CN104738036A - Bactericidal composition containing zoxamide and validamycin - Google Patents
Bactericidal composition containing zoxamide and validamycin Download PDFInfo
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- CN104738036A CN104738036A CN201510136578.4A CN201510136578A CN104738036A CN 104738036 A CN104738036 A CN 104738036A CN 201510136578 A CN201510136578 A CN 201510136578A CN 104738036 A CN104738036 A CN 104738036A
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- zoxamide
- bactericidal composition
- validamycin
- jinggangmeisu
- bactericidal
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Abstract
The invention discloses a bactericidal composition containing zoxamide and validamycin, wherein the mass ratio of zoxamide to validamycin, which are taken as active components, is 15:1 to 1:15. The bactericidal composition disclosed by the invention is remarkable in the effects of preventing and treating crop fungal diseases such as rice sheath blight disease, and the two chemicals of zoxamide and validamycin are co-used, so that a dosage can be reduced, ecological damages and environmental pollution can be effectively reduced, and crop yield and quality can be improved; zoxamide and validamycin in the bactericidal composition disclosed by the invention are both low in toxicity, and safe to people and livestock as well as beneficial organisms; the drug resistance of germs to a single chemical can be delayed. Zoxamide and validamycin have different structure types and action mechanisms with a difference, and by combining zoxamide and validamycin in a certain ratio, the bactericidal composition is high in bactericidal activity in actual use, is capable of avoiding the selective pressure caused on pathogens when zoxamide and validamycin are independently used to a higher extent, delaying the generation and development of the drug resistance of the pathogens, and reducing a total dosage in unit area, and is economic, efficient, and environmentally friendly.
Description
Technical field
The invention belongs to disinfectant use in agriculture field, be specifically related to the bactericidal composition of a kind of zoxamide and jinggangmeisu.
Background technology
Zoxamide (English name: ZOXAMIDE molecular formula is C
13h
22nO
5pS, structural formula is as follows:
Chemical name: (RS)-3,5-bis-chloro-N-(the chloro-1-ethyl of 3--1-methyl-2-oxopropyl) to methyl benzamide; The mechanism of action of zoxamide is very unique in Oomycete bactericide, and it suppresses sclerotium to divide by the combination of tubulin-subunit and breaking of microtubule cytoskeleton.Zoxamide do not affect travelling spore in travelling, sporangiocyst formed or sprout.Along with caryocinetic first circulation of bacterium, the elongation of germ tube is suppressed, thus stops disease mattress to penetrate host plant.Controlling object is mainly used in control ovum mattress guiding principle disease as potato and tomato late blight, cucumber downy mildew and downy mildew of garpe etc.; Special efficacy is had to downy mildew of garpe.Infer grey mould of sweet potato, lettuce dish stalk is mould, and the cercospora brown spot of peanut, powdery mildew etc. have certain activity.
Jinggangmeisu (English common name: Validamycin), molecular formula is C
20h
35o
13n, structural formula is as follows:
Chemical common name is N-((1S)-(1,4,6/5)-3-methylol-4,5,6-trihydroxy-2-cyclohexenyl group)-(O-β-D-glycopyranosyl-(1 → 3)-(1S)-(1,2,4/3,5)-2,3,4-trihydroxy-5-Hydroxymethylcycloheamines amines, it is the antibiotic that a kind of actinomycetes produce, there is stronger interior absorption, easily absorbed by somatic cells and within it conduct rapidly, interference and suppression somatic cells g and D.Sterling is white amorphous powder, and water-soluble, dimethyl formamide, is slightly soluble in ethanol, be insoluble to acetone, benzene, ethyl acetate, etc. organic solvent, hygroscopicity is strong, stable in the room temperature PH3-9 aqueous solution.Be mainly used in rice sheath blight disease, also can be used for rice green smut, corn northern and southern leaf blight and vegetables and the crop pest such as cotton, beans, have preventive effect high, without poisoning, the plurality of advantages such as pollution-free.
Summary of the invention
The object of the present invention is to provide a kind of new type bactericide composition containing zoxamide and jinggangmeisu, for various crop diseases such as the water prevention rice sheath blight.Zoxamide and jinggangmeisu possess different structure types and discrepant mechanism of action, the two is combined by a certain percentage, there is bactericidal activity in actual use high, simultaneously can when avoiding zoxamide to a greater extent and jinggangmeisu single dose is used alone to the selection pressure that pathogen causes, delay pathogen pesticide resistance emergence and development, and dosage total in unit are is declined, economic, efficient, environmental protection.
A kind of bactericidal composition containing zoxamide and jinggangmeisu of the present invention, includes active component zoxamide and jinggangmeisu that mass ratio is 15:1 ~ 1:15.
Preferably, the mass ratio of described zoxamide and jinggangmeisu is 10:1 ~ 1:5, is more preferably 5:1 ~ 1:1.
Composition of the present invention makes agriculturally conventional bactericidal composition formulation being added with conventional agricultural bactericidal agent aid.
Described bactericidal composition formulation can be aqueous suspension agent, wetting powder, water-dispersible granules.The agricultural bactericidal agent aid adopted comprises each analog assistants such as wetting agent, dispersant, thickener, defoamer, filler, the wetting agent adopted, dispersant can be alkylnaphthalene sulfonate formaldehyde condensation products, nekal formaldehyde condensation products, oleic acid methylaminoethyl sodium sulfonate, one or more in sodium lignin sulfonate, calcium lignosulfonate, alkylphenol-polyethenoxy base ether, alkylphenol-polyethenoxy base phosphate, castor oil polyoxyethylene ether etc.; The thickener adopted can be xanthans, polyvinyl alcohol etc.; The defoamer adopted to can be in phosphoric acid ester defoamer and silicone defoaming agent one or more; The filler adopted can be in white carbon, kaolin, attapulgite etc. one or more;
The active ingredient of preferred described zoxamide and jinggangmeisu composition accounts for 10% ~ 60% of bactericidal composition gross mass.
Bactericidal composition of the present invention can be used for the fungal disease of the crops such as the water prevention rice sheath blight.
By the careful analysis to zoxamide and the jinggangmeisu mechanism of action and sterilization idiocratic, Wadley method is used to carry out experimental scheme and result treatment.First the EC of zoxamide and jinggangmeisu two single compound (hereinafter referred to as medicament) is measured
50, according to the EC of two single medicaments
50set the portfolio ratio of two medicaments by Wadley method, and according to Wadley synergy index SR value, determine suitable composition ratio, then verified by the abundant method of Sun Yun.
Test objective thing is rice sheath blight disease.Test adopts colony diameter method.Get zoxamide, jinggangmeisu mother liquor, be configured to need liquid dull and stereotyped, every ware is about 14ml, arranges without medicine flat board contrast (CK) simultaneously, often processes repetition 3 ware, namely repeat 3 times.Produce the mycelia block of 5mm diameter at the card punch of preculture colony edge sterilizing, move on on different culture media flat board respectively, cultivate 4d, measure colony diameter (mm), by following formulae discovery growth inhibition ratio for 28 DEG C:
Mycelial growth inhibition rate is converted into and suppresses probit value (Y), drug concentration is converted into log concentration (X), by log concentration be abscissa, probit value is that ordinate makes toxicity regression straight line, try to achieve zoxamide and jinggangmeisu single dose and mixture thereof to the virulence regression equation of Rhizoctonia solani Kuhn, and calculate EC
50, EC
90value and correlation coefficient r value.
According to the interaction of Wadley method evaluation mixture, computing formula is as follows:
EC
50 (theoretical values)=(a+b)/(a/EC
50a+ b/EC
50b), SR=EC
50 (theoretical values)/ EC
50 (real values).
Wherein a, b are each component content ratio in mixture, analyze the effect of mixture with SR value.SR≤0.5, then two kinds of medicament mixtures have antagonism; SR=0.5 ~ 1.5, then two kinds of medicament mixtures have addition; SR >=1.5, then two kinds of medicament mixtures have synergistic effect.
Table 1 zoxamide and jinggangmeisu single dose and mixture thereof are to rice sheath blight disease toxicity test result
From table 1, data can be analyzed and obtain, and zoxamide and jinggangmeisu, can suppress the growth of rice sheath blight disease mycelia during 15:1 ~ 1:15 ratio mixture, with 5:1 ratio mixture, compared with the growth of high inhibition rice sheath blight disease mycelia, can show synergistic effect.
The present invention has good control efficiency to crop fungal diseases such as rice sheath blight diseases, and two medicament couplings, can reduce dosage, effectively reduces ecological disruption and environmental pollution, and can improve crop yield and quality; In the present invention, zoxamide and jinggangmeisu all belong to the toxicity such as low, to people and animals, beneficial organism safety; The pesticide resistance of germ to single medicament can be delayed.
Embodiment
Following embodiment further illustrates using as the explaination to the technology of the present invention content for content of the present invention; but flesh and blood of the present invention is not limited in described in following embodiment, those of ordinary skill in the art can and should know any simple change based on connotation of the present invention or replace all should belong to protection domain of the presently claimed invention.
Embodiment 1
The preparation method of 33% zoxamide jinggangmeisu suspending agent: by mass percentage.
Preparation method: according to formula, weighs in proportion by above component, adds ball mill ball milling 30 minutes, filter, suction dispersion tank high speed shear was fully ground through sand mill after 3 minutes, controlled solid constituent particle diameter within 2 ~ 5 microns, stir after grinding terminates, obtain suspending agent product.Every mu of 100-120g is used for water prevention rice sheath blight effect and can reaches more than 85%.
Embodiment 2
The preparation method of 30% zoxamide jinggangmeisu suspending agent: by mass percentage.
Preparation method, with embodiment 1.Every mu of 100-120g is used for water prevention rice sheath blight effect and can reaches more than 90%.
Embodiment 3
The preparation method of 20% zoxamide jinggangmeisu suspending agent: by mass percentage.
Preparation method, with embodiment 1.Every mu of 120-140g is used for water prevention rice sheath blight effect and can reaches 80%.
Embodiment 4
The preparation method of 40% zoxamide jinggangmeisu wetting powder: by mass percentage.
Preparation method: above component is added mixer by formula rate and mixes laggard row air-flow crushing, stir after having pulverized, wetting powder product.Every mu of 100-120g can reach 86% for preventing and treating wheat sharp eyespot effect.
Embodiment 5
The preparation method of 30% zoxamide jinggangmeisu wetting powder: by mass percentage.
Preparation method, with embodiment 4.Every mu of 60-80g is used for water prevention rice sheath blight effect and is about 90%.
Embodiment 6
The preparation method of 10% zoxamide jinggangmeisu water dispersible granules: by mass percentage.
Preparation method: above component is added mixer by formula rate and mixes laggard row air-flow crushing, add a small amount of purified water after having pulverized and stir, extruder grain, after oven dry water dispersible granules product.Every mu of 140-160g is used for water prevention rice sheath blight effect and can reaches 80%.
Claims (7)
1. contain a bactericidal composition for zoxamide and jinggangmeisu, it is characterized in that: include active component zoxamide and jinggangmeisu that mass ratio is 15:1 ~ 1:15.
2. bactericidal composition according to claim 1, is characterized in that: the mass ratio of described zoxamide and jinggangmeisu is 10:1 ~ 1:5.
3. bactericidal composition according to claim 2, is characterized in that: the mass ratio of described zoxamide and jinggangmeisu is 5:1 ~ 1:1.
4. the bactericidal composition according to any one of claim 1-3, is characterized in that: be added with conventional agricultural bactericidal agent aid and make agriculturally conventional bactericidal composition formulation.
5. bactericidal composition according to claim 4, is characterized in that: described bactericidal composition formulation is aqueous suspension agent, wetting powder, water-dispersible granules.
6. bactericidal composition according to claim 4, is characterized in that: the active ingredient of described zoxamide and jinggangmeisu composition accounts for 10% ~ 60% of bactericidal composition gross mass.
7. the bactericidal composition described in any one of claim 1-6 is used for the crop fungal disease of the water prevention rice sheath blight.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510136578.4A CN104738036A (en) | 2015-03-25 | 2015-03-25 | Bactericidal composition containing zoxamide and validamycin |
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|---|---|---|---|
| CN201510136578.4A CN104738036A (en) | 2015-03-25 | 2015-03-25 | Bactericidal composition containing zoxamide and validamycin |
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|---|---|---|---|
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102860307A (en) * | 2012-09-13 | 2013-01-09 | 倪烈 | Compound pesticide containing validamycin and cyprosulfamide and application of compound pesticide |
| CN103355298A (en) * | 2012-03-29 | 2013-10-23 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing fenhexamid and antibiotics |
| CN103385243A (en) * | 2012-05-09 | 2013-11-13 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing tiadinil and antibiotics |
| CN104115838A (en) * | 2014-06-27 | 2014-10-29 | 何芳 | Pesticide preparation for preventing and controlling rice sheath blight |
-
2015
- 2015-03-25 CN CN201510136578.4A patent/CN104738036A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103355298A (en) * | 2012-03-29 | 2013-10-23 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing fenhexamid and antibiotics |
| CN103385243A (en) * | 2012-05-09 | 2013-11-13 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing tiadinil and antibiotics |
| CN102860307A (en) * | 2012-09-13 | 2013-01-09 | 倪烈 | Compound pesticide containing validamycin and cyprosulfamide and application of compound pesticide |
| CN104115838A (en) * | 2014-06-27 | 2014-10-29 | 何芳 | Pesticide preparation for preventing and controlling rice sheath blight |
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