CN104920388A - Sterilizing composite comprising fenoxanil and tiadinil - Google Patents

Abstract

The invention discloses a sterilizing composite comprising fenoxanil and tiadinil. The fenoxanil and the tiadinil serve as active components, and the mass ratio of the fenoxanil to the tiadinil ranges from 15:1 to 1:15. The sterilizing composite has the advantages that obvious prevention and treatment effects on crop fungus diseases such as rice blast are achieved, dosage can be reduced through joint use of the two chemicals, biological damage and environmental pollution can be reduced effectively, and crop yield and quality can be improved; the fenoxanil and the tiadinil in the sterilizing composite are low in poison and safe to human, livestock and beneficial organisms; chemical resistance of pathogenic bacteria to a single chemical can be delayed; the fenoxanil and the tiadinil different in structural type and function mechanism are composited proportionally, so that high sterilization activity is high during practical use, selection pressure on pathogens during individual use of the single fenoxanil or the single tiadinil can be avoided to the greatest extent, generation and development of chemical resistance of the pathogens are delayed, total dosage for unit area is reduced, and the sterilizing composite is economic, efficient and environment friendly.

Description

A kind of bactericidal composition containing zarilamid and tiadinil

Technical field

The invention belongs to disinfectant use in agriculture field, be specifically related to a kind of bactericidal composition containing zarilamid and tiadinil.

Background technology

Zarilamid (English common name: Fenoxanil), molecular formula is C15H18Cl2N2O2, and structural formula is as follows:

Chemical common name is N-(1-itrile group-1,2-dimethyl propyl)-2-(2,4-dichlorophenoxy) propionamide, there is novel mechanism of action, belong to melanin biosynthesis inhibitor (MBI), prevent and treat rice blast excellent on blade face with when using under water, and holding effect is remarkable.Be mainly used in preventing and treating rice blast, comprise leaf pest and Miho pest.

Tiadinil (English common name: Tiadinil Standard), molecular formula is C ₁₁h ₁₀clN ₃oS, structural formula is as follows:

Chemical common name is chloro-4,4'-dimethyl-1,2, the 3-thiadiazoles-5-formailides of 3'-, and novel systemic fungicide, is transmitted to rapidly other positions by root absorption.The inhibit activities of this medicament to germ itself is poor, by stoping germ mycelia to invade contiguous healthy cell, and can induce generation disease-resistant gene.Suitable water reason uses, and the lasting period is long, has good control efficiency, be specially adapted to seedling cultivation of rice case to leaf blast disease and fringe rice blast.Send out initial stage medication in disease to have better effect.

Summary of the invention

The object of the present invention is to provide a kind of new type bactericide composition containing zarilamid and tiadinil, for preventing and treating the various crop diseases such as rice blast.Zarilamid and tiadinil possess different structure types and discrepant mechanism of action, the two is combined by a certain percentage, there is bactericidal activity in actual use high, simultaneously can when avoiding zarilamid to a greater extent and tiadinil single dose is used alone to the selection pressure that pathogen causes, delay pathogen pesticide resistance emergence and development, and dosage total in unit are is declined, economic, efficient, environmental protection.

A kind of bactericidal composition containing zarilamid and tiadinil of the present invention, includes active component zarilamid and tiadinil that mass ratio is 15:1 ~ 1:15.

Preferably, the mass ratio of described zarilamid and tiadinil is 10:1 ~ 1:1, is more preferably 10:1 ~ 5:1, most preferably is 5:1.

Composition of the present invention makes agriculturally conventional bactericidal composition formulation being added with conventional agricultural bactericidal agent aid.

Described bactericidal composition formulation can be aqueous suspension agent, wetting powder, water-dispersible granules.The agricultural bactericidal agent aid adopted comprises each analog assistants such as wetting agent, dispersant, thickener, defoamer, filler, the wetting agent adopted, dispersant can be alkylnaphthalene sulfonate formaldehyde condensation products, nekal formaldehyde condensation products, oleic acid methylaminoethyl sodium sulfonate, one or more in sodium lignin sulfonate, calcium lignosulfonate, alkylphenol-polyethenoxy base ether, alkylphenol-polyethenoxy base phosphate, castor oil polyoxyethylene ether etc.; The thickener adopted can be xanthans, polyvinyl alcohol etc.; The defoamer adopted to can be in phosphoric acid ester defoamer and silicone defoaming agent one or more; The filler adopted can be in white carbon, kaolin, attapulgite etc. one or more;

The active ingredient of preferred described zarilamid and tiadinil composition accounts for 2% ~ 60% of bactericidal composition gross mass, is preferably 10% ~ 60%.

Bactericidal composition of the present invention can be used for the fungal disease preventing and treating the crops such as rice blast.

By the careful analysis to zarilamid and the tiadinil mechanism of action and sterilization idiocratic, Wadley method is used to carry out experimental scheme and result treatment.First the EC of zarilamid and tiadinil two single compound (hereinafter referred to as medicament) is measured ₅₀, according to the EC of two single medicaments ₅₀set the portfolio ratio of two medicaments by Wadley method, and according to Wadley synergy index SR value, determine suitable composition ratio, then verified by the abundant method of Sun Yun.

Test objective thing is rice blast.Test adopts colony diameter method.Get zarilamid, tiadinil mother liquor, be configured to need liquid dull and stereotyped, every ware is about 14ml, arranges without medicine flat board contrast (CK) simultaneously, often processes repetition 3 ware, namely repeat 3 times.Produce the mycelia block of 5mm diameter at the card punch of preculture colony edge sterilizing, move on on different culture media flat board respectively, cultivate 4d, measure colony diameter (mm), by following formulae discovery growth inhibition ratio for 28 DEG C:

Mycelial growth inhibition rate is converted into and suppresses probit value (Y), drug concentration is converted into log concentration (X), by log concentration be abscissa, probit value is that ordinate makes toxicity regression straight line, try to achieve zarilamid and tiadinil single dose and mixture thereof to the virulence regression equation of rice blast fungus, and calculate EC ₅₀, EC ₉₀value and correlation coefficient r value.

According to the interaction of Wadley method evaluation mixture, computing formula is as follows:

EC _{50 (theoretical values)}=(a+b)/(a/EC _50a+ b/EC _50b), SR=EC _{50 (theoretical values)}/ EC _{50 (real values)}.

Wherein a, b are each component content ratio in mixture, analyze the effect of mixture with SR value.SR≤0.5, then two kinds of medicament mixtures have antagonism; SR=0.5 ~ 1.5, then two kinds of medicament mixtures have addition; SR >=1.5, then two kinds of medicament mixtures have synergistic effect.

Table 1 zarilamid and tiadinil single dose and mixture thereof are to rice blast toxicity test result

From table 1, data can be analyzed and obtain, zarilamid and tiadinil are can suppress the growth of rice blast mycelia during 15:1 ~ 1:15 ratio mixture, can compared with the growth of high inhibition rice blast mycelia, wherein zarilamid and tiadinil 10:1 ~ 5:1 suppress rice blast mycelia to show synergistic effect, especially the most obvious with 5:1 synergy.

The present invention has good control efficiency to crop fungal diseases such as rice blasts, and two medicament couplings, can reduce dosage, effectively reduces ecological disruption and environmental pollution, and can improve crop yield and quality; In the present invention, zarilamid and tiadinil all belong to the toxicity such as low, to people and animals, beneficial organism safety; The pesticide resistance of germ to single medicament can be delayed.

Embodiment

Following embodiment further illustrates using as the explaination to the technology of the present invention content for content of the present invention; but flesh and blood of the present invention is not limited in described in following embodiment, those of ordinary skill in the art can and should know any simple change based on connotation of the present invention or replace all should belong to protection domain of the presently claimed invention.

embodiment 1

The preparation method of 60% zarilamid tiadinil suspending agent: by mass percentage.

Zarilamid 50%;

Tiadinil 10%;

Alkylnaphthalene sulfonate formaldehyde condensation products 4%;

Alkylphenol-polyethenoxy base phosphate 3%;

Xanthans 0.2%;

Silicone defoaming agent 0.4%;

Water surplus.

Preparation method: according to formula, weighs in proportion by above component, adds ball mill ball milling 30 minutes, filter, suction dispersion tank high speed shear was fully ground through sand mill after 3 minutes, controlled solid constituent particle diameter within 2 microns, stir after grinding terminates, obtain suspending agent product.Every mu of 60-80g can reach more than 88% for preventing and treating rice blast effect.

embodiment 2

The preparation method of 30% zarilamid tiadinil suspending agent: by mass percentage.

Zarilamid 25%;

Tiadinil 5%;

Sodium lignin sulfonate 4%;

Alkylphenol-polyethenoxy base phosphate 4%;

Xanthans 0.2%;

Phosphate defoamer 0.3%;

Water surplus.

Preparation method, with embodiment 1.Every mu of 60-80g can reach 86% for preventing and treating rice blast effect.

embodiment 3

The preparation method of 2% zarilamid tiadinil suspending agent: by mass percentage.

Zarilamid 1.67%;

Tiadinil 0.33%;

Nekal 2%;

Castor oil polyoxyethylene ether 1.5%;

Polyvinyl alcohol 0.2%;

Phosphate defoamer 0.1%;

Water surplus.

Preparation method, with embodiment 1.Every mu of 60-80g can reach 80% for preventing and treating rice blast effect.

embodiment 4

The preparation method of 48% zarilamid tiadinil wetting powder: by mass percentage.

Zarilamid 40%;

Tiadinil 8%;

Calcium dodecyl benzene sulfonate 3%

Nekal 4%;

White carbon 10%;

Kaolin surplus;

Preparation method: above component is added mixer by formula rate and mixes laggard row air-flow crushing, stir after having pulverized, wetting powder product.Every mu of 60-80g can reach 86% for preventing and treating rice blast effect.

embodiment 5

The preparation method of 30% zarilamid tiadinil wetting powder: by mass percentage.

Zarilamid 25%;

Tiadinil 5%;

Alkylnaphthalene sulfonate formaldehyde condensation products 4%

Sodium lignin sulfonate 4%;

White carbon 10%;

Attapulgite surplus

Preparation method, with embodiment 4.Every mu of 60-80g is about 80% for preventing and treating rice blast effect.

embodiment 6

The preparation method of 10% zarilamid tiadinil water dispersible granules: by mass percentage.

Zarilamid 8.33%;

Tiadinil 1.67%;

Oleic acid methylaminoethyl sodium sulfonate 5%;

Calcium lignosulfonate 2%;

Polyvinyl alcohol 4%

Ammonium sulfate 8%

White carbon 10%;

Kaolin surplus;

Preparation method: above component is added mixer by formula rate and mixes laggard row air-flow crushing, add a small amount of purified water after having pulverized and stir, extruder grain, after oven dry water dispersible granules product.Every mu of 60-80g can reach 82% for preventing and treating rice blast effect.

embodiment 7

The preparation method of 20% zarilamid tiadinil wetting powder: by mass percentage.

Zarilamid 10%;

Tiadinil 10%;

Alkylnaphthalene sulfonate formaldehyde condensation products 4%

Calcium lignosulfonate 5%;

White carbon 8%;

Attapulgite surplus

Preparation method: above component is added mixer by formula rate and mixes laggard row air-flow crushing, stir after having pulverized, wetting powder product.Every mu of 60-80g is about 76% for preventing and treating rice blast effect.

embodiment 8

The preparation method of 30% zarilamid tiadinil wetting powder: by mass percentage.

Zarilamid 5%;

Tiadinil 25%;

Calcium dodecyl benzene sulfonate 3%

Nekal 2%;

White carbon 5%;

Kaolin surplus;

Preparation method: above component is added mixer by formula rate and mixes laggard row air-flow crushing, stir after having pulverized, wetting powder product.Every mu of 100-120g can reach 78% for preventing and treating rice blast effect.

embodiment 9

The preparation method of 44% zarilamid tiadinil water dispersible granules: by mass percentage.

Zarilamid 4%;

Tiadinil 40%;

Oleic acid methylaminoethyl sodium sulfonate 4%;

Calcium lignosulfonate 3%;

Polyvinyl alcohol 3%

Ammonium sulfate 4%

Kaolin surplus;

Preparation method: above component is added mixer by formula rate and mixes laggard row air-flow crushing, add a small amount of purified water after having pulverized and stir, extruder grain, after oven dry water dispersible granules product.Every mu of 60-80g can reach 75% for preventing and treating rice blast effect.

embodiment 10

The preparation method of 22% zarilamid tiadinil suspending agent: by mass percentage.

Zarilamid 20%;

Tiadinil 2%;

Nekal 2%;

Castor oil polyoxyethylene ether 3%;

Polyvinyl alcohol 0.5%;

Phosphate defoamer 0.5%;

Water surplus.

Preparation method: according to formula, weighs in proportion by above component, adds ball mill ball milling 30 minutes, filter, suction dispersion tank high speed shear was fully ground through sand mill after 3 minutes, controlled solid constituent particle diameter within 2 microns, stir after grinding terminates, obtain suspending agent product.Every mu of 60-80g can reach 75% for preventing and treating rice blast effect.

embodiment 11

The preparation method of 16% zarilamid tiadinil suspending agent: by mass percentage.

Zarilamid 1%;

Tiadinil 15%;

Sodium lignin sulfonate 2%;

Alkylphenol-polyethenoxy base phosphate 1%;

Xanthans 0.3%;

Phosphate defoamer 0.5%;

Water surplus.

Preparation method: according to formula, weighs in proportion by above component, adds ball mill ball milling 30 minutes, filter, suction dispersion tank high speed shear was fully ground through sand mill after 3 minutes, controlled solid constituent particle diameter within 2 microns, stir after grinding terminates, obtain suspending agent product.Every mu of 60-80g can reach 74% for preventing and treating rice blast effect.

embodiment 12

The preparation method of 32% zarilamid tiadinil wetting powder: by mass percentage.

Zarilamid 30%;

Tiadinil 2%;

Calcium dodecyl benzene sulfonate 4%

Nekal 2%;

White carbon 5%;

Kaolin surplus;

Preparation method: above component is added mixer by formula rate and mixes laggard row air-flow crushing, stir after having pulverized, wetting powder product.Every mu of 100-120g can reach 73% for preventing and treating rice blast effect.

Claims (7)

1. contain a bactericidal composition for zarilamid and tiadinil, it is characterized in that: include active component zarilamid and tiadinil that mass ratio is 15:1 ~ 1:15.

2. bactericidal composition according to claim 1, is characterized in that: the mass ratio of described zarilamid and tiadinil is 10:1 ~ 1:1.

3. bactericidal composition according to claim 2, is characterized in that: the mass ratio of described zarilamid and tiadinil is 10:1 ~ 5:1.

4. the bactericidal composition according to any one of claim 1-3, is characterized in that: be added with conventional agricultural bactericidal agent aid and make agriculturally conventional bactericidal composition formulation.

5. bactericidal composition according to claim 4, is characterized in that: described bactericidal composition formulation is aqueous suspension agent, wetting powder or water-dispersible granules.

6. bactericidal composition according to claim 4, is characterized in that: the active ingredient of described zarilamid and tiadinil composition accounts for 2% ~ 60% of bactericidal composition gross mass.

7. the bactericidal composition described in any one of claim 1-6 is for preventing and treating the crop fungal disease of rice blast.