CN103314967B - A kind of bactericidal composition containing fenhexamid - Google Patents
A kind of bactericidal composition containing fenhexamid Download PDFInfo
- Publication number
- CN103314967B CN103314967B CN201210075985.5A CN201210075985A CN103314967B CN 103314967 B CN103314967 B CN 103314967B CN 201210075985 A CN201210075985 A CN 201210075985A CN 103314967 B CN103314967 B CN 103314967B
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- CN
- China
- Prior art keywords
- fenhexamid
- thifluzamide
- probenazole
- isoprothiolane
- bactericidal composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000005776 Fenhexamid Substances 0.000 title claims abstract description 189
- VDLGAVXLJYLFDH-UHFFFAOYSA-N fenhexamid Chemical compound C=1C=C(O)C(Cl)=C(Cl)C=1NC(=O)C1(C)CCCCC1 VDLGAVXLJYLFDH-UHFFFAOYSA-N 0.000 title claims abstract description 189
- 239000000203 mixture Substances 0.000 title claims abstract description 89
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 25
- WOSNCVAPUOFXEH-UHFFFAOYSA-N thifluzamide Chemical compound S1C(C)=NC(C(F)(F)F)=C1C(=O)NC1=C(Br)C=C(OC(F)(F)F)C=C1Br WOSNCVAPUOFXEH-UHFFFAOYSA-N 0.000 claims abstract description 97
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 28
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- 235000009566 rice Nutrition 0.000 claims description 31
- 239000000375 suspending agent Substances 0.000 claims description 28
- 239000000843 powder Substances 0.000 claims description 24
- 239000003094 microcapsule Substances 0.000 claims description 22
- 239000004562 water dispersible granule Substances 0.000 claims description 21
- 238000009736 wetting Methods 0.000 claims description 21
- 239000000725 suspension Substances 0.000 claims description 17
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 239000004530 micro-emulsion Substances 0.000 claims description 13
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims description 7
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- WHHIPMZEDGBUCC-UHFFFAOYSA-N probenazole Chemical compound C1=CC=C2C(OCC=C)=NS(=O)(=O)C2=C1 WHHIPMZEDGBUCC-UHFFFAOYSA-N 0.000 abstract description 102
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- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- DJOJDHGQRNZXQQ-AWEZNQCLSA-N sakuranetin Chemical compound C1([C@@H]2CC(=O)C3=C(O)C=C(C=C3O2)OC)=CC=C(O)C=C1 DJOJDHGQRNZXQQ-AWEZNQCLSA-N 0.000 description 1
- RNAPFFYGJWALAQ-UHFFFAOYSA-N sakuranetin Natural products O1C2=CC(C)=CC(O)=C2C(=O)CC1C1=CC=C(O)C=C1 RNAPFFYGJWALAQ-UHFFFAOYSA-N 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Abstract
The invention discloses a kind of bactericidal composition containing fenhexamid, comprise the bactericidal composition of active components A and active component B, active components A is selected from fenhexamid, active component B is selected from any one compound following: Isoprothiolane, probenazole, thifluzamide, and the weight ratio of active components A and active component B is 1: 70 ~ 70: 1.The present composition has greater activity to the multiple diseases in various crop, and has obvious synergistic effect, expands fungicidal spectrum.And have that dosage is little, resistance of rainwater washing against, the obvious feature of synergy.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition in crop pest containing fenhexamid.
Technical background
Fenhexamid (Fenhexamid) chemical name: N-(the chloro-4-hydroxy phenyl of 2,3-bis-)-1-methyl-cyclohexyl base formamide, molecular formula: C
14h
17cl
2nO
2.A kind of acid amide fungicides, seed treatment, seedling growing box inorganic agent, belongs to interior suction, protective fungicide.Different from existing bactericide, without bactericidal activity, do not suppress the growth of pathogen mycelia.Check melanin biosynthesis and can accelerate the generation of plant antibiotic as momilactoneA and sakuranetin after bacteria infection, this mechanism of action indication ring propionyl bacterium amine also may have activity to other diseases.Crop resistance is improved by increasing with paddy rice epidemic disease infects the phytoalexin of generation.
Isoprothiolane (Isoprothiolane) chemical name: diisopropyl-1,3-dithiolane-a-phenyl malonic ester, molecular formula: C
12h
18o
4s
2.Systemic fungicide, has special efficacy to rice blast.Rice plant absorbs after medicament and accumulates on leaf texture, concentrates on cob especially with branch obstruct, thus suppresses germ to invade, and obstruction germ lipid-metabolism, suppression pathogen growth, plays prevention and treatment.
Probenazole (Probenazole) chemical name: PROBENAZOLE, molecular formula: C
10h
9nO
3s.Can extensively protect and eradicate land for growing field crops effect, fruit tree, grassland, vegetables germ.Slightly antimicrobial acivity in isolated test; Process paddy rice, promotes Root Absorption, cover crop infecting by Pyricularia oryzae and rice bacterial leaf spot pathogenic bacteria.
Thifluzamide (Thifluzamide) chemical name: 2,6-bis-bromo-2-methyl-4-trifluoromethoxy-4-Trifluoromethyl-1,3-thiazole-5-carbonyl acyl for aniline, molecular formula: C
13h
6br
2f
6n
2o
2s.This medical instrument has stronger systemic action, and the lasting period is long.Main Function suppresses the acidohydrogenase in disease fungus tricarbonic acid cycle, causes thalline dead.Foliage spray or soil eluviation, root leaf absorbs, and xylem conducts to whole plant.
In the real process of agricultural production, the problem that controlling disease the most easily produces is the generation of disease drug resistance.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistance disease.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really has the seldom composite of synergistic effect, especially synergistic effect clearly, very high composite just less of synergy ratio.Study through inventor, find fenhexamid and Isoprothiolane, probenazole, thifluzamide mutually composite, there is good synergistic effect within the specific limits, and about fenhexamid and Isoprothiolane, probenazole, thifluzamide relevant composite, there is not yet relevant report at home and abroad at present.
Summary of the invention
The object of the invention is to propose a kind of to there is the bactericidal composition containing fenhexamid that synergistic function, use cost are low, preventive effect is good.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition containing fenhexamid, it is characterized in that comprising active components A and active component B, active components A and active component B weight ratio are 1: 70 ~ 70: 1, described active components A is selected from fenhexamid, and active component B is selected from the one in Isoprothiolane, probenazole, thifluzamide.
The described bactericidal composition containing fenhexamid, is characterized in that: the weight ratio of active components A and active component B is 1: 50 ~ 35: 1.
The described bactericidal composition containing fenhexamid, is characterized in that: the weight ratio of fenhexamid and Isoprothiolane is 1: 20 ~ 10: 1.
The described bactericidal composition containing fenhexamid, is characterized in that: the weight ratio of fenhexamid and probenazole is 1: 25 ~ 5: 1.
The described bactericidal composition containing fenhexamid, is characterized in that: the weight ratio of fenhexamid and thifluzamide is 1: 5 ~ 20: 1.
The described bactericidal composition containing fenhexamid, is characterized in that: composition makes wetting powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
The described bactericidal composition containing fenhexamid is for preventing and treating the disease of crop, and described crop comprises vegetables, fruit tree, cereal crops, fiber crop.
Described disease comprises rice blast, bacterial leaf-blight, banded sclerotial blight, false smut, damping off, rust, fusarium wilt, leaf spot, balck shank, stalk break.
In the present composition, the content of active component depends on amount of application when being used alone, and also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, simultaneously also relevant with target disease.In usual composition, the weight percentage of active component is 2% ~ 90% of gross weight, is preferably 5% ~ 80%.According to different preparation types, active component content scope is different.Usually, liquid preparation contains the active substance of by weight 1% ~ 60%, is preferably 5% ~ 50%; Solid pharmaceutical preparation contains the active substance of by weight 5% ~ 80%, is preferably 10% ~ 80%.
At least containing a kind of surfactant in bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 2% ~ 30% of total formulation weight amount, and surplus is solid or liquid diluent.
Surfactant selected by bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, thickener or defoamer.According to different dosage form, in preparation, stabilizing agent known in those skilled in the art, antifreeze etc. can also be contained.
Bactericidal composition of the present invention can by user before use through diluting or directly using.Its preparation can be prepared by processing method known in those skilled in the art, after mixing, then adds surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, defoamer etc. by active component with liquid flux or solid carrier.
Bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein preferred dosage form is wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
Composition comprises following component and content when making wetting powder: active components A 1 ~ 70%, active component B1 ~ 70%, dispersant 1 ~ 12%, wetting agent 1 ~ 8%, filler surplus.
Composition comprises following component and content when making water dispersible granules: active components A 1 ~ 70%, active component B1 ~ 70%, dispersant 1 ~ 12%, wetting agent 1 ~ 8%, disintegrant 1 ~ 10%, binding agent 0 ~ 8%, filler surplus.
Composition comprises following component and content when making suspending agent: active components A 1 ~ 50%, active component B1 ~ 50%, dispersant 1 ~ 10%, wetting agent 1 ~ 10%, defoamer 0.1 ~ 2%, thickener 0.05 ~ 2%, antifreeze 0 ~ 8%, deionized water add to 100%.
Composition comprises following component and content when making suspension emulsion: active components A 1% ~ 50%, active component B1% ~ 50%, emulsifier 1% ~ 10%, dispersant 1% ~ 10%, solvent 0 ~ 20%, defoamer 0.1% ~ 2%, thickener 0.05% ~ 2%, antifreeze 0% ~ 8%, stabilizing agent 0% ~ 3%, deionized water add to 100%.
Composition comprises following component and content when making microemulsion: active components A 1% ~ 50%, active component B1% ~ 50%, emulsifier 1% ~ 15%, solvent 1% ~ 10%, antifreeze 0% ~ 8%, stabilizing agent 0% ~ 3%, defoamer 0.1% ~ 2%, deionized water add to 100%.
Composition comprises following component and content when making aqueous emulsion: active components A 1% ~ 50%, active component B1% ~ 50%, solvent 1% ~ 20%, emulsifier 1% ~ 12%, antifreeze 0% ~ 8%, defoamer 0.1% ~ 2%, thickener 0.05% ~ 2%, deionized water add to 100%.
Composition comprises following component and content when making microcapsule suspending agent: active components A 1% ~ 50%, active component B1% ~ 50%, macromolecule cyst material 1% ~ 10%, dispersant 2% ~ 10%, solvent 1% ~ 10%, emulsifier 1% ~ 7%, pH adjusting agent 0.1% ~ 5%, defoamer 0.1% ~ 2%, deionized water add to 100%.
Composition comprises following component and content when making microcapsule suspension-suspendinagent agent: active components A 1% ~ 50%, active component B1% ~ 50%, macromolecule cyst material 1% ~ 12%, surfactant 2% ~ 15%, solvent 1% ~ 15%, emulsifier 1% ~ 8%, defoamer 0.1% ~ 2%, thickener 0.05% ~ 2%, pH adjusting agent 0.1% ~ 5%, deionized water add to 100%.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension-suspendinagent agent the key technical indexes of the present invention:
The invention has the advantages that:
(1) present composition has good synergy and lasting effect within the specific limits, and preventive effect is higher than single dose.
(2) pesticide usage amount reduces, and reduces the residual quantity of agricultural chemicals on crop, alleviates environmental pollution.
(3) fungicidal spectrum is expanded, to multiple diseases as gray mold, epidemic disease, rice blast, leaf blight, banded sclerotial blight, false smut, damping off, rust, fusarium wilt, leaf spot, balck shank, stalk break have greater activity.
Application Example one
Below in conjunction with embodiment to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Example 160% fenhexamid Isoprothiolane wetting powder
Fenhexamid 20%, Isoprothiolane 40%, octylphenol polyethylene oxyethylene group ether sulfate 6%, soapberry powder 4%, precipitated calcium carbonate add to 100%, and mixture carries out air-flow crushing, obtained 60% fenhexamid Isoprothiolane wetting powder.
Isoprothiolane is changed to probenazole, thifluzamide and can obtains novel formulation equally.
Example 250% fenhexamid Isoprothiolane wetting powder
Fenhexamid 30%, Isoprothiolane 20%, polycarboxylate 4%, lauryl sodium sulfate 5%, kaolin add to 100%, and mixture carries out air-flow crushing, obtained 50% fenhexamid Isoprothiolane wetting powder.
Isoprothiolane is changed to probenazole, thifluzamide and can obtains novel formulation equally.
Example 380% fenhexamid Isoprothiolane wetting powder
Fenhexamid 60%, Isoprothiolane 20%, alkylnaphthalene sulfonate 6.5%, neopelex 6%, attapulgite add to 100%, and mixture carries out air-flow crushing, obtained 80% fenhexamid Isoprothiolane wetting powder.
Isoprothiolane is changed to probenazole, thifluzamide and can obtains novel formulation equally.
Example 420% fenhexamid 'Daowenling ' water dispersible granule
Fenhexamid 10%, Isoprothiolane 10%, lignosulfonates 4.5%, wetting and penetrating agent F5%, sodium bicarbonate 3.1%, precipitated calcium carbonate add to 100%, the obtained 20% fenhexamid 'Daowenling ' water dispersible granule of mixing.
Isoprothiolane is changed to probenazole, thifluzamide and can obtains novel formulation equally.
Example 515% fenhexamid Isoprothiolane suspending agent
Fenhexamid 10%, Isoprothiolane 5%, aliphatic alcohol polyethenoxy base ether 4%, Nekal BX 6%, capric acid 0.4%, Magnesiumaluminumsilicate 0.12%, ethylene glycol 1%, deionized water add to 100%, the obtained 15% fenhexamid Isoprothiolane suspending agent of mixing.
Isoprothiolane is changed to probenazole, thifluzamide and can obtains novel formulation equally.
Example 645% fenhexamid Isoprothiolane suspension emulsion
Fenhexamid 15%, Isoprothiolane 30%, alkyl benzene sulfonate calcium salt 6.2%, acetonitrile 7%, thermally coupled distillation columns 5%, silicone 0.2%, melon glue 0.15%, propane diols 4%, deionized water add to 100%, the obtained 45% fenhexamid Isoprothiolane suspension emulsion of mixing.
Isoprothiolane is changed to probenazole, thifluzamide and can obtains novel formulation equally.
Example 750% fenhexamid Isoprothiolane suspension emulsion
Fenhexamid 10%, Isoprothiolane 40%, alkylphenol-polyethenoxy are phonetic 6%, vegetable oil 6%, ethylene oxide-propylene oxide block copolymer 4%, silicone oil 0.6%, CMC 0.14%, ethylene glycol 2.4%, deionized water add to 100%, the obtained 50% fenhexamid Isoprothiolane suspension emulsion of mixing.
Isoprothiolane is changed to probenazole, thifluzamide and can obtains novel formulation equally.
Example 835% fenhexamid Isoprothiolane suspension emulsion
Fenhexamid 25%, Isoprothiolane 10%, alkylnaphthalene sulfonate 6%, toluene 4%, thermally coupled distillation columns 6%, C
10 ~ 20saturated fat acids 0.4%, phenolic resins 0.13%, diethylene glycol (DEG) 2.4%, deionized water add to 100%, the obtained 35% fenhexamid Isoprothiolane suspension emulsion of mixing.
Isoprothiolane is changed to probenazole, thifluzamide and can obtains novel formulation equally.
Example 925% fenhexamid Isoprothiolane microemulsion
Fenhexamid 10%, Isoprothiolane 15%, fatty alcohol-polyoxyethylene ether 8%, NOP 9%, propane diols 3%, silicone oil 0.2%, deionized water supply 100%, the obtained 25% fenhexamid Isoprothiolane microemulsion of mixing.
Isoprothiolane is changed to probenazole, thifluzamide and can obtains novel formulation equally.
Example 1030% fenhexamid isoprothiolane emulsion in water
Fenhexamid 10%, Isoprothiolane 20%, alkyl benzene calcium sulfonate 6.8%, N-pyrrolidones 7%, glycerine 5%, organosilicon 0.5%, melon glue 0.3%, deionized water supply 100%, obtained 30% fenhexamid isoprothiolane emulsion in water.
Isoprothiolane is changed to probenazole, thifluzamide and can obtains novel formulation equally.
Example 1135% fenhexamid isoprothiolane emulsion in water
Fenhexamid 10%, Isoprothiolane 25%, sodium alginate 0.05%, glycerine 5%, C
8 ~ 10aliphatic alcohols 0.4%, benzyl dimethyl phenol polyoxyethyl ether 9%, cyclohexanone 3%, deionized water supply 100%, obtained 35% fenhexamid isoprothiolane emulsion in water.
Isoprothiolane is changed to probenazole, thifluzamide and can obtains novel formulation equally.
Example 1245% fenhexamid isoprothiolane emulsion in water
Fenhexamid 10%, Isoprothiolane 35%, polyoxyethylene nonylphenol ether 5%, hydroxyethylcellulose 0.05%, triethylene glycol 4%, C
8 ~ 10aliphatic alcohols 0.09%, propyl alcohol 6%, deionized water supply 100%, obtained 45% fenhexamid isoprothiolane emulsion in water.
Isoprothiolane is changed to probenazole, thifluzamide and can obtains novel formulation equally.
Example 1342% fenhexamid Isoprothiolane microcapsule suspending agent
Fenhexamid 2%, Isoprothiolane 40%, sodium alginate 7.5%, polyoxyethylene carboxylate 5%, vegetable oil 7%, sorbitan fatty acid ester APEO 5%, hydrochloric acid 0.7%, sodium hydroxide 0.6%, silicone 0.4%, deionized water add to 100%, the obtained 42% fenhexamid Isoprothiolane microcapsule suspending agent of mixing.
Isoprothiolane is changed to probenazole, thifluzamide and can obtains novel formulation equally.
Example 1433% fenhexamid Isoprothiolane microcapsule suspension-suspendinagent agent
Fenhexamid 30%, Isoprothiolane 3%, soapberry powder 8%, lignosulfonates 8%, PIC 7%, polyvinyl alcohol 0.15%, N-pyrrolidones 6%, phenethyl phenol polyoxyethanyl polypropylene-base ether 8%, silicone 0.2%, citric acid 1.2%, sodium hydroxide 0.9%, deionized water add to 100%, the obtained 33% fenhexamid Isoprothiolane microcapsule suspension-suspendinagent agent of mixing.
Isoprothiolane is changed to probenazole, thifluzamide and can obtains novel formulation equally.
Example 1571% fenhexamid probenazole wetting powder
The phonetic formaldehyde condensation products sulphate 4% of fenhexamid 1%, probenazole 70%, alkylphenol-polyethenoxy, wetting and penetrating agent F5%, kaolin add to 100%, and mixture carries out air-flow crushing, obtained 71% fenhexamid probenazole wetting powder.
Probenazole is changed to Isoprothiolane, thifluzamide and can obtains novel formulation equally.
Example 1675% fenhexamid probenazole wetting powder
Fenhexamid 15%, probenazole 60%, naphthalene sulfonic acid-formaldehyde condensation product 7.3%, neopelex 6%, attapulgite add to 100%, and mixture carries out air-flow crushing, obtained 75% fenhexamid probenazole wetting powder.
Probenazole is changed to Isoprothiolane, thifluzamide and can obtains novel formulation equally.
Example 1770% fenhexamid probenazole water dispersible granules
Fenhexamid 20%, probenazole 50%, octylphenol polyethylene oxyethylene group ether sulfate 5%, spaonin powder 5%, ammonium sulfate 3%, white carbon add to 100%, the obtained 70% fenhexamid probenazole water dispersible granules of mixing.
Probenazole is changed to Isoprothiolane, thifluzamide and can obtains novel formulation equally.
Example 1850% fenhexamid probenazole water dispersible granules
Fenhexamid 30%, probenazole 20%, aryl phenol polyoxyethylene succinate sulfonate 4.5%, Nekal BX 5%, glucose 3%, kaolin add to 100%, the obtained 50% fenhexamid probenazole water dispersible granules of mixing.
Probenazole is changed to Isoprothiolane, thifluzamide and can obtains novel formulation equally.
Example 1940% fenhexamid probenazole suspending agent
Fenhexamid 10%, probenazole 30%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 7%, lauryl sodium sulfate 5%, silicone 0.5%, gum Arabic 0.2%, deionized water add to 100%, the obtained 40% fenhexamid probenazole suspending agent of mixing.
Probenazole is changed to Isoprothiolane, thifluzamide and can obtains novel formulation equally.
Example 2025% fenhexamid probenazole suspending agent
Fenhexamid 20%, probenazole 5%, lignosulfonates 6.6%, tea are withered 5%, silicone 0.1%, gelatin 0.12%, deionized water add to 100%, the obtained 25% fenhexamid probenazole suspending agent of mixing.
Probenazole is changed to Isoprothiolane, thifluzamide and can obtains novel formulation equally.
Example 2125% fenhexamid probenazole suspension emulsion
Fenhexamid 5%, probenazole 20%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 7%, Nekal BX 6%, DMF 8%, phenyl phenol polyoxyethanyl ether phosphate 5%, C
8 ~ 10aliphatic alcohols 0.2%, gum Arabic 0.05%, glycerine 1.8%, deionized water add to 100%, the obtained 25% fenhexamid probenazole suspension emulsion of mixing.
Probenazole is changed to Isoprothiolane, thifluzamide and can obtains novel formulation equally.
Example 2230% fenhexamid probenazole suspension emulsion
The phonetic formaldehyde condensation products sulphate 4.5% of fenhexamid 10%, probenazole 20%, alkylphenol-polyethenoxy, lauryl sodium sulfate 6%, 3-methyl cyclohexanol ketenes 7%, alkyl benzene calcium sulfonate 6%, capric acid 0.4%, sodium alginate 0.3%, triethylene glycol 2.5%, deionized water add to 100%, the obtained 30% fenhexamid probenazole suspension emulsion of mixing.
Probenazole is changed to Isoprothiolane, thifluzamide and can obtains novel formulation equally.
Example 2335% fenhexamid probenazole microemulsion
Fenhexamid 25%, probenazole 10%, castor oil polyoxyethylene ether 5.3%, polyethylene glycol 8.1%, acetone 6%, capric acid 0.25%, deionized water supply 100%, obtained 35% fenhexamid probenazole microemulsion.
Probenazole is changed to Isoprothiolane, thifluzamide and can obtains novel formulation equally.
Example 2430% fenhexamid probenazole aqueous emulsion
Fenhexamid 5%, probenazole 25%, alkylphenol-formaldehyde resin polyoxyethyl ether 11%, ethylene glycol monomethyl ether 5%, methylcellulose 0.15%, propane diols 3%, silicone oil 0.15%, deionized water supply 100%, obtained 30% fenhexamid probenazole aqueous emulsion.
Probenazole is changed to Isoprothiolane, thifluzamide and can obtains novel formulation equally.
Example 2525% fenhexamid probenazole aqueous emulsion
Fenhexamid 10%, probenazole 15%, white dextrin 0.06%, polyethylene glycol 5%, silicone oil 0.4%, styrene polyoxyethylene ether ammonium sulfate salt 9%, ethanol 5%, deionized water supply 100%, obtained 25% fenhexamid probenazole aqueous emulsion.
Probenazole is changed to Isoprothiolane, thifluzamide and can obtains novel formulation equally.
Example 2630% fenhexamid probenazole microcapsule suspending agent
Fenhexamid 25%, probenazole 5%, alkylphenol-polyethenoxy are phonetic 6%, polyfunctional group acyl halide polyamines 4.5%, butyl ether 12%, alkylaryl polyoxyethylene poly-oxygen propylene aether 6%, sodium hydroxide 0.6%, citric acid 0.9%, organosilicon 0.5%, deionized water add to 100%, the obtained 30% fenhexamid probenazole microcapsule suspending agent of mixing.
Probenazole is changed to Isoprothiolane, thifluzamide and can obtains novel formulation equally.
Example 2726% fenhexamid probenazole microcapsule suspension-suspendinagent agent
Fenhexamid 1%, probenazole 25%, alkylaryl APEO 6%, tea are withered 5%, formaldehyde 8%, CMC 0.1%, propyl alcohol 7%, phenethyl fluosite polyoxyethyl ether 5.5%, organosilicon 0.1%, sodium hydroxide 1.1%, hydrochloric acid 0.9%, deionized water add to 100%, the obtained 26% fenhexamid probenazole microcapsule suspension-suspendinagent agent of mixing.
Probenazole is changed to Isoprothiolane, thifluzamide and can obtains novel formulation equally.
Example 2860% fenhexamid thifluzamide wetting powder
Fenhexamid 30%, thifluzamide 30%, naphthalene sulfonic acid-formaldehyde condensation product 4%, spaonin powder 5%, bentonite add to 100%, the obtained 60% fenhexamid thifluzamide wetting powder of mixing.
Thifluzamide is changed to probenazole, Isoprothiolane and can obtains novel formulation equally.
Example 2975% fenhexamid thifluzamide wetting powder
Fenhexamid 60%, thifluzamide 15%, lignosulfonates 6.1%, Nekal BX 5%, attapulgite add to 100%, the obtained 75% fenhexamid thifluzamide wetting powder of mixing.
Thifluzamide is changed to probenazole, Isoprothiolane and can obtains novel formulation equally.
Example 3071% fenhexamid thifluzamide water dispersible granule
The phonetic formaldehyde condensation products sulphate 5% of fenhexamid 70%, thifluzamide 1%, alkylphenol-polyethenoxy, sldium lauryl sulfate 4.5%, bentonite 3%, kaolin add to 100%, the obtained 71% fenhexamid thifluzamide water dispersible granule of mixing.
Thifluzamide is changed to probenazole, Isoprothiolane and can obtains novel formulation equally.
Example 3160% fenhexamid thifluzamide water dispersible granule
Fenhexamid 40%, thifluzamide 20%, polycarboxylate 4%, tea are withered 3%, bentonite 2%, precipitated calcium carbonate add to 100%, the obtained 60% fenhexamid thifluzamide water dispersible granule of mixing.
Thifluzamide is changed to probenazole, Isoprothiolane and can obtains novel formulation equally.
Example 3250% fenhexamid thifluzamide suspending agent
Fenhexamid 40%, thifluzamide 10%, ester polyoxyethylene are phonetic 5.3%, soapberry powder 6%, C
8 ~ 10aliphatic alcohols 0.3%, hydroxyethylcellulose 0.15%, deionized water add to 100%, the obtained 50% fenhexamid thifluzamide suspending agent of mixing.
Thifluzamide is changed to probenazole, Isoprothiolane and can obtains novel formulation equally.
Example 3340% fenhexamid thifluzamide suspending agent
Fenhexamid 30%, thifluzamide 10%, alkylaryl APEO 5%, silkworm excrement 7%, silicone 0.2%, hydroxyethylcellulose 0.15%, deionized water add to 100%, the obtained 40% fenhexamid thifluzamide suspending agent of mixing.
Thifluzamide is changed to probenazole, Isoprothiolane and can obtains novel formulation equally.
Example 3430% fenhexamid thifluzamide suspension emulsion
Fenhexamid 25%, thifluzamide 5%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 5.3%, lauryl sodium sulfate 6%, 3-methyl cyclohexanol ketenes 7%, alkyl benzene calcium sulfonate 6%, silicone oil 0.4%, gelatin 0.3%, ethylene glycol 2.4%, deionized water add to 100%, the obtained 30% fenhexamid thifluzamide suspension emulsion of mixing.
Thifluzamide is changed to probenazole, Isoprothiolane and can obtains novel formulation equally.
Example 3535% fenhexamid thifluzamide microemulsion
Fenhexamid 30%, thifluzamide 5%, alkylaryl polyoxyethylene polyoxypropylene ether 7%, glycerine 8%, cyclohexanone 5%, C
10 ~ 20saturated fat acids 0.3%, deionized water supply 100%, obtained 35% fenhexamid thifluzamide microemulsion.
Thifluzamide is changed to probenazole, Isoprothiolane and can obtains novel formulation equally.
Example 3630% fenhexamid thifluzamide aqueous emulsion
Fenhexamid 10%, thifluzamide 20%, benzyl dimethyl phenol polyoxyethyl ether 9%, ethanol 5%, sodium alginate 0.05%, glycerine 5%, C
8 ~ 10aliphatic alcohols 0.4%, deionized water supply 100%, obtained 30% fenhexamid thifluzamide aqueous emulsion.
Thifluzamide is changed to probenazole, Isoprothiolane and can obtains novel formulation equally.
Example 3742% fenhexamid thifluzamide microcapsule suspending agent
Fenhexamid 40%, thifluzamide 2%, polyfunctional group acyl halide dihydroxylic alcohols 7%, aliphatic amine polyoxyethylene are phonetic 8%, ethyl acetate 6%, C
10 ~ 20saturated fat acids 0.3%, sorbitan monostearate 5%, sorbic acid 0.5%, sodium hydroxide 0.3%, deionized water add to 100%, the obtained 42% fenhexamid thifluzamide microcapsule suspending agent of mixing.
Thifluzamide is changed to probenazole, Isoprothiolane and can obtains novel formulation equally.
Example 3830% fenhexamid thifluzamide microcapsule suspension-suspendinagent agent
Fenhexamid 5%, thifluzamide 25%, polycarboxylate 8%, silkworm excrement 6%, urea 9%, polyethylene glycol 0.06%, toluene 8%, phenethyl fluosite polyoxyethyl ether 7%, silicone oil 0.12%, hydrochloric acid 0.8%, sodium hydroxide 0.9%, deionized water add to 100%, the obtained 30% fenhexamid thifluzamide microcapsule suspension-suspendinagent agent of mixing.
Thifluzamide is changed to probenazole, Isoprothiolane and can obtains novel formulation equally.
The embodiment of the present invention is the method adopting Toxicity Determination and field trial to combine.First pass through Toxicity Determination, synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carry out field trial.
Test method: determine that after the effective inhibition concentration scope of each medicament, medicament establishes 5 dosage process respectively by active constituent content through prerun, if clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure medicament to the virulence of crop germ.Measure colony diameter by right-angled intersection method after 72h, calculate each process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) converts logarithm value (x) to, try to achieve virulence regression equation (y=a+bx) with method of least squares, and calculate the EC of often kind of medicament thus
50value.Calculate two medicament different ratio synergies ratio (SR) according to Wadley method, SR < 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action simultaneously, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active components A and the ratio of active component B shared by combination;
A is fenhexamid;
B choosing is to the one in Isoprothiolane, probenazole, thifluzamide.
Application Example two:
For examination disease: rice blast.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fenhexamid and isoprothiolane and the two different ratio mixture.
Toxicity test result
Table 1 fenhexamid and the composite toxicity test analysis of results table to rice blast of Isoprothiolane
As shown in Table 1, fenhexamid and Isoprothiolane proportioning are all greater than 1.5 to rice blast synergy ratio SR 1: 70 ~ 70: 1 time, both explanations mixture in 1: 70 ~ 70: 1 scope all shows synergistic effect, especially when the proportioning of fenhexamid and Isoprothiolane is 1: 20 ~ 10: 1 time, synergistic effect is more obviously given prominence to, test through applicant, the optimum ratio of discovery fenhexamid and Isoprothiolane is 10: 1, 9: 1, 8: 1, 7: 1, 6: 1, 5: 1, 4: 1, 3: 1, 2: 1, 1: 1, 1: 2, 1: 3, 1: 4, 1: 5, 1: 6, 1: 7, 1: 8, 1: 9, 1: 10, 1: 15, 1: 20 wherein when fenhexamid and Isoprothiolane weight ratio are 1: 2 synergy ratio maximum, synergistic effect is the most obvious.In inventor's experimentation, find that fenhexamid and the composite control to rice blast, leaf blight, banded sclerotial blight, false smut, damping off, rust, fusarium wilt, leaf spot, balck shank, stalk break of Isoprothiolane have obvious synergistic effect.
Application Example three:
For examination disease: Rice Leaf rot.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fenhexamid and the former medicine of probenazole and the two different ratio mixture.
Toxicity test result
Table 2 fenhexamid and the composite toxicity test analysis of results table to Rice Leaf rot of probenazole
As shown in Table 2, fenhexamid and probenazole to the proportioning of Rice Leaf rot 1: 70 ~ 70: 1 time, synergy ratio SR is all greater than 1.5, both explanations mixture in 1: 70 ~ 70: 1 scope all shows synergistic effect, especially when the proportioning of fenhexamid and probenazole is 1: 25 ~ 5: 1 time, synergistic effect is more outstanding, test through applicant, the optimum ratio of discovery fenhexamid and probenazole is 5: 1, 4: 1, 3: 1, 2: 1, 3: 2, 1: 1, 2: 3, 1: 2, 1: 3, 1: 4, 1: 5, 1: 10, 1: 15, 1: 20, 1: 25 wherein when fenhexamid and probenazole weight ratio are 1: 5 synergy ratio maximum, synergistic effect is the most obvious.In inventor's experimentation, find that fenhexamid and the composite control to rice blast, leaf blight, banded sclerotial blight, false smut, damping off, rust, fusarium wilt, leaf spot, balck shank, stalk break of probenazole have obvious synergistic effect.
Application Example four:
For examination disease: rice sheath blight disease.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination fenhexamid and the former medicine of thifluzamide and the two different ratio mixture.
Toxicity test result
Table 3 fenhexamid and the composite toxicity test analysis of results table to rice sheath blight disease of thifluzamide
As shown in Table 3, fenhexamid and thifluzamide to the proportioning of rice sheath blight disease 1: 70 ~ 70: 1 time, synergy ratio SR is all greater than 1.5, both explanations mixture in 1: 70 ~ 70: 1 scope all shows synergistic effect, especially when the proportioning of fenhexamid and thifluzamide is 1: 5 ~ 20: 1 time, synergistic effect is more obviously given prominence to, test through applicant, the optimum ratio of discovery fenhexamid and thifluzamide is 20: 1, 15: 1, 10: 1, 5: 1, 4: 1, 3: 1, 2: 1, 3: 2, 1: 1, 2: 3, 1: 2, 1: 3, 1: 4, 1: 5, wherein when fenhexamid and thifluzamide weight ratio are 4: 1, synergy ratio is maximum, synergistic effect is the most obvious.In inventor's experimentation, find that fenhexamid and the composite control to rice blast, leaf blight, banded sclerotial blight, false smut, damping off, rust, fusarium wilt, leaf spot, balck shank, stalk break of thifluzamide have obvious synergistic effect.
Application Example five fenhexamid and Isoprothiolane and the composite control rice blast test of pesticide effectiveness thereof
This test arrangement is at Shaanxi Province's Hanzhong City, and test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., provided, contrast medicament 50% fenhexamid water dispersible granules (autogamy), 18% Isoprothiolane microemulsion (commercial).
The investigation rice blast state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 7 days, 14 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 4 fenhexamid and Isoprothiolane and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 4, fenhexamid and Isoprothiolane composite after effectively can prevent and treat rice blast, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example six fenhexamid and Isoprothiolane and the composite control gray mold of cucumber test of pesticide effectiveness thereof
This test arrangement is in Jingyang County, Shaanxi Province, and test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., provided, contrast medicament 50% fenhexamid water dispersible granules (autogamy), 18% Isoprothiolane microemulsion (commercial).
The investigation gray mold of cucumber state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 7 days, 14 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 5 fenhexamid and Isoprothiolane and the composite control gray mold of cucumber test of pesticide effectiveness thereof
As can be seen from Table 5, fenhexamid and Isoprothiolane composite after effectively can prevent and treat gray mold of cucumber, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example seven fenhexamid and probenazole and the composite control rice green smut test of pesticide effectiveness thereof
This test arrangement is at Shaanxi Province's Hanzhong City, and test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., provided, contrast medicament 50% fenhexamid water dispersible granules (autogamy), 8% probenazole granule (commercial).
The investigation rice green smut state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 7 days, 14 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 6 fenhexamid and probenazole and the composite control rice green smut test of pesticide effectiveness thereof
As can be seen from Table 6, fenhexamid and probenazole composite after can preventing and controlling green smut of rice, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example eight fenhexamid and probenazole and the composite control paddy rice leaf blight test of pesticide effectiveness thereof
This test arrangement is at Shaanxi Province's Hanzhong City, and test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., provided, contrast medicament 50% fenhexamid water dispersible granules (autogamy), 8% probenazole granule (commercial).
The investigation Rice Leaf rot state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 7 days, 14 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 7 fenhexamid and probenazole and the composite control paddy rice leaf blight test of pesticide effectiveness thereof
As can be seen from Table 7, fenhexamid and probenazole composite after can effectively prevent and treat paddy rice leaf blight, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example nine fenhexamid and thifluzamide and the composite control cotton seedling blight test of pesticide effectiveness thereof
This test arrangement is in Dali County, Weinan, Shaanxi Province; test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., is provided, contrast medicament 50% fenhexamid water dispersible granules (autogamy), 240g/L thifluzamide suspending agent (commercial).
The investigation cotton seedling blight state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 7 days, 14 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 8 fenhexamid and thifluzamide and the composite control cotton seedling blight test of pesticide effectiveness thereof
As can be seen from Table 8, fenhexamid and thifluzamide composite after effectively can prevent and treat cotton seedling blight, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten fenhexamid and thifluzamide and the composite water prevention rice sheath blight test of pesticide effectiveness thereof
This test arrangement is at Shaanxi Province's Hanzhong City, and test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., provided, contrast medicament 50% fenhexamid water dispersible granules (autogamy), 240g/L thifluzamide suspending agent (commercial).
The investigation rice sheath blight disease state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 7 days, 14 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 9 fenhexamid and thifluzamide and the composite water prevention rice sheath blight test of pesticide effectiveness thereof
As can be seen from Table 9, fenhexamid and thifluzamide composite after can the effective water prevention rice sheath blight, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
After draw through tests different local throughout the country, fenhexamid and Isoprothiolane, probenazole, the composite rear preventive effect to Common Diseases such as the rice blast in various crop, leaf blight, banded sclerotial blight, false smut, damping off, rust, fusarium wilt, leaf spot, balck shank, stalk breaks of thifluzamide are all more than 95%, be better than single dose preventive effect, synergistic effect is obvious.
Claims (6)
1. the bactericidal composition containing fenhexamid, it is characterized in that: effective active composition is active components A and active component B, active components A and active component B weight ratio are 1 ︰ 70 ~ 70 ︰ 1, and described active components A is fenhexamid, and active component B is thifluzamide.
2. the bactericidal composition containing fenhexamid according to claim 1, is characterized in that: the weight ratio of active components A and active component B is 1 ︰ 50 ~ 35 ︰ 1.
3. the bactericidal composition containing fenhexamid according to claim 2, is characterized in that: the weight ratio of fenhexamid and thifluzamide is 1 ︰ 5 ~ 20 ︰ 1.
4. any one according to claims 1 to 3 contains the bactericidal composition of fenhexamid, it is characterized in that: composition makes wetting powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
5. the bactericidal composition containing fenhexamid according to claim 4 is for preventing and treating the application of crop pest.
6. application according to claim 5, is characterized in that: described disease is gray mold, epidemic disease, rice blast, leaf blight, banded sclerotial blight, false smut, damping off, rust, fusarium wilt, leaf spot, balck shank, stalk break.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094221A (en) * | 1993-04-28 | 1994-11-02 | 拜尔公司 | Fungicidal combinations of active substances |
| CN1132591A (en) * | 1994-10-17 | 1996-10-09 | 拜尔公司 | Fungicidal active compound combinations |
| CN101518257A (en) * | 2009-04-10 | 2009-09-02 | 利尔化学股份有限公司 | Bactericidal pesticide composition |
| CN101755845A (en) * | 2009-11-23 | 2010-06-30 | 陈章艳 | Bactericide composition containing flutolanil |
| CN101755825A (en) * | 2009-11-23 | 2010-06-30 | 陈章艳 | Bactericide composition containing thifluzamide |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094221A (en) * | 1993-04-28 | 1994-11-02 | 拜尔公司 | Fungicidal combinations of active substances |
| CN1132591A (en) * | 1994-10-17 | 1996-10-09 | 拜尔公司 | Fungicidal active compound combinations |
| CN101518257A (en) * | 2009-04-10 | 2009-09-02 | 利尔化学股份有限公司 | Bactericidal pesticide composition |
| CN101755845A (en) * | 2009-11-23 | 2010-06-30 | 陈章艳 | Bactericide composition containing flutolanil |
| CN101755825A (en) * | 2009-11-23 | 2010-06-30 | 陈章艳 | Bactericide composition containing thifluzamide |
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