CN109464506A - One kind plus taste Compound Hydrochloride Phenylpropanolamine and preparation method - Google Patents
One kind plus taste Compound Hydrochloride Phenylpropanolamine and preparation method Download PDFInfo
- Publication number
- CN109464506A CN109464506A CN201811590905.3A CN201811590905A CN109464506A CN 109464506 A CN109464506 A CN 109464506A CN 201811590905 A CN201811590905 A CN 201811590905A CN 109464506 A CN109464506 A CN 109464506A
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- China
- Prior art keywords
- jujube
- rhizoma atractylodis
- compound hydrochloride
- atractylodis macrocephalae
- radix astragali
- Prior art date
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- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 title claims abstract description 37
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
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- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
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- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to traditional Chinese medicine fields, disclose a kind of plus taste Compound Hydrochloride Phenylpropanolamine and preparation method, are made of by mass parts Radix Astragali 500g, radix saposhnikoviae 200g, Rhizoma Atractylodis Macrocephalae (stir-fry) 200g and jujube 100g.The preparation method includes: to choose good Radix Astragali, radix saposhnikoviae, Rhizoma Atractylodis Macrocephalae and jujube；Radix saposhnikoviae is cataclasm, volatile oil is extracted, aqueous solution is collected in distillation；The dregs of a decoction and Radix Astragali, Rhizoma Atractylodis Macrocephalae and jujube add water to cook secondary, first time 1.5h, second of 1h, collecting decoction filtration, filtrate concentration；Ethanol in proper amount, which is added, to be made to precipitate, and takes supernatant, recycles ethyl alcohol, water is added to stir evenly, and stands, supernatant is taken to filter, and is concentrated；Aqueous solution after volatile oil and distillation is added, adjusts total amount to 1000ml, stirs evenly, and filters, filling, sterilizing to get.Tonifying middle-Jiao and Qi of the present invention, Gu table, hidroschesis；For exterior deficiency, spontaneous perspiration foul wind, spleen and lung weakness or physically weak susceptible ailment said due to cold or exposure person.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, more particularly to a kind of plus taste Compound Hydrochloride Phenylpropanolamine and preparation method.
Background technique
Currently, the prior art commonly used in the trade is such that
Tonifying middle-Jiao and Qi is Chinese medicine verification treatment term, and traditional chinese medical term is one of " mend, let out, clearly, dissipate " equal treatment skills.It mends
Middle QI invigorating is exactly to raise taste.The physiological functions such as the internal organs such as taste transfer the digestion of ingesta, ascending the clear and descending the turbid.Also known as taste it
Gas.It is that body has certain defence capability, defence is wind, cold, wet, fire, heat etc. Gu table is to reinforce human body safeguard function
The disease and evil of illness can be caused.Perspiration is a kind of normal physiological phenomena of human body, and the sweating of human body has moist skin, adjusts human body
The effect of equilibrium between yin and yang.Such as hot weather, lid of wearing the clothes are by excessively warm, drink hot soup, labour are run and moved later and occur for the moment yearningly
Sweat is more, has no uncomfortable feeling；Or the medicine of diverging is taken after exogenous disease, so that the evil normal physiological that belongs to sweat solution etc. is perspired.Disease
Rationality, which is perspired, can behave as sweat and leaks the exception of excessive or sweating time, position, color and perspiration form, be generally divided into from
Sweat, night sweat, sweating in shock, shivering and sweating, yellow sweat etc..Hidroschesis is to control with the drug with anti-hidropoiesis what sweating was excessively treated
Method, perspiration-eliminating medicine taste polyacid is puckery, warm-natured or flat, and master enters lung, spleen, kidney, large intestine channel.Hold back the function of dissipation, solid slippage.
In the prior art for exterior deficiency, spontaneous perspiration foul wind, spleen and lung weakness or physically weak susceptible wind, tonifying middle-Jiao and Qi is being carried out,
Gu table when hidroschesis, is treated, especially young man often through Western medicine, often relies on Western medicine and treat to illness, although
Quick result, but contain the danger that perhaps hormonal components or latent side effect are contained in part, damage internal organ etc.；Meanwhile
There are some patientss to take Chinese materia medica preparation list to take effect slowly, it is of long duration, there is the phenomenon that not feeling any better slowly.
In conclusion problem of the existing technology is:
(1) in the prior art, it takes Western medicine to be treated, especially young man, often relies on Western medicine and illness is controlled
It treats, although quick result, contains the danger that perhaps hormonal components or latent side effect are contained in part, damage internal organ etc.；
(2) in the prior art, Chinese materia medica preparation list takes effect slowly, of long duration, the phenomenon that not feeling any better slowly occurs.
The difficulty and meaning to solve the above problems:
Yupingfeng San is originated from " danxi's experiential therapy " of Yuan Dynasty's ZHU Dan-xi, and drug composition is total to by Radix Astragali, Rhizoma Atractylodis Macrocephalae, windproof three taste medicines
With composition, prescription is simple, and effect is unique.It is to strengthen the body resistance to consolidate the constitution, real table dissipates evil recipe.The sweet temperature of Radix Astragali in side, both can help spleen and lung
Gas, and can invigorating qi for consolidating superficies hidroschesis, be monarch drug in a prescription；Rhizoma Atractylodis Macrocephalae is drying damp and strengthening spleen key medicine, helps Radix Astragali invigorating qi for consolidating superficies, is ministerial drug；Assistant with
Radix saposhnikoviae walks table and relieve heat is imperial evil；We increase jujube, tonifying middle-Jiao and Qi, the effect of nourishing blood and tranquilization.Yupingfeng San is in the treatment deficiency of vital energy
Effect is obvious during flu.During prevention and treatment human avian influenza dialectical for traditional Chinese medicine, Yupingfeng San effect is obvious.It is existing
Show the immunity for adding taste Compound Hydrochloride Phenylpropanolamine that can not only improve human body for medicine, opens the protection response of Organism immunoregulation
Mechanism all has facilitation to body nospecific immunity, humoral and cellular immune response, moreover it is possible to inhibit the increment of virus and stick
It is attached, while infected by influenza also has direct repression.
Postpartum sweat disease is obstetrics' common disease, and postpartum sweating is excessive, is easy to cause puerpera's affection of exogenous wind-cold, invades in perverse trend, is influenced
Lactation and puerperium restore.Chinese medicine thinks that this disease main pathogenesis is postpartum gas consumption blood trouble, and deficiency of vital energy yang-energy is not solid, and yin asthenia generating intrinsic heat compels sweat
It is outgoing.Therefore postpartum " blood is insufficient and gas is also empty ", the deficiency of vital energy defend sun not admittedly, it is outgoing to compel saliva.If Postpartum constitution difference nurses discomfort in addition, become
Disease is then confusingly risen.Add taste sample expense oral solution, prescription cures mainly exterior deficiency spontaneous perspiration, susceptible ailment said due to cold or exposure；Prescription Effect tonifying spleen is defended in fact, and Tuoli is solid
Table.So QI invigorating, right sweet person's property is slow for Rhizoma Atractylodis Macrocephalae, Radix Astragali, cannot speed up in table, therefore assistant with radix saposhnikoviae.Rhizoma Atractylodis Macrocephalae strengthening the spleen and stomach, ridging i.e. with
Peaceful wind.Husband obtains Radix Astragali jujube with the kind wind dispelling of radix saposhnikoviae with solid table, then outer to be defended, and obtains Rhizoma Atractylodis Macrocephalae in solid, then in evidence,
Ailment said due to cold or exposure goes such as to shield without coming again when leaning on, precious as beautiful.Add and separately increase jujube in taste Compound Hydrochloride Phenylpropanolamine side, tonifying middle-Jiao and Qi is supported
The function of blood and tranquilizing mind is stronger, all medicines share, and strengthening exterior and reducing sweat has nourishing blood and tranquilization concurrently simultaneously, and full side brings out the best in each other.Therefore, add taste Yupingfeng
Oral solution is preferable to treatment postpartum qi-deficiency type sweat disease curative effect, can improve puerpera's postpartum quality of life, improves breastfeeding rate, subtracts
The generation of few puerpera's complication of the puerperium is of great significance to promotion puerpera's postpartum quick recovery.
Add taste Compound Hydrochloride Phenylpropanolamine, being particularly suitable for ferritic, healthy energy is insufficient, physically weak repeated cold person caused by weakened defensive QI, existing
Generation research confirms that Yupingfeng San can promote the secretion of immunoglobulin (Ig) A, IgG, IgE and mononuclear macrophage, improves body
Immune function, in recent years plus taste Compound Hydrochloride Phenylpropanolamine treatment infantile respiratory tract infection repeatedly shows unique curative effect and advantage,
Have accumulated more rich experience.Constitution Theory in TCM thinks, constitution has an impact to the progress of disease of disease and lapsing to, and often dominates disease
The variation tendency of disease, constitutive character is the premise of disease personalization diagnosis and treatment, adds taste Compound Hydrochloride Phenylpropanolamine, improves Qi deficiency physique, is prevented
Repeated cold is controlled to play an important role.
Summary of the invention
In view of the problems of the existing technology, the present invention provides one kind to add taste Compound Hydrochloride Phenylpropanolamine and preparation method,
The invention is realized in this way a kind of plus taste Compound Hydrochloride Phenylpropanolamine, by quality by Radix Astragali 500g, radix saposhnikoviae 200g, white
Art (stir-fry) 200g and jujube 100g composition.
Another object of the present invention is to provide a kind of plus taste Compound Hydrochloride Phenylpropanolamine preparation methods to include:
Step 1: according to " Chinese Pharmacopoeia " 2015 editions, carry out respectively identification choose qualified Radix Astragali 500g, radix saposhnikoviae 200g,
Rhizoma Atractylodis Macrocephalae (stir-fry) 200g and jujube 100g；
Step 2: Radix Astragali 500g, radix saposhnikoviae 200g, Rhizoma Atractylodis Macrocephalae (stir-fry) 200g and jujube 100g are cleaned；Silt, impurity etc. are removed,
Step 3: Radix Astragali, Rhizoma Atractylodis Macrocephalae, radix saposhnikoviae and jujube being impregnated half an hour, (water did not had powder 2cm), and decoction is secondary, and first
Secondary 1.5 hours, second 1 hour, merge decocting liquid about 1500ml twice, filtration, filtrate is concentrated into right amount, obtains concentrate；
Step 4: make to precipitate by ethanol in proper amount is added in above-mentioned concentrate, take supernatant, ethyl alcohol is recovered under reduced pressure, recycle second
Medical fluid after alcohol, adds water to stir evenly, and stands 12 hours, supernatant is taken to filter, and filtrate concentration obtains concentrate, spare；
Step 5: the concentrate into step 4 adds sucrose, the oxybenzene that adjustment total amount is dissolved to 1000ml, addition with ethyl alcohol
Ethyl ester, stirring while adding, filtration is boiled except the impurity in desaccharification, heating.
Step 6: by medical fluid inspection by sampling, after the assay was approved, the adjustment dress of loading amount every 10ml is filling, sterilize to get.
In conclusion advantages of the present invention and good effect are as follows:
Provided by the invention plus taste Compound Hydrochloride Phenylpropanolamine has Radix Astragali: sweet, tepor；Enter return lung, spleen, liver and kidney channel；It is beneficial
The effect of superficies-consolidating, arrest sweating admittedly take off, torr sore myogenic, inducing diuresis for removing edema；For treating deficiency of vital energy and acking in strength, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, just
Metrorrhagia leakage, exterior deficiency spontaneous perspiration, ulcer is difficult to burst, burst for a long time and does not holds back, blood deficiency chlorosis, Heat Diabetes, chronic nephritis, albuminuria, diabetes etc..
Radix saposhnikoviae: acrid flavour, sweet, slightly warm in nature；It expels pathogenic wind from the body surface, the effect of expel endogenous wind to relieve convulsion, relieving convulsion.Rhizoma Atractylodis Macrocephalae: bitter, it is sweet, it is warm-natured；Returns spleen, stomach
Through；Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, miscarriage prevention；For spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, movement of the foetus
It is uneasy.Rhizoma atractylodis macrocephalae has strengthening the spleen and replenishing qi and other effects.Jujube: warm-natured, returns spleen stomach meridian sweet in flavor has tonifying middle-Jiao and Qi, nourishing blood and tranquilization, delays
With the function of pharmacological property；Modern pharmacology then finds, jujube contains protein, carbohydrate, organic acid, vitamin A, vitamin C, more
The kind nutrition abundant such as micro-calcium and amino acid.
Provided by the invention plus taste Compound Hydrochloride Phenylpropanolamine, pure Chinese medicinal preparation, ingredient hormone-free have no toxic side effect, drug effect
It is good, it is quick, there is tonifying middle-Jiao and Qi, Gu table, the function of hidroschesis；Cure mainly exterior deficiency, spontaneous perspiration foul wind, spleen and lung weakness or physically weak easy
Feel ailment said due to cold or exposure person.
Detailed description of the invention
Fig. 1 is provided in an embodiment of the present invention plus the preparation method flow chart of taste Compound Hydrochloride Phenylpropanolamine.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
A kind of plus taste Compound Hydrochloride Phenylpropanolamine and preparation method provided by the invention, described plus taste Compound Hydrochloride Phenylpropanolamine press quality
It is made of Radix Astragali 500g, radix saposhnikoviae 200g, Rhizoma Atractylodis Macrocephalae (stir-fry) 200g and jujube 100g.
The present invention will be described in further detail with reference to the accompanying drawing；
As shown in Figure 1, provided by the invention plus taste Compound Hydrochloride Phenylpropanolamine preparation method includes:
S101: according to " Chinese Pharmacopoeia " 2015 editions, identification is carried out respectively and chooses qualified Radix Astragali 500g, radix saposhnikoviae 200g, white
Art (stir-fry) 200g and jujube 100g；
S102: Radix Astragali 500g, radix saposhnikoviae 200g, Rhizoma Atractylodis Macrocephalae (stir-fry) 200g and jujube 100g are cleaned；Silt, impurity etc. are removed,
S103: Radix Astragali, Rhizoma Atractylodis Macrocephalae, radix saposhnikoviae and jujube being impregnated half an hour, (water did not had powder 2cm), decoct secondary, first time
1.5 hours, second 1 hour, merge decocting liquid about 1500ml twice, filtration, filtrate is concentrated into right amount, obtains concentrate；
S104: make to precipitate by ethanol in proper amount is added in above-mentioned concentrate, take supernatant, ethyl alcohol is recovered under reduced pressure, recycle ethyl alcohol
Medical fluid afterwards, adds water to stir evenly, and stands 12 hours, supernatant is taken to filter, and filtrate concentration obtains concentrate, spare；
S105: the concentrate into step 4 adds sucrose, the oxybenzene second that adjustment total amount is dissolved to 1000ml, addition ethyl alcohol
Ester, stirring while adding, filtration is boiled except the impurity in desaccharification, heating.
S106: by medical fluid inspection by sampling, after the assay was approved, the adjustment dress of loading amount every 10ml is filling, sterilize to get.
It is further elaborated below with reference to the drug effect of each bulk pharmaceutical chemicals；
Radix Astragali: sweet, tepor；Enter return lung, spleen, liver and kidney channel；There are invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, inducing diuresis for removing edema
The effect of；For treating deficiency of vital energy and acking in strength, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult to burst bursts not long
It holds back, blood deficiency chlorosis, Heat Diabetes, chronic nephritis, albuminuria, diabetes etc..
Radix saposhnikoviae: acrid flavour, sweet, slightly warm in nature；It expels pathogenic wind from the body surface, the effect of expel endogenous wind to relieve convulsion, relieving convulsion.
Rhizoma Atractylodis Macrocephalae: bitter, it is sweet, it is warm-natured；Returns spleen, stomach meridian；Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, miscarriage prevention；For spleen eating less,
Abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, threatened abortion.Rhizoma atractylodis macrocephalae has strengthening the spleen and replenishing qi and other effects.
Jujube: warm-natured, returns spleen stomach meridian sweet in flavor has tonifying middle-Jiao and Qi, nourishing blood and tranquilization, the function of mitigating pharmacological property；Modern pharmacology
Then find that it is rich that jujube contains protein, carbohydrate, organic acid, vitamin A, vitamin C, lot of trace calcium and amino acid etc.
Rich nutrition.
The present invention will be described in further detail combined with specific embodiments below；
Embodiment 1. identifies
This product 10ml is taken, the n-butanol shaking being saturated with water is extracted 2 times, each 15ml, is merged n-butanol liquid, is used ammonia solution
15ml is washed 1 time, then is washed 1 time with the water 15ml that n-butanol is saturated.N-butanol liquid is taken to be evaporated, residue adds methanol 1ml to make to dissolve,
As the solution of test sample, Astragaloside IV reference substance is separately taken, adds methanol that solution of every 1ml containing 1mg is made, it is molten as reference substance
Liquid.It is tested according to thin-layered chromatography (one VI B of annex of Chinese Pharmacopoeia version in 2010), draws above-mentioned each 5 μ l of 2 kinds of solution, respectively point
In on the same silica gel g thin-layer plate using sodium carboxymethylcellulose as binder, under chloroform-methanol-water (13:7:2)
Layer solution is solvent, is unfolded, and takes out, dries, and sprays with 10% ethanol solution of sulfuric acid, it is clear to be heated to spot development.Test sample
In chromatography, at the position corresponding to the chromatogram of the reference substance, the spot of same color is shown；It sets and is inspected under ultraviolet lamp (365nm), shown
The fluorescence spot of same color.
Provided by the invention plus taste Compound Hydrochloride Phenylpropanolamine character: the liquid of brownish red to sepia；It is slightly sweet, slight bitter, puckery.
Provided by the invention plus taste Compound Hydrochloride Phenylpropanolamine inspection meets: (1) relative density, should be not less than 1.10 (China
One VII A of annex of pharmacopeia version in 2010)；(2) pH value should be 4.0~6.0 (one VII G of annex of Chinese Pharmacopoeia version in 2010)；
(3) other, related every regulation (one I J of annex of Chinese Pharmacopoeia version in 2010) under Ying Fuhe mixture item.
The function of provided by the invention plus taste Compound Hydrochloride Phenylpropanolamine with the major functions: tonifying middle-Jiao and Qi, Gu table, hidroschesis；For exterior deficiency
Not admittedly, spontaneous perspiration foul wind, spleen and lung weakness or physically weak susceptible ailment said due to cold or exposure person.
Provided by the invention plus taste Compound Hydrochloride Phenylpropanolamine usage and dosage: oral a, 10ml, 3 times a day.Observation group
It gives plus taste Compound Hydrochloride Phenylpropanolamine (main component be Radix Astragali, Rhizoma Atractylodis Macrocephalae, radix saposhnikoviae, jujube) is oral, 3 times a day, 1 every time, boiled water
It takes after mixing it with water.Control group gives Yupingfeng placebo, and (main component is supplementary product starch, sucrose, and bead dosage form, placebo is in shape, packet
It is consistent with raw medicine on dress, color) it is oral, 3 times a day, 1 every time, boiled water is taken after mixing it with water.Every group administration 1 month be 1 course for the treatment of, even served
3 courses for the treatment of, observe the period 1 year, in detail record administration before, administration after 3,6,9,12 month observation index, and to annual index into
Row statistical analysis.
Before different time point deficiency of vital energy matter clinical manifestation total marks compare administration after two groups of patient's administrations, two groups of subject's deficiency of vital energy bodies
Matter clinical manifestation total mark no significant difference.3 after administration, June, two groups of patient's Qi deficiency physique clinical manifestation total marks were reduced, and saw
Group is examined lower than control group (P < 0.05)；9, December, two groups of subject's Qi deficiency physique clinical manifestation total marks gradually rose, observation group
Higher than control group (P < 0.05).It is shown in Table 1.
Different time point deficiency of vital energy matter clinical manifestation total marks compare after 1 two groups of patient's administrations of table
Before each clinical manifestation scoring deduction rate of Qi deficiency physique compares administration before and after two groups of patients are administered, two groups of subject's deficiency of vital energys
Each clinical manifestation scoring no significant difference of constitution.After administration, perspiration, voice are easy in two groups of subject's Qi deficiency physique clinical manifestations
The scoring of low, lazy speech reduces (P < 0.05) before being relatively administered, and observation group be easy tired, shortness of breath, lassitude scoring also relatively to
(P < 0.05) is reduced before medicine；Each clinical manifestation scoring of observation group's Qi deficiency physique is below control group (P < 0.05) after administration.It gives
After medicine, observation group's items clinical manifestation scoring deduction rate is followed successively by voice low 59.06%, lazyness speech 55.82%, shortness of breath
53.43%, it is easy perspiration 50.30%, is easy tired 48.11%, lassitude 14.91% is above each clinical table of control group
The voice low 15.71% for the deduction rate that now scores, lazyness speech 15.39%, shortness of breath 8.86% are easy perspiration 14.56%, are easy tired
9.17%, lassitude 13.63%.It is shown in Table 2.
Each clinical manifestation integral of front and back Qi deficiency physique is administered in 2 two groups of patients of table and its deduction rate compares
Two groups of patient safeties and analysis of adverse reactions were to progress safety tracking in snibject 3 months, without bad anti-
It answers.
Adding taste Compound Hydrochloride Phenylpropanolamine is that the representative prescription of table consolidate in righting, is usually used in treatment lung and defends syndrome of qi deficiency, as exterior deficiency spontaneous perspiration,
Weakness type cold etc..Add the function of taste Compound Hydrochloride Phenylpropanolamine based on invigorating qi for consolidating superficies, Gu in have it is thin, dissipate in have benefit, mend dissipate and use, phase
It is auxiliary to coordinate.The sweet temperature of Radix Astragali, jujube fills flourish nourish and seeks Wei Zhiqi, the gas of help lung spleen, therefore invigorating qi for consolidating superficies hidroschesis is monarch；Rhizoma Atractylodis Macrocephalae is strong
Spleen QI invigorating, biochemical qi and blood are minister, with Radix Astragali compatibility with using, are just accord with " the big opinion of Plain Questions YIN YANG classification of natural phenomena " and are sayed: " shape deficiency person, temperature
With gas ", it is intended to enhance the effect of invigorating qi for consolidating superficies, table defends that gas is sturdy, then sweat is cured from disease is gone out, and exopathogen is then not easy to invade fleshy exterior battalion
It defends；Assistant walks table with radix saposhnikoviae and relieve heat is evil, closes Radix Astragali, Rhizoma Atractylodis Macrocephalae function walks fleshy exterior, solid protection battalion Wei Zhiqi, heresy of the expeling in table.And
Radix Astragali obtain it is windproof, Gu and table will not stay heresy；Windproof to obtain Radix Astragali, without hurting just, the two is mutually used for eliminating evil, is had bowl spares residence to dredge, is dissipated middle residence
The meaning of benefit, and the effect of jujube then blood-nourishing bowl spares is increased in side.Modern pharmacology research also confirms, adds taste Compound Hydrochloride Phenylpropanolamine
Middle Radix Astragali contains there are many microelements such as amino acid, folic acid and iron, zinc, manganese, has enhancing reticuloendothelial cell phagocytic activity, carefully
Born of the same parents' immune function can promote immunoglobulin generation；Rhizoma Atractylodis Macrocephalae can enhance reticuloendothelial system phagocytic function, improve human leukocytes
Promote lymphocyte transformation rate and natural rosettes are formed, promotes cellular immune function；Radix saposhnikoviae contains volatile oil, bitter taste glycosides, sweet dew
Alcohol polysaccharide, organic acid etc. add taste Compound Hydrochloride Phenylpropanolamine treatment repetitive upper respiratory tract infection that can make lymphocyte absolute value and red thin
C3b receptor rosette rate, which is immunized, in born of the same parents raising, and serum sIgA is significantly increased, and shows plus taste Compound Hydrochloride Phenylpropanolamine can enhance body and resist
Sick immunocompetence resists exopathogen, delays the multiple sense time.The above pharmacological experiments prompt, adds taste Compound Hydrochloride Phenylpropanolamine right
The nospecific immunity and specific immunity adjustment effect of Immune Organs of Body have multiple target point and multipath adjustment mechanism, improve machine
Body immunocompetence., add taste Compound Hydrochloride Phenylpropanolamine not only to have positive effect to treatment Qi deficiency physique repeated cold by invigorating qi for consolidating superficies,
And it can be effectively improved Qi deficiency physique, this has fully demonstrated the academic thought of Chinese medicine " searching for the primary cause of disease in treatment ".And its follow-up carried out is ground
Study carefully, further explains the thought for applying Chinese medicine " organic conception " and " preventiveing treatment of disease ", while curing the disease and adjusting body, disease can be passed through
Treatment reaches that improve constitution biased, realizes to the causal prophylaxis of disease, preclinical phase prevents and clinical prevention, to reach tune
Body refuses purpose that is evil, adjusting body diseases prevention.
Provided by the invention plus taste Compound Hydrochloride Phenylpropanolamine specification: every dress 10ml.
Provided by the invention plus taste Compound Hydrochloride Phenylpropanolamine holding conditions: shady place is set in sealing.
Provided by the invention plus taste Compound Hydrochloride Phenylpropanolamine validity period: 2 years.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (3)
1. one kind plus taste Compound Hydrochloride Phenylpropanolamine, which is characterized in that described plus taste Compound Hydrochloride Phenylpropanolamine is by Radix Astragali 500g, radix saposhnikoviae
200g, Rhizoma Atractylodis Macrocephalae 200g and jujube 100g composition.
2. a kind of preparation method for adding taste Compound Hydrochloride Phenylpropanolamine as described in claim 1, which is characterized in that described adds taste jade screen
The preparation method of wind oral solution includes:
Step 1: Radix Astragali 500g, radix saposhnikoviae 200g, Rhizoma Atractylodis Macrocephalae 200g and jujube 100g are chosen；
Step 2: radix saposhnikoviae is carried out to cataclasm, extraction volatile oil, distillation, collection aqueous solution；
Step 3: by step 2 the windproof dregs of a decoction and Radix Astragali, Rhizoma Atractylodis Macrocephalae and jujube add water to cook it is secondary, 1.5 hours for the first time, the
Secondary 1 hour, collecting decoction filtered, and filtrate is concentrated into right amount, obtained concentrate；
Step 4: ethanol in proper amount is added in concentrate to be made to precipitate, and takes supernatant, ethyl alcohol is recovered under reduced pressure, water is added to stir evenly, stand, take
Supernatant filtration, filtrate concentration, obtains concentrate, spare；
Step 5: the aqueous solution after volatile oil and distillation is added in the concentrate into step 4, adjusts total amount to 1000ml, stirs
It is even, filtration, it is filling, sterilizing to get.
3. adding the preparation method of taste Compound Hydrochloride Phenylpropanolamine as claimed in claim 2, which is characterized in that in the step 5, fill
Fill every dress 10ml.
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