CN104983854A - Kidney tonifying, center opening, and heart enhancing particle and preparation method thereof - Google Patents
Kidney tonifying, center opening, and heart enhancing particle and preparation method thereof Download PDFInfo
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- CN104983854A CN104983854A CN201510430518.3A CN201510430518A CN104983854A CN 104983854 A CN104983854 A CN 104983854A CN 201510430518 A CN201510430518 A CN 201510430518A CN 104983854 A CN104983854 A CN 104983854A
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Abstract
The invention discloses a kidney tonifying, center opening, and heart enhancing particle, which comprises the following components in parts by weight: 9 to 13.5 parts of radix aconiti preparata, 15 to 22.5 parts of radix codonopsis, 10 to 15 parts of epimedium, 12 to 18 parts of semen cuscutae, 20 to 30 parts of poria cocos, 10 to 15 parts of bighead atractylodes rhizome, 10 to 15 parts of dried orange peel, 6 to 9 parts of cassia twig, and 10 to 15 parts of cortex acanthopanacis. The preparation method of the particle comprises the following steps: weighing the raw materials according to the formula mentioned above, adding water, decocting, adding ethanol into concentrate to carry out alcohol precipitation, filtering and condensing to obtain extract; mixing the extract with dextrin, adding ethanol, drying, and finally adding water to product the particles. The particle can improve the situation of ventricular remodeling, and has the advantages of simpleness, convenience, verified effect, and cheapness. In the provided preparation method, the raw materials are decocted for three times, thus the effective components in the herbals can be fully extracted, and moreover, the particle is convenient to eat.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, particularly relate to a kind of the kidney invigorating and open pivot heart tonifying granule and preparation method thereof.
Background technology
Heart failure is the final result of multiple heart disease development caused by different pathogeny, is the more common whole late-stage clinical performance of various heart disease.Along with the quickening of aged tendency of population process and the rising of the common incidence of cardiovascular disease such as hypertension, coronary heart disease, the prevalence of heart failure raises just gradually, be unique disease kind that in major cardiovascular diseases, sickness rate significantly increases, just becoming the important public hygiene problem of 21 century.In recent years since, the Drug therapy of heart failure and complication thereof achieves marked improvement, but usually there will be the side effect of electrolyte disturbance during diuretic long-term taking as Drug therapy foundation stone; Improve gastrointestinal blood stasis, promote the proton pump inhibitor, H2 receptor antagonist, sucralfate etc. of gastric motility also to there is the side effect such as diarrhoea, constipation; ACEI preparation (as Captopril tablets) is proved to be the effect having and improve remodeling ventricle, but many patients are forced to due to side effect such as dry cough select drug withdrawal.Chinese medicine is acute in diagnosis and treatment, have obvious advantage in chronic heart failure, and traditional decoction decoction should not carry, deposit and enter amount to Patient controlled and bring difficulty; Market lacks again effective Chinese medicine granules in this respect.
Summary of the invention
In order to overcome defect of the prior art, a kind of the kidney invigorating is provided to open pivot heart tonifying granule.
The present invention is realized by following proposal:
Pivot heart tonifying granule is opened in a kind of the kidney invigorating, in mass parts, comprise following component: Radix Aconiti Lateralis Preparata 9-13.5 part, Radix Codonopsis 15-22.5 part, Herba Epimedii 10-15 part, Semen Cuscutae 12-18 part, Poria 20-30 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Ramulus Cinnamomi 6-9 part, Cortex Acanthopancis 10-15 part.
In mass parts, this granule also comprises following component: Polyporus 10-15 part, Rhizoma Alismatis 10-15 part, Radix Glycyrrhizae Preparata 5-7.5 part.
A preparation method for pivot heart tonifying granule is opened in the kidney invigorating, comprises the following steps:
The first step, in mass parts, taking Radix Aconiti Lateralis Preparata 9-13.5 part, Radix Codonopsis 15-22.5 part, Herba Epimedii 10-15 part, Semen Cuscutae 12-18 part, Poria 20-30 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Ramulus Cinnamomi 6-9 part, all taste Chinese medicine of Cortex Acanthopancis 10-15 part decocts with water, being concentrated into decocting after the decocting liquid obtained filters the concentrated solution that density is 1.1g/mL;
Second step, adds ethanol to concentrated solution and carries out precipitate with ethanol, then filter, and being concentrated into density is 1.14g/mL, reclaims ethanol and obtains extractum;
3rd step, mixes extractum with dextrin, then adds the ethanol drying that volume fraction is 95%, then adds water and make granule, namely obtain the kidney invigorating and open pivot heart tonifying finished granule.
In a first step, described all taste Chinese medicine decocts with water and is divided into three times, the first time decocted for three times decocts as 50-70 minute, second time decocts as 35-55 minute, third time decocts as 20-40 minute, merges and be concentrated into the concentrated solution that density is 1.1g/mL after third time decocts after being filtered by twice decocting liquid respectively.
In second step, in concentrated solution, add ethanol to volume fraction of ethanol is 65% carry out precipitate with ethanol.
In the third step, the mass ratio of extractum and dextrin is 1:2-2.5.
In a first step, in mass parts, also take following all taste Chinese medicine and decoct with water: Polyporus 10-15 part, Rhizoma Alismatis 10-15 part, Radix Glycyrrhizae Preparata 5-7.5 part.
Beneficial effect of the present invention is:
1. a kind of the kidney invigorating of the present invention is opened pivot heart tonifying granule and is had the effect improving remodeling ventricle, for acute and chronic heart failure, the chronic cardiac insufficiency that the various cause of disease causes has higher curative effect, can effectively improve the symptoms of heart failure such as pain uncomfortable in chest, asthma, cardiopalmus, poor appetite, two lower limbs edema, have letter, just, test, the advantage such as honest and clean;
2. pivot heart tonifying granule is opened in a kind of the kidney invigorating of the present invention is pure Chinese medicinal preparation, and pick up from crude drug, side effect is very little, can long-term taking, can improve clinical symptoms very well and the side effect avoiding diuretic to cause;
3. a kind of the kidney invigorating of the present invention opens pivot heart tonifying granule the kidney invigorating warming YANG to promote diuresis, the patient that edema is lighter, only can take we and control; The patient that edema is heavier, adds with we, can reduce the consumption of diuretic, and can improve the subjective symptoms of patient, improve the quality of living while taking diuretic;
4. to open the side effect of pivot heart tonifying granule little for a kind of the kidney invigorating of the present invention, and long-term taking is conducive to improving body, improves patient's Long-Term Quality of Life, to reach the object for the treatment of must aim at the pathogenesis of disease;
5. pivot heart tonifying granule is opened in a kind of the kidney invigorating of the present invention is pure Chinese medicine sugar-free granule, easily absorbs, Portable belt, has the features such as the compliance improving patient;
6. a kind of the kidney invigorating of the present invention opens the preparation method of pivot heart tonifying granule by three decoctions, and effectively can extract the effective ingredient of medicine, the granule made is easy to use.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described:
Embodiment 1
Pivot heart tonifying granule is opened in a kind of the kidney invigorating, in mass parts, comprises following component: Radix Aconiti Lateralis Preparata 13.5 parts, Radix Codonopsis 19 parts, Herba Epimedii 10 parts, Semen Cuscutae 18 parts, 25 parts, Poria, the Rhizoma Atractylodis Macrocephalae 10 parts, Pericarpium Citri Reticulatae 15 parts, Ramulus Cinnamomi 8 parts, Cortex Acanthopancis 10 parts.
In mass parts, this granule also comprises following component: Polyporus 15 parts, Rhizoma Alismatis 12 parts, Radix Glycyrrhizae Preparata 5 parts.
Heart failure pathogenesis is that negative and positive of qi and blood void declines, and the heart is become homeless foster, and sick position is at the heart, dirty closely related with spleen, kidney two; Lid water built in spleen, the master of water is at kidney, and deficiency of spleen-YANG is wet difficult transporting then, insufficiency of kidney-YANG then water failing to be transformed into QI and cause retention of water-damp in the body.A kind of the kidney invigorating of the present invention to be opened in pivot heart tonifying granule with Radix Aconiti Lateralis Preparata, Radix Codonopsis for monarch drug, the warming the kidney to activate YANG heart tonifying of use, and with promote the circulation of qi and water, warm spleen soil of holding concurrently, wets with Wen Yunshui, replenishing QI to invigorate the spleen opens pivot; Cortex Acanthopancis, Herba Epimedii, Semen Cuscutae, Ramulus Cinnamomi warming and recuperating the kidney-YANG, make kidney yang be enough to inspire heart-yang; Poria, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae the spleen strengthening and damp drying, Rhizoma Alismatis, Polyporus eliminating dampness and diuresis, make pathogenic water go from urine; Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription.Full side plays the kidney invigorating warming YANG heart tonifying altogether, and QI invigorating opens the merit of pivot diuretic.
A kind of the kidney invigorating of the present invention opens pivot heart tonifying granule for acute and chronic heart failure, the chronic cardiac insufficiency that the various cause of disease causes has higher curative effect, can effectively improve the symptoms of heart failure such as pain uncomfortable in chest, asthma, cardiopalmus, poor appetite, two lower limbs edema, have letter, just, test, the advantage such as honest and clean.
A preparation method for pivot heart tonifying granule is opened in the kidney invigorating, comprises the following steps:
The first step, in mass parts, taking Radix Aconiti Lateralis Preparata 13.5 parts, Radix Codonopsis 19 parts, Herba Epimedii 10 parts, Semen Cuscutae 18 parts, 25 parts, Poria, the Rhizoma Atractylodis Macrocephalae 10 parts, Pericarpium Citri Reticulatae 15 parts, Ramulus Cinnamomi 8 parts, all taste Chinese medicine of Cortex Acanthopancis 10 parts decocts with water, being concentrated into decocting after the decocting liquid obtained filters the concentrated solution that density is 1.1g/mL;
Second step, in concentrated solution, add ethanol to volume fraction of ethanol is 65% carry out precipitate with ethanol, and then filter, being concentrated into density is 1.14g/mL, reclaims ethanol and obtains extractum;
3rd step, mixes extractum with dextrin, and the mass ratio of extractum and dextrin is 1:2.5, then adds the ethanol drying that volume fraction is 95%, then adds water and make granule, namely obtain the kidney invigorating and open pivot heart tonifying finished granule.
In a first step, described all taste Chinese medicine decocts with water and is divided into three times, and it is 60 minutes that the first time decocted for three times decocts, and it is 35 minutes that second time decocts, it is 40 minutes that third time decocts, and merges and be concentrated into the concentrated solution that density is 1.1g/mL after third time decocts after being filtered by twice decocting liquid respectively.
In a first step, in mass parts, also take following all taste Chinese medicine and decoct with water: Polyporus 15 parts, Rhizoma Alismatis 12 parts, Radix Glycyrrhizae Preparata 5 parts.
Embodiment 2
Pivot heart tonifying granule is opened in a kind of the kidney invigorating, in mass parts, comprises following component: Radix Aconiti Lateralis Preparata 9 parts, Radix Codonopsis 22.5 parts, Herba Epimedii 12 parts, Semen Cuscutae 12 parts, 30 parts, Poria, the Rhizoma Atractylodis Macrocephalae 13 parts, Pericarpium Citri Reticulatae 10 parts, Ramulus Cinnamomi 9 parts, Cortex Acanthopancis 12 parts.
In mass parts, this granule also comprises following component: Polyporus 10 parts, Rhizoma Alismatis 15 parts, Radix Glycyrrhizae Preparata 6 parts.
A kind of the kidney invigorating of the present invention is opened pivot heart tonifying granule and is mainly used in Patients with Chronic Heart Failure, and this type of patient's ordinary water swells situation, and Western medicine diuretic, usually there will be the side effect of electrolyte disturbance when particularly Time of Administration is longer.Patients with Chronic Heart Failure often has gastrointestinal upset, dyspepsia and so on symptom, Western medicine protects stomach medicine often proton pump inhibitor, H2 receptor antagonist, sucralfate etc., and these medicines itself also exist the side effect such as diarrhoea, constipation, and we adjust liver spleen, function of gallbladder promoting stomach function regulating, these side effect can be avoided.Meanwhile, the symptom of the stagnated blood of liver caused because of heart failure can also be improved.Western medicine ACEI preparation (as Captopril tablets) is proved to be the effect having and improve remodeling ventricle; but be forced to drug withdrawal owing to easily causing the side effect such as dry cough; heart tonifying No. 1 side applies to clinical more than 15 years; according to clinical observation; there is the effect improving remodeling ventricle; now be made into granule, also will have the effect of protection target organ preferably.
It is pure Chinese medicinal preparation that pivot heart tonifying granule is opened in a kind of the kidney invigorating of the present invention, and pick up from crude drug, side effect is very little, can long-term taking, can improve clinical symptoms very well and the side effect avoiding diuretic to cause.We's the kidney invigorating warming YANG to promote diuresis, the patient that edema is lighter, only can take we and control; The patient that edema is heavier, adds with we, can reduce the consumption of diuretic, and can improve the subjective symptoms of patient, improve the quality of living while taking diuretic.
A preparation method for pivot heart tonifying granule is opened in the kidney invigorating, comprises the following steps:
The first step, in mass parts, taking Radix Aconiti Lateralis Preparata 9 parts, Radix Codonopsis 22.5 parts, Herba Epimedii 12 parts, Semen Cuscutae 12 parts, 30 parts, Poria, the Rhizoma Atractylodis Macrocephalae 13 parts, Pericarpium Citri Reticulatae 10 parts, Ramulus Cinnamomi 9 parts, all taste Chinese medicine of Cortex Acanthopancis 12 parts decocts with water, being concentrated into decocting after the decocting liquid obtained filters the concentrated solution that density is 1.1g/mL;
Second step, in concentrated solution, add ethanol to volume fraction of ethanol is 65% carry out precipitate with ethanol, and then filter, being concentrated into density is 1.14g/mL, reclaims ethanol and obtains extractum;
3rd step, mixes extractum with dextrin, and the mass ratio of extractum and dextrin is 1:2, then adds the ethanol drying that volume fraction is 95%, then adds water and make granule, namely obtain the kidney invigorating and open pivot heart tonifying finished granule.
In a first step, described all taste Chinese medicine decocts with water and is divided into three times, and it is 70 minutes that the first time decocted for three times decocts, and it is 40 minutes that second time decocts, it is 20 minutes that third time decocts, and merges and be concentrated into the concentrated solution that density is 1.1g/mL after third time decocts after being filtered by twice decocting liquid respectively.
In a first step, in mass parts, also take following all taste Chinese medicine and decoct with water: Polyporus 10 parts, Rhizoma Alismatis 15 parts, Radix Glycyrrhizae Preparata 6 parts.
Embodiment 3
Pivot heart tonifying granule is opened in a kind of the kidney invigorating, in mass parts, comprises following component: Radix Aconiti Lateralis Preparata 11 parts, Radix Codonopsis 15 parts, Herba Epimedii 15 parts, Semen Cuscutae 15 parts, 20 parts, Poria, the Rhizoma Atractylodis Macrocephalae 15 parts, Pericarpium Citri Reticulatae 12 parts, Ramulus Cinnamomi 6 parts, Cortex Acanthopancis 15 parts.
In mass parts, this granule also comprises following component: Polyporus 13 parts, Rhizoma Alismatis 10 parts, Radix Glycyrrhizae Preparata 7.5 parts.
A preparation method for pivot heart tonifying granule is opened in the kidney invigorating, comprises the following steps:
The first step, in mass parts, taking Radix Aconiti Lateralis Preparata 11 parts, Radix Codonopsis 15 parts, Herba Epimedii 15 parts, Semen Cuscutae 15 parts, 20 parts, Poria, the Rhizoma Atractylodis Macrocephalae 15 parts, Pericarpium Citri Reticulatae 12 parts, Ramulus Cinnamomi 6 parts, all taste Chinese medicine of Cortex Acanthopancis 15 parts decocts with water, being concentrated into decocting after the decocting liquid obtained filters the concentrated solution that density is 1.1g/mL;
Second step, in concentrated solution, add ethanol to volume fraction of ethanol is 65% carry out precipitate with ethanol, and then filter, being concentrated into density is 1.14g/mL, reclaims ethanol and obtains extractum;
3rd step, mixes extractum with dextrin, and the mass ratio of extractum and dextrin is 1:2.25, then adds the ethanol drying that volume fraction is 95%, then adds water and make granule, namely obtain the kidney invigorating and open pivot heart tonifying finished granule.
In a first step, described all taste Chinese medicine decocts with water and is divided into three times, and it is 50 minutes that the first time decocted for three times decocts, and it is 55 minutes that second time decocts, it is 30 minutes that third time decocts, and merges and be concentrated into the concentrated solution that density is 1.1g/mL after third time decocts after being filtered by twice decocting liquid respectively.
In a first step, in mass parts, also take following all taste Chinese medicine and decoct with water: Polyporus 13 parts, Rhizoma Alismatis 10 parts, Radix Glycyrrhizae Preparata 7.5 parts.
Pivot heart tonifying granule effect is opened in a kind of the kidney invigorating of the present invention: the kidney invigorating warming YANG heart tonifying, QI invigorating opens pivot diuretic.
Cure mainly: the deficiency of heart-YANG and kidney-YANG of chronic heart failure, insufficiency of the spleen leading to overabundance of dampness, water overflows the diseases such as skin.
A kind of the kidney invigorating of the present invention is opened pivot heart tonifying granule side and is separated as follows:
Monarch drug: Radix Aconiti Lateralis Preparata, Radix Codonopsis (reinforcing the kidney and supporting YANG heart tonifying, replenishing QI to invigorate the spleen opens pivot);
Ministerial drug: Herba Epimedii, Semen Cuscutae, Poria, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, Cortex Acanthopancis (the kidney invigorating warming YANG heart tonifying, QI invigorating opens pivot diuretic);
Adjuvant drug: Polyporus, Rhizoma Alismatis (promoting diuresis to eliminate damp pathogen);
Make medicine: Radix Glycyrrhizae Preparata (coordinating the actions of various ingredients in a prescription).
Although done comparatively detailed elaboration to technical scheme of the present invention and enumerated; be to be understood that; to those skilled in the art; amendment is made to above-described embodiment or adopts equivalent replacement scheme; this is apparent to those skilled in the art; these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (7)
1. pivot heart tonifying granule is opened in a kidney invigorating, it is characterized in that, in mass parts, comprise following component: Radix Aconiti Lateralis Preparata 9-13.5 part, Radix Codonopsis 15-22.5 part, Herba Epimedii 10-15 part, Semen Cuscutae 12-18 part, Poria 20-30 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Ramulus Cinnamomi 6-9 part, Cortex Acanthopancis 10-15 part.
2. pivot heart tonifying granule is opened in a kind of the kidney invigorating according to claim 1, it is characterized in that, in mass parts, this granule also comprises following component: Polyporus 10-15 part, Rhizoma Alismatis 10-15 part, Radix Glycyrrhizae Preparata 5-7.5 part.
3. a preparation method for pivot heart tonifying granule is opened in the kidney invigorating, it is characterized in that, comprises the following steps:
The first step, in mass parts, taking Radix Aconiti Lateralis Preparata 9-13.5 part, Radix Codonopsis 15-22.5 part, Herba Epimedii 10-15 part, Semen Cuscutae 12-18 part, Poria 20-30 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Ramulus Cinnamomi 6-9 part, all taste Chinese medicine of Cortex Acanthopancis 10-15 part decocts with water, being concentrated into decocting after the decocting liquid obtained filters the concentrated solution that density is 1.1g/mL;
Second step, adds ethanol to concentrated solution and carries out precipitate with ethanol, then filter, and being concentrated into density is 1.14g/mL, reclaims ethanol and obtains extractum;
3rd step, mixes extractum with dextrin, then adds the ethanol drying that volume fraction is 95%, then adds water and make granule, namely obtain the kidney invigorating and open pivot heart tonifying finished granule.
4. the preparation method of pivot heart tonifying granule is opened in a kind of the kidney invigorating according to claim 3, it is characterized in that: in a first step, described all taste Chinese medicine decocts with water and is divided into three times, the first time decocted for three times decocts as 50-70 minute, second time decocts as 35-55 minute, third time decocts as 20-40 minute, merges and be concentrated into the concentrated solution that density is 1.1g/mL after third time decocts after being filtered by twice decocting liquid respectively.
5. the preparation method of pivot heart tonifying granule is opened in a kind of the kidney invigorating according to claim 3, it is characterized in that: in second step, and in concentrated solution, add ethanol to volume fraction of ethanol is 65% carry out precipitate with ethanol.
6. the preparation method of pivot heart tonifying granule is opened in a kind of the kidney invigorating according to claim 3, it is characterized in that: in the third step, and the mass ratio of extractum and dextrin is 1:2-2.5.
7. the preparation method of pivot heart tonifying granule is opened in a kind of the kidney invigorating according to claim 3, it is characterized in that, in a first step, in mass parts, also takes following all taste Chinese medicine and decocts with water: Polyporus 10-15 part, Rhizoma Alismatis 10-15 part, Radix Glycyrrhizae Preparata 5-7.5 part.
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| CN201510430518.3A CN104983854B (en) | 2015-07-22 | 2015-07-22 | Pivot heart tonifying particle and preparation method thereof is opened in a kind of kidney tonifying |
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| CN110859908A (en) * | 2019-11-27 | 2020-03-06 | 佛山科学技术学院 | Traditional Chinese medicine composition for tonifying kidney and strengthening heart |
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| CN102716255A (en) * | 2012-06-21 | 2012-10-10 | 贵州百花医药股份有限公司 | Eucommia ulmoides medicinal wine and preparation method thereof |
| CN102961706A (en) * | 2012-11-20 | 2013-03-13 | 西安泰科迈医药科技有限公司 | Pure traditional Chinese medicine compound preparation for treating chronic glomerulonephritis and preparation method thereof |
| CN104096193A (en) * | 2013-04-09 | 2014-10-15 | 刘瑞林 | Kidney qi marrow powder |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716255A (en) * | 2012-06-21 | 2012-10-10 | 贵州百花医药股份有限公司 | Eucommia ulmoides medicinal wine and preparation method thereof |
| CN102961706A (en) * | 2012-11-20 | 2013-03-13 | 西安泰科迈医药科技有限公司 | Pure traditional Chinese medicine compound preparation for treating chronic glomerulonephritis and preparation method thereof |
| CN104096193A (en) * | 2013-04-09 | 2014-10-15 | 刘瑞林 | Kidney qi marrow powder |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110859908A (en) * | 2019-11-27 | 2020-03-06 | 佛山科学技术学院 | Traditional Chinese medicine composition for tonifying kidney and strengthening heart |
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