CN104984164A - Traditional Chinese medicine for treating liver-yin and kidney-yin deficiency type pediatric iron-deficiency anemia and preparing method of traditional Chinese medicine - Google Patents

Abstract

The invention provides traditional Chinese medicine for treating liver-yin and kidney-yin deficiency type pediatric iron-deficiency anemia and a preparing method of the traditional Chinese medicine. The traditional Chinese medicine comprises the following raw medical materials including sensitive plant, centella, coix lacryma-jobi leaves, wild fragrant-flowered garlic, coriaceous knotweed rhizome, cockscomb, pumpkin, cynanchum glaucescens, eleusine indica, yellow fungus, goldfussia psilostachys, myrcia, grapevine stems and leaves and rhodobryum roseum. The traditional Chinese medicine has the beneficial effects that the traditional Chinese medicine is used for treating liver-yin and kidney-yin deficiency type pediatric iron-deficiency anemia; the curative effect is exact; the side effects are few; the use is convenient. The preparing method has the advantages that the process is simple, and the industrial production is easy.

Description

A kind of Chinese medicine and preparation method for the treatment of liver-kidney yin deficiency iron Deficiency Anemia

Technical field

The present invention relates to pharmaceutical technology, particularly relate to a kind of Chinese medicine and preparation method for the treatment of liver-kidney yin deficiency iron Deficiency Anemia.

Background technology

Iron deficiency anemia (iron deficiency ancemia) is the commonly encountered diseases of children's, mainly occurs in the infant in June to 3 year old.There is the features such as the low color of minicell, serum levels of iron and transferrin saturation reduce, iron in treatment is respond well.After liberation, various food deficiency disease all obviously reduces, but iron deficiency anemia is still the food deficiency disease of common threat child health.According to national 16 provinces and cities in 1981 to the investigation of 8435 29 days to 7 years old children's, hemoglobin in the prevalence of the nutritional anemia of below 110g/L up to 36.31%; June to 6 year old children's 9027, prevalence is 43.03%.Thus this is problem anxious to be resolved in child health care work.

Chalybeate is the specific drug for the treatment of iron deficiency anemia, and its kind is a lot, is generally most economical, convenient and effective method with oral inorganic salt.Ferrous iron absorption easier than ferric iron, therefore adopt, conventional has ferrous lactate, and iron-holder is 20%, and this amount can reach the maximum of absorption, and exceed this amount and absorb decline, increase the stimulation to gastric mucosa on the contrary, dosage is excessive produces intoxicating phenomenon. moreTake medicine best between two meal, both reduced the stimulation to gastric mucosa, and be beneficial to absorption again.Should avoid taking with great deal of milk simultaneously, because milk is phosphorous higher, the absorption of ferrum can be affected.

For can not tolerate Oral Iron Preparations, diarrhoea is serious and sick child that anemia is heavier, needs consideration chalybeate to inject.Conventional rail injection agent has: iron dextran, every ml iron content 50mg, intramuscular injection; Saccharated iron oxide, every ml iron content 20mg, intravenous injection.Intramuscular injection chalybeate local can produce pain and urticaria, is also shown in heating, arthralgia, headache or regional glandular enlargement etc.Also can there is angiitis obliterans in intravenous injection chalybeate.The response to treatment of injection chalybeate unlike soon oral, therefore must be cautious use of.

Iron in treatment generally must continue to be applied to erythrocyte and hemoglobin and reach after normal level at least 6 ~ 8 weeks.Because of iron deficiency anemia, not only hemoglobin reduction, storage iron also exhausts.Due to the continuous growth promoter of children's, blood volume constantly expands, and can not meet the needs of ferrum in diet, and therapeutic purposes only should not correct iron deficiency anemia, and should store enough ferrum, for future use.Vitamin B12, folic acid or extractum hepatis are invalid for treatment iron deficiency anemia, can not abuse.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of Chinese medicine and preparation method for the treatment of liver-kidney yin deficiency iron Deficiency Anemia, and this Chinese medicine is to treatment liver-kidney yin deficiency iron Deficiency Anemia, and determined curative effect, side effect is little, easy to use.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of liver-kidney yin deficiency iron Deficiency Anemia, wherein, comprise following raw medicinal material: Herba Mimosae Pudicae, Herba Centellae, Folium Coicis, Herba Allii bulleyani, Rhizoma Polygoni coriacei, Flos Celosiae Cristatae, Caulis Cucurbitae, Rhizoma Cynanchi Stauntonii, Herba Eleusines Indicae, Tremella mesenterica Retz ex Fr., Herba Goldffussiae Psilostachydis, Herba Pelargonii Graveolentis, Caulis et Folium vitis viniferae and Rhodobryum roseum Limpr..

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Mimosae Pudicae 5 ~ 15 parts, Herba Centellae 10 ~ 20 parts, Folium Coicis 15 ~ 25 parts, Herba Allii bulleyani 10 ~ 20 parts, Rhizoma Polygoni coriacei 25 ~ 35 parts, Flos Celosiae Cristatae 22 ~ 32 parts, Caulis Cucurbitae 30 ~ 40 parts, Rhizoma Cynanchi Stauntonii 15 ~ 25 parts, Herba Eleusines Indicae 26 ~ 36 parts, Tremella mesenterica Retz ex Fr. 20 ~ 30 parts, Herba Goldffussiae Psilostachydis 8 ~ 18 parts, Herba Pelargonii Graveolentis 20 ~ 30 parts, Caulis et Folium vitis viniferae 16 ~ 26 parts and Rhodobryum roseum Limpr. 14 ~ 24 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Mimosae Pudicae 6 ~ 11 parts, Herba Centellae 15 ~ 20 parts, Folium Coicis 17 ~ 22 parts, Herba Allii bulleyani 12 ~ 17 parts, Rhizoma Polygoni coriacei 30 ~ 35 parts, Flos Celosiae Cristatae 24 ~ 29 parts, Caulis Cucurbitae 32 ~ 37 parts, Rhizoma Cynanchi Stauntonii 17 ~ 22 parts, Herba Eleusines Indicae 28 ~ 33 parts, Tremella mesenterica Retz ex Fr. 25 ~ 30 parts, Herba Goldffussiae Psilostachydis 11 ~ 16 parts, Herba Pelargonii Graveolentis 25 ~ 30 parts, Caulis et Folium vitis viniferae 19 ~ 24 parts and Rhodobryum roseum Limpr. 17 ~ 22 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Mimosae Pudicae 10 parts, Herba Centellae 16 parts, Folium Coicis 21 parts, Herba Allii bulleyani 13 parts, Rhizoma Polygoni coriacei 34 parts, Flos Celosiae Cristatae 25 parts, Caulis Cucurbitae 36 parts, Rhizoma Cynanchi Stauntonii 18 parts, Herba Eleusines Indicae 32 parts, Tremella mesenterica Retz ex Fr. 26 parts, Herba Goldffussiae Psilostachydis 15 parts, Herba Pelargonii Graveolentis 26 parts, Caulis et Folium vitis viniferae 20 parts and Rhodobryum roseum Limpr. 18 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Mimosae Pudicae 8 parts, Herba Centellae 18 parts, Folium Coicis 19 parts, Herba Allii bulleyani 15 parts, Rhizoma Polygoni coriacei 30 parts, Flos Celosiae Cristatae 28 parts, Caulis Cucurbitae 33 parts, Rhizoma Cynanchi Stauntonii 21 parts, Herba Eleusines Indicae 30 parts, Tremella mesenterica Retz ex Fr. 28 parts, Herba Goldffussiae Psilostachydis 12 parts, Herba Pelargonii Graveolentis 29 parts, Caulis et Folium vitis viniferae 22 parts and Rhodobryum roseum Limpr. 20 parts.

Wherein, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Wherein, when the dosage form of described Chinese medicine is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Beneficial effect of the present invention: Chinese medicine of the present invention is to treating liver-kidney yin deficiency iron Deficiency Anemia, determined curative effect, and side effect is little, easy to use; It is simple that preparation method has technique, is easy to industrial advantage.

Detailed description of the invention

Of the present inventionly provide a kind of Chinese medicine for the treatment of liver-kidney yin deficiency iron Deficiency Anemia, wherein, comprise following raw medicinal material: Herba Mimosae Pudicae, Herba Centellae, Folium Coicis, Herba Allii bulleyani, Rhizoma Polygoni coriacei, Flos Celosiae Cristatae, Caulis Cucurbitae, Rhizoma Cynanchi Stauntonii, Herba Eleusines Indicae, Tremella mesenterica Retz ex Fr., Herba Goldffussiae Psilostachydis, Herba Pelargonii Graveolentis, Caulis et Folium vitis viniferae and Rhodobryum roseum Limpr..

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Herba Mimosae Pudicae: [another name] know shy grass, coy grass, drink exhale grass, be afraid of ugly grass, Herba cassiae occidentalis, henpecked grass, Biophytum nanum H. Chuang sp. Nov. Ined.-B. Sensitivum auct. Non (L.) DC..[source] medical material Ji Yuan: be the herb of leguminous plant Herba Mimosae Pudicae.[nature and flavor] are bitter; Puckery; Micro-hardship; Be slightly cold; Mild toxicity.[return through] heart; Liver; Stomach; Large intestine channel.[function cures mainly] removing pathogenic heat from blood and toxic substance from the body; Clearing away heat-damp and promoting diuresis; Tranquillizing and allaying excitement.Main flu; Infantile hyperpyrexia; Bronchitis; Hepatitis; Intestinal is scorching; Conjunctivitis; Urinary system calculus; Edema; Impairment caused by overstrain hemoptysis; Epistaxis; Hematuria; Neurasthenia; Insomnia; Sore swollen toxin; Herpes zoster; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Herba Centellae: [another name] Herba Glechomae, marchantia grass, Herba Calthae Membranaceae, Gotu Kola, certain herbaceous plants with big flowers Penglai, chipping bowl, Herba sambuci chinensis, Chinese bush cherry grass, large Herba Calthae Membranaceae, TUXIXIN, collapse jorum, Gotu Kola, the Congo dragon, Herba Centellae taro grass, something that gives the game away mark, bud Dendrobium denneanum Kerr., careless as one wishes, Carnis Arca inflata shell is careless, determine containing shell grass, bowl of begging for food, old jackal bowl, flood money, Hydrocotyle sibthorpioides lam.Var.Batvachium (Hand.-Mazz.) et shan. grass, Hydrocotyle vulgaris L., old duck, bowl is broken in ferrum oil lamp, half of bowl, Herba speranskiae tuberculatae, jumping, Thunder God bowl, Herba Asari, Herba lysimachiae capillipedis.[source] medical material Ji Yuan: be the herb of samphire Herba Centellae.[nature and flavor] bitter in the mouth; Pungent; Cold in nature.[return through] returns lung; Spleen; Kidney; Urinary bladder channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Promoting blood circulation and hemostasis; Removing toxic substances and promoting subsidence of swelling.Main heating; Cough with asthma; Laryngopharynx swelling and pain; Intestinal for for; Dysentery; Jaundice due to damp-heat; Edema; Stranguria; Hematuria; Epistaxis; Dysmenorrhea; Metrorrhagia; Erysipelas; Scrofula; Parent's pyogenic infections from tumour or sore; Herpes zoster; Treating swelling and pain by traumatic injury; Traumatic hemorrhage; Snake bite and insect sting.[extracts] " China's book on Chinese herbal medicine "

Folium Coicis: [source] medical material Ji Yuan: the leaf of grass Semen Coicis.[function cures mainly] warming spleen and stomach for dispelling cold; Benefiting vital QI and blood.Main cold syndrome of the stomach pain; Deficient qi and blood.[extracts] " China's book on Chinese herbal medicine "

Herba Allii bulleyani: [another name] Sempervivum tectorum, Radix Ophiopogonis, wild leek, wild Radix Ophiopogonis, book band are careless, black spends wild fragrant-flowered garlic, black colored fragrant-flowered garlic.[source] medical material Ji Yuan: be the herb of liliaceous plant Allium wallichii.Latin plant animal mineral name: Allium wallichii Kunth [A.tchongchanense Levl.; A.bulleyanrmDiels].[nature and flavor] acrid in the mouth; Sweet; Property is put down.[return through] liver; Spleen channel.[function cures mainly] promoting blood circulation to remove blood stasis; Dispelling wind for relieving itching.Main traumatic injury; Gunshot wound; Urticaria; Psoriasis; Dermatitis rhus.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Polygoni coriacei: [another name] chicken feet king, Rhizoma Bistortae, hornet seven, Rhizoma Polygoni Paleachi.[source] medical material Ji Yuan: be the rhizome of polygonaceae plant leather leaf knotweed.Latin plant animal mineral name: Polygonum coriaceumSam.[nature and flavor] are bitter; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing.Main hygropyretic dysentery; Diarrhoea; Carbuncle; Hemorrhoid; Gingival swelling and pain; Erosion of the oral mucosa; Burn; Venom.[extracts] " China's book on Chinese herbal medicine "

Flos Celosiae Cristatae: [another name] chicken hair worn in a bun or coil flower, cock flower, chicken angle rifle, cockscomb head, Os Gallus domesticus flower, an old person having a young heart' a person old in age but young in spirit.[source] medical material Ji Yuan: be the inflorescence of amaranthaceous plant Flos Celosiae Cristatae.[nature and flavor] are sweet; Cool; Nontoxic.[return through] liver; Kidney channel.[function cures mainly] removing heat from blood; Hemostasis.Main anal fistula hematochezia; Red white dysentery; Spit blood; Hemoptysis; Stranguria with blood; Women's metrorrhagia; Leucorrhea with red and white discharge.[extracts] " China's book on Chinese herbal medicine "

Caulis Cucurbitae: [source] medical material Ji Yuan: be the stem of cucurbitaceous plant Fructus Cucurbitae moschatae.[nature and flavor] sweet in the mouth; Bitter; Cold nature.[return through] enters liver; Stomach; Lung meridian.[function cures mainly] lung heat clearing; Suppressing the hyperactive liver; Stomach function regulating; Dredging collateral.Main pulmonary tuberculosis low grade fever; Stomachache due to hyperactive liver-QI attacking the stomach; Menoxenia; Acute catarrhal conjunctivitis swelling pain; Burn due to hot liquid or fire.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Cynanchi Stauntonii: [another name] Shi Lan, medicine of coughing, rhizoma et radix cynanchi stauntoni, Radix Homonoiae Ripariae, large crane wooden dipper, water willow, leaves of Daphne genkwa Rhizoma Cynanchi Stauntonii, small stream wooden dipper thick soup, the knot grass that disappears, crow obstruct son, sweet Rhizoma Cynanchi Stauntonii, fry Rhizoma Cynanchi Stauntonii, goose pipe Rhizoma Cynanchi Stauntonii.[source] medical material Ji Yuan: be the root and rhizome of dicotyledon medicine asclepiadaceae plant rhizoma et radix cynanchi stauntoni or leaves of Daphne genkwa Rhizoma Cynanchi Stauntonii.[nature and flavor] Xin Gan; Tepor; Nontoxic.[return through] lung meridian.[function cures mainly] eliminating the pathogens from the lung sending down the abnormal ascending QI; Lower expectorant antitussive.Main smelting lung qi stops up the cough with copious phlegm of reality; Dyspnea due to adverseness of QI; Gastralgia; Youngster's infantile malnutrition; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Herba Eleusines Indicae: [another name] a thousand pieces of gold grass, 1,000 to step on, young grass of being unworthy of the honour, thousand people pull out, Shen grass, Niu Duncao, duck foot grass, foxtail millet are young more, pheasant pawl, chestnut cattle eggplant grass, yard grass, flat grass, water bull grass, careless, the very heavy grass of Cryllus testaceus wallker, chi basin grass, Pathways Grass, millet grass, flaccid anemone, wild duck foot dish, old donkey is careless, hundred nights are careless.[source] medical material Ji Yuan: be root or the herb of grass Herba Eleusines Indicae.[nature and flavor] are sweet; Light; Cool.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body.Main Sunstroke heating; Infantile convulsion; Encephalitis b; Epidemic encephalitis; Jaundice; Stranguria; Dysuria; Dysentery; Have blood in stool; Skin infection swells and ache; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Tremella mesenterica Retz ex Fr.: [another name] golden Auricularia, Tremella mesenterica, yellow ear.[source] medical material Ji Yuan: be the sporophore of Tremellaceae plant Tremella aurantialba Bandoni et Zang.[nature and flavor] are sweet; Flat.[return through] lung meridian.[function cures mainly] nourishing YIN and moistening the lung; Promoting the production of body fluid to quench thirst.Main cough due to consumptive disease; Sputum mixed with blood; Tianjin is few thirsty; Osteopyrexia and fever; Night sweat.[extracts] " China's book on Chinese herbal medicine "

Herba Goldffussiae Psilostachydis: [another name] Championella maclurei (Merr) c. Y. Wu et H. S. L..[source] medical material Ji Yuan: be stem, the leaf of acanthaceous plant thin fringe gold foot grass.[nature and flavor] taste is micro-pungent; Bitter cool.[function cures mainly] heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Main furuncle toxic swelling; Tinea versicolor; Treating swelling and pain by traumatic injury; Venom.[extracts] " China's book on Chinese herbal medicine "

Herba Pelargonii Graveolentis: [another name] Artemisia argyi.[source] medical material Ji Yuan: be the stem and leaf of MangNiu Er Seedling section plant Pelargonium gravelens.Latin plant animal mineral name: Pelargonium graveolens L ＇ Herit.[nature and flavor] acrid in the mouth; Warm in nature.[return through] lung; Liver Channel.[function cures mainly] expelling wind and removing dampness; Promoting the circulation of QI to relieve pain; Parasite killing.Main air pain of dampness syndrome; Hernia; Eczema scrotum; Scabies.[extracts] " China's book on Chinese herbal medicine "

Caulis et Folium vitis viniferae: [another name] seedling of Fructus Vitis viniferae.[source] medical material Ji Yuan: be the rattan leaf of vitaceae Fructus Vitis viniferae.Latin plant animal mineral name: Vitis vinifera L.[nature and flavor] are sweet; Flat.[return through] kidney; Liver; Urinary bladder channel.[function cures mainly] expelling wind and removing dampness; Inducing diuresis to remove edema; Removing toxic substances.Main air pain of dampness syndrome; Edema; Diarrhoea; Wind heat conjunctival congestion; Carbuncle furuncle.[extracts] " China's book on Chinese herbal medicine "

Rhodobryum roseum Limpr.: [another name] great Ye moss, ferrum foot Rhizoma Arisaematis, Herba Polygoni Capitati.[source] medical material Ji Yuan: be the herb of the red great Ye moss of Bryaceae plant.Latin plant animal mineral name: Rhodobryum roseum (Hedw.) Limpr. [Mnium roseum Hedw.].[nature and flavor] are light; Micro-hardship; Flat.[return through] heart channel.[function cures mainly] tranquilizing by nourishing the heart; Calm.Main heart disease; Nervous; Severe palpitation; Neurasthenia.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Mimosae Pudicae 5 ~ 15 parts, Herba Centellae 10 ~ 20 parts, Folium Coicis 15 ~ 25 parts, Herba Allii bulleyani 10 ~ 20 parts, Rhizoma Polygoni coriacei 25 ~ 35 parts, Flos Celosiae Cristatae 22 ~ 32 parts, Caulis Cucurbitae 30 ~ 40 parts, Rhizoma Cynanchi Stauntonii 15 ~ 25 parts, Herba Eleusines Indicae 26 ~ 36 parts, Tremella mesenterica Retz ex Fr. 20 ~ 30 parts, Herba Goldffussiae Psilostachydis 8 ~ 18 parts, Herba Pelargonii Graveolentis 20 ~ 30 parts, Caulis et Folium vitis viniferae 16 ~ 26 parts and Rhodobryum roseum Limpr. 14 ~ 24 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Mimosae Pudicae 6 ~ 11 parts, Herba Centellae 15 ~ 20 parts, Folium Coicis 17 ~ 22 parts, Herba Allii bulleyani 12 ~ 17 parts, Rhizoma Polygoni coriacei 30 ~ 35 parts, Flos Celosiae Cristatae 24 ~ 29 parts, Caulis Cucurbitae 32 ~ 37 parts, Rhizoma Cynanchi Stauntonii 17 ~ 22 parts, Herba Eleusines Indicae 28 ~ 33 parts, Tremella mesenterica Retz ex Fr. 25 ~ 30 parts, Herba Goldffussiae Psilostachydis 11 ~ 16 parts, Herba Pelargonii Graveolentis 25 ~ 30 parts, Caulis et Folium vitis viniferae 19 ~ 24 parts and Rhodobryum roseum Limpr. 17 ~ 22 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Mimosae Pudicae 10 parts, Herba Centellae 16 parts, Folium Coicis 21 parts, Herba Allii bulleyani 13 parts, Rhizoma Polygoni coriacei 34 parts, Flos Celosiae Cristatae 25 parts, Caulis Cucurbitae 36 parts, Rhizoma Cynanchi Stauntonii 18 parts, Herba Eleusines Indicae 32 parts, Tremella mesenterica Retz ex Fr. 26 parts, Herba Goldffussiae Psilostachydis 15 parts, Herba Pelargonii Graveolentis 26 parts, Caulis et Folium vitis viniferae 20 parts and Rhodobryum roseum Limpr. 18 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Mimosae Pudicae 8 parts, Herba Centellae 18 parts, Folium Coicis 19 parts, Herba Allii bulleyani 15 parts, Rhizoma Polygoni coriacei 30 parts, Flos Celosiae Cristatae 28 parts, Caulis Cucurbitae 33 parts, Rhizoma Cynanchi Stauntonii 21 parts, Herba Eleusines Indicae 30 parts, Tremella mesenterica Retz ex Fr. 28 parts, Herba Goldffussiae Psilostachydis 12 parts, Herba Pelargonii Graveolentis 29 parts, Caulis et Folium vitis viniferae 22 parts and Rhodobryum roseum Limpr. 20 parts.

Wherein, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Wherein, when the dosage form of described Chinese medicine is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: tablet

Get Herba Mimosae Pudicae 80g, Herba Centellae 180g, Folium Coicis 190g, Herba Allii bulleyani 150g, Rhizoma Polygoni coriacei 300g, Flos Celosiae Cristatae 280g, Caulis Cucurbitae 330g, Rhizoma Cynanchi Stauntonii 210g, Herba Eleusines Indicae 300g, Tremella mesenterica Retz ex Fr. 280g, Herba Goldffussiae Psilostachydis 120g, Herba Pelargonii Graveolentis 290g, Caulis et Folium vitis viniferae 220g and Rhodobryum roseum Limpr. 200g;

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 95%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.1 times of lactose, the starch of 0.2 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.03 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 2: injectable powder

Get Herba Mimosae Pudicae 100g, Herba Centellae 160g, Folium Coicis 210g, Herba Allii bulleyani 130g, Rhizoma Polygoni coriacei 340g, Flos Celosiae Cristatae 250g, Caulis Cucurbitae 360g, Rhizoma Cynanchi Stauntonii 180g, Herba Eleusines Indicae 320g, Tremella mesenterica Retz ex Fr. 260g, Herba Goldffussiae Psilostachydis 150g, Herba Pelargonii Graveolentis 260g, Caulis et Folium vitis viniferae 200g and Rhodobryum roseum Limpr. 180g;

Its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 4 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 28 hours under the condition of 7 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 2 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.35g needle-use activated carbon, fully stirs 30 minutes; Decarbonization filtering; With 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Toxicity test:

Acute toxicity testing: application NIH mice 60, SPF level, male and female half and half, body weight 15 ~ 22g, carries out acute toxicity testing.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 6.14g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 30.7g crude drug/kg), and matched group gives normal saline, administration in 1 day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, ingest, drink water, body weight increases all normal.Mouse oral gavage tablet LD of the present invention ₅₀> 30.7g crude drug/kg, every day, maximum dosage-feeding was 61.4g crude drug/kg/ day.Chinese medicine clinical application amount of the present invention in 6g crude drug/day/people, adult body weight in 60kg, average dosage is 0.1g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 18g) oral administration gavage Chinese medicine of the present invention is 614 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.

Long term toxicity test: tablet prepared by the embodiment of the present invention 1 presses 8.27,19.38 and 36.47g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: fetch and come from my institute of in February, 2013 ~ in December, 2014 and be in hospital and the 126 routine iron Deficiency Anemia patients of outpatient, man 69 example, female 57 is routine; 6 months ~ 12 years old age; The anemia order of severity: slight 31 examples, moderate 73 example, severe 22 example.126 routine patients are divided into treatment by Chinese herbs group and western medicine group at random, treatment group 66 people, man 36 example, female 30 example; 6 months ~ 12 years old age; The anemia order of severity: slight 16 examples, moderate 38 example, severe 12 example.Matched group 60 people, man 33 example, female 27 example; 6 months ~ 12 years old age; The anemia order of severity: slight 15 examples, moderate 35 example, severe 10 example.

The anemia order of severity (hemoglobin standard) classification: slight: within being less than normal value 30g/L; Moderate: be less than normal value 31g/L ~ 60g/L; Severe: be less than normal value 61g/L ~ 90g/L.

Diagnostic criteria:

Western medicine diagnose standard: 1, anemia is the low color of minicell: (1) red cell morphology has the performance of obvious low pigment minicell, MCHC < 31%, MCV < 80FL, MCH < 27pg.(2) diagnostic criteria (in sea level) of anemia: blood of neonate Lactoferrin < 145g/L in raw latter 10 days, the standard that 10 days to 3 months babies affect anemia because of factors such as physiologic anemias is difficult to determine, suggestion temporarily with hemoglobin < 100g/L for anemia; 3 months to less than 6 years old < 110g/L, 6 ~ 14 years old < 120g/L.Height above sea level often increases 1000m, and hemoglobin raises about 4%.2, clear and definite Fe deficiency symptoms is had to increase or chronic blood loss etc. because of such as iron supply deficiency, malabsorption, needs.3, serum (slurry) ferrum < 10.7 μm of ol/L (60 μ g/d1).4, total iron binding capacity > 62.7 μm of ol/L (350 μ g/d1); Transferrin saturation < 15% has reference significance, and < 100% has exact meaning.5, the outer ferrum of medullary cell obviously reduces or disappear (0 ~+); Sideroblast < 15%.6, EP > 500 μ g/L.7, serum ferritin < 16 μ g/L.8, iron in treatment is effective.With iron in treatment after 6 weeks, hemoglobin more than rising 10g/L.Meet at least two articles of persons in the 1st article and 2 ~ 8 articles, diagnosable is iron deficiency anemia.

Syndrome Differentiation of Traditional Chinese Medicine standard: liver-kidney yin deficiency: dizziness and tinnitus, two dryness and uneasy feeling of the eye, Facial flush, burning pain in the hypochondrium, dysphoria with feverish sensation in the chest palms and soles, hectic fever night sweat, dry mouth and throat, or see wriggling of the limbs, red tongue with a little fluid, stringy,thready and rapid pulse.

Therapeutic Method:

Treatment by Chinese herbs group: take tablet prepared by the embodiment of the present invention 1, less than 3 years old, each 1, more than 3 years old each 2, every day 3 times, early, middle and late each once; Within 2 weeks, be 1 course for the treatment of, treat 3 courses for the treatment of.

Western medicine group: children's's ferrous sulfate syrup (contain logical Pharmaceutical, the accurate word H42022382 of traditional Chinese medicines), less than 1 years old, one time 1.5 milliliters, 3 times on the one; 1 ~ 5 year old, one time 3 milliliters, 3 times on the one; 6 ~ 12 years old, one time 8 milliliters, 2 times on the one; Within 2 weeks, be 1 course for the treatment of, treat 3 courses for the treatment of.

The standard of curative effect evaluation: draft with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".Clinical cure: clinical symptoms and sign disappear, the lab testings such as chemical examination hemogram, serum levels of iron and iron-binding capacity are all normal.Effective: clinical symptoms and sign are obviously improved or substantially disappeared, lab testing such as chemical examination hemogram, serum levels of iron and iron-binding capacity etc. is clearly better or close to normal value.Invalid: clinical symptoms, sign and lab testing are all without improvement.

Therapeutic outcome: in table 1 and table 2.

Table 1 liang group treats Clinical efficacy comparison example (%) after 3 courses for the treatment of respectively

Group	Number of cases	Clinical cure	Effectively	Invalid	Total effective rate
						Treatment group	66	56	8	2	64(97.0％)
Matched group	60	35	17	8	52(86.7％)

As can be seen from Table 1, adopt Children Treated with Chinese Traditional Drugs iron deficiency anemia of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement.

Table 2 liang group treats clinical cure number and time comparative example (%) after 3 courses for the treatment of respectively

Group	Number of cases	Treat 2 weeks	Treat 4 weeks	Treat 6 weeks
					Treatment group	56	19(28.8％)	47(71.2％)	56(84.8％)
Matched group	35	6(10％)	20(33.3％)	35(58.3％)

As can be seen from Table 2, adopt treatment by Chinese herbs iron deficiency anemia of the present invention, relative to Western medicine, treatment the course for the treatment of on significantly shorten, take effect faster.

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, safety is high, the advantage that has no side effect.

Untoward reaction: treatment group 66 routine patient have no adverse reaction.The routine patient of matched group 60, nausea and vomiting 12 example, inappetence 16 example, upper abdomen distending pain 9 example, constipation 4 example, disappears in one week after general drug withdrawal.

Model case: Zhao, male, 5 years old, always say dizziness and tinnitus, face and trick heating, after being admitted to hospital, have a medical check-up, chemically examine and trace element test result: MIDA, TCM Syndrome Type: dizziness and tinnitus, two dryness and uneasy feeling of the eye, Facial flush, burning pain in the hypochondrium, dysphoria with feverish sensation in the chest palms and soles, hectic fever night sweat, dry mouth and throat, red tongue with a little fluid, stringy,thready and rapid pulse, further typing is liver-kidney yin deficiency iron Deficiency Anemia.Take tablet prepared by the embodiment of the present invention 1, every day 3 times, each 2, after taking medicine 2 weeks, all diseases disappear substantially; Continue to take medicine to 3 weeks, clinical symptoms and sign disappear completely, and the lab testings such as chemical examination hemogram, serum levels of iron and iron-binding capacity all recover normal, and woods Chu cures.Follow up a case by regular visits to half a year, do not recur.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat a Chinese medicine for liver-kidney yin deficiency iron Deficiency Anemia, it is characterized in that, comprise following raw medicinal material: Herba Mimosae Pudicae, Herba Centellae, Folium Coicis, Herba Allii bulleyani, Rhizoma Polygoni coriacei, Flos Celosiae Cristatae, Caulis Cucurbitae, Rhizoma Cynanchi Stauntonii, Herba Eleusines Indicae, Tremella mesenterica Retz ex Fr., Herba Goldffussiae Psilostachydis, Herba Pelargonii Graveolentis, Caulis et Folium vitis viniferae and Rhodobryum roseum Limpr..

2. Chinese medicine as claimed in claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Mimosae Pudicae 5 ~ 15 parts, Herba Centellae 10 ~ 20 parts, Folium Coicis 15 ~ 25 parts, Herba Allii bulleyani 10 ~ 20 parts, Rhizoma Polygoni coriacei 25 ~ 35 parts, Flos Celosiae Cristatae 22 ~ 32 parts, Caulis Cucurbitae 30 ~ 40 parts, Rhizoma Cynanchi Stauntonii 15 ~ 25 parts, Herba Eleusines Indicae 26 ~ 36 parts, Tremella mesenterica Retz ex Fr. 20 ~ 30 parts, Herba Goldffussiae Psilostachydis 8 ~ 18 parts, Herba Pelargonii Graveolentis 20 ~ 30 parts, Caulis et Folium vitis viniferae 16 ~ 26 parts and Rhodobryum roseum Limpr. 14 ~ 24 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Mimosae Pudicae 6 ~ 11 parts, Herba Centellae 15 ~ 20 parts, Folium Coicis 17 ~ 22 parts, Herba Allii bulleyani 12 ~ 17 parts, Rhizoma Polygoni coriacei 30 ~ 35 parts, Flos Celosiae Cristatae 24 ~ 29 parts, Caulis Cucurbitae 32 ~ 37 parts, Rhizoma Cynanchi Stauntonii 17 ~ 22 parts, Herba Eleusines Indicae 28 ~ 33 parts, Tremella mesenterica Retz ex Fr. 25 ~ 30 parts, Herba Goldffussiae Psilostachydis 11 ~ 16 parts, Herba Pelargonii Graveolentis 25 ~ 30 parts, Caulis et Folium vitis viniferae 19 ~ 24 parts and Rhodobryum roseum Limpr. 17 ~ 22 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Mimosae Pudicae 10 parts, Herba Centellae 16 parts, Folium Coicis 21 parts, Herba Allii bulleyani 13 parts, Rhizoma Polygoni coriacei 34 parts, Flos Celosiae Cristatae 25 parts, Caulis Cucurbitae 36 parts, Rhizoma Cynanchi Stauntonii 18 parts, Herba Eleusines Indicae 32 parts, Tremella mesenterica Retz ex Fr. 26 parts, Herba Goldffussiae Psilostachydis 15 parts, Herba Pelargonii Graveolentis 26 parts, Caulis et Folium vitis viniferae 20 parts and Rhodobryum roseum Limpr. 18 parts.

5. the Chinese medicine as described in claims 1 to 3, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Herba Mimosae Pudicae 8 parts, Herba Centellae 18 parts, Folium Coicis 19 parts, Herba Allii bulleyani 15 parts, Rhizoma Polygoni coriacei 30 parts, Flos Celosiae Cristatae 28 parts, Caulis Cucurbitae 33 parts, Rhizoma Cynanchi Stauntonii 21 parts, Herba Eleusines Indicae 30 parts, Tremella mesenterica Retz ex Fr. 28 parts, Herba Goldffussiae Psilostachydis 12 parts, Herba Pelargonii Graveolentis 29 parts, Caulis et Folium vitis viniferae 22 parts and Rhodobryum roseum Limpr. 20 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is injectable powder, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is injectable powder, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.