CN108782578A - Composition pesticide containing folpet and fluorine azoles bacterium aniline - Google Patents

Composition pesticide containing folpet and fluorine azoles bacterium aniline Download PDF

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Publication number
CN108782578A
CN108782578A CN201710310374.7A CN201710310374A CN108782578A CN 108782578 A CN108782578 A CN 108782578A CN 201710310374 A CN201710310374 A CN 201710310374A CN 108782578 A CN108782578 A CN 108782578A
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CN
China
Prior art keywords
folpet
fluorine azoles
azoles bacterium
microbicide compositions
bacterium aniline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710310374.7A
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Chinese (zh)
Inventor
李文欧
殷素侠
李治伟
夏衍
王斯研
彭军
刘世勇
吴光辉
王世银
陈锐东
陈志超
蔡丹群
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangdong Guangkang Biochemical Polytron Technologies Inc
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Guangdong Guangkang Biochemical Polytron Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangdong Guangkang Biochemical Polytron Technologies Inc filed Critical Guangdong Guangkang Biochemical Polytron Technologies Inc
Priority to CN201710310374.7A priority Critical patent/CN108782578A/en
Publication of CN108782578A publication Critical patent/CN108782578A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/02Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
    • A01N47/04Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom containing >N—S—C≡(Hal)3 groups
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/561,2-Diazoles; Hydrogenated 1,2-diazoles

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention discloses a kind of microbicide compositions containing folpet and fluorine azoles bacterium aniline, the folpet of show activity ingredient and the weight ratio of fluorine azoles bacterium aniline are 1 in affiliated bactericidal composition:80~80:1, further preferred weight ratio is 1:20~20:1, it is still more preferably 5:1.The present composition can prepare several formulations type, any one in water dispersible granules, missible oil, suspending agent, wettable powder, suspension seed-coating agent etc..Compared with single dose, microbicide compositions of the invention compounding has notable synergistic effect, and the lasting period is long, can effectively reduce drug cost, improves drug effect.

Description

Composition pesticide containing folpet and fluorine azoles bacterium aniline
Technical field
The invention belongs to technical field of pesticide combination, it relates in particular to be a kind of to contain folpet and fluorine azoles bacterium benzene The composition pesticide of amine, the composition pesticide are suitable for prevention multiple kinds of crops disease.
Background technology
Folpet(folpet), Chinese nickname has Folpat, a Fu Erpei, No. CAS:133-07-3, chemical name:N- trichlorines Methyl mercapto phthalimide, molecular formula:C9H4Cl3NO2S.Structural formula:
Folpet is broad spectrum protection organosulfureous fungicide, and it is a variety of mainly to prevent grain and oil crop, vegetables, fruit tree, flowers etc. Disease has stimulation to growth and development of plants, can prevent rice blast, rice sheath blight disease, wheat rust, head blight, rape frost Mildew, leaf spot of peanut, the late blight of potato, tomato early blight, anthracnose of tobacco, the various crops disease such as apple anthracnose, And to crop safety.
Fluorine azoles bacterium aniline,(penflufen), No. CAS:494793-67-8, molecular formula:C18H24FN3O.Chemical name:2 '- The fluoro- 1,3- dimethyl pyrazoles -4- formailides of [(RS) -1,3- dimethylbutyls] -5-.Structural formula:
Fluorine azoles bacterium aniline is a kind of succinate dehydrogenase inhibitors, can prevent kind of a biography, the basidiomycetes and sac fungus that soil passes Disease, main mechanism are worked on respiratory chain electron transmission Complex II, and correlation energy metabolism is blocked.Mainly there is silk Disease caused by pyrenomycetes, black scurf of potato, wheat sharp eyespot, rice sheath blight disease, sclerotinia sclerotiorum etc., also wheat dissipate Smut, the bunt of wheat, corn southern leaf blight etc..Treated, and seed can absorb fluorine azoles bacterium aniline in germination process, It is transmitted to other positions of plant by xylem, plays the role of cover crop.
The simple pesticide single using mechanism of action, using effect are often restricted.Fluorine azoles bacterium aniline mechanism of action Novelty, controlling disease effect is fine on the crop of part, but use scope is easy to be limited to, and folpet is protective fungicide, Action site is more, and drug resistance is not likely to produce, and notable to multiple diseases preventive effect.Therefore it is a kind of reasonably to select complex preparation Wise, the economical and effective method using pesticide.Retrieval is studied by my company researcher, fluorine azoles bacterium aniline and is gone out at present Bacterium pellet respectively has composition research with other parts product respectively, such as application No. is the patent of invention of CN201610480915, relates to And the Bactericidal composite to fluorine azoles bacterium aniline and Metalaxyl-M;Application No. is the patented inventions of CN201610399399 to be related to fluorine azoles The Bactericidal composite of bacterium aniline and pyraclostrobin;Application No. is the patented inventions of CN201510074857 to be related to fluorine azoles bacterium aniline With the Bactericidal composite of thifluzamide;Application No. is the patents of invention of CN201510147932 to be related to killing for folpet and metconazole Bacterium combines;Application No. is the antimicrobial combinations that the patent of invention of CN201610365548 is related to folpet and fluorine ether bacterium amide. However, there has been no the antimicrobial combinations that folpet and fluorine azoles bacterium aniline compound for technology at present.The present invention sieves through a large number of experiments Choosing confirms that, by the compounding of folpet and fluorine azoles bacterium aniline, prevention spectrum has obtained prodigious expansion, and synergistic effect is apparent, right Delay drug resistance to play positive effect, to solve excessive pesticide residues, a series of problems, such as environmental pollution provide compared with Good thinking.
Invention content
It is an object of the invention to the vacancy for the existing research and development technology in market, providing a kind of can effectively prevent phytopathy Evil, have wider prevention spectrum, have and can notable synergistic antimicrobial combination.
Another object of the present invention is to provide the application of the microbicide compositions, the pesticide combination is particularly suitable for preventing Control the multiple diseases of the crops such as potato, wheat, rice, rape, vegetables, fruit tree kind, including but not limited to sclerotinia sclerotiorum, Wheat powdery mildew, rust, banded sclerotial blight, damping-off, smut, black scurf of potato, corn southern leaf blight, downy mildew of garpe, white rot Disease, anthracnose, ring rot of apple, spot defoliation, anthracnose, brown spot, leaf muld of tomato etc..
The present invention is achieved by the following technical solutions:
A kind of pesticide bacteriostat composition containing folpet and fluorine azoles bacterium aniline, the folpet and fluorine azoles bacterium aniline of the composition Weight ratio is 1:50~50:1.
Further, the folpet of the composition and the ratio of fluorine azoles bacterium aniline preferred weight are 1:20~20:1, further Preferably 5:1.
Further, the content for the preparation active ingredient that preferred fungicide composition is done is 1-90%.
Further, preferably composite preparation, active ingredient ratio are 20 ~ 80%, remaining is in Pesticide formulation Conventional auxiliary element.
Auxiliary agent belonging to the present invention includes emulsifier, spreader, wetting agent, dispersant, antifreezing agent, solvent, cosolvent, thickening It is one or more in agent, antifoaming agent, disintegrant etc..
Further, microbicide compositions of the invention are prepared by a conventional method into dosage form and are suitble to agriculturally make Any one dosage form, including but not limited to missible oil, wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion.
Technical program of the present invention also lies in above-mentioned microbicide compositions answering on prevention fungal diseases of plants drug With using with remarkable result especially in terms of the diseases such as Cereal, fruit tree, vegetable crop.
Compared with prior art, microbicide compositions of the present invention have the beneficial effect that:
1, folpet and fluorine azoles bacterium aniline used in the present invention, two kinds of active ingredient mechanisms of action are completely different, and mutual mixture will not Mutual antagonism, opposite the two can be effectively synergistic;
2, the crop range on probation that than two kinds compositions of the present composition scope of application are used alone increases, and is suitble to and anti-Zhiduo County The fungal disease of kind field crop such as Cereal, fruit tree, vegetables, especially to damping-off, sclerotiniose, with good prevention effect Fruit.And it can effectively inhibit generation of the germ to single active ingredient drug resistance;
3, preparation process of the present invention is simple to operation, the use of low for equipment requirements, convenient big production and field crop.
Specific implementation mode
One, example of formulations
1, embodiment 1:44% folpet fluorine azoles bacterium aniline missible oil(10:1)
Folpet 40%
Fluorine azoles bacterium aniline 4%
Agriculture breast 020,1#8 6%
Cyclohexanone 15%
Prosene surplus
By folpet, fluorine azoles bacterium aniline and auxiliary agent is divided uniformly to mix by above-mentioned formula, you can be made of the present invention 44% Missible oil.
2, embodiment 2:50% folpet fluorine azoles bacterium aniline suspending agent(4:1)
Folpet 40%
Fluorine azoles bacterium aniline 10%
Aliphatic acid polyethenoxy ether 2.5%
Alkyl phenol polyoxyethylene ether 6%
Xanthans 0.2%
Carboxymethyl cellulose 2%
Organosilicon 0.4%
Deionized water surplus
Folpet, fluorine azoles bacterium aniline and each host proportioning are sufficiently mixed uniformly by above-mentioned formula, made under sand mill effect The suspending agent for being 50% at active ingredient percentage.
3, embodiment 3:40% folpet fluorine azoles bacterium aniline suspending agent(3:1)
Folpet 30%
Fluorine azoles bacterium aniline 10%
Phosphate ester sulfonate 4%
Polycarboxylate 5%
Xanthans 0.5%
Lauryl sodium sulfate 2%
Ethylene glycol 5%
Oleic acid 6%
Solvent naphtha 10%
Deionized water surplus
Folpet, fluorine azoles bacterium aniline and each auxiliary agent are sufficiently mixed uniformly by above-mentioned formula, are formed under sand mill effect Imitate the suspending agent that percentage composition is 40%.
4, embodiment 4:42% folpet fluorine azoles bacterium aniline water dispersible granules(5:1)
Folpet 35%
Fluorine azoles bacterium aniline 7%
Sodium lignin sulfonate 6%
Polyvinyl alcohol 4%
Ammonium sulfate 8%
White carbon 10%
Kaolin surplus
Folpet, fluorine azoles bacterium aniline and each auxiliary agent are added by formula rate by above-mentioned formula and carry out air-flow powder after mixing It is broken, after a small amount of deionized water be added be stirred well to and uniformly can be prepared by required water dispersible granules product after drying.
5, embodiment 5:44% folpet fluorine azoles bacterium aniline suspension seed-coating agent(10:1)
Folpet 40%
Fluorine azoles bacterium aniline 4%
Fulvic acid 2%
Polyvinyl acetate 3%
Sodium lignin sulfonate 5%
Alkyl phenol polyoxyethylene ether 6%
Xanthans 0.2%
Carboxymethyl cellulose 2%
Ethylene glycol 5%
Acid red 0.4%
Kathon CG 0.4%
Deionized water surplus
Folpet, fluorine azoles bacterium aniline and each auxiliary agent proportioning are sufficiently mixed uniformly by above-mentioned formula, active ingredient percentage is made Than the suspension seed-coating agent for 44%.
Two, biological activity determination
1, subjects:Rice sheath blight disease;
2, test method:Using mycelial growth rate method, fluorine azoles bacterium aniline and folpet mother liquor are taken, liquid tablet is made into, per ware About 10 mL, each drug concentration are arranged 3 repetitions, blank control are separately arranged(Add sterile water).By cultured rice banded sclerotial blight Disease draws mycelia block with the sterilization punchers of a diameter of 0.5 cm, is moved respectively on different culture medium flat plates, is cultivated at 28 DEG C 3 days, measure colony diameter(mm), and bacteriostasis rate is calculated, the logarithm matter of niqueMin and series concentration by inhibiting inhibiting rate The linear regression analysis of inspection finds out the EC of processing50, use co-toxicity coefficient(CTC)To evaluate, medicament is specific to the activity of germ to be calculated Mode is as follows:
Survey toxicity index (ATI)=(standard agent EC50/ reagent agent EC50)×100
In theoretical toxicity index (TTI)=A medicament toxicity index × mixture in percentage composition+B medicament toxicity index × mixture of A The percentage composition of B
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] × 100
As CTC < 80, then composition shows as antagonism, and as 80 < CTC < 120, then composition shows as summation action, when CTC > 120, then composition show as synergistic effect.
Test result is as shown in table 1.
The Toxicity Determination result shows:Folpet and fluorine azoles bacterium aniline are with weight ratio for 1:50~50:1 is mixed to rice Banded sclerotial blight has preferable virulence, weight ratio 1:20-20:1 synergistic effect is notable, and especially weight ratio is 5:1 synergistic effect is most It is notable.
Three, field control effectiveness test
The composite preparation of 1-4 of the embodiment of the present invention is selected to carry out the field control effectiveness test of rice sheath blight disease to determine the present invention's Composition pesticide is with 80% folpet water dispersible granules and 22% fluorine azoles bacterium aniline suspending agent to the control effect of rice sheath blight disease Comparison medicament tests 4 repetitions of each processing setting, each plot area 20m2, share 20 cells, random district's groups arrangement.It adopts Hand spray processing is carried out with conventional spray-on process, to plant cauline leaf even spraying, sprays complete stool.In rice sheath blight disease early stage First time dispenser is carried out, second is carried out after 10 days and is sprayed, respectively 7 days, 14 days investigation prevention effects after the second application.Examination Test that the results are shown in Table 2:
Field test results are as shown in table 2, and folpet and the independent dispenser of fluorine azoles bacterium aniline have rice sheath blight disease certain anti- Control effect, and the raising for rationally increasing advantageous preventive effect of dosage, but pharmaceutical use needs significantly improve, preventive effect with when Between extension, gradually weaken.Contrastingly, to rice sheath blight disease after second of dispenser of mixture of folpet and fluorine azoles bacterium aniline Control effect is substantially better than the control effect of two kinds of single doses.And the preventive effect after dispenser 14 days is generally better than the prevention after 7 days Effect shows apparent synergistic effect to the control effect of crops.It is fool proof to trial crops during experiment, without poisoning Reaction.

Claims (9)

1. a kind of bactericide pesticide composite, which is characterized in that its active constituent includes folpet and fluorine azoles bacterium aniline.
2. microbicide compositions according to claim 1, which is characterized in that the weight of the folpet and fluorine azoles bacterium aniline Proportioning is 1:50~50:1.
3. microbicide compositions according to claim 2, which is characterized in that the weight of the folpet and fluorine azoles bacterium aniline Than being 1:20~20:1.
4. microbicide compositions according to claim 3, which is characterized in that the weight of the folpet and fluorine azoles bacterium aniline It is preferred that than being 5:1.
5. according to the microbicide compositions described in any one of claim 1-4, which is characterized in that active constituent accounts for composition Weight percentage be 1-90%, preferably 20-80%.
6. according to the microbicide compositions described in any one of claim 1-5, which is characterized in that the microbicide compositions Further include agricultural agent, the auxiliary agent includes emulsifier, wetting agent, dispersant, antifreezing agent, solvent, cosolvent, thickener, disappears It is one or more in infusion, disintegrant etc.;Content of the auxiliary agent in microbicide compositions is 1-99%.
7. according to the microbicide compositions described in claim 1-6 any one, which is characterized in that the dosage form of composition is wettable Property pulvis, water dispersible granules, missible oil, suspending agent, microcapsule suspending agent, microemulsion, aqueous emulsion, suspension seed-coating agent etc.;It is further excellent Turn to wettable powder, missible oil, suspending agent, water dispersible granules.
8. the microbicide compositions described in claim 7 are used to prevent the purposes of fungus-caused plant disease.
9. purposes according to claim 8, wherein the plant disease includes but not limited to sclerotinia sclerotiorum, wheat white powder Disease, rust, banded sclerotial blight, damping-off, smut, black scurf of potato, corn southern leaf blight, downy mildew of garpe, white rot, anthrax Disease, ring rot of apple, spot defoliation, anthracnose, brown spot, leaf muld of tomato.
CN201710310374.7A 2017-05-05 2017-05-05 Composition pesticide containing folpet and fluorine azoles bacterium aniline Pending CN108782578A (en)

Priority Applications (1)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020141512A1 (en) * 2018-12-31 2020-07-09 Adama Makhteshim Ltd. Fungicidal mixture

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1229580A (en) * 1998-01-27 1999-09-29 罗姆和哈斯公司 Fungicidal compositions containing N-acetonylbenzamides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1229580A (en) * 1998-01-27 1999-09-29 罗姆和哈斯公司 Fungicidal compositions containing N-acetonylbenzamides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
山边正显: "《无处不在的氟》", 31 October 2014, 中国科学技术大学出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020141512A1 (en) * 2018-12-31 2020-07-09 Adama Makhteshim Ltd. Fungicidal mixture

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Application publication date: 20181113