CN106110186A

CN106110186A - A kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift

Info

Publication number: CN106110186A
Application number: CN201610575042.7A
Authority: CN
Inventors: 王志学; 赵林; 杨晶; 刘粉叶; 齐芳华; 蔡平平
Original assignee: Shandong Provincial Hospital
Current assignee: Shandong Provincial Hospital
Priority date: 2016-07-21
Filing date: 2016-07-21
Publication date: 2016-11-16

Abstract

The present invention provides a kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift, including: the Radix Astragali, Fructus Ligustri Lucidi, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Semen Coicis, Herba Scutellariae Barbatae, Rhizoma Curcumae, Scorpio, Spina Gleditsiae, Concha Ostreae, Carapax Trionycis, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae Preparata.The present invention reuses the Radix Astragali, Fructus Ligustri Lucidi is monarch drug.The common gas of tumor post-operation patient, blood, yin, yang virtual loss, the Radix Astragali is monarch, can strongly invigorating primordial QI, lung benefiting spleen invigorating.For a long time and kidney, deficiency of kidney-essence, Fructus Ligustri Lucidi enriching yin and nourishing kidney, can be Kidney-Yin in the kidney invigorating, unit is so incensed that multiple, then disease is from removing.The Radix Astragali, Fructus Ligustri Lucidi two medicine match, and play QI and blood regulating negative and positive altogether, the merit of the body resistance strengthening and constitution consolidating.Ministerial drug is with Herba Scutellariae Barbatae, Rhizoma Curcumae, Spina Gleditsiae, Concha Ostreae, Carapax Trionycis heat-clearing and toxic substances removing, blood circulation promoting and dispersing pathogen accumulation.Scorpio, Ramulus Uncariae Cum Uncis treating the poisonous disease with poisonous drugs, calming wind and dredging collateral.Assistant is with the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Semen Coicis, the spleen strengthening and damp drying, dissipating phlegm and resolving masses.Make with Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription.Full side has " Fuzheng Huoxue, detoxicating and resolving stagnation of pathogens, the effect of the only shifting that relieves dizziness, high fever, infantile convulsions, epilepsy, etc..

Description

A kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift

Technical field

The present invention relates to a kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift, belong to Chinese medicine Field.

Background technology

Malignant tumor is one of disease that harm human health is the most serious, and its sickness rate is in ascendant trend year by year.According to generation Boundary's health organization (WHO) and American Society of Clinical Oncology (ASCO) statistics, the de novo cancer patient in the whole world is 10,000,000 people, Die from the patient of cancer between 600～7,000,000, averagely account for the 12% of dead sum.Resident's common cause of death is being sent out Reach state's household first (accounting for the 22.3% of total death toll), developing china household second (accounting for the 9.5% of total death toll).? China, annual de novo cancer patient about 1,600,000, die from about the 1300000 of cancer.China's tumor mortality rate in 1997 is in city Being 1,36/,100,000 populations, account for first of Disease causation, rural area is 1,08/,100,000, occupies second.Most important of which cancer Disease is pulmonary carcinoma, gastric cancer, breast carcinoma, colorectal cancer, oral cancer, hepatocarcinoma, cervical cancer and the esophageal carcinoma.Tumor is to causing on patient body Misery, the financial burden brought to family and the destruction causing social productive forces are difficult to the appraisal.Therefore, WHO and China Cancer has been classified as one of emphasis problem being badly in need of solution by government.

Neoplasm metastasis (metastasis) is that tumor cell is sent out the process being far apart organ by original site, is that tumor is disliked The most essential performance of property.Although the current operation to tumor, chemotherapy, radiotherapy, Non-surgical combined treatment have made great progress, but Still fail to stop the infiltration of tumor, transfer process.Having conclusive evidence to show, the malignant tumor patient of more than 90% ultimately succumbs to swell Tumor metastasis or recurrence, and shift and occur the most in early days.Therefore, transfer is the main cause that treatment of cancer is failed, controls transfer It it is the key factor determining cancer patient's prognosis.Neoplasm metastasis be a multi-step, multifactor, polygenes comprehensive function extremely Complicated dynamic changing process.Numerous studies confirm: new vessels is that malignant tumor quickly increases necessary prerequisite, Also being a key step distally shifting of malignant tumor and channel, each step of neoplasm metastasis is all raw with the blood capillary of tumor Become closely related.Therefore, suppression tumor-blood-vessel growth is prevention and controls the important channel that neoplasm metastasis occurs.With tumor Vascularization is based on the metastasis research of target spot becomes and the focus of clinical research, finds new high-efficiency low-toxicity angiogenesis Inhibitor has become the emphasis problem of current anti-metastasis drug research.

Chinese medicine has the status become more and more important in combined therapy of tumour, multi-level, too many levels, the Mutiple Targets of Chinese medicine Mechanism of action feature, the treatment that exactly compensate for the single action target spot of Western medicine single component is often difficult to reach thoroughly to effect a radical cure effect The shortcoming of fruit, the development for medicine for anti transfer of tumor provides a natural Drug Storage.Therefore, with traditional Chinese medicine theory for instructing And combine with the modern study achievement of tumor-blood-vessel growth and transfer, exploitation has suppression tumor angiogenesis, blocking-up The new Chinese medicine of neoplasm metastasis approach, for controlling tumor invasion, transfer, improves patient's prognosis and improves long-dated survival further Rate tool is of great significance.

Summary of the invention

It is an object of the invention to, it is provided that a kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift, tool There are " Fuzheng Huoxue, detoxicating and resolving stagnation of pathogens, the effect of the only shifting that relieves dizziness, high fever, infantile convulsions, epilepsy, etc..

Technical solution of the present invention is as follows: a kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift, with weight Amount part meter, including the crude drug of following component: the Radix Astragali 45～60 parts, Fructus Ligustri Lucidi 15～30 parts, the Rhizoma Pinelliae 10～15 parts, Pericarpium Citri Reticulatae 10～ 15 parts, Endothelium Corneum Gigeriae Galli 10～18 parts, Semen Coicis 18～30 parts, Herba Scutellariae Barbatae 20～30 parts, Rhizoma Curcumae 20～30 parts, Scorpio 10～15 Part, Spina Gleditsiae 10～15 parts, Concha Ostreae 30～60 parts, Carapax Trionycis 10～20 parts, Ramulus Uncariae Cum Uncis 10～15 parts, Radix Glycyrrhizae Preparata 6～10 parts.

Preparation method: be decocted in water for oral dose, potion on the one, divides and sooner or later takes for twice.

Chinese medicine composition of the present invention can also be prepared as the dosage forms such as Chinese medicine capsules, granule, tablet, powder, pill.

Transfer is the main cause that treatment of cancer is failed, and controlling transfer is the key factor determining cancer patient's prognosis.This The purport of invention prescription is recurrence and the transfer of anti-curing oncoma.Inventors believe that tumor is a systemic disease, transfer is The concrete manifestation of its generalization；Healthy energy virtual loss, the most not pressing down heresy is the basic reason that neoplasm metastasis occurs；Propose the deficiency of vital energy of transfer Blood stasis, expectorant poison multiple abscess, the theory of pathogenesis of obstruction of collateral caused by windphlegm, the pathogenesis development law of transfer is healthy energy virtual loss, accumulates, in wind syndrome caused by deficiency in evil poison Dynamic, wind holds expectorant poison under the arm, and multiple abscess meridians, the stasis of blood forms long-pending.Clinical application must be started with in terms of void, the stasis of blood, poison, expectorant, wet, wind etc., can treat Effect is notable.

Therefore, the present invention reuses the Radix Astragali, Fructus Ligustri Lucidi is monarch drug.The common gas of tumor post-operation patient, blood, yin, yang virtual loss, the Radix Astragali For monarch, can strongly invigorating primordial QI, lung benefiting spleen invigorating is sick.For a long time and kidney, deficiency of kidney-essence, Fructus Ligustri Lucidi enriching yin and nourishing kidney, can be Kidney-Yin in the kidney invigorating, unit is so incensed that Multiple, then disease is from removing.The Radix Astragali, Fructus Ligustri Lucidi two medicine match, and play QI and blood regulating negative and positive altogether, the merit of the body resistance strengthening and constitution consolidating.Ministerial drug with Herba Scutellariae Barbatae, Rhizoma Curcumae, Spina Gleditsiae, Concha Ostreae, Carapax Trionycis heat-clearing and toxic substances removing, blood circulation promoting and dispersing pathogen accumulation.Scorpio, Ramulus Uncariae Cum Uncis treating the poisonous disease with poisonous drugs, calming wind and dredging collateral.Help with the Rhizoma Pinelliae, old Skin, Endothelium Corneum Gigeriae Galli, Semen Coicis, the spleen strengthening and damp drying, dissipating phlegm and resolving masses.Make with Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription.

Specifically, in side of the present invention, the pharmacological action of each crude drug is as follows:

The Radix Astragali: nature and flavor are sweet, tepor.Return lung, spleen, liver, kidney channel.The special QI invigorating of Radix Astragali merit, lung benefiting spleen invigorating, there is invigorating QI to consolidate the body surface resistance, Diuresis poison holding, evacuation of pus, the merit of expelling pus and promoting granulation, it is the function of its invigorating vital QI at all, since ancient times for the key medicine of righting.Existing Generation research confirms the effect of the Radix Astragali: 1 strengthens immunologic function 2 promotees effect 3 enhancing body anoxia enduring and the stress ability 4 of interferon Enter organism metabolism 5 to improve cardiac function 6 hypotensive effect 7 hepatoprotective effect 8 and regulate that blood glucose 9 is antibacterial and antiviral effect 10 hormonelike is made With.

Fructus Ligustri Lucidi: sweet, bitter, cold.Return liver, kidney channel.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, palpus Send out the whitest, poor vision.

Herba Scutellariae Barbatae: pungent, bitter, cold.Return lung, liver, kidney channel.Heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, Venom, falls and flutters the pain of injury, edema, jaundice.

Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation Distending pain；Early cervical carcinoma.

Spina Gleditsiae: nature and flavor are pungent, temperature.Return liver, stomach warp.Detumescence poison holding, evacuation of pus, parasite killing.For carbuncle from the beginning of or difficulty in discharging of pus； External treatment scabies leprosy

Concha Ostreae: salty, is slightly cold.Return liver, gallbladder, kidney channel.Tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.For insomnia of palpitating with fear, dizzy Dizzy tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, metrorrhagia and leukorrhagia of passing out semen, acid regurgitation of having a stomachache.

Carapax Trionycis: salty, is slightly cold.Return liver, kidney channel.Nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, bring down a fever except steaming.For fever due to yin deficiency, consumptive fever bone Steam, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea, abdominal mass, chronic malaria malaria with splenomegaly.

Scorpio: pungent, flat；Poisonous.Return Liver Channel.Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic convulsion Contraction, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.

Ramulus Uncariae Cum Uncis: sweet is cool.Return liver, pericardium channel.Heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.For dizziness of having a headache, dysphoric cold, infantile convulsion is taken out Jerk, pre-eclampsia；Hypertension.

The Rhizoma Pinelliae: pungent, temperature；Poisonous.Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, Phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomits regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus；Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is many For stopping nausea and vomiting by lowering the adverse flow of QI.

Pericarpium Citri Reticulatae: bitter, pungent, temperature.Return lung, spleen channel.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough Abundant expectoration.

Endothelium Corneum Gigeriae Galli: sweet is flat.Return spleen, stomach, small intestinal, bladder warp.Invigorating the stomach and promoting digestion, arresting seminal emission.Do not disappear for food stagnation, vomiting Dysentery, infantile malnutrition, the enuresis, seminal emission.

Semen Coicis: sweet, light is cool.Return spleen, stomach, lung meridian.Spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away.For edema, foot Gas, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, acute appendicitis；Verruca plana.

Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, it is in harmonious proportion all Medicine.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, abirritant Thing toxicity, strong.

There is advantages that medicament composing prescription of the present invention has significantly suppression tumor-blood-vessel growth and anti-rotation Shifting recurrence effect, and notable prolongation tumor post-operation survival of patients phase, quality of making the life better, alleviate chemical therapy toxic side effect.Its effect By reducing tumor and interstitial MVD thereof, suppression promotees the expression of tumor angiogenesis factor VEGF, BFGF, MMP-9, lowers sudden change The expression of type P53 gene protein, improves anti-metastasis gene NM23 gene expression, improves that body height is viscous, hypercoagulability, protects Protect body immune system, improve that cellular immune function etc. is multi-level, the multi-mechanism of too many levels, Mutiple Targets realizes.

Below in conjunction with Sero-pharmacological experiment, animal experiment in vivo, clinical research (rear attached clinical case), the present invention is imitated Fruit is described further.

One, research purpose

Transfer is the main cause that treatment of cancer is failed, and controlling transfer is the key factor determining cancer patient's prognosis.Newly Angiogenic is that malignant tumor quickly increases necessary prerequisite, is also a main step distally shifting of malignant tumor Rapid and channel, each step of neoplasm metastasis is all closely related with the Angiogenesis of tumor.Therefore, suppression tumor-blood-vessel growth is The important channel that prevention and control neoplasm metastasis occur.

This research, according to tumor-blood-vessel growth and the pathogenic characteristic of transfer " weakened body resistance blood stasis, evil poison multiple abscess, obstruction of collateral caused by windphlegm ", is intended This medicament composing prescription of fixed " " Fuzheng Huoxue, detoxicating and resolving stagnation of pathogens, calming wind and dredging collateral ".Utilize modern medical research methods, respectively from different layers Secondary, varying level, different angles illustrate the Antineoplastic angiogenesis of this medicament composing prescription and tumor suppression metastasis effect and mechanism, for the present After the further extensively application of this medicine scientific basis is provided.

Two, research method and content

(1) basic research

1 experiment in vitro (Sero-pharmacological experiment)

1.1 medicament composing prescription Contained Serums of the present invention, the preparation of normal mouse serum

Wistar rat is randomly divided into 2 groups, and Contained Serum group gives medicament composing prescription aqueous solution of the present invention every day, and (every milliliter contains Crude drug 2 grams) 3ml/ time, 3 times/day of gavages, blank serum group gives normal saline gavage every day, in being administered the 3rd day, abdomen master Arterial blood drawing, aseptic separation serum, through 56 DEG C, 30 minutes inactivation treatment, the degerming rear subpackage of membrane filtration, put-20 DEG C of refrigerators and protect Deposit standby.

1.2 Cell culture invitro

" cancer therapy drug research and experiment technology " is edited with reference to Han Rui.High-transfer human giant cell carcinoma of lung cell line PG cell strain 2×10⁵/ ml is inoculated in containing 10% calf serum and the penicillin of 1%, streptomycin RPMI1640 culture fluid, and 37 DEG C, 5% is saturated Cultivating under humidity, cell attachment grows, and the next day passes on once, cultivates 24 hours to the vigorous rear addition variable concentrations of cell growth Normal mouse serum, this medicament composing prescription Contained Serum, CTX test.

1.3 observation items:

1. the impact on chick chorioallantoic membrane (CAM) angiogenesis: the method introduced with reference to Peter etc. is improved slightly, is solving Cut open the branching-point quantity of counted under microscope chorioallantoic membrane blood vessel.The branching-point that vascular index=drug treating is crossed/untreated Branching-point.

2. microplate reader is used to detect this medicament composing prescription Vitro Cytotoxicity to PG cell strain by MTT reducing process；

3. flow cytometer, laser confocal microscope, enzyme linked immunosorbent assay detection medicine it are respectively adopted to PG cell The impact of strain cytokine vegf expression；

4. use flow cytomery medicine to PG cell strain bFGF, MMP-9, P53 gene, nm23 gene, cell week Phase and apoptosis-induced impact.

2 animal experiment in vivo

2.1 method for building animal model

Lewis lung cancer transplanted tumor and the foundation of spontaneous Blood route metastasis model: take Lewis lung cancer cells suspension (concentration is 1 × 10 to 0.2ml⁷/ ml) it is inoculated in inbred line C₅₇The right axillary fossa of BL/6 mice is subcutaneous, within 14th, observes Local tumor growth Situation.Operation group: Lweis lung cancer tumor cell suspension inoculation is in C₅₇At BL/6 mice right lower extremity leg muscle, the 6th day, at tumor body Upside sterile working excision band tumor limbs, the 21st day observe Lung metastases situation,.

H₂₂Hepatocarcinoma (ascitic type) transplanted tumor and experimental blood road, the foundation of lymphatic metastasis model: take mice H₂₂Hepatocarcinoma is thin Born of the same parents suspension 0.2ml (2 × 10⁶Individual) to be inoculated in the right axillary fossa of Kunming mouse subcutaneous.Observe H₂₂During hepatocarcinoma experimental lung metastasis, mice Tail vein injection 0.2ml (2 × 10⁶Individual) oncocyte.Lymphatic metastasis model: take tumor cell suspension 0.05ml (concentration is 1 × 10⁸/ ml, containing oncocyte number 5 × 10⁶Individual), it is inoculated in inbred line Kunming mouse left hind sole subcutaneous.

2.2 packets and treatment

Divide five groups of 1. NS groups: gavage normal saline 2. this medicament composing prescription small dose group: this medicament composing prescription is by 40g/kg body weight Gavage 3. this medicament composing prescription heavy dose group every day: this medicament composing prescription gavages 4. CTX group by 60g/kg body weight every day: CTX is by 30mg/ Lumbar injection × 6 5. this medicament composing prescription low dose+CTX group next day of Kg body weight: usage is ibid.

2.3 observation item

Observe medicine to Lewis lung cancer mice, H₂₂The growth of liver cancer mouse subcutaneous transplantation tumor, blood road and lymphatic metastasis, swollen Tumor microvessel density (MVD) and vascular endothelial cell growth factor (VEGF) expression (ImmunohistochemistryMethods Methods), immune organ The impact of protective effect etc..

(2) clinical research

1 case inclusive criteria

(1) this research selects pulmonary carcinoma, human primary gastrointestinal cancers, patient with breast cancer to be the object of observation；(2) have pathology, cytology examines Disconnected foundation and the clear and definite person of histological classification；(3) clinical stages II～III phase person (UICC world TNM staging scale), and it is hands Postoperative patient (being main person with row radical correction)；(4) in 3 months after operation, and the therapist such as non-row radiotherapy, chemotherapy and BRM；(5) nothing Metastasis and recurrence sign person；(6) Ka Shi (Karnofaky) scoring^[23]Person more than 60 points；(7) without the serious heart, liver, Organic or the functional illness such as brain, kidney and hemopoietic function of bone marrow obstacle person.

Exclusion standard is: (1) does not meets above-mentioned inclusion criteria person；(2) it is unwilling to participate in clinical trial person.

All cases totally 95 example, the maleest 42 examples, female 53 example, the oldest 67 years old, minimum 35 years old, the mean age 57.63 Year, wherein less than 40 years old person 14 example, 40～60 years old person 59 example, more than 60 years old person 22 example.Pulmonary carcinoma 33 example, human primary gastrointestinal cancers 28 example, mammary gland Cancer 34 example,.

2 group technologies

It is divided into nonsmall-cell lung cancer (NSCLC), human primary gastrointestinal cancers, breast carcinoma (ABC) 3 groups, after planting packet by disease by project It is respectively divided into matched group (alone chemotherapy) and observation group's (this medicament composing prescription adds chemotherapy) again with random method (random table method).

3 Therapeutic Method

(1) matched group (chemotherapy): chemotherapy regimen:

Nonsmall-cell lung cancer group: by CAP or NP scheme；Every 4 weeks is a cycle, totally 3～6 cycle.

Human primary gastrointestinal cancers group: by DLF or ELF or HDLF scheme；Every 4 weeks is a cycle, totally 3～6 cycle.

Breast carcinoma CMF or CAF scheme: every 4 weeks is a cycle, continuously 6 cycles for the treatment of

(2) observation group's (medicament composing prescription of the present invention adds chemotherapy): medicament composing prescription of the present invention is added by Shandong Prov. Hospital Drug Manufacturing Room Work produces, and often wraps 9g (being equivalent to crude drug 80g).Patient per takes 1 bag, day 3 times, is monthly a course for the treatment of.Coordinate matched group simultaneously Scheme chemotherapy.Take at least three course for the treatment of continuously.

4 observation index

Within 4.1 1, two years, metastasis, recurrence are observed.

Each position situation is checked, respectively according to clinical symptoms, sign, the inspection of lump Puncture cytology and image analysis etc. Observe treatment and metastasis positions such as () lung, liver, brain, bone, adrenal gland, kidney, pericardium, subcutaneous tissue and in situ occurs in 1,2 years Recurrence.

4.2 1, biennial rate of depositing is observed.

4.3 short term effects are observed.

After treating 3 months, observe VEGF in treatment Life For The Residents of Three Gorges Reservoir Before (K, S mark), body weight, cardinal symptom, peripheral blood The change of the indexs such as content, immune indexes, Hemorheology.

4.4 untoward reaction are observed

Peripheral blood leucocyte, erythrocyte, hemoglobin, platelet and Liver and kidney function, ECG Change before and after detection treatment Situation, toxicity evaluation is carried out with reference to the performance of WHO (1979) cancer therapy drug acute and subacute toxicity and indexing standard Evaluation.

5. statistical method

All experiments and clinical data all input computer, use SPSS8.0 statistical package to set up data base also Carry out statistical analysis, predominantly t inspection, x²Inspection, Ridit analysis, variance analysis.

Three, result of study

(1) basic research

1 experiment in vitro (Sero-pharmacological experiment)

The experiment of 1.1 pairs of chick chorioallantoic membrane (CAM) angiogenesis

Matched group CAM vascularity is uniform, and, disruption tortuous without blood vessel, medicament composing prescription Contained Serum group of the present invention can Seeing that avascular area, circular chick chorioallantoic membrane produce blood vessel avoidance zone, angiogenesis significantly reduces.Statistical result showed under mirror: Matched group, normal mouse serum group, low medicine group, high medicine group CAM vascular index are respectively 85.78 ± 10, and 82.55 ± 12.17, 44.29 ± 8.52,30.93 ± 7.35, CAM angiogenic growth is all had substantially by this medicament composing prescription Contained Serum low medicine group, high medicine group Inhibitory action (P 0.01).

The impact on CAM angiogenesis of the table 1 medicament composing prescription of the present invention Contained Serum

Q detects note: with normal saline group ratio ▲ ▲ P 0.01

The observation of 1.2 pairs of PG cell toxic actions

This medicament composing prescription Contained Serum has obvious inhibiting effect to PG cell proliferation, and improves with medicine serum-concentration, acts on Time lengthening inhibitory action strengthens

1.3 impacts that PG cell VEGE, bFGF, MMP-9 are expressed

Human lung carcinoma cell PG VEGF, bFGF, MMP-9 expression is higher, normal mouse serum to PG cell VEGE, bFGF, MMP-9 expression has no significant effect, and this medicament composing prescription Contained Serum can significantly lower PG cell VEGE, bFGF, MMP-9 express Level, and with medicine serum-concentration raise and extended durations of action, inhibitory action strengthen, chemotherapy to PG cell VEGE, bFGF, MMP-9 expression also has a notable downward effect, and chemotherapy and this medicament composing prescription share to suppression PG cell VEGE, bFGF, The expression of MMP-9 has synergism.

The table 2 impact on the expression of people's giant cell carcinoma of lung cell line PG cell VEGE

Note: Q detects: with calf serum group ratio ▲ P 0.05 ▲ ▲ P 0.01 and CTX group than * P 0.05 * * P 0.01

Each group of impact on the expression of bFGF of table 3

Q detects note: with matched group ratio ▲ P 0.05 ▲ ▲ P 0.01 and CTX group than * P 0.05 * * P 0.01

Each group of impact on the expression of MMP-9 of table 4

1.4 on PG cell P53 gene, the impact of nm23 gene expression

Human lung carcinoma cell PG P53 gene expression dose is higher, and nm23 gene expression dose is relatively low.Normal mouse serum is thin to PG Born of the same parents' P53 Genes nm23 gene expression dose has no significant effect.This medicament composing prescription Contained Serum can significantly lower PG cell P53 gene Expression, the notable nm23 gene expression dose that raises, and act on increasing with the rising of medicine serum-concentration and the prolongation of action time By force, chemotherapy also has certain effect, and chemotherapy and this medicament composing prescription share and have synergism.

The impact that P53 is expressed by each group of table 5

Each group of impact on nm23 gene expression of table 6

1.5 may act on tumor cell G to induction apoptotic this medicament composing prescription Contained Serum that affects of PG₁/ S node, Tumor cell is made to block in G₀-G₁Phase, and stop tumor cell malignant proliferation, its apoptosis-induced effect by starting Apoptosis mechanism Strengthen with the increase of medicine serum-concentration and the prolongation of action time.

This medicament composing prescription Contained Serum impact on PG cell cycle of table 7

2 animal experiment in vivo

2.1 impacts on local tumor

H₂₂Hepatocarcinoma, Lewis lung cancer each treatment group tumor weight average is substantially less than matched group, compares with matched group, is respectively provided with notable Sex differernce (P 0.05～0.01).This medicament composing prescription and CTX have share notable synergistic effect.

Table 8 medicament composing prescription of the present invention is to Lewis lung cancer mice in vivo antitumor effect result

Q detects note: with normal saline group ratio ▲ P 0.05 ▲ ▲ P 0.01 and CTX group than * P 0.05

2.2 impacts that tumor microvessel density (MVD) is expressed

Each medication group H₂₂Hepatocarcinoma, Lewis lung cancer mouse tumor and microvasculatures surface density value thereof are all substantially less than comparison Group (P 0.01), with CTX group ratio, this medicament composing prescription heavy dose group, this medicament composing prescription low dose+CTX group MVD value is substantially less than CTX group, (P 0.01).

Table 9 H₂₂Hepatocarcinoma, Lewis lung cancer tumor tissues mean vascular density

Q detects note: with normal saline group ratio ▲ P 0.05 ▲ ▲ P 0.01 and CTX group than * * P 0.01

2.3 impacts on tumor vegf expression

Each medication group VEGF positive cell surface density value, average gray value are all substantially less than matched group (P 0.05, P 0.01), this medicament composing prescription heavy dose group, this medicament composing prescription low dose+CTX group is substantially less than CTX group, (P 0.05, P 0.01).

Table 10 H22 hepatocarcinoma, Lewis lung cancer tumor tissues vegf expression averaged areal density

Q detects note: with normal saline group ▲ ▲ P 0.01 and CTX group than * P 0.05 * * P 0.01

Table 11 H22 hepatocarcinoma, Lewis lung cancer tumor tissues vegf expression average gray

Q detects note: with normal saline group ratio ▲ P 0.05 ▲ ▲ P 0.01 and CTX group than * P 0.05 * * P 0.01

2.4 couples of Lewis lung cancer, H₂₂The impact of hepatocarcinoma Blood route metastasis

Each medication group Lung metastases rate, Pulmonary metastasis focuses number, metastatic tumor growth index, primary tumor tumor weight average are less than matched group；Chinese mugwort Little+CTX group Pulmonary metastasis focuses number, primary tumor weight are significantly less than CTX group (P 0.05)；End big group, the little+CTX that ends group Lung metastases suppression Rate, pulmonary metastases growth inhibition ratio are significantly better than CTX group.

This medicament composing prescription of table 12 is to H₂₂The impact of liver cancer mouse experimental lung metastasis

Note: Q detects with normal saline group ratio ▲ P 0.05 ▲ ▲ P 0.01 and CTX group than * P 0.01

The impact that Lewis lung cancer mice spontaneous lung is shifted by this medicament composing prescription of table 13

2.5 couples of H₂₂The impact of liver cancer mouse lymphatic metastasis

Each medication group is to H₂₂Hepatocarcinoma palmula transplanting mouse lung, rate of lymph-node metastasis, metastasis (individual) number are below matched group； Little+the CTX that ends group Pulmonary metastasis focuses number significantly less than CTX group (P 0.01), end big group, the little+CTX that ends group number of involved lymph node notable Less than CTX group (P 0.01), and lung, metastasis of lymph substantially alleviate；

Table 14 medicament composing prescription of the present invention is to H₂₂The impact of liver cancer mouse lymphatic metastasis model Lung metastases

Q detects note: with normal saline group ratio ▲ P 0.05 ▲ ▲ P 0.01 and CTX group than * P 0.01

Table 15 medicament composing prescription of the present invention is to H₂₂The impact of liver cancer mouse lymphatic metastasis model lymphatic metastasis

2.7 on Lewis lung cancer mice postoperative pulmonary, the impact of lymphatic metastasis

Each medication group is below matched group to the Mice Bearing Lewis Lung Cancer postoperative pulmonary rate of transform, Pulmonary metastasis focuses number, metastasis degree； Little+the CTX that ends group Pulmonary metastasis focuses number is substantially less than CTX group (P < 0.05)；Lymphatic metastasis situation: the taken lymph tying-in tissue of each group Pathology serial section is observed and is had no lymphatic metastasis.

The impact that Mice Bearing Lewis Lung Cancer postoperative pulmonary is shifted by table 16 medicament composing prescription of the present invention

2.8 impacts on mouse immune organ

This medicament composing prescription can increase tumor-bearing mice thymus index, index and spleen index, increases bright with this medicament composing prescription group low dose of Aobvious (P < 0.05)；CTX group can significantly reduce thymus index, index and spleen index (P < 0.05～0.01)；This medicament composing prescription low dose of with CTX share, and tumor-bearing mice thymus, spleen atrophy caused by CTX can be had certain antagonism.

(2) clinical research

1. on tumor post-operation patient transfer in 1,2 years and the impact of recurrence

1,2 years transfer and relapse rates of pulmonary carcinoma observation group are respectively 10.00%, 25.00%, substantially less than matched group 38.46%, 61.54% (P all < 0.01)；1,2 years transfer and relapse rates of total inspection group are respectively 6.67%, 16.67%, the lowest 28.57%, 48.57% (P < 0.05～0.01) in total matched group；This medicament composing prescription is pointed out to have significant metastasis, anti-recurrence Effect.

Table 17 medicament composing prescription of the present invention is on tumor post-operation patient transfer and the impact of recurrence

Note: compare ▲ P 0.05 ▲ ▲ P 0.01 (P value is calculated by " the definite probabilistic method of four fold table data ") with matched group

2. 1,2 years survival rates of couple tumor post-operation patient compare

Observation group one, the biennial rate of depositing are respectively 93.33%, 86.67%, be significantly higher than matched group 74.29%, 54.29% (P 0.05, P 0.01).Point out this medicament composing prescription combined with chemotherapy can significantly improve the survival rate of tumor post-operation patient.

Tumor postoperative patient survival rate is compared by table 18 medicament composing prescription of the present invention

3. change (k.s) scoring for the treatment of Life For The Residents of Three Gorges Reservoir Before

Quality of life improves, stable, reduce observation group and be respectively 45.00%, 36.67%, 18.33%, matched group is respectively It is 28.57%, 28.57%, 42.86%.Significant difference (P 0.05) is had between two groups

Life For The Residents of Three Gorges Reservoir Before change treated by table 19

Note: Ridit analyzes, U=2.3574 ▲ P 0.05 R_Observe=0.5429 R_Comparison=0.6781

4. the change of body weight before and after treatment

Observation group rises, stable, reduction respectively 55.00%, 33.33%, 11.67%, and matched group is respectively 25.71%, 34.29%, 40.00%, there is significant difference (P 0.05) between two groups

The change of body weight before and after table 20 treatment

Note: Ridit analyzes, U=2.1857 P 0.05 R_Observe=0.5681 R_Comparison=0.7041

5. clinical primary symptom change before and after treatment

Observation group improves, stablizes, increases the weight of respectively 54.29%, 31.43%, 14.29%, and matched group is respectively 28.00%, 30.00%, 42.00%, there is significant difference (P 0.05) between two groups

Before and after table 21 treatment, the change of clinical primary symptom is compared

Note: Ridit analyzes, U=1.8781 P 0.05 R_Observe=0.5681 R_Comparison=0.7041

6. the change of VEGF content in peripheral blood before and after treatment

Treatment Hou Ge observation group reduces before the most relatively treating with VEGF content in matched group peripheral blood.Wherein pulmonary carcinoma observation group controls After treatment, 23.87 ± 12.82pg/ml relatively treats front 31.59 ± 11.59pg/ml and significantly reduces (P 0.05).

Before and after table 22 treatment in peripheral blood VEGF content change (pg/ml)

Note: t detection compares ▲ P 0.05 before treatment

7. the change of immunologic function before and after treatment

CD before two groups of treatments₃、CD₄、CD₄/CD₈The most in various degree less than normal value, but two groups of no significant difference (P 0.05).Observation group CD after treatment₃、CD₄、CD₄/CD₈Relatively before treatment the most significantly raised (P 0.05), matched group CD₃、CD₄、CD₄/ CD₈Relatively treat the decline (P 0.05) that takes a step forward.Prompting chemotherapy has the side effect suppressing Cellular Immunologic Function In Patients further, and This medicament composing prescription can alleviate the chemotherapy damage to Immune Function.

The change of immune indexes before and after table 23 treatment

Note: t detection compares ▲ P 0.05 before treatment

8. the change of hemorheology index before and after treatment

Before treatment, observation group and matched group lectin from hemolymph index are in the higher range of normal value or mostly beyond normal, treatment Rear observation group indices (in addition to deformable index) significantly reduces before the most relatively treating (P 0.05～0.01), and matched group Plasma viscosity, whole blood viscosity, blood reduced viscosity, ESR equation K value, erythrocyte aggregation index, Fibrinogen are the most relatively treated Before significantly increase (P 0.05～0.01).

Hemorheological change before and after table 24 treatment

Note: t detection compares ▲ P 0.05 ▲ ▲ P 0.01 before treatment

9. untoward reaction is observed

Two groups all have leukocyte in various degree, hemoglobin, platelet to decline, periphery after observation group's relatively treatment of control group Blood WBC, HGB, PLT decline mild degree, and number of cases is few, and matched group WBC reduces substantially, compares for two groups and has significant difference (P 0.05), no significant difference (P 0.05) between HGB, PLT two groups.Two groups of hearts, Liver and kidney function damage relatively light, based on I grade of infringement, No significant difference (P 0.05) between two groups.

25 liang of table group toxicity compares

Four, research conclusion

" weakened body resistance blood stasis, evil poison multiple abscess, obstruction of collateral caused by windphlegm " is the pathogenic characteristic of tumor-blood-vessel growth and transfer, " " Fuzheng Huoxue, Detoxicating and resolving stagnation of pathogens, calming wind and dredging collateral " for suppressing tumor-blood-vessel growth and the therapeutic rules of metastasis.This medicament composing prescription has and significantly presses down Tumor-blood-vessel growth processed and metastasis recurrence effect, and notable prolongation tumor post-operation survival of patients phase, quality of making the life better, alleviate Chemical therapy toxic side effect.It acts through minimizing tumor and interstitial MVD thereof, suppression promote tumor angiogenesis factor VEGF, BFGF, The expression of MMP-9, lowers the expression of Mutation P53 gene protein, improves anti-metastasis gene NM23 gene expression, improves Body height is viscous, hypercoagulability, protects body immune system, improves that cellular immune function etc. is multi-level, the combining of too many levels, Mutiple Targets Conjunction mechanism realizes.

Attached clinical case:

(1) pulmonary carcinoma example: Lee xx, female, 65 years old.

First visit: cough, expectoration, right chest pain 6 months, breast CT is shown: the most vertical phrenic lymph nodes transfer of right lung cancer, postoperative pathological Show: right lung adenocarcinoma, low-middle differentiation.The postoperative pemetrexed of row+cisplatin chemotherapy four cycle.More than 20 skies after existing chemotherapy, tell light Degree cough, few expectorant, without chest pain, weak, asthma sometimes is felt oppressed, poor appetite, and two is just normal, and dormancy can.Previously body is good for.

Hope and hear palpation: typically can, god's clear language profit, lusterless complexion.Superficial lymph is tied not and substantially enlargement, the heart (-), right lung Respiratory murmur is lower slightly, rale (-), liver spleen (-).The body of the tongue stasis of blood is dark, yellow fur, stringy and hesitant pulse.

Chinese medical discrimination: insufficiency of lung-QI, qi depression to blood stasis, knot in ecchymosis.

Western medicine diagnose: after right lung cancer mediastinal lymph node metastasis postoperative chemotherapy.

Method for the treatment of: " Fuzheng Huoxue, blood stasis-eliminating and stagnation-dissipating, detoxicating and fighting cancer；

Radix Astragali 45g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, Rhizoma Atractylodis Macrocephalae 10g, Poria 15g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, Rhizoma Curcumae 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Fructus Psoraleae 30g, Radix Glycyrrhizae Preparata 6g.Be decocted in water for oral dose, every day potion.

Examine again: cough still weighs, time cough white expectorant, food sleep two just can, yellow fur, thready pulse stringy and rapid pulse.

Upper prescription is drunk and is added: Bulbus Fritillariae Uninbracteatae 15g, Radix Platycodonis 10g, Fructus Trichosanthis 30g.

Repeatedly further consultation: based on Traditional Chinese Medicine Anti oncotherapy, foster lung QI invigorating, heat-clearing and toxic substances removing, dissipating phlegm and resolving masses are method, and main formula is such as Under: Radix Astragali 60g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, Rhizoma Curcumae 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Radix Platycodonis 10g, Semen Armeniacae Amarum 10g Radix Glycyrrhizae Preparata 6g, be decocted in water for oral dose, day 1 dose.

Plus-minus: rush of panting less, dry cough, adds Radix Panacis Quinquefolii 3g, Radix Asteris 15g, Radix Adenophorae (Radix Glehniae) 20g；Cough expectorant is yellow, and red tongue rolling pulse adds gold Semen Fagopyri Esculenti 15g, Arisaema Cum Bile 10g, Radix Peucedani 10g；Weakness due to chronic disease is unable, adds Fructus Lycii 15g, Rhizoma Atractylodis Macrocephalae 20g, seed of Job's tears 30g.

Adhere to taking medicine nearly more than 3 years, add and subtract according to above symptom, periodic review tumor presence, stable disease, have no that tumor is multiple Send out and metastasis.Patient's ordinary circumstance is good, and diet two is just normal, and life is normal.

(2) pulmonary carcinoma example: Zheng xx, man, 66 years old.

First visit: patient is medical because of " paroxysmal zest dry cough May more than, increase the weight of January ", looks into breast CT and shows: upper right pulmonary carcinoma, Mediastinal lymph node metastasis, patient disagrees operation, because of this journey Gamma knife treatment, totally 13 times, weight loss during Gamma knife treatment 5kg, checks further and finds right Kidney neoplasms, neoplasm metastasis not except.First visit disease is seen: cough, based on dry cough, without obvious breast Vexed, chest pain, red tongue, thick, yellow and greasy fur.Examining it is: lump in the right hypochondrium, lung yin virtual loss, ecchymosis internal resistance.Patient's elderly men, old, Deficiency of both QI and YIN, lung yin virtual loss then cannot go up honor, causes cough, based on dry cough, red tongue；Taking a broad view of the four diagnostic methods, patient demonstrate,proves genus lung yin and loses Void, the card of ecchymosis internal resistance.

Method for the treatment of: nourishing lung yin, dissolving blood stasis and detoxication prescription: Radix Adenophorae (Radix Glehniae) 10g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 10g, Bulbus Lilii 30g, Bulbus Fritillariae Uninbracteatae 15g, Semen Armeniacae Amarum 15g, Radix Scutellariae 9g, Herba Agrimoniae 18g, Semen Ziziphi Spinosae 30g, Caulis Polygoni Multiflori 30g, Rhizoma Curcumae 30g, Herba Scutellariae Barbatae 30g, Radix Salviae Miltiorrhizae 10g, Colla Corii Asini 15g, The each 15g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), is decocted in water for oral dose, day 1 dose.

Further consultation: take medicine 14 doses, cough takes a turn for the better earlier above, no more side effects, it is contemplated that after patient's Gamma knife treatment, hemogram is relatively low, Therefore treatment by Chinese herbs side is still with front as the end, adds and subtracts in right amount, to improve symptom.Prescription: Radix Adenophorae (Radix Glehniae) 10g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 10g, Bulbus Lilii 30g, Bulbus Fritillariae Uninbracteatae 15g, Endothelium Corneum Gigeriae Galli 30g, each 15g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Herba Patriniae 30g, Semen Ziziphi Spinosae 30g, Caulis Polygoni Multiflori 30g, Herba Solani Nigri 30g, Radix Salviae Miltiorrhizae 10g, Fructus Jujubae 7 pieces, Colla Corii Asini 15g, Radix Scutellariae 9g, it is decocted in water for oral dose, day 1 dose.

Repeatedly further consultation: first to treat radiotherapy side effect, be arranged above main plus-minus.After based on Traditional Chinese Medicine Anti oncotherapy, " Fuzheng Huoxue, heat-clearing and toxic substances removing, dissipating phlegm and resolving masses are method, and main formula is as follows: Radix Astragali 60g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, chicken Endothelium corneum 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, Rhizoma Curcumae 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Carapax Trionycis 10g, hook Rattan 10g, Radix Platycodonis 10g, Semen Armeniacae Amarum 10g Radix Glycyrrhizae Preparata 6g, be decocted in water for oral dose, day 1 dose.

Take the circumstances into consideration to add and subtract according to symptom variation: rush of panting less, dry cough, add Radix Panacis Quinquefolii 3g, Radix Asteris 15g, Radix Adenophorae (Radix Glehniae) 20g；Cough expectorant Huang, red tongue rolling pulse, add Rhizoma Fagopyri Dibotryis 15g, Semen Coicis 30g, Radix Peucedani 10g；Tumor increases, and chest pain is coughed, and adds Eupolyphaga Seu Steleophaga 6g, Nidus Vespae 10g, Herba Salviae Chinensis 15g；Weakness due to chronic disease is unable, adds Rhizoma Atractylodis Macrocephalae 15g, Fructus Lycii 15g, Caulis Spatholobi 30g.

Coordinate Chinese patent medicine FUFANG BANMAO JIAONANG, Shenyi capsule, Jinlong capsule etc..

Adhering to taking medicine more than 6 years, add and subtract according to above symptom, check lung, Kidney neoplasms are change after radiotherapy, and tumor change is not clear Aobvious.Patient's ordinary circumstance is good, and diet two is just normal, takes care of oneself, and band tumor is survived the most so far.

(3) pulmonary carcinoma example: king x, female, 55 years old.

First visit: patient's " cough sputum mixed with blood January ", right upper lung occupy-place seen from breast CT, row excision, pathology shows: right Leaf small cell carcinoma on lung, swollen thing size 4.5 × 4 × 3cm, involve pleura, the bronchus broken ends of fractured bone is clean, lymph node: bronchus 0/3, leaf Between 0/2, SABC: CD56 (+), Syn (+), ek focal (+), LCA (), post-operative recovery is fair, postoperative January begin be in hospital row EP scheme chemotherapy: VP16 100mg × 5；DDP 40mg×3.Digestive tract side reaction III degree, bone marrow depression II degree, through Chinese and western drugs Symptomatic treatment takes a turn for the better, and in 2 cycles after existing chemotherapy, cough occurs without obvious inducement, look into NSE18ng/ml before Yu Yizhou, and rabat shows: vertical Every the streak shadow of upper right, prepare to continue chemotherapy.

Inscribing disease, cough, few expectorant, poor appetite, the few China of shallow complexion, dynamic then shortness of breath and fatigue, two just adjust.Red tongue with thin fur, thready pulse Number.Examining it is: the postoperative deficiency of both QI and YIN of lump in the right hypochondrium, and waste heat is not to the greatest extent (small cell lung cancer).Patient's old women, has chronic lung disease medical history 20 Yu Nian, lung qi deficiency in origin, pathogen is taken advantage of a weak point, and is reluctant to leave with the passing of time, and blood stasis dispelling is reduced phlegm, and accumulates to hinder and forms lump in the right hypochondrium in lung, after postoperative and chemotherapy just Gas is more hindered, and deficiency of vital energy blood deficiency then body loses supports, therefore primary disease is always deficiency of both QI and YIN, the card that residual poison is not most.Chemotherapy in Patients side reaction is heavier, Therefore Chinese medicine is to alleviate chemotherapy side effect, and with benefiting QI and nourishing blood, nourishing the liver and kidney is method, adds and subtracts in right amount, the combination of Chinese and Western medicine, suits the medicine to the illness Process.

Prescription is as follows: Rhizoma Coptidis 6g, Radix Aucklandiae 10g, Radix Codonopsis 20g, Rhizoma Atractylodis Macrocephalae 15g, Poria 15g, Radix Glycyrrhizae 10g, Flos Inulae 10g, generation Haematitum 10g, Rhizoma Zingiberis 6g.Caulis Bambusae In Taenia 20g.JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 45g.Radix Peucedani 10g, is decocted in water for oral dose by 7 doses, day 1 dose.

Further consultation: taking medicine 7 doses, symptom take a favorable turn, it is contemplated that patient's hemogram is relatively low, and therefore Chinese medicine changes benefiting QI and nourishing blood into, nourishing Liver and kidney is method.Prescription: Radix Astragali Preparata 40g, Radix Angelicae Sinensis 10g, Radix Codonopsis 20g, each 15g of Radix Asparagi and Radix Ophiopogonis, Rhizoma Polygonati 20g, Caulis Spatholobi 30g, Rhizoma Fagopyri Dibotryis 10g, Endothelium corneum 15g, each 15g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Fructus Lycii 15g, Semen Cuscutae 15g, Fructus Ligustri Lucidi 15g, Caulis Bambusae In Taenia 20g, Herba Hedyotidis Diffusae 20g, crow gallbladder Sub-6g, is decocted in water for oral dose by 7 doses, day 1 dose.

Repeatedly further consultation: patient makes a definite diagnosis pulmonary carcinoma the nearlyest 6 years, the first half, chemotherapy was main, coordinates Chinese medicine, relatively smoothly completes the course for the treatment of, Tumor is controlled.Within nearly 5 years, adhere to that treatment by Chinese herbs is main, dialectical decoction and antineoplastic Chinese traditional medicine fit applications.Traditional Chinese Medicine Anti tumor Treatment is with " Fuzheng Huoxue, heat-clearing and toxic substances removing, dissipating phlegm and resolving masses as method, and main formula is as follows: Radix Astragali 60g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, Rhizoma Curcumae 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Radix Platycodonis 10g, Semen Armeniacae Amarum 10g Radix Glycyrrhizae Preparata 6g, be decocted in water for oral dose, day 1 dose.

Take the circumstances into consideration to add and subtract according to symptom variation: rush of panting less, dry cough, add Bulbus Lilii 20g, the Rhizoma Atractylodis Macrocephalae 10, Radix Asteris 15g, Radix Adenophorae (Radix Glehniae) 20g；Cough expectorant is yellow, and red tongue rolling pulse adds Rhizoma Fagopyri Dibotryis 15g, Bulbus Fritillariae Thunbergii 10g, Radix Peucedani 10g；Tumor increases, and chest pain is coughed, and adds Herba Selaginellae 10g, Eupolyphaga Seu Steleophaga 6g, Nidus Vespae 10g, Herba Salviae Chinensis 15g；Weakness due to chronic disease is unable, adds Fructus Lycii 15g, Semen Coicis 30g, Caulis Spatholobi 30g。

Adhering to taking Chinese medicine more than 5 years so far always, add and subtract according to above symptom, often the check state of an illness is without recurrence and transfer, Whole body ordinary circumstance is good, has recovered part work, and quality of life is preferable.

(4) breast carcinoma, Liu xx, female, 60 years old.

First visit: during health check-up, breast examination touches left swelling of the breast thing, mobility can, with surrounding tissue without obvious adhesion, row mammary gland Tumor resection art, pathology prompting infiltration ductal carcinomas of breast, then at general anesthesia descending left breast cancer radical correction, postoperative pathological shows (left) Infiltration ductal carcinomas of breast, axillary gland (-), ER (-), PR (-).Postoperative row conventional chemotherapy, chemotherapy regimen is TC.

Inscribe patient diet can, defecation is normal, dormancy can, this is old women, and body constitution virtual loss is the most old, Post operation, After chemotherapy 2 months at present, belong to the card of phlegm and blood stasis.Examine it: red tongue, have indentation, white and thin fur, weak pulse.Method for the treatment of: reducing phlegm and fever, solves Poison eliminating stagnation.Prescription is as follows: Radix Rehmanniae 15g, Fructus Corni 15g, Caulis Spatholobi 20g, Herba Epimedii 15g, Radix Astragali 20g, Herba Agrimoniae 20g, the Rhizoma Anemarrhenae 10g, Radix Curcumae 10g, Herba Taraxaci 20g, Nidus Vespae 10g, Radix Polygoni Multiflori 20g, Pseudobulbus Cremastrae Seu Pleiones 10g, Herba Scutellariae Barbatae 20g, Fructus Lycii 15g, be decocted in water for oral dose, Day 1 dose.

Further consultation: after taking medicine, private prosecution is the most slightly better, muscle power has increasing, no more side effects, and side's medicine slightly increases and decreases, and goes Herba Agrimoniae, summer Hay, adds by Radix Sophorae Flavescentis, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), strengthens antitumor action, need Gu to protect patient's gastric qi simultaneously.

Taking Chinese medicine during chemotherapy, top is added and subtracted, and side reaction is inconspicuous, and chemotherapy smoothly completes always.Chinese medicine spleen invigorating soothing liver-QI, Heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating are method, and prescription is as follows: Radix Codonopsis 30g, Rhizoma Atractylodis Macrocephalae 10g, Poria 15g, Semen Coicis 20g, Radix Bupleuri 10g, Radix Scutellariae 10g, Herba Salviae Chinensis 15g, Fructus Akebiae 15g, Herba Scutellariae Barbatae 20g, Pseudobulbus Cremastrae Seu Pleiones 10g, Radix Ranunculi Ternati 10g, Carapax Trionycis (processed) 15g, dry maxima skin 9g, Rhizoma Curcumae 15g, each 15g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), be decocted in water for oral dose, day 1 dose.

Repeatedly further consultation: after chemotherapy completes, long-term treatment by Chinese herbs is main, with " Fuzheng Huoxue, heat-clearing and toxic substances removing, dissipating phlegm and resolving masses is Method, main formula is as follows: Radix Astragali 60g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, Rhizoma Curcumae 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Radix Bupleuri 10g, Radix Curcumae 10g, Rhizoma Cyperi 10g, Radix Angelicae Dahuricae 10g, Rhizoma Chuanxiong 10g, Radix Glycyrrhizae Preparata 6g, be decocted in water for oral dose, day 1 dose.

Plus-minus is taken the circumstances into consideration: the most tired according to symptom variation, indigestion and loss of appetite lack of appetite, loose stool, add Radix Pseudostellariae 15g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Dioscoreae 30g；Being irritable and getting angry easily, sleeps poor, worries too much, and adds Fructus Gardeniae 10g, Caulis Polygoni Multiflori 20g, Cortex Albiziae 20g；Take the circumstances into consideration nourishing the liver and kidney, add Fructus Lycii 15g, Fructus Ligustri Lucidi 15g, Semen Cuscutae 15g.

Coordinate Chinese patent medicine XIHUANG WAN, FUFANG BANMAO JIAONANG, Shenyi capsule etc..

Adhering to taking medicine more than 6 years, add and subtract according to above symptom, repeatedly check has no obvious relapse and metastasis sign, and patient is general All right, diet two is just normal, and stable disease is for many years.

(5) breast carcinoma: yellow ××, female, 59 years old.

First visit: be not intended to find more than left swelling of the breast thing April, crater nipple, gradually to grow up, first visit is breast carcinoma, row left breast cancer Radical correction, postoperative pathological " infiltration ductal carcinomas of breast, axillary lymph carry down shifting 3/12 ", surgery recovery is good, postoperative row chemotherapy one Journey, medicinal TP scheme chemotherapy.Existing the most in high spirits, diet two is just normal, dormancy can, but nocturia frequency, without dysurea.Dimly red tongue, thin fur, arteries and veins Heavy thin.Chinese medical discrimination: residual poison is not clear, spleen kidney deficiency.Legislation: eliminating toxic substances to remove stasis, tonifying speen and tonifying kidney, prescription is as follows: Herba Taraxaci 20g, yellow A kind of reed mentioned in ancient books 9g, Pseudobulbus cremastrae seu pleiones 9g, Rhizoma Bolbostematis 15g, Rhizoma Curcumae 9g, Herba Scutellariae Barbatae 30g, Caulis Spatholobi 30g, Pericarpium Citri Reticulatae 9g, Rhizoma Atractylodis Macrocephalae 9g, Poria 9g, the Radix Aucklandiae 9g, each 9g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Fructus Alpiniae Oxyphyllae 9g, Fructus Lycii 15g, be decocted in water for oral dose, every day potion.

Examine again: during chemotherapy, add and subtract with disease.Sleep poor, vexed, yellow and thin fur, deep-thready pulse.Top adds Fructus Gardeniae (parched) 9g, Semen Ziziphi Spinosae 20g；Frequent micturition, adds Semen Plantaginis 15g seed of Job's tears 30g.

Further consultation: sleep takes a turn for the better, urine frequency takes a turn for the better, and left upper extremity is ached sometimes, thin fur, deep-thready pulse.The party is as follows: Herba Taraxaci 20g, Caulis Spatholobi 30g, fry Pericarpium Citri Reticulatae 9g, Rhizoma Atractylodis Macrocephalae 9g, Poria 9g, each 15g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Ramulus Cinnamomi 9g, Caulis Piperis Kadsurae 30g, Retinervus Luffae Fructus 9g, female Loyal sub-15g, Pseudobulbus cremastrae seu pleiones 9g, Herba Scutellariae Barbatae 30g, be decocted in water for oral dose, every day potion.

Repeatedly further consultation: chemotherapy smoothly completes, long-term treatment by Chinese herbs is main afterwards, Chinese medicine method plan benefiting QI and nourishing blood, invigorating the spleen and regulating the stomach, Eliminating toxic substances to remove stasis is main, and main formula is as follows: Radix Astragali 60g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, Rhizoma Curcumae 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Radix Bupleuri 10g, strongly fragrant Gold 10g, Rhizoma Cyperi 10g, Radix Angelicae Dahuricae 10g, Rhizoma Chuanxiong 10g, Radix Glycyrrhizae Preparata 6g, be decocted in water for oral dose, day 1 dose.

Plus-minus is taken the circumstances into consideration: the most tired according to symptom variation, indigestion and loss of appetite lack of appetite, add Radix Pseudostellariae 15g, Rhizoma Atractylodis Macrocephalae 20g, lumbar and back pain adds osmanthus Branch 5g, Caulis Piperis Kadsurae 20g, Cortex Eucommiae 15g；Being irritable and getting angry easily, sleeps poor, worries too much, and adds Caulis Polygoni Multiflori 20g, Cortex Albiziae 20g；Take the circumstances into consideration nourishing the liver and kidney, Add Radix Angelicae Sinensis 10g, Fructus Lycii 15g.

Tamoxifen 10mg Bid is coordinated to take 5 years.

Adhering to taking traditional Chinese medicine more than 6 years, add and subtract according to above symptom, repeatedly check has no obvious relapse and metastasis sign, patient Ordinary circumstance is good, and diet two is just normal, and stable disease for many years, has no that tumor recurrence shifts.

(6) human primary gastrointestinal cancers: road, female, 55 years old.

First visit: patient often occurred abdominal distention before 1 year, stomachache, based on epigastrium dull pain, and time have singultus, do not give To pay special attention to, rear patient gradually occurs that epigastrium pain increases the weight of, and epigastrium can touch hard lump, and row gastroscopy of being admitted to hospital is pointed out Gastric cancer, row total gastrectomy, postoperative pathological points out: poorly differentiated adenocarcinoma cancer, penetrates muscle layer and reaches placenta percreta, lymphatic metastasis 11/22, Post-operative recovery can, postoperative January row systemic chemotherapy, oxaliplatin, xeloda chemotherapy 2 cycle.

Existing conscious inappetence, feed is few, and fatigue and weak examines it: shallow complexion is simple and unadorned, and red tongue with thin fur, sublingual vessel is light Purple thick long, examine deep-thready pulse.Patient demonstrate,proves and always belongs to weakness of the spleen and stomach, method for the treatment of: invigorating the spleen and stomach, detoxicating and resolving stagnation of pathogens.Side intends Xiangsha Liujunzi decoction and adds Subtract.Prescription is as follows: Radix Pseudostellariae 15g, Rhizoma Atractylodis Macrocephalae 10g, Poria 15g, Endothelium corneum 20g, Radix Aucklandiae (Radix Vladimiriae) 6g, Rhizoma Coptidis 6g, each 15g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), raw Semen Coicis 20g, Colla Corii Asini 10g, Arillus Longan 15g, Radix Angelicae Sinensis 10g, Fructus Lycii 15g, Carapax Trionycis 15g, Semen Cuscutae 15g, Caulis Spatholobi 30g, be decocted in water for oral dose, Day 1 dose.

Further consultation: patient's muscle power takes a turn for the better earlier above, takes food the most, but soft stools, shapeless, desire for hot drinks, thin fur, thready and stringy pulse. The most square as follows: Radix Pseudostellariae 15g, Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Pericarpium Citri Reticulatae 10g, Radix Aucklandiae (Radix Vladimiriae) 9g, each 15g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Endothelium corneum 20g, raw Job's tears Rice 30g, Fructus Jujubae 2 pieces, Caulis Spatholobi 30g, Colla Corii Asini 15g, Pseudobulbus Cremastrae Seu Pleiones 10g, Cortex Albiziae 10g, Herba Scutellariae Barbatae 20g, Semen Myristicae 15g, it is decocted in water for oral dose, Day 1 dose.

Patient continues 10 cycles of chemotherapy, coordinates and takes above Chinese medicine plus-minus, and process is smooth, is the most just adjusting diet two Often, without other chemotherapy side effects, general status is good.

Repeatedly further consultation: after chemotherapy, always based on Chinese medicine antineoplaston, is aided with Supporting Therapy to the ill, with spleen invigorating benefit Gas, heat-clearing and toxic substances removing, dissipating phlegm and resolving masses are method, and main formula is as follows: Radix Astragali 60g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, Rhizoma Curcumae 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Radix Sanguisorbae 15g, Herba Patriniae 15g, Caulis Sargentodoxae 10g, Radix Glycyrrhizae Preparata 6g are decocted in water for oral dose, day 1 dose.

Take the circumstances into consideration to add and subtract according to symptom variation: fatigue and weak, indigestion and loss of appetite lack of appetite, add Radix Codonopsis 20g, Rhizoma Atractylodis Macrocephalae 15g, Poria 20g, Semen Coicis 30g；Big loose stool is thin, or just frequency diarrhoea, adds Cortex Phellodendri 10g, Semen Euryales 20g, Rhizoma Dioscoreae 20g；Antitumor preventing tumor relapse and metastasis, adds Fructus actinidiae chinensis Root 10g, Eupolyphaga Seu Steleophaga 9g, Nidus Vespae 10g, Herba Hedyotidis Diffusae 20g；Weakness due to chronic disease is unable, adds Radix Pseudostellariae 20g, Radix Angelicae Sinensis 10g, Fructus Lycii 15g。

Adhering to taking medicine for many years, add and subtract according to above symptom, periodic review tumor presence, patient belongs to Gerontal gastric cancer, postoperative 1 year Relapse and metastasis, treatment by Chinese herbs is main, though the state of an illness is in slowly progress, but patient's ordinary circumstance is good, and diet two is the most normal, life Basic self-care, band tumor were survived more than in February, 2.

(7) liver pancreas cancer example: Zhao xx, man, 54 years old.

First visit: more than right side side of body flank pain, dull pain half a year, without being clearly better after certainly taking tablet for alleviating pain, increase the weight of first quarter moon and go to a doctor, OK Abdominal B type ultrasonography shows that right lobe of liver has a Space-occupying lesion, row biopsy prompting primary hepatocyte hepatocarcinoma, looks into abdominal CT further and shows right lobe of liver Multiple Space-occupying lesion, rear 3 row interventional therapys, liver function transaminase disorder after intervention.Existing patient's pain in the hepatic region, diet sleep is poor, Examine it: dimly red tongue yellow fur is thick, string of feeling the pulse.Examining it is: dampness and heat stasis liver and gall (hepatocellular carcinoma).This suffers from previously chronic hepatitis B For many years, for many years, the irritability stasis of blood is stagnant for liver cirrhosis for history, causes liver and gall unfavorable, and dampness and heat stasis forms the liver rump, and patient's tongue is dark red, and yellow fur thickness is wet Hot stasis blocking liver and gall as.Prescription is as follows: Radix Astragali 30g, Herba Artemisiae Scopariae 20g, Semen Coicis 20g, Herba Salviae Chinensis 15g, Fructus Akebiae 15g, half Lotus 20g, Fructus Bruceae 6g, Flos Campsis 10g, Herba Duchesneae Indicae 15g, dry maxima skin 6g, Herba Hedyotidis Diffusae 20g, Radix Curcumae 15g, each 15g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Herba Pogostemonis 10g, Radix Scutellariae 10g, Fructus Lycii 15g, be decocted in water for oral dose, day 1 dose.

Further consultation: after taking medicine, subjective symptoms take a favorable turn earlier above, therefore no more side effects, serve on.

Repeatedly further consultation: because of abnormal liver function, fails to continue interventional therapy, always based on Chinese medicine antineoplaston, auxiliary With Supporting Therapy to the ill, with invigorating the spleen and benefiting QI, Shugan Qingre, dissipating phlegm and resolving masses as method, main formula is as follows: Radix Astragali 60g, Fructus Ligustri Lucidi 30g, half Summer 10g, Pericarpium Citri Reticulatae 10g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, Rhizoma Curcumae 30g, Scorpio 10g, Spina Gleditsiae 15g, raw male Oyster 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Radix Bupleuri 10g, Fructus Aurantii 5g, Radix Paeoniae Alba 10g, Radix Glycyrrhizae Preparata 6g are decocted in water for oral dose, day 1 dose.

Take the circumstances into consideration to add and subtract according to symptom variation: fatigue and weak, indigestion and loss of appetite lack of appetite, add Radix Codonopsis 20g, Rhizoma Atractylodis Macrocephalae 15g, Poria 20g, Semen Coicis 30g；Big loose stool is thin, or just frequency diarrhoea, with Semen Euryales 20g, Rhizoma Dioscoreae 20g, Radix Paeoniae Alba 15g；Hepatalgia, coerces rib feeling of distension and oppression, easily flies into a rage, Add Radix Curcumae 10g, Cortex Albiziae 20g, Radix Bupleuri (processed with vinegar) 10g.Antitumor preventing tumor relapse and metastasis, adds Fructus Akebiae 10g, Eupolyphaga Seu Steleophaga 9g, reveals honeybee Room 10g, Herba Duchesneae Indicae 10g, Carapax Trionycis 15g；Ascites abdominal distention, adds Herba Solani Nigri 10g, Semen Plantaginis 20g, Pericarpium Arecae 15g；Jaundice yellowish body, yellowish urine, add Herba Artemisiae Scopariae 20g, Rhizoma Polygoni Cuspidati 15g, Herba Patriniae 20g；Weakness due to chronic disease is unable, adds Semen Cuscutae 20g, Radix Angelicae Sinensis 10g, Fructus Lycii 15g.

Patient adheres to taking medicine more than 1 year, and band tumor is survived 1 year 4 months, adds and subtracts according to above symptom, the time of about 1 year In, although for later period of hepatocarcinoma, symptom is more heavier, according to symptom to top appropriate adaptation after, life in patients can be improved, Extend life cycle.Patient's ordinary circumstance still can, without serious painful symptom, quality of life is preferable.Ultimately succumb to liver failure.

(8) liver pancreas cancer example: poplar xx, female, 79 years old.

First visit: jaundice occur 1 week, companion's yellowish urine, just white, epigastrium pain, abdominal CT and B ultrasonic all point out head of pancreas occupy-place sexually transmitted disease (STD) Becoming, size is 3.2 × 3.1cm, obscure boundary.In BJ Union Hospital's row exploratory laparotomy, art being shown in, swollen thing is positioned at Diseases In Pancreatic Head, All there is adhesion with santorini's papilla portion, stomach, fail to excise, close abdomen.Taking definitive pathological diagnosis is pancreas adenocarcinoma.Postoperative persistence upper abdomen Portion's pain, abdominal distention, epigastric fullness, postemphasis of taking food, more than ten jin of becoming thin, appetite is poor, skin yellow sclera, dark coloured urine, and stool is not smooth, Red tongue, dry, rough and yellow fur, stringy pulse.Method for the treatment of: relieving distension and oppression, invigorating the spleen and regulating the stomach, heat clearing away jaundice eliminating.Intend zhishi xiaopi pills and close Herba Artemisiae Scopariae Decoctionization sanction. Radix Codonopsis 20g, Fructus Aurantii Immaturus 10g, Poria 20g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Zingiberis 10g, Cortex Magnoliae Officinalis 10g, Rhizoma Pinelliae 10g, Carapax Trionycis (processed) 10g, Rhizoma Curcumae 10g, tiger Cane 10g, Herba Artemisiae Scopariae 20g, Fructus Gardeniae 10g, Herba Salviae Chinensis 15g, Endothelium corneum 10g, each 15g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), be decocted in water for oral dose, every day potion.

Further consultation: after medicine, feed take a favorable turn, and relaxes suitable under the heart, and stomachache alleviates, and jaundice is slightly taken a favourable turn, red tongue, thin and whitish fur, stringy pulse.Abdomen Pain is the lightest but still continuous has a pain.Top adds Radix Angelicae Sinensis 10g, Fructus Toosendan 10g.

Examining: pain substantially alleviates, two just adjust, and xanthochromia is the most inconspicuous again, check Abdominal B type ultrasonography show head of pancreas swell thing 3 × 3cm.Add and subtract above following the service.Treating more than four months, stable disease, patients ' life quality is preferable.

Repeatedly further consultation: laparotomy exploration is postoperative does not does chemicotherapy, always based on Chinese medicine antineoplaston, is aided with and props up to the ill Holding treatment, with invigorating the spleen and benefiting QI, Shugan Qingre, dissipating phlegm and resolving masses as method, main formula is as follows: Radix Astragali 60g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, old Skin 10g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, Rhizoma Curcumae 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Trionyx sinensis Wiegmann First 10g, Ramulus Uncariae Cum Uncis 10g, Radix Sanguisorbae 15g, Herba Patriniae 15g, Caulis Sargentodoxae 10g, Radix Glycyrrhizae Preparata 6g are decocted in water for oral dose, day 1 dose.

Take the circumstances into consideration to add and subtract according to symptom variation: fatigue and weak, indigestion and loss of appetite lack of appetite, add Radix Codonopsis 20g, Rhizoma Atractylodis Macrocephalae 15g, Poria 20g, Semen Coicis 30g；Epigastrium pain, coerces rib feeling of distension and oppression, adds Radix Curcumae 10g, Rhizoma Corydalis 20g, Herba Solani Lyrati 10g, Pericarpium Arecae 20g；Antitumor preventing tumor recurs Transfer, adds Fructus Akebiae 10g, Eupolyphaga Seu Steleophaga 9g, Nidus Vespae 10g, Herba Duchesneae Indicae 10g, Carapax Trionycis 15g；Ascites abdominal distention, adds Herba Solani Nigri 10g, Semen Plantaginis 20g, Pericarpium Arecae 15g；Jaundice yellowish body, yellowish urine, add Herba Artemisiae Scopariae 20g, Rhizoma Polygoni Cuspidati 15g, Herba Patriniae 20g；Weakness due to chronic disease is unable, adds Semen Cuscutae 20g, Radix Angelicae Sinensis 10g, Fructus Lycii 15g.

Patient cancer of pancreas late period, laparotomy exploration is postoperative does not does chemicotherapy, always based on Chinese medicine antineoplaston, according to After symptom is to top appropriate adaptation, life in patients can be improved with mitigation symptoms, extend life cycle.Patient carries tumor to survive 1 Nian Yu, patient's ordinary circumstance still can, without serious painful symptom, life can be taken care of oneself, and quality of life is preferable.

Tumor is a systemic disease, and the concrete embodiment of neoplasm metastasis its generalization especially.Present inventors have proposed and turn The pathogenesis hypothesis " weakened body resistance blood stasis is said " " expectorant poison multiple abscess is said " " obstruction of collateral caused by windphlegm is said " moved.The basic reason of its transfer is that healthy energy is lost Void, accumulates in evil poison.Its pathogenesis develops in being then and accumulates evil poison, gas consumption blood trouble, does not the most press down heresy, and evil poison is taken advantage of a weak point in opponent's defence, and flees meridians, QI and blood, Visitor, in internal organs, with the passing of time becomes long-pending.Its process fully demonstrates in causing a disease because of void, the most due to illness causes void, and positive exogenous pathogen is contained, and does not the most press down the pernicious of heresy Development law.The present inventor is postoperative for cancer patient and after Radiotherapy chemotherapy, the pathogenesis of transfer and relapse also has novel viewpoint: 1. think No matter perform the operation, after Radiotherapy chemotherapy, uncharm purpose though having reached effectively to subtract tumor, but fail fundamentally to release patient's internal organs, the moon Sun, the imbalance of QI and blood function, void, poison, the stasis of blood, expectorant, knot run through its evolution process.Therefore, by after cancer patient's operation, Radiotherapy chemotherapy Pathogenic characteristic can be attributed to " weakened body resistance blood stasis, residual poison are the most clear "；2. after operation, Radiotherapy chemotherapy, transfer is positive exogenous pathogen Sheng, heresy Poison Gua opens, does not the most press down the result of heresy, can set forth one's views from " ailment said due to cold or exposure ", and wind holds expectorant, the stasis of blood under the arm, the most nowhere less than, or hinder in lung that (lung turns Move), or strongly fragrant in liver (hepatic metastases), or move in kidney (kidney transfer), or flee meridians, then expectorant, the stasis of blood can and not all right, then deteriorated case clump Raw.Opinion its " wind ", when duty in visceral dysfunction, negative and positive of qi and blood virtual loss, gradually give birth to wind syndrome caused by deficiency.Therefore, by transfer occur and The pathogenic characteristic of evolution can be attributed to " stirring-up of pathogenic wind in the interior resulting from deficiency, phlegm stagnation in collateral (expectorant poison multiple abscess) ", and the former is the root of transfer and relapse, The latter is the power of transfer and relapse, and the former is this, and the latter is mark.This is Mechanism Study phase to tumor invasion and metastasis with modern medicine It coincide: empty--it is embodied in the immunosurveillance inferior capabilities of body, and the immune state of host is to affect the weight of Nasopharyngeal neoplasms Wanting factor, weakened body resistance pathological examination is that tumor cell is survived in vivo；Poison--it is embodied in residual poison unclear, after operation, Radiotherapy chemotherapy still The subclinical focus of remaining, becomes revivable, the root of transfer and relapse；The stasis of blood--be embodied in the Gao Ning of blood, high viscous and height is poly- State；Expectorant is tied--it is embodied in propagation rapidly and the growth of attached wall, implantation and the metastatic tumor of micro-tumor bolt.Wind may be embodied in cancerous cell Easy transfer characteristic.

About the tumor-blood-vessel growth of one of neoplasm metastasis main mechanism, inventors believe that it belongs to motherland's medical science " network Sick " category.The concept of the traditional Chinese medical science " network " is in form with functionally similar to microcirculation concept to the blood capillary of modern medicine, and motherland cures Think, channels is the branch of channel system, just as network, crisscross, throughout whole body, and interior network the five internal organs, outer even podomere, have The physiological functions such as through the exterior and the interior is upper and lower, circulation qi-blood-body fluid, infiltrating irrigation internal organs.As " Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates " is sayed: " passages through which vital energy circulates 12 Person, between volt row boundary between muscles, loses deeply ... the floating and common person of all feeling pulse, all channels are also." under normal circumstances, channels system is made For linking up inside and outside body, maintain equilibrium between yin and yang, ensureing the functional network that internal organs QI and blood irrigates, also it is to coordinate body internal and external environment The unified important feature maintaining body homeostasis, for maintaining human normal vital movement tool to be of great significance；But Under various pathological states, the regulatory mechanism such as tumour patient angiogenesis factor is not normal, causes body imbalance between YIN and YANG, performance Then increasing for angiogenic factors secretion in tumor-blood-vessel growth process, and inhibitive factor secretion reduces, angiogenesis is just Negative growth factor is unbalance, causes this functional network system structure, distribution and function that significantly change occurs, shows as network body Tortuous, expansion, channels abnormal distribution, cause local meridian qi and blood body fluid to dredge cloth and irrigate not normal, the internal organs of its network genus, tissue, device A series of channels such as official's 26S Proteasome Structure and Function is abnormal block the disease being characterized.This is microcirculatory with tumour patient focus local morbid state Set up very much like.Therefore, the Angiogenesis process of tumor, namely the traditional Chinese medical science it " pathogen usually intruding into collateral in protracted disease ", " obstruction of collateral caused by windphlegm (evil poison stream Note) " and form the process of channels pathological changes.Its pathogenesis initiating agent is healthy energy deficiency in origin, accumulates in cancer poison, and its pathogenesis evolution process is cancer Accumulate with the passing of time in poison, vital QI cannot conquer pathogen, cause internal organs, negative and positive, QI and blood functional disorder, body homeostasis structural deterioration, and the damage of channels Wound is the main pathological product of its pathogenesis evolution process, be again its pathological changes gradually deeply, become sick and all cause the state of an illness further The approach deteriorated and essential condition.Due to carcinoma local channels structure, distribution, dysfunction so that cancer heresy is prone to invade venation, Cancer heresy once enters network visitor's arteries and veins, affects the operation of QI and blood in network and the defeated cloth of body fluid, causes network to lose unobstructed, and infiltrating irrigation is not normal, causes cancer Poison, the stagnant network of blood stasis, the pathological change such as cause in network in various degree the stagnation of QI, blood stasis or Tianjin solidifying, with the passing of time prolong void, empty gas is detained, blood Stasis of blood Tianjin is solidifying etc. interacts, and knot is the most sick mutually, accumulates in the course of time and accumulates poison, poison consumed pulse network, alters by ecchymosis perverse and unreasonable manner, ruins internal organs, damage body.This Evolution process has fully demonstrated empty stagnant, the expectorant stasis of blood, poison this basic pathology of consumed pulse network change, for pathogenic factor gradually deeply, vital QI being weakened and pathogen being violent, A kind of pathological state that patient's condition is deadlocked, and thus cause the prolonged difficulty of canceration more, gradually become obstinate disease.

In view of to above neoplasm metastasis and the heightened awareness of angiogenesis pathogenic characteristic thereof, focus on " prevention of diseae " in clinic " preventing exacerbation after being taken ill " " " under thought guidance, present inventors believe that tumor is a systemic disease, transfer is its generalization to preventive treatment of disease Concrete manifestation；Healthy energy virtual loss, the most not pressing down heresy is the basic reason that neoplasm metastasis occurs；Propose the blood stasis due to qi deficiency of transfer, expectorant The poison theory of pathogenesis such as multiple abscess, obstruction of collateral caused by windphlegm, the pathogenesis development law of transfer is healthy energy virtual loss, accumulates in evil poison, and stirring-up of pathogenic wind in the interior resulting from deficiency, wind is held under the arm Expectorant poison, multiple abscess meridians, the stasis of blood forms long-pending.Clinical application is many starts with in terms of void, the stasis of blood, poison, expectorant, wet, wind etc., evident in efficacy.This medicine Thing is i.e. on above experiential basis, in conjunction with the modern study achievement of tumor-blood-vessel growth and transfer, at treatment must aim at the pathogenesis of disease, giving consideration to both the incidental and fundamental And under strengthening vital QI to eliminate pathogenic factors principle instructs, with " " Fuzheng Huoxue, detoxicating and resolving stagnation of pathogens, calming wind and dredging collateral " as the rule for the treatment of, it then follows prescription combination principle, essence The compound pure Chinese medicine preparation with antitumor, metastasis effect of heart prescription.

Therefore treatment must aim at the pathogenesis of disease, giving consideration to both the incidental and fundamental, strengthening vital QI to eliminate pathogenic factors principle instruct under according to transfer and angiogenesis void, the stasis of blood, poison, Expectorant, knot, the basic pathology change of wind, in conjunction with clinical practice for many years, present inventors have proposed that " " Fuzheng Huoxue, relieves dizziness, high fever, infantile convulsions, epilepsy, etc. at detoxicating and resolving stagnation of pathogens Dredging collateral " method for the treatment of, and meticulously prescription, repeatedly practise and grope, having createed compound Chinese medicinal preparation, to by with operation, change Treatment, the connected applications of radiotherapy means, from the function of internal organs, negative and positive, QI and blood and the meridians of integrally-regulated body, by shifting Journey Mutiple Targets regulation " reducing for the excess syndrome, tonifying for deficiency syndrome ", checks tumor-blood-vessel growth, and cut-out tumors of nutrients, route of metastasis reach anti- Tumor, the purpose of metastasis.

Detailed description of the invention

Embodiment 1, a kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift, including following component Crude drug:

Radix Astragali 45g, Fructus Ligustri Lucidi 15g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, Endothelium Corneum Gigeriae Galli 10g, Semen Coicis 18g, Herba Scutellariae Barbatae 20g, cowherb Art 20g, Scorpio 10g, Spina Gleditsiae 10g, Concha Ostreae 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Radix Glycyrrhizae Preparata 6g.

Preparation method: medical material clear water soaks half an hour, after big fire is boiled, then slow fire boiling 40 minutes, take head and decoct, then add Soak by water 30 minutes, takes two and decocts, and two decoct and even, and a point morning and evening takes for twice.

Embodiment 2, a kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift, including following component Crude drug:

Radix Astragali 60g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 15g, Pericarpium Citri Reticulatae 15g, Endothelium Corneum Gigeriae Galli 18g, Semen Coicis 30g, Herba Scutellariae Barbatae 30g, cowherb Art 30g, Scorpio 15g, Spina Gleditsiae 15g, Concha Ostreae 60g, Carapax Trionycis 20g, Ramulus Uncariae Cum Uncis 15g, Radix Glycyrrhizae Preparata 10g.

Preparation method:

(1) extract: after above-mentioned all medicines are weighed by weight, add deionized water and soak 30 minutes, decoct twice, 45 points first Clock, filters, and retains filtrate.The soak by water of medicinal residues addition 4-5 times amount 30 minutes, merging filtrate after filtration, it is condensed into 1:1.Add 95% ethanol, stirring while adding, make alcohol content reach 70%, stand and make precipitation.Taking supernatant, heating concentrates as extractum standby.

(2) soft material is prepared: add sucrose, dextrin, mixing, add appropriate 95% ethanol, stirring while adding, become soft material, in 50 DEG C of oven dryings are standby after 15 minutes.

(3) granulate: cross 16 mesh sieves, subpackage.

Embodiment 3, a kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift, including following component Crude drug:

Radix Astragali 60g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, cowherb Art 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Radix Glycyrrhizae Preparata 6g.

Preparation method: after being weighed by weight by above-mentioned all medicines, adds deionized water and soaks 30 minutes, decoct twice, and first 45 Minute, filter, retain filtrate.The soak by water of medicinal residues addition 4-5 times amount 30 minutes, merging filtrate after filtration, it is condensed into 1:1, cold Adding the ethanol of 1.5 times amount the most afterwards, fully mix, stand overnight, take supernatant, precipitate is cleaned with a small amount of 95% ethanol, washing liquid Merging with filtrate, after decompression recycling ethanol, concentrate cooling and stand, after filtration, vacuum and low temperature is concentrated into thick paste, and thick paste proportion is 1.33 are spray-dried finely ground mistake 300 mesh sieve, obtain extract powder, fill and make capsule.

Embodiment 4, a kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift, including following component Crude drug:

Radix Astragali 60g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, cowherb Art 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Radix Glycyrrhizae Preparata 6g, Radix Platycodonis 10g, Semen Armeniacae Amarum 10g.

Preparation method: be dried according to after above-mentioned weight weighting raw materials, microgranule more than micronizing to 800 mesh, adds Appropriate dextrin makes tablet after stirring.

Embodiment 5, a kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift, including following component Crude drug:

Radix Astragali 45g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, cowherb Art 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Radix Glycyrrhizae Preparata 6g, Rhizoma Atractylodis Macrocephalae 10g, Poria 15g, benefit Bone fat 30g.

Preparation method: with embodiment 1.

Embodiment 6, a kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift, including following component Crude drug:

Radix Astragali 45g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, cowherb Art 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Radix Glycyrrhizae Preparata 6g, Rhizoma Atractylodis Macrocephalae 10g, Poria 15g, benefit Bone fat 30g, Bulbus Fritillariae Uninbracteatae 15g, Radix Platycodonis 10g, Fructus Trichosanthis 30g.

Preparation method: with embodiment 1.

Embodiment 7, a kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift, including following component Crude drug:

Radix Astragali 60g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, cowherb Art 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Radix Glycyrrhizae Preparata 6g, Radix Bupleuri 10g, Radix Curcumae 10g, perfume (or spice) Attached 10g, Radix Angelicae Dahuricae 10g, Rhizoma Chuanxiong 10g.

Preparation method: with embodiment 2.

Embodiment 8, a kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift, including following component Crude drug:

Radix Astragali 60g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, cowherb Art 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Radix Glycyrrhizae Preparata 6g, Radix Sanguisorbae 15g, Herba Patriniae 15g, Caulis Sargentodoxae 10g.

Preparation method: with embodiment 3.

Embodiment 9, a kind of Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift, including following component Crude drug:

Radix Astragali 60g, Fructus Ligustri Lucidi 30g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 10g, Endothelium Corneum Gigeriae Galli 15g, Semen Coicis 30g, Herba Scutellariae Barbatae 13g, cowherb Art 30g, Scorpio 10g, Spina Gleditsiae 15g, Concha Ostreae 30g, Carapax Trionycis 10g, Ramulus Uncariae Cum Uncis 10g, Radix Glycyrrhizae Preparata 6g, Radix Bupleuri 10g, Fructus Aurantii 5g, white Chinese herbaceous peony 10g.

Preparation method: with embodiment 2.

Claims

1. the Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift, is characterized in that, in parts by weight, including The crude drug of following component: the Radix Astragali 45～60 parts, Fructus Ligustri Lucidi 15～30 parts, the Rhizoma Pinelliae 10～15 parts, Pericarpium Citri Reticulatae 10～15 parts, Endothelium Corneum Gigeriae Galli 10～18 parts, Semen Coicis 18～30 parts, Herba Scutellariae Barbatae 20～30 parts, Rhizoma Curcumae 20～30 parts, Scorpio 10～15 parts, Spina Gleditsiae 10～ 15 parts, Concha Ostreae 30～60 parts, Carapax Trionycis 10～20 parts, Ramulus Uncariae Cum Uncis 10～15 parts, Radix Glycyrrhizae Preparata 6～10 parts.

The Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift the most as claimed in claim 1, is characterized in that, with Weight portion meter, including the crude drug of following component: the Radix Astragali 60 parts, Fructus Ligustri Lucidi 30 parts, the Rhizoma Pinelliae 10 parts, Pericarpium Citri Reticulatae 10 parts, Endothelium Corneum Gigeriae Galli 15 Part, Semen Coicis 30 parts, Herba Scutellariae Barbatae 13 parts, Rhizoma Curcumae 30 parts, Scorpio 10 parts, Spina Gleditsiae 15 parts, Concha Ostreae 30 parts, Carapax Trionycis 10 parts, Ramulus Uncariae Cum Uncis 10 parts, Radix Glycyrrhizae Preparata 6 parts.

The Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift the most as claimed in claim 1 or 2, is characterized in that, In parts by weight, including the crude drug of following component: the Radix Astragali 60 parts, Fructus Ligustri Lucidi 30 parts, the Rhizoma Pinelliae 10 parts, Pericarpium Citri Reticulatae 10 parts, Endothelium Corneum Gigeriae Galli 15 parts, Semen Coicis 30 parts, Herba Scutellariae Barbatae 13 parts, Rhizoma Curcumae 30 parts, Scorpio 10 parts, Spina Gleditsiae 15 parts, Concha Ostreae 30 parts, Carapax Trionycis 10 Part, Ramulus Uncariae Cum Uncis 10 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Platycodonis 10 parts, 10 parts of Semen Armeniacae Amarum.

The Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift the most as claimed in claim 1 or 2, is characterized in that, In parts by weight, including the crude drug of following component: the Radix Astragali 45 parts, Fructus Ligustri Lucidi 30 parts, the Rhizoma Pinelliae 10 parts, Pericarpium Citri Reticulatae 10 parts, Endothelium Corneum Gigeriae Galli 15 parts, Semen Coicis 30 parts, Herba Scutellariae Barbatae 13 parts, Rhizoma Curcumae 30 parts, Scorpio 10 parts, Spina Gleditsiae 15 parts, Concha Ostreae 30 parts, Carapax Trionycis 10 Part, Ramulus Uncariae Cum Uncis 10 parts, Radix Glycyrrhizae Preparata 6 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 15 parts of Poria, Fructus Psoraleae 30 parts.

The Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift the most as claimed in claim 1 or 2, is characterized in that, In parts by weight, including the crude drug of following component: the Radix Astragali 45 parts, Fructus Ligustri Lucidi 30 parts, the Rhizoma Pinelliae 10 parts, Pericarpium Citri Reticulatae 10 parts, Endothelium Corneum Gigeriae Galli 15 parts, Semen Coicis 30 parts, Herba Scutellariae Barbatae 13 parts, Rhizoma Curcumae 30 parts, Scorpio 10 parts, Spina Gleditsiae 15 parts, Concha Ostreae 30 parts, Carapax Trionycis 10 Part, Ramulus Uncariae Cum Uncis 10 parts, Radix Glycyrrhizae Preparata 6 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 15 parts of Poria, Fructus Psoraleae 30 parts, Bulbus Fritillariae Uninbracteatae 15 parts, Radix Platycodonis 10 parts, Fructus Trichosanthis 30 Part.

The Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift the most as claimed in claim 1 or 2, is characterized in that, In parts by weight, including the crude drug of following component: the Radix Astragali 60 parts, Fructus Ligustri Lucidi 30 parts, the Rhizoma Pinelliae 10 parts, Pericarpium Citri Reticulatae 10 parts, Endothelium Corneum Gigeriae Galli 15 parts, Semen Coicis 30 parts, Herba Scutellariae Barbatae 13 parts, Rhizoma Curcumae 30 parts, Scorpio 10 parts, Spina Gleditsiae 15 parts, Concha Ostreae 30 parts, Carapax Trionycis 10 Part, Ramulus Uncariae Cum Uncis 10 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Bupleuri 10 parts, Radix Curcumae 10 parts, Rhizoma Cyperi 10 parts, the Radix Angelicae Dahuricae 10 parts, Rhizoma Chuanxiong 10 parts.

The Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift the most as claimed in claim 1 or 2, is characterized in that, In parts by weight, including the crude drug of following component: the Radix Astragali 60 parts, Fructus Ligustri Lucidi 30 parts, the Rhizoma Pinelliae 10 parts, Pericarpium Citri Reticulatae 10 parts, Endothelium Corneum Gigeriae Galli 15 parts, Semen Coicis 30 parts, Herba Scutellariae Barbatae 13 parts, Rhizoma Curcumae 30 parts, Scorpio 10 parts, Spina Gleditsiae 15 parts, Concha Ostreae 30 parts, Carapax Trionycis 10 Part, Ramulus Uncariae Cum Uncis 10 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Sanguisorbae 15 parts, Herba Patriniae 15 parts, Caulis Sargentodoxae 10 parts.

The Chinese medicine composition suppressing tumor-blood-vessel growth, anti-tumor to shift the most as claimed in claim 1 or 2, is characterized in that, In parts by weight, including the crude drug of following component: the Radix Astragali 60 parts, Fructus Ligustri Lucidi 30 parts, the Rhizoma Pinelliae 10 parts, Pericarpium Citri Reticulatae 10 parts, Endothelium Corneum Gigeriae Galli 15 parts, Semen Coicis 30 parts, Herba Scutellariae Barbatae 13 parts, Rhizoma Curcumae 30 parts, Scorpio 10 parts, Spina Gleditsiae 15 parts, Concha Ostreae 30 parts, Carapax Trionycis 10 Part, Ramulus Uncariae Cum Uncis 10 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Bupleuri 10 parts, Fructus Aurantii 5 parts, the Radix Paeoniae Alba 10 parts.

9. described in claim 1, suppress the preparation method of the Chinese medicine composition of tumor-blood-vessel growth, anti-tumor transfer, its feature It is that step is as follows

(1) extract: after above-mentioned all medicines are weighed by weight, add deionized water and soak 30 minutes, decoct twice, 45 minutes first, Filter, retain filtrate；The soak by water of medicinal residues addition 4-5 times amount 30 minutes, merging filtrate after filtration, it is condensed into 1:1；Add 95% Ethanol, stirring while adding, make alcohol content reach 70%, stand and make precipitation；Taking supernatant, heating concentrates as extractum standby；

(2) soft material is prepared: add sucrose, dextrin, mixing, add appropriate 95% ethanol, stirring while adding, become soft material, in 50 DEG C Oven drying is standby after 15 minutes；

(3) granulate: cross 16 mesh sieves, subpackage.