN105831132A (en) | Sterilization composition containing benzothiostrobin and fluoride ether bacteria amide | |
| CN104430492B (en) | A kind of bactericidal composition containing thifluzamide and Silthiopham | |
| CN103141495B (en) | A kind of bactericidal composition containing carbendazim and mepanipyrim | |
| CN104738078B (en) | A kind of containing zoxamide with the bactericidal composition of Silthiopham | |
| CN104738035A (en) | Bactericidal composition containing benzamide and validamycin | |
| CN104186480A (en) | Bactericidal composition containing JS399-19 and penflufen | |
| CN104770366A (en) | Sterilization composition containing JS399-19 and benzamide | |
| CN104920388A (en) | Sterilizing composite comprising fenoxanil and tiadinil | |
| CN104996436B (en) | A kind of bactericidal composition of containing fluazinam and tiadinil | |
| CN106035355A (en) | Sterilization composition containing picoxystrobin and captan | |
| CN104542599A (en) | Bactericidal composition containing JS399-19 and fluazinam |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150624 |
|
| RJ01 | Rejection of invention patent application after publication |