CN103355298A - Bactericidal composition containing fenhexamid and antibiotics - Google Patents
Bactericidal composition containing fenhexamid and antibiotics Download PDFInfo
- Publication number
- CN103355298A CN103355298A CN2012100880252A CN201210088025A CN103355298A CN 103355298 A CN103355298 A CN 103355298A CN 2012100880252 A CN2012100880252 A CN 2012100880252A CN 201210088025 A CN201210088025 A CN 201210088025A CN 103355298 A CN103355298 A CN 103355298A
- Authority
- CN
- China
- Prior art keywords
- fenhexamid
- jinggangmeisu
- kasugarnycin
- bactericidal composition
- antibiotics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000005776 Fenhexamid Substances 0.000 title claims abstract description 139
- VDLGAVXLJYLFDH-UHFFFAOYSA-N fenhexamid Chemical compound C=1C=C(O)C(Cl)=C(Cl)C=1NC(=O)C1(C)CCCCC1 VDLGAVXLJYLFDH-UHFFFAOYSA-N 0.000 title claims abstract description 139
- 239000000203 mixture Substances 0.000 title claims abstract description 68
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 26
- 239000003242 anti bacterial agent Substances 0.000 title claims abstract description 17
- 229940088710 antibiotic agent Drugs 0.000 title claims abstract description 17
- 241000607479 Yersinia pestis Species 0.000 claims abstract description 3
- 239000000843 powder Substances 0.000 claims description 38
- 238000009736 wetting Methods 0.000 claims description 36
- 201000010099 disease Diseases 0.000 claims description 35
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 35
- 239000000375 suspending agent Substances 0.000 claims description 34
- 235000007164 Oryza sativa Nutrition 0.000 claims description 17
- 235000009566 rice Nutrition 0.000 claims description 17
- 239000000839 emulsion Substances 0.000 claims description 13
- 239000003094 microcapsule Substances 0.000 claims description 13
- 239000004562 water dispersible granule Substances 0.000 claims description 11
- 239000004530 micro-emulsion Substances 0.000 claims description 9
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims description 5
- 241001530056 Athelia rolfsii Species 0.000 claims description 5
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- 206010027146 Melanoderma Diseases 0.000 claims description 5
- 241000221696 Sclerotinia sclerotiorum Species 0.000 claims description 5
- 208000025865 Ulcer Diseases 0.000 claims description 5
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- 230000000694 effects Effects 0.000 abstract description 6
- 150000001875 compounds Chemical class 0.000 abstract description 5
- PVTHJAPFENJVNC-MHRBZPPQSA-N kasugamycin Chemical compound N[C@H]1C[C@H](NC(=N)C(O)=O)[C@@H](C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O PVTHJAPFENJVNC-MHRBZPPQSA-N 0.000 abstract description 4
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- 229910021641 deionized water Inorganic materials 0.000 description 20
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- 239000002270 dispersing agent Substances 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 241000255789 Bombyx mori Species 0.000 description 3
- 244000241257 Cucumis melo Species 0.000 description 3
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 3
- 229920001732 Lignosulfonate Polymers 0.000 description 3
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 3
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- 206010011732 Cyst Diseases 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
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- 238000004458 analytical method Methods 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
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- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
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- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
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- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- PYIXHKGTJKCVBJ-UHFFFAOYSA-N Astraciceran Natural products C1OC2=CC(O)=CC=C2CC1C1=CC(OCO2)=C2C=C1OC PYIXHKGTJKCVBJ-UHFFFAOYSA-N 0.000 description 1
- NDVRQFZUJRMKKP-UHFFFAOYSA-N Betavulgarin Natural products O=C1C=2C(OC)=C3OCOC3=CC=2OC=C1C1=CC=CC=C1O NDVRQFZUJRMKKP-UHFFFAOYSA-N 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
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- 241000196324 Embryophyta Species 0.000 description 1
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- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
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- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention discloses a bactericidal composition containing fenhexamid and antibiotics. The bactericidal composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is selected from fenhexamid, and the active ingredient B is selected from any one of the following compounds: jinggangmycin and kasugamycin; and the weight ratio of the active ingredient A to the active ingredient B is (1:60)-(80:1). The composition has higher activity towards various pests on various crops, has obvious synergism, expands the bactericidal spectrum and has the characteristics of small dosage, rain wash resistance and obvious synergism.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on crop pest that contains fenhexamid and antibiotics.
Technical background
Fenhexamid (Fenhexamid) chemical name: N-(2,3-, two chloro-4-hydroxy phenyls)-1-methyl-cyclohexyl base formamide, molecular formula: C
14H
17Cl
2NO
2A kind of acid amide fungicides, seed treatment, the seedling growing box inorganic agent belongs to interior suction, protective fungicide.Different from existing bactericide, without bactericidal activity, do not suppress the growth of pathogen mycelia.Check melanin biosynthesis and can accelerate the generation of plant antibiotic such as momilactoneA and sakuranetin behind bacteria infection, this mechanism of action indication ring propionyl bacterium amine may also have activity to other diseases.Can follow the paddy rice epidemic disease to infect the phytoalexin that produces by increase and improve the crop resistance.
Jinggangmeisu (Jingangmycin) chemical name: N-[(1S)-(1,4,6/5)-3-methylol-4,5,6-trihydroxy-2-cyclohexenyl group] [O-β-D-glucopyranosyl-(1-3)]-1S-(1,2,4,3,5)-2,3,4-trihydroxy-5-methylol-cyclo-hexylamine, molecular formula: C
20H
35O
13N.Be the very strong agricultural antibiotic of systemic action, after the mycelia of Rhizoctonia solani Kuhn touches jinggangmeisu, can absorbed by somatic cells very soon and in thalline, conduct, disturb and the growth of inhibition somatic cells normal growth, thereby play therapeutic action.Jinggangmeisu also can be used for preventing and treating wheat sharp eyespot, false smut etc.
Kasugarnycin (Kasugamycin) chemical name: [5-amino-2-methyl-6-(2,3,4,5,6-carbonyl cyclohexyl oxo) pyrans-3-base amino-a-IMDA], molecular formula: C
14H
25N
3O
9Be agricultural antibiotic, have stronger interior absorption, this medicine mainly disturbs amino acid whose metabolism esterase system, thereby affects the synthetic of protein, suppress the mycelia elongation and cause cell granulations, but on spore germination without impact.
In the real process of agricultural production, preventing and treating the problem that disease the most easily produces is the generation of disease drug resistance.The different cultivars composition carries out composite, is to prevent and treat the very common method of resistance disease.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals all is additive effect, and the seldom composite of synergistic effect really arranged, especially synergistic effect very obviously, synergy ratio very high composite just still less.Through inventor's research, discovery is mutually composite with fenhexamid and jinggangmeisu, kasugarnycin, good synergistic effect is arranged within the specific limits, and relevant composite about fenhexamid and jinggangmeisu, kasugarnycin, there is not yet at present relevant report at home and abroad.
Summary of the invention
The objective of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains fenhexamid and antibiotics.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains fenhexamid and antibiotics, it is characterized in that containing active components A and active component B, active components A and active component B weight ratio are 1: 60～80: 1, described active components A is selected from fenhexamid, and active component B is selected from a kind of in jinggangmeisu, the kasugarnycin.
The described bactericidal composition that contains fenhexamid and antibiotics is characterized in that: the weight ratio of active components A and active component B is 1: 30～40: 1.
The described bactericidal composition that contains fenhexamid and antibiotics is characterized in that: the weight ratio of fenhexamid and jinggangmeisu is 1: 10～20: 1.
The described bactericidal composition that contains fenhexamid and antibiotics is characterized in that: the weight ratio of fenhexamid and kasugarnycin is 1: 5～25: 1.
The described bactericidal composition that contains fenhexamid and antibiotics is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, microemulsion, aqueous emulsion, microcapsule suspending agent, also can make suspension emulsion or microcapsule suspension-suspending agent.
The described bactericidal composition that contains fenhexamid and antibiotics is used for the disease of control crop, and described crop comprises vegetables, fruit tree, cereal crops, ornamental crops.
Described disease comprises rice blast, banded sclerotial blight, false smut, brown spot, fusarium wilt, leaf mold, angular leaf spot, ulcer disease, stalk break, black spot, epidemic disease, gray mold.
Amount of application when the content of active component depends on independent use in the present composition also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with the target disease.Usually the weight percentage of active component is 0.1%～90% of gross weight in the composition, and better is 5%～80%.According to different preparation types, the active component content scope is different.Usually, liquid preparation contains by weight 0.1%～60% active substance, preferably is 5%～50%; Solid pharmaceutical preparation contains by weight 0.1%～80% active substance, preferably is 10%～80%.
At least contain a kind of surfactant in the bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 2%～30% of total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, thickener or the defoamer.According to different dosage form, can also contain stabilizing agent known in those skilled in the art, antifreeze etc. in the preparation.
Bactericidal composition of the present invention can be by the user before use through dilution or directly use.Its preparation can by processing method preparation known in those skilled in the art, after being about to active component and liquid flux or solid carrier mixing, add one or more in surfactant such as dispersant, stabilizing agent, wetting agent, binding agent, the defoamer etc. again.
Bactericidal composition of the present invention can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein preferred dosage form is wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule suspension-suspending agent.
When making wetting powder, composition comprises following component and content: active components A 0.1～80%, active component B 0.1～60%, dispersant 1～12%, wetting agent 1～8%, filler surplus.
When making water dispersible granules, composition comprises following component and content: active components A 0.1～80%, active component B 0.1～60%, dispersant 1～12%, wetting agent 1～8%, disintegrant 1～10%, binding agent 0～8%, filler surplus.
Comprise following component and content when composition is made suspending agent: active components A 0.1～60%, active component B 0.1～50%, dispersant 1～10%, wetting agent 1～10%, defoamer 0.1～2%, thickener 0.05～2%, antifreeze 0～8%, deionized water add to 100%.
Comprise following component and content when composition is made suspension emulsion: active components A 0.1%～60%, active component B 0.1%～50%, emulsifier 1%～10%, dispersant 1%～10%, solvent 0～20%, defoamer 0.1%～2%, thickener 0.05%～2%, antifreeze 0%～8%, stabilizing agent 0%～3%, deionized water add to 100%.
Comprise following component and content when composition is made microemulsion: active components A 0.1%～60%, active component B 0.1%～50%, emulsifier 1%～15%, solvent 1%～10%, antifreeze 0%～8%, stabilizing agent 0%～3%, defoamer 0.1%～2%, deionized water add to 100%.
Comprise following component and content when composition is made aqueous emulsion: active components A 0.1%～60%, active component B 0.1%～50%, solvent 1%～20%, emulsifier 1%～12%, antifreeze 0%～8%, defoamer 0.1%～2%, thickener 0.05%～2%, deionized water add to 100%.
Comprise following component and content when composition is made microcapsule suspending agent: active components A 0.1%～60%, active component B 0.1%～50%, macromolecule cyst material 1%～10%, dispersant 2%～10%, solvent 1%～10%, emulsifier 1%～7%, pH adjusting agent 0.1%～5%, defoamer 0.1%～2%, deionized water add to 100%.
Composition comprises following component and content when making microcapsule suspension-suspending agent: active components A 0.1%～60%, active component B 0.1%～50%, macromolecule cyst material 1%～12%, surfactant 2%～15%, solvent 1%～15%, emulsifier 1%～8%, defoamer 0.1%～2%, thickener 0.05%～2%, pH adjusting agent 0.1%～5%, deionized water add to 100%.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension of the present invention-suspending agent the key technical indexes:
The invention has the advantages that:
(1) present composition has good synergy and lasting effect within the specific limits, and preventive effect is higher than single dose.
(2) the agricultural chemicals dosage reduces, and reduces the residual quantity of agricultural chemicals on crop, alleviates environmental pollution.
(3) enlarged fungicidal spectrum, multiple diseases such as rice blast, banded sclerotial blight, false smut, brown spot, fusarium wilt, leaf mold, angular leaf spot, ulcer disease, stalk break, black spot, epidemic disease, gray mold have been had greater activity.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
Application Example one
Example 1 55% fenhexamid jinggangmeisu wetting powder
Fenhexamid 50%, jinggangmeisu 5%, octylphenol polyethylene oxyethylene group ether sulfate 3.8%, soapberry powder 4%, precipitated calcium carbonate add to 100%, and mixture carries out air-flow crushing, make 55% fenhexamid jinggangmeisu wetting powder.
Example 2 50% fenhexamid jinggangmeisu wetting powders
Fenhexamid 40%, jinggangmeisu 10%, polycarboxylate 4%, lauryl sodium sulfate 5%, kaolin add to 100%, and mixture carries out air-flow crushing, make 50% fenhexamid jinggangmeisu wetting powder.
Example 3 12% fenhexamid jinggangmeisu wetting powders
Fenhexamid 8%, jinggangmeisu 4%, alkylnaphthalene sulfonate 6.5%, neopelex 6%, attapulgite add to 100%, and mixture carries out air-flow crushing, make 12% fenhexamid jinggangmeisu wetting powder.
Example 4 48% fenhexamid jinggangmeisu wetting powders
Fenhexamid 40%, jinggangmeisu 8%, aryl phenol polyoxyethylene succinate sulfonate 5.5%, sldium lauryl sulfate 6%, bentonite add to 100%, and mixture carries out air-flow crushing, make 48% fenhexamid jinggangmeisu wetting powder.
Example 5 15% fenhexamid jinggangmeisu wetting powders
Fenhexamid 10%, jinggangmeisu 5%, lignosulfonates 4.5%, wetting and penetrating agent F 5%, precipitated calcium carbonate add to 100%, mix to make 15% fenhexamid jinggangmeisu wetting powder.
Example 6 36% fenhexamid jinggangmeisu wetting powders
Fenhexamid 32%, jinggangmeisu 4%, alkylphenol-polyethenoxy are phonetic 4.5%, silkworm excrement 5%, starch add to 100%, mix making 36% fenhexamid jinggangmeisu wetting powder.
Example 7 6.1% fenhexamid jinggangmeisu water dispersible granules
Fenhexamid 0.1%, jinggangmeisu 6%, aliphatic amine polyoxyethylene are phonetic 4%, soapberry powder 5%, bentonite 2.5%, polyvinyl alcohol 0.06%, kaolin add to 100%, mix making 6.1% fenhexamid jinggangmeisu water dispersible granules.
Example 8 10% fenhexamid jinggangmeisu suspending agents
Fenhexamid 5%, jinggangmeisu 5%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 4%, wetting and penetrating agent F 4%, silicone oil 0.4%, gum Arabic 0.13%, diethylene glycol (DEG) 1%, deionized water add to 100%, mix to make 10% fenhexamid jinggangmeisu suspending agent.
Example 9 16% fenhexamid jinggangmeisu suspending agents
Fenhexamid 12%, jinggangmeisu 4%, naphthalene sulfonic acid-formaldehyde condensation product 4% spaonin powder 3.6%, organosilicon 0.3%, xanthans 0.11%, triethylene glycol 2%, deionized water add to 100%, mix to make 16% fenhexamid jinggangmeisu suspending agent.
Example 10 21% fenhexamid jinggangmeisu suspending agents
Fenhexamid 20%, jinggangmeisu 1%, alkyl benzene sulfonate calcium salt 5.2%, silkworm excrement 4%, silicone 0.2%, melon glue 0.11%, deionized water add to 100%, mix to make 21% fenhexamid jinggangmeisu suspending agent.
Example 11 20.5% fenhexamid jinggangmeisu microemulsions
Fenhexamid 20%, jinggangmeisu 0.5%, fatty alcohol-polyoxyethylene ether 3%, NOP 6%, propane diols 3%, silicone oil 0.2%, deionized water supply 100%, mix to make 20.5% fenhexamid jinggangmeisu microemulsion.
Example 12 10.25% fenhexamid jinggangmeisu aqueous emulsions
Fenhexamid 0.25%, jinggangmeisu 10%, alkyl benzene calcium sulfonate 3.8%, N-pyrrolidones 5%, glycerine 5%, organosilicon 0.5%, melon glue 0.12%, deionized water supply 100%, make 10.25% fenhexamid jinggangmeisu aqueous emulsion.
Example 13 10.5% fenhexamid jinggangmeisu microcapsule suspending agents
Fenhexamid 0.5%, jinggangmeisu 10%, sodium alginate 5%, polyoxyethylene carboxylate 5%, vegetable oil 4%, sorbitan fatty acid ester APEO 5%, hydrochloric acid 0.7%, sodium hydroxide 0.6%, silicone 0.4%, deionized water add to 100%, mix to make 10.5% fenhexamid jinggangmeisu microcapsule suspending agent.
Example 14 9% fenhexamid jinggangmeisu suspending agents
Fenhexamid 3%, jinggangmeisu 6%, soapberry powder 4%, lignosulfonates 4.4%, polyvinyl alcohol 0.13%, silicone 0.2%, deionized water add to 100%, mix to make 9% fenhexamid jinggangmeisu suspending agent.
Jinggangmeisu among the example 1-14 is changed to kasugarnycin can makes novel formulation equally.
Example 15 63% fenhexamid kasugarnycin wetting powders
Fenhexamid 60%, kasugarnycin 3%, the phonetic formaldehyde condensation products sulphate 4% of alkylphenol-polyethenoxy, wetting and penetrating agent F 5%, kaolin add to 100%, and mixture carries out air-flow crushing, make 63% fenhexamid kasugarnycin wetting powder.
Example 16 24% fenhexamid kasugarnycin wetting powders
Fenhexamid 21%, kasugarnycin 3%, naphthalene sulfonic acid-formaldehyde condensation product 4.3%, neopelex 5%, attapulgite add to 100%, and mixture carries out air-flow crushing, make 24% fenhexamid kasugarnycin wetting powder.
Example 17 20% fenhexamid kasugarnycin wetting powders
Fenhexamid 16%, kasugarnycin 4%, polyoxyethylene carboxylate 3.3%, lauryl sodium sulfate 5%, diatomite add to 100%, and mixture carries out air-flow crushing, make 20% fenhexamid kasugarnycin wetting powder.
Example 18 33% fenhexamid kasugarnycin wetting powder agent
Fenhexamid 30%, kasugarnycin 3%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 4%, lauryl sodium sulfate 5%, attapulgite add to 100%, mix to make 33% fenhexamid kasugarnycin wetting powder.
Example 19 5.2% fenhexamid kasugamycin water-dispersion granules
Fenhexamid 0.2%, kasugarnycin 5%, octylphenol polyethylene oxyethylene group ether sulfate 5%, spaonin powder 5%, ammonium sulfate 3%, gelatin 0.05%, white carbon add to 100%, mix to make 5.2% fenhexamid kasugamycin water-dispersion granule.
Example 20 24% fenhexamid kasugarnycin wetting powders
Fenhexamid 20%, kasugarnycin 4%, aryl phenol polyoxyethylene succinate sulfonate 4.5%, Nekal BX 5%, kaolin add to 100%, mix to make 24% fenhexamid kasugarnycin wetting powder.
Example 21 12% fenhexamid kasugarnycin wetting powders
Fenhexamid 9%, kasugarnycin 3%, ester polyoxyethylene are phonetic 4.5%, silkworm excrement 5%, kaolin add to 100%, mix making 12% fenhexamid kasugarnycin wetting powder.
Example 22 27% fenhexamid kasugarnycin suspending agents
Fenhexamid 24%, kasugarnycin 3%, lignosulfonates 5.6%, tea are withered 3%, silicone 0.1%, gelatin 0.12%, deionized water add to 100%, mix making 27% fenhexamid kasugarnycin suspending agent.
Example 23 21% fenhexamid kasugarnycin suspending agents
Fenhexamid 18%, kasugarnycin 3%, alkylnaphthalene sulfonate 4.6%, alkylnaphthalene sulfonate 5%, acid amides 0.2%, melon glue 0.13%, deionized water add to 100%, mix to make 21% fenhexamid kasugarnycin suspending agent.
Example 24 11% fenhexamid kasugarnycin suspending agents
Fenhexamid 1%, kasugarnycin 10%, octylphenol polyethylene oxyethylene group ether sulfate 4%, tea are withered 4%, acid amides 0.5%, gum Arabic 0.05%, deionized water add to 100%, mix making 11% fenhexamid kasugarnycin suspending agent.
Example 25 20.25% fenhexamid kasugarnycin microemulsions
Fenhexamid 20%, kasugarnycin 0.25%, castor oil polyoxyethylene ether 5.3%, polyethylene glycol 4.1%, acetone 4%, capric acid 0.25%, deionized water supply 100%, make 20.25% fenhexamid kasugarnycin microemulsion.
Example 26 26% fenhexamid kasugarnycin aqueous emulsions
Fenhexamid 25%, kasugarnycin 1%, alkylphenol-formaldehyde resin polyoxy ethyl ether 5%, ethylene glycol monomethyl ether 5%, methylcellulose 0.11%, propane diols 3%, silicone oil 0.15%, deionized water supply 100%, make 26% fenhexamid kasugarnycin aqueous emulsion.
Example 27 30.5% fenhexamid kasugarnycin microcapsule suspending agents
Fenhexamid 30%, kasugarnycin 0.5%, alkylphenol-polyethenoxy are phonetic 4%, polyfunctional group acyl halide polyamines 4.5%, butyl ether 12%, alkylaryl polyoxyethylene poly-oxygen propylene aether 5%, sodium hydroxide 0.5%, citric acid 0.9%, organosilicon 0.4%, deionized water add to 100%, mix making 30.5% fenhexamid kasugarnycin microcapsule suspending agent.
Example 28 32% fenhexamid kasugarnycin suspending agents
Fenhexamid 30%, kasugarnycin 2%, alkylaryl APEO 6%, tea are withered 5%, CMC 0.1%, organosilicon 0.1%, deionized water add to 100%, mix making 32% fenhexamid kasugarnycin suspending agent.
Kasugarnycin among the example 15-28 is changed to jinggangmeisu can makes novel formulation equally.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
Test method: after each medicament establishment concentration range was determined in prerun, medicament was established respectively 5 dosage by active constituent content and is processed, and established the clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt the mycelial growth rate method to measure medicament to the virulence of crop germ.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active components A and active component B shared ratio in combination;
A is fenhexamid;
B selects a kind of to jinggangmeisu, the kasugarnycin.
Application Example two:
For trying disease: wheat sharp eyespot.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: the establishment concentration range of determining the former medicine of fenhexamid and jinggangmeisu and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 1 fenhexamid and composite jinggangmycin are to the toxicity test analysis of results table of wheat sharp eyespot
As shown in Table 1, fenhexamid and jinggangmeisu proportioning 1: 60～80: 1 o'clock to wheat sharp eyespot synergy ratio SR all greater than 1.5, illustrating that both were mixed in the scope at 1: 60～80: 1 all shows synergistic effect, especially when the proportioning of fenhexamid and jinggangmeisu during at 1: 10～20: 1, synergistic effect is more obviously outstanding, test through the applicant, the optimum ratio of finding fenhexamid and jinggangmeisu is 20: 1,15: 1,10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,1: 8,1: 9,1: 10, wherein synergy ratio is maximum when fenhexamid and jinggangmeisu weight ratio are 2: 1, and synergistic effect is the most obvious.
Application Example three: for trying disease: rice blast.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: the establishment concentration range of determining the former medicine of fenhexamid and kasugarnycin and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to rice blast of table 2 fenhexamid and kasugarnycin
As shown in Table 2, fenhexamid and kasugarnycin to the proportioning of rice blast at 1: 60～80: 1 o'clock, synergy ratio SR is all greater than 1.5, illustrating that both were mixed in the scope at 1: 60～80: 1 all shows synergistic effect, especially when the proportioning of fenhexamid and kasugarnycin during at 1: 5～25: 1, synergistic effect is more outstanding, test through the applicant, the optimum ratio of finding fenhexamid and kasugarnycin is 25: 1,20: 1,15: 1,10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5, wherein synergy ratio is maximum when fenhexamid and kasugarnycin weight ratio are 5: 1, and synergistic effect is the most obvious.
Find that in inventor's experimentation fenhexamid and jinggangmeisu, the composite control to rice blast, banded sclerotial blight, false smut, brown spot, fusarium wilt, leaf mold, angular leaf spot, ulcer disease, stalk break, black spot, epidemic disease, gray mold of kasugarnycin have obvious synergistic effect.
Application Example four fenhexamids and jinggangmeisu, kasugarnycin and the composite rice sheath blight disease test of pesticide effectiveness of preventing and treating thereof
This test arrangement is at Shaanxi Province's Hanzhong City; test medicine is researched and developed, is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 50% fenhexamid water dispersible granules (autogamy), 3% jinggangmeisu aqua (commercial), 4% kasugarnycin wetting powder (commercial).
The investigation rice sheath blight disease state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 3 days, 7 days, 14 days after for the second time dispenser.Experimental result is as follows:
Table 3 fenhexamid and jinggangmeisu, kasugarnycin and the composite rice sheath blight disease test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 3, can effectively prevent and treat rice sheath blight disease after fenhexamid and jinggangmeisu, kasugarnycin are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
Application Example five fenhexamids and jinggangmeisu, kasugarnycin and the composite control Brown patch disease test of pesticide effectiveness thereof
This test arrangement is in the suburb, Xian District, Shanxi Province; test medicine is researched and developed, is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 50% fenhexamid water dispersible granules (autogamy), 3% jinggangmeisu aqua (commercial), 4% kasugarnycin wetting powder (commercial).
The investigation Brown patch disease state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 3 days, 7 days, 14 days after for the second time dispenser.Experimental result is as follows:
Table 4 fenhexamid and jinggangmeisu, kasugarnycin and the composite control Brown patch disease test of pesticide effectiveness thereof
As can be seen from Table 4, can effectively prevent and treat Brown patch disease after fenhexamid and jinggangmeisu, kasugarnycin are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
Application Example six fenhexamids and jinggangmeisu, kasugarnycin and the composite control rice blast test of pesticide effectiveness thereof
This test arrangement is at Shaanxi Province's Hanzhong City; test medicine is researched and developed, is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 50% fenhexamid water dispersible granules (autogamy), 3% jinggangmeisu aqua (commercial), 4% kasugarnycin wetting powder (commercial).
The investigation rice blast state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 3 days, 7 days, 14 days after for the second time dispenser.Experimental result is as follows:
Table 5 fenhexamid and jinggangmeisu, kasugarnycin and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 5, can effectively prevent and treat rice blast after fenhexamid and jinggangmeisu, kasugarnycin are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
Application Example seven fenhexamids and jinggangmeisu, kasugarnycin and the test of composite control citrus bacterial canker disease effect thereof
This test arrangement is in the Xianyang, Shanxi province city; test medicine is researched and developed, is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 50% fenhexamid water dispersible granules (autogamy), 3% jinggangmeisu aqua (commercial), 4% kasugarnycin wetting powder (commercial).
The investigation citrus bacterial canker disease state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 3 times.Investigated respectively disease index and calculated preventive effect in 3 days, 7 days, 14 days after the dispenser for the third time.Experimental result is as follows:
Table 6 fenhexamid and jinggangmeisu, kasugarnycin and the composite control citrus bacterial canker disease test of pesticide effectiveness thereof
As can be seen from Table 6, can effectively prevent and treat citrus bacterial canker disease after fenhexamid and jinggangmeisu, kasugarnycin are composite, control efficiency all is better than the preventive effect of single dose, and the preventive effect phase is long.In the test scope of medication, the target crop is had no adverse effects.
After draw through different local throughout the country tests, the composite rear preventive effect to Common Diseases such as the rice blast on the various crop, banded sclerotial blight, false smut, brown spot, fusarium wilt, leaf mold, angular leaf spot, ulcer disease, stalk break, black spot, epidemic disease, gray molds of fenhexamid and jinggangmeisu, kasugarnycin is all more than 95%, be better than the single dose preventive effect, synergistic effect is obvious.
Claims (7)
1. bactericidal composition that contains fenhexamid and antibiotics, it is characterized in that containing active components A and active component B, active components A and active component B weight ratio are 1: 60～80: 1, described active components A is selected from fenhexamid, and active component B is selected from a kind of in jinggangmeisu, the kasugarnycin.
2. the bactericidal composition that contains fenhexamid and antibiotics according to claim 1, it is characterized in that: the weight ratio of active components A and active component B is 1: 30～40: 1.
3. the bactericidal composition that contains fenhexamid and antibiotics according to claim 2, it is characterized in that: the weight ratio of fenhexamid and jinggangmeisu is 1: 10～20: 1.
4. the bactericidal composition that contains fenhexamid and antibiotics according to claim 2, it is characterized in that: the weight ratio of fenhexamid and kasugarnycin is 1: 5～25: 1.
5. contain the bactericidal composition of fenhexamid and antibiotics to 4 described each according to claim 1, it is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, microemulsion, aqueous emulsion, microcapsule suspending agent.
6. the bactericidal composition that contains fenhexamid and antibiotics according to claim 5 is used for preventing and treating the application of crop pest.
7. application according to claim 6 is characterized in that: described disease comprises rice blast, banded sclerotial blight, false smut, brown spot, fusarium wilt, leaf mold, angular leaf spot, epidemic disease, ulcer disease, stalk break, black spot, epidemic disease, gray mold.
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| CN104738036A (en) * | 2015-03-25 | 2015-07-01 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Bactericidal composition containing zoxamide and validamycin |
| CN106508937A (en) * | 2016-12-09 | 2017-03-22 | 山东省农业科学院植物保护研究所 | Bactericidal composition containing fenhexamid and Zhongshengmycin as well as application of bactericidal composition |
| CN106508937B (en) * | 2016-12-09 | 2018-11-23 | 山东省农业科学院植物保护研究所 | A kind of bactericidal composition and its application containing fenhexamid and Zhongshengmycin |
| CN107711857A (en) * | 2017-09-30 | 2018-02-23 | 京博农化科技股份有限公司 | A kind of bactericidal composition containing gliocladin and fenhexamid |
| CN109845738A (en) * | 2019-01-11 | 2019-06-07 | 山东省农业科学院植物保护研究所 | A kind of bactericidal composition and its application containing fenhexamid and shenqinmycin |
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| CN103355298B (en) | 2016-04-06 |
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