CN104983854B - Pivot heart tonifying particle and preparation method thereof is opened in a kind of kidney tonifying - Google Patents
Pivot heart tonifying particle and preparation method thereof is opened in a kind of kidney tonifying Download PDFInfo
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Abstract
The invention discloses a kind of kidney tonifying to open pivot heart tonifying particle, in terms of mass parts, including following components: black suitable 9-13.5 parts of piece, 15-22.5 parts of Radix Codonopsis, 10-15 parts of Herba Epimedii, 12-18 parts of Semen Cuscutae, 20-30 parts of Poria cocos, 10-15 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of dried orange peel, 6-9 parts of ramulus cinnamomi, 10-15 parts of cortex acanthopanacis.The preparation method of pivot heart tonifying particle is opened in a kind of kidney tonifying, includes the following steps that weighing all taste Chinese medicine adds water to cook, and ethyl alcohol is added in concentrate and carries out alcohol precipitation, filtering and concentrating obtains medicinal extract；It is mixed with dextrin, ethyl alcohol drying is added, then plus water is made particle and opens pivot heart tonifying finished granule to get to kidney tonifying.The present invention has the function of improving remodeling ventricle, have letter, just, the advantages such as test, be honest and clean；The preparation method of granule of the present invention can effectively extract the effective component of drug, manufactured particle is convenient to use by decocting three times.
Description
Technical field
The present invention relates to a kind of Chinese materia medica preparations and preparation method thereof more particularly to a kind of kidney tonifying to open pivot heart tonifying particle and its system
Preparation Method.
Background technique
Heart failure is the final result of a variety of heart disease development caused by different pathogeny, is that various heart diseases are more typical
The clinical manifestation of terminal phase.With the common incidence of cardiovascular disease such as the quickening of aging of population process and hypertension, coronary heart disease
Rise, it is unique disease that disease incidence dramatically increases in major cardiovascular diseases, just that the illness rate of heart failure, which just gradually rises,
Important public hygiene problem as 21 century.In recent years since, the drug therapy of heart failure and its complication is achieved significantly
It usually will appear the side effect of electrolyte disturbance when improving, but taking for a long time as the diuretics of drug therapy foundation stone；Improve stomach
Also there is the secondary work such as diarrhea, constipation in intestines hemostasis, the proton pump inhibitor, H2 receptor antagonist, the ulcerlmin that promote WeiDongLi Capsule etc.
With；ACEI preparation (such as Captopril tablets) is proved to have the function of improving remodeling ventricle, but many patients are due to pairs such as dry cough
It acts on and is forced selection and is discontinued.Traditional Chinese medicine is diagnosis and treatment are acute, have apparent advantage, tradition decoction soup in terms of chronic heart failure
Agent, which should not be carried, be stored and enter amount to Patient controlled, brings difficulty；Lack effective Chinese medicine in this respect again in the market
Granule.
Summary of the invention
In order to overcome the defects of the prior art, a kind of kidney tonifying is provided and opens pivot heart tonifying particle.
The present invention is realized by following proposal:
Pivot heart tonifying particle is opened in a kind of kidney tonifying, in terms of mass parts, including following components: black suitable 9-13.5 parts of piece, Radix Codonopsis 15-
22.5 parts, 10-15 parts of Herba Epimedii, 12-18 parts of Semen Cuscutae, 20-30 parts of Poria cocos, 10-15 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of dried orange peel, ramulus cinnamomi
6-9 parts, 10-15 parts of cortex acanthopanacis.
In terms of mass parts, which further includes following component: 10-15 parts of umbellate pore furgus, 10-15 parts of rhizoma alismatis, and radix glycyrrhizae preparata 5-7.5
Part.
The preparation method of pivot heart tonifying particle is opened in a kind of kidney tonifying, comprising the following steps:
The first step weighs black suitable 9-13.5 parts of piece, 15-22.5 parts of Radix Codonopsis, 10-15 parts of Herba Epimedii, Tu in terms of mass parts
Silk is 12-18 parts sub-, 20-30 parts of Poria cocos, 10-15 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of dried orange peel, 6-9 parts of ramulus cinnamomi, in 10-15 parts of all tastes of cortex acanthopanacis
Medicine adds water to cook, and will decoct after obtained decocting liquid filters and is concentrated into the concentrate that density is 1.1g/mL；
Second step is added ethyl alcohol to concentrate and carries out alcohol precipitation, then filters, and being concentrated into density is 1.14g/mL, recycles second
Alcohol obtains medicinal extract；
Third step mixes medicinal extract with dextrin, the ethyl alcohol drying that volume fraction is 95% is then added, then plus water is made
Particle opens pivot heart tonifying finished granule to get to kidney tonifying.
In the first step, it is 50-70 points that all taste Chinese medicine, which adds water to cook the first time decoction for being divided into and three times, decocting three times,
Clock, it is 35-55 minutes that second, which decocts, and it is 20-40 minutes that third time, which decocts, and third time will filter decocting liquid twice respectively after decocting
Merge the concentrate for being concentrated into that density is 1.1g/mL afterwards.
In second step, it is 65% progress alcohol precipitation that ethyl alcohol to volume fraction of ethanol is added into concentrate.
In the third step, the mass ratio of medicinal extract and dextrin is 1:2-2.5.
In the first step, it in terms of mass parts, also weighs following all taste Chinese medicine and adds water to cook: 10-15 parts of umbellate pore furgus, rhizoma alismatis 10-
15 parts, 5-7.5 parts of radix glycyrrhizae preparata.
The invention has the benefit that
1. pivot heart tonifying particle is opened in a kind of kidney tonifying of the present invention to be had the function of improving remodeling ventricle, for acute and chronic heart failure
Exhaust, chronic cardiac insufficiency caused by the various causes of disease has higher curative effect, can effectively improve pain uncomfortable in chest, asthma, palpitaition, receive it is poor, double
The symptoms of heart failure such as edema of lower extremity, have letter, just, the advantages such as test, be honest and clean；
2. it is pure Chinese medicinal preparation that pivot heart tonifying particle is opened in a kind of kidney tonifying of the present invention, crude drug is picked up from, side effect very little can be grown
Phase takes, and can improve very well clinical symptoms and avoid side effect caused by diuretics；
3. pivot heart tonifying particle kidney tonifying warming yang for diuresis is opened in a kind of kidney tonifying of the present invention, the lighter patient of oedema, can only take we into
Row control；The heavier patient of oedema adds while taking diuretics and uses we, can reduce the dosage of diuretics, and can change
The subjective symptoms of kind patient, improves the quality of living；
4. pivot heart tonifying particle Small side effects are opened in a kind of kidney tonifying of the present invention, long-term use is conducive to improve body, improve
Patient's Long-Term Quality of Life, to achieve the purpose that search for the primary cause of disease in treatment；
5. it is pure Chinese medicine sugar-free type granular formulation that pivot heart tonifying particle is opened in a kind of kidney tonifying of the present invention, easily absorb, Portable belt, has and mention
The features such as compliance of high patient；
6. a kind of kidney tonifying of the present invention opens the preparation method of pivot heart tonifying particle by decocting three times, drug can be effectively extracted
Effective component, manufactured particle is convenient to use.
Specific embodiment
The present invention is further described combined with specific embodiments below:
Embodiment 1
Pivot heart tonifying particle is opened in a kind of kidney tonifying, in terms of mass parts, including following components: black suitable 13.5 parts of piece, 19 parts of Radix Codonopsis, excessive
10 parts of the sheep leaves of pulse plants, 18 parts of Semen Cuscutae, 25 parts of Poria cocos, 10 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of dried orange peel, 8 parts of ramulus cinnamomi, 10 parts of cortex acanthopanacis.
In terms of mass parts, which further includes following component: 15 parts of umbellate pore furgus, 12 parts of rhizoma alismatis, 5 parts of radix glycyrrhizae preparata.
The heart failure interpretation of the cause, onset and process of an illness is that negative and positive of qi and blood void declines, and the heart is become homeless feeding, and sick position is closely related with spleen and kidney in the heart；The system of lid water
In spleen, the master of water is in kidney, the insufficiency of the spleen-yang then wet difficult transporting, kidney-yang deficiency then disturbance of body-fluid metabolism and cause retention of water-damp in the body.A kind of kidney tonifying of the present invention
Open using monkshood, Radix Codonopsis as monarch drug in a prescription in pivot heart tonifying particle, with warming kidney and enhancing yang heart tonifying, to change gas row water, and warm spleen soil, with Wen Yunshui
It is wet, replenish qi to invigorate the spleen and open pivot；Cortex acanthopanacis, Herba Epimedii, Semen Cuscutae, ramulus cinnamomi warming and invigorating kidney Yang, make kidney yang be enough to inspire heart-yang；It is Poria cocos, white
Art, dried orange peel invigorating the spleen to dry, rhizoma alismatis, umbellate pore furgus eliminating dampness and diuresis, go water heresy from urine；Radix glycyrrhizae preparata coordinating the drug actions of a prescription.Benefit is played altogether in full side
The kidney temperature penis ultroerection heart, QI invigorating open the function of pivot benefit water.
A kind of kidney tonifying of the present invention opens pivot heart tonifying particle for acute and chronic heart failure, chronic heart function caused by the various causes of disease
Can not have higher curative effect entirely, can effectively improve pain uncomfortable in chest, asthma, palpitaition, the symptoms of heart failure such as poor, double lower limb oedema of receiving, have letter,
Just, the advantages such as test, be honest and clean.
The preparation method of pivot heart tonifying particle is opened in a kind of kidney tonifying, comprising the following steps:
The first step weighs black suitable 13.5 parts of piece, 19 parts of Radix Codonopsis, 10 parts of Herba Epimedii, 18 parts of Semen Cuscutae, Fu in terms of mass parts
25 parts of Siberian cocklebur, 10 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of dried orange peel, 8 parts of ramulus cinnamomi, 10 parts of cortex acanthopanacis all taste Chinese medicines add water to cook, the decocting liquid that decoction is obtained
The concentrate that density is 1.1g/mL is concentrated into after filtering；
Second step, it is 65% progress alcohol precipitation that ethyl alcohol to volume fraction of ethanol is added into concentrate, then filters, is concentrated into
Density is 1.14g/mL, and recycling ethyl alcohol obtains medicinal extract；
Third step mixes medicinal extract with dextrin, and the mass ratio of medicinal extract and dextrin is 1:2.5, and volume fraction is then added and is
95% ethyl alcohol is dry, and then plus water is made particle and opens pivot heart tonifying finished granule to get to kidney tonifying.
In the first step, it is 60 minutes that all taste Chinese medicine, which adds water to cook the first time decoction for being divided into and three times, decocting three times,
Second to decoct be 35 minutes, and it is 40 minutes that third time, which decocts, and third time will merge after decocting liquid filtering twice dense respectively after decocting
It is reduced to the concentrate that density is 1.1g/mL.
In the first step, it in terms of mass parts, also weighs following all taste Chinese medicine and adds water to cook: 15 parts of umbellate pore furgus, 12 parts of rhizoma alismatis, toast
5 parts of Radix Glycyrrhizae.
Embodiment 2
Pivot heart tonifying particle is opened in a kind of kidney tonifying, in terms of mass parts, including following components: black suitable 9 parts of piece, 22.5 parts of Radix Codonopsis, excessive
12 parts of the sheep leaves of pulse plants, 12 parts of Semen Cuscutae, 30 parts of Poria cocos, 13 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of dried orange peel, 9 parts of ramulus cinnamomi, 12 parts of cortex acanthopanacis.
In terms of mass parts, which further includes following component: 10 parts of umbellate pore furgus, 15 parts of rhizoma alismatis, 6 parts of radix glycyrrhizae preparata.
A kind of kidney tonifying of the present invention opens pivot heart tonifying particle and is mainly used for Patients with Chronic Heart Failure, and such patient's ordinary water swells feelings
Condition, Western medicine diuretics usually will appear the side effect of electrolyte disturbance when especially Time of Administration is longer.Chronic heart failure is suffered from
Person often has a gastrointestinal discomfort, indigestion etc symptom, Western medicine shield stomach medicine product often have proton pump inhibitor, H2 receptor antagonist,
Ulcerlmin etc., there is also the side effects such as diarrhea, constipation for these medicines itself, and we adjust liver spleen, cholagogue stomach function regulating, can avoid these
Side effect.Meanwhile the symptom of stagnated blood of liver caused by can also improving because of heart failure.Western medicine ACEI preparation (such as Captopril tablets) is proved to
Have the function of improving remodeling ventricle, but be forced to be discontinued due to easily causing the side effects such as dry cough, No. 1 side of heart tonifying applies to clinic
More than 15 years had the function of improving remodeling ventricle, and were now fabricated to granule according to clinical observation, will also there is preferable protection target
The effect of organ.
It is pure Chinese medicinal preparation that pivot heart tonifying particle is opened in a kind of kidney tonifying of the present invention, picks up from crude drug, side effect very little can be long-term
It takes, clinical symptoms can be improved very well and avoids side effect caused by diuretics.Our kidney tonifying warming yang for diuresis, the lighter disease of oedema
People can only take we and control；The heavier patient of oedema adds while taking diuretics and uses we, can reduce diuretics
Dosage, and the subjective symptoms of patient can be improved, improved the quality of living.
The preparation method of pivot heart tonifying particle is opened in a kind of kidney tonifying, comprising the following steps:
The first step weighs black suitable 9 parts of piece, 22.5 parts of Radix Codonopsis, 12 parts of Herba Epimedii, 12 parts of Semen Cuscutae, Fu in terms of mass parts
30 parts of Siberian cocklebur, 13 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of dried orange peel, 9 parts of ramulus cinnamomi, 12 parts of cortex acanthopanacis all taste Chinese medicines add water to cook, the decocting liquid that decoction is obtained
The concentrate that density is 1.1g/mL is concentrated into after filtering；
Second step, it is 65% progress alcohol precipitation that ethyl alcohol to volume fraction of ethanol is added into concentrate, then filters, is concentrated into
Density is 1.14g/mL, and recycling ethyl alcohol obtains medicinal extract；
Third step mixes medicinal extract with dextrin, and the mass ratio of medicinal extract and dextrin is 1:2, and it is 95% that volume fraction, which is then added,
Ethyl alcohol it is dry, then plus water is made particle and opens pivot heart tonifying finished granule to get to kidney tonifying.
In the first step, it is 70 minutes that all taste Chinese medicine, which adds water to cook the first time decoction for being divided into and three times, decocting three times,
Second to decoct be 40 minutes, and it is 20 minutes that third time, which decocts, and third time will merge after decocting liquid filtering twice dense respectively after decocting
It is reduced to the concentrate that density is 1.1g/mL.
In the first step, it in terms of mass parts, also weighs following all taste Chinese medicine and adds water to cook: 10 parts of umbellate pore furgus, 15 parts of rhizoma alismatis, toast
6 parts of Radix Glycyrrhizae.
Embodiment 3
Pivot heart tonifying particle is opened in a kind of kidney tonifying, in terms of mass parts, including following components: black suitable 11 parts of piece, 15 parts of Radix Codonopsis, excessive sheep
15 parts of the leaves of pulse plants, 15 parts of Semen Cuscutae, 20 parts of Poria cocos, 15 parts of Rhizoma Atractylodis Macrocephalae, 12 parts of dried orange peel, 6 parts of ramulus cinnamomi, 15 parts of cortex acanthopanacis.
In terms of mass parts, which further includes following component: 13 parts of umbellate pore furgus, 10 parts of rhizoma alismatis, 7.5 parts of radix glycyrrhizae preparata.
The preparation method of pivot heart tonifying particle is opened in a kind of kidney tonifying, comprising the following steps:
The first step weighs black suitable 11 parts of piece, 15 parts of Radix Codonopsis, 15 parts of Herba Epimedii, 15 parts of Semen Cuscutae, Poria cocos in terms of mass parts
20 parts, 15 parts of Rhizoma Atractylodis Macrocephalae, 12 parts of dried orange peel, 6 parts of ramulus cinnamomi, 15 parts of cortex acanthopanacis all taste Chinese medicines add water to cook, obtained decocting liquid mistake will be decocted
The concentrate that density is 1.1g/mL is concentrated into after filter；
Second step, it is 65% progress alcohol precipitation that ethyl alcohol to volume fraction of ethanol is added into concentrate, then filters, is concentrated into
Density is 1.14g/mL, and recycling ethyl alcohol obtains medicinal extract；
Third step mixes medicinal extract with dextrin, and the mass ratio of medicinal extract and dextrin is 1:2.25, and volume fraction is then added and is
95% ethyl alcohol is dry, and then plus water is made particle and opens pivot heart tonifying finished granule to get to kidney tonifying.
In the first step, it is 50 minutes that all taste Chinese medicine, which adds water to cook the first time decoction for being divided into and three times, decocting three times,
Second to decoct be 55 minutes, and it is 30 minutes that third time, which decocts, and third time will merge after decocting liquid filtering twice dense respectively after decocting
It is reduced to the concentrate that density is 1.1g/mL.
In the first step, it in terms of mass parts, also weighs following all taste Chinese medicine and adds water to cook: 13 parts of umbellate pore furgus, 10 parts of rhizoma alismatis, toast
7.5 parts of Radix Glycyrrhizae.
Pivot heart tonifying particle effect is opened in a kind of kidney tonifying of the present invention: the kidney tonifying temperature penis ultroerection heart, QI invigorating open pivot Li Shui.
The major functions: the heart-kidney yang deficiency of chronic heart failure, the insufficiency of the spleen with overabundance of dampness, the diseases such as excessive skin of water.
It is as follows that pivot heart tonifying particle side solution is opened in a kind of kidney tonifying of the present invention:
Monarch drug in a prescription: black suitable piece, Radix Codonopsis (heart tonifying of tonifying the kidney and support yang, replenish qi to invigorate the spleen and open pivot)；
Ministerial drug: (the kidney tonifying temperature penis ultroerection heart, QI invigorating open pivot benefit for Herba Epimedii, Semen Cuscutae, Poria cocos, Rhizoma Atractylodis Macrocephalae, dried orange peel, ramulus cinnamomi, cortex acanthopanacis
Water)；
Adjutant: umbellate pore furgus, rhizoma alismatis (clearing damp and promoting diuresis)；
Make medicine: radix glycyrrhizae preparata (coordinating the drug actions of a prescription).
Although having done more detailed elaboration to technical solution of the present invention and having enumerated, it should be understood that for ability
For field technique personnel, modifications to the embodiments described above may be made or uses equivalent alternative solution, this is to those skilled in the art
It is it is clear that these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the present invention for member
Claimed range.
Claims (1)
1. pivot heart tonifying particle is opened in a kind of kidney tonifying, which is characterized in that in terms of mass parts, be made of the following components: black suitable piece 9-13.5
Part, 15-22.5 parts of Radix Codonopsis, 10-15 parts of Herba Epimedii, 12-18 parts of Semen Cuscutae, 20-30 parts of Poria cocos, 10-15 parts of Rhizoma Atractylodis Macrocephalae, dried orange peel 10-
15 parts, 6-9 parts of ramulus cinnamomi, 10-15 parts of cortex acanthopanacis, 10-15 parts of umbellate pore furgus, 10-15 parts of rhizoma alismatis, 5-7.5 parts of radix glycyrrhizae preparata；
The preparation method of pivot heart tonifying particle is opened in the kidney tonifying the following steps are included: the first step weighs black suitable piece 9- in terms of mass parts
13.5 parts, 15-22.5 parts of Radix Codonopsis, 10-15 parts of Herba Epimedii, 12-18 parts of Semen Cuscutae, 20-30 parts of Poria cocos, 10-15 parts of Rhizoma Atractylodis Macrocephalae, dried orange peel
10-15 parts, 6-9 parts of ramulus cinnamomi, 10-15 parts of cortex acanthopanacis, 10-15 parts of umbellate pore furgus, 10-15 parts of rhizoma alismatis, 5-7.5 parts of radix glycyrrhizae preparata, in all tastes
Medicine adds water to cook, and decocting for the first time is 50-70 minutes, and it is 35-55 minutes that second, which decocts, and it is 20-40 minutes that third time, which decocts,
Third time will merge after the filtering of decocting liquid twice respectively after decocting is concentrated into the concentrate that density is 1.1g/mL；Second step, to concentration
Liquid is added 65% ethyl alcohol and carries out alcohol precipitation, then filters, and being concentrated into density is 1.14g/mL, and recycling ethyl alcohol obtains medicinal extract；Third step,
Medicinal extract is mixed with dextrin, the mass ratio of medicinal extract and dextrin is 1:2-2.5, and it is dry that the ethyl alcohol that volume fraction is 95% is then added
Dry, then plus water is made particle and opens pivot heart tonifying finished granule to get to kidney tonifying.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716255A (en) * | 2012-06-21 | 2012-10-10 | 贵州百花医药股份有限公司 | Eucommia ulmoides medicinal wine and preparation method thereof |
| CN102961706A (en) * | 2012-11-20 | 2013-03-13 | 西安泰科迈医药科技有限公司 | Pure traditional Chinese medicine compound preparation for treating chronic glomerulonephritis and preparation method thereof |
| CN104096193A (en) * | 2013-04-09 | 2014-10-15 | 刘瑞林 | Kidney qi marrow powder |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716255A (en) * | 2012-06-21 | 2012-10-10 | 贵州百花医药股份有限公司 | Eucommia ulmoides medicinal wine and preparation method thereof |
| CN102961706A (en) * | 2012-11-20 | 2013-03-13 | 西安泰科迈医药科技有限公司 | Pure traditional Chinese medicine compound preparation for treating chronic glomerulonephritis and preparation method thereof |
| CN104096193A (en) * | 2013-04-09 | 2014-10-15 | 刘瑞林 | Kidney qi marrow powder |
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