CN104955841B - 用于检测1,25-二羟基维生素d的方法和试剂盒以及相关抗体 - Google Patents

用于检测1,25-二羟基维生素d的方法和试剂盒以及相关抗体 Download PDF

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CN104955841B
CN104955841B CN201480006190.6A CN201480006190A CN104955841B CN 104955841 B CN104955841 B CN 104955841B CN 201480006190 A CN201480006190 A CN 201480006190A CN 104955841 B CN104955841 B CN 104955841B
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vdr
lbd
vitamin
receptor
antibody
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CN104955841A (zh
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乔舒亚·索尔多
格雷戈里·奥尔森
迈克尔·卢特曼
约翰·瓦尔
迈克尔·纽
赫克托耳·弗洛伊德·德卢卡
法布里齐奥·博内利
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Soring Italian Ag
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Diasorin SpA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201480006190.6A 2013-01-28 2014-01-27 用于检测1,25-二羟基维生素d的方法和试剂盒以及相关抗体 Active CN104955841B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13152851.5 2013-01-28
EP13152851.5A EP2759550B1 (en) 2013-01-28 2013-01-28 Method and kit for detecting 1,25-dihydroxyvitamin D and related antibodies
PCT/EP2014/051482 WO2014114780A1 (en) 2013-01-28 2014-01-27 Method and kit for detecting 1,25-dihydroxyvitamin d and related antibodies

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CN104955841A CN104955841A (zh) 2015-09-30
CN104955841B true CN104955841B (zh) 2018-05-04

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US (2) US10196449B2 (enExample)
EP (3) EP2759550B1 (enExample)
JP (1) JP6471099B2 (enExample)
KR (1) KR102196924B1 (enExample)
CN (1) CN104955841B (enExample)
AU (1) AU2014209857B2 (enExample)
CA (1) CA2899350C (enExample)
DK (2) DK2759550T3 (enExample)
ES (2) ES2696075T3 (enExample)
PL (2) PL2759550T3 (enExample)
PT (2) PT2759550T (enExample)
WO (1) WO2014114780A1 (enExample)
ZA (1) ZA201505263B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11261257B2 (en) 2013-01-28 2022-03-01 Diasorin S.P.A. Methods for detecting 1,25-dihydroxyvitamin D and related antibodies
EP2759550B1 (en) 2013-01-28 2018-08-15 DiaSorin S.p.A. Method and kit for detecting 1,25-dihydroxyvitamin D and related antibodies
US10983136B2 (en) 2013-01-28 2021-04-20 Diasorin S.P.A. Use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker
CN104502599B (zh) * 2014-12-19 2016-08-24 同昕生物技术（北京）有限公司 25-羟基维生素d定量检测试纸条及其应用
AU2016207734A1 (en) * 2015-01-18 2017-08-03 Diasorin S.P.A. Use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker
WO2017127833A1 (en) * 2016-01-22 2017-07-27 Affimedix, Inc. Device for detection of vitamin d metabolites
US10247728B1 (en) 2016-03-17 2019-04-02 Charm Sciences, Inc. Method and assay for detection of residues
EP3401681B1 (en) 2017-05-11 2023-03-29 Boditech Med Inc. Method for quick quantification assay of vitamin d based on fluorescence measurement using lateral flow cartridge
CN108362688B (zh) * 2018-01-02 2021-08-24 北京利德曼生化股份有限公司 一种25羟基维生素d磁微粒化学发光检测试剂盒
JP7434144B2 (ja) * 2018-02-27 2024-02-20 株式会社島津製作所 ＡＰＰ６６９－ｘのＮ末端を特異的に認識する抗体、及び免疫測定法
EP3829734A4 (en) * 2018-07-27 2022-06-15 Veravas, Inc. METHODS OF DEPLETION AND ENRICHMENT
CN109601477A (zh) * 2018-12-21 2019-04-12 云南农业大学 一种基于维生素d受体血液生化标记选育武定鸡的方法
CN110058028B (zh) * 2019-05-05 2021-03-02 苏州长光华医生物医学工程有限公司 一种24,25-双羟基维生素d免疫检测试剂盒及其应用
CN113999311B (zh) * 2020-07-28 2022-11-04 东莞市朋志生物科技有限公司 可特异性结合25-羟基维生素d的抗体、其应用以及诊断试剂盒
CN113884687B (zh) * 2021-12-08 2022-02-11 南京岚轩生物科技有限公司 用于检测25-羟基维生素d含量的解离剂及其制备方法
CN119080938B (zh) * 2023-06-05 2025-06-24 东莞市朋志生物科技有限公司 抗25羟维生素d抗体、检测25羟维生素d的试剂和试剂盒
CN119827779A (zh) * 2023-10-12 2025-04-15 菲鹏生物股份有限公司 维生素d均相检测方法和试剂
CN119846237B (zh) * 2024-11-22 2025-10-31 厦门康基生物科技有限公司 一种基于VDR和RXRα双夹心检测25-OH-VD的方法
CN119322137A (zh) * 2024-12-17 2025-01-17 凯莱谱科技股份有限公司 血清维生素d代谢通路代谢物的液相色谱串联质谱检测方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001631A1 (en) * 1987-08-14 1989-02-23 Wisconsin Alumni Research Foundation Assay for 1,25-dihydroxy vitamin d
EP0583945A2 (en) * 1992-08-14 1994-02-23 Wisconsin Alumni Research Foundation Assay for 1,25 Dihydroxy Vitamin D
CN102046812A (zh) * 2008-04-02 2011-05-04 赛特克罗公司 用于维生素d缺乏症和相关障碍的方法、组合物、用途和试剂盒

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8408193D0 (en) * 1984-03-30 1984-05-10 Cambridge Patent Dev Antibodies
US5260199A (en) * 1991-07-30 1993-11-09 Wisconsin Alumni Research Foundation Method of producing 1,25-dihydroxyvitamin D3 receptor protein
KR940009957A (ko) * 1992-10-09 1994-05-24 정명식 높은 보자력을 갖는 코발트/파라디움 광자기 다층박막 및 그 제조방법
JPH07330800A (ja) * 1994-06-08 1995-12-19 Yamasa Shoyu Co Ltd ビタミンｄ受容体に対するモノクローナル抗体
US6516294B1 (en) 1999-07-01 2003-02-04 The Regents Of The University Of California Nuclear receptor for 1α,25-dihydroxyvitamin D3 useful for selection of vitamin D3 ligands and a method therefor
DK2126586T3 (da) * 2007-02-01 2010-10-11 Immundiagnostik Ag Direkte bestemmelse af vitamin D i serum eller plasma
GB0903469D0 (en) * 2009-03-02 2009-04-08 Axis Shield Diagnostics Ltd Assay
WO2010128393A1 (en) 2009-05-06 2010-11-11 Cytochroma Inc. Method and composition for measuring the amount of vitamin d derivatives
EP2457916A1 (en) * 2010-11-16 2012-05-30 DiaSorin S.p.A. Compound for the covalent attachment of the chemiluminescent probe N-(4-Aminobutyl)-N-ethylisoluminol (ABEI) to target molecules and uses thereof
GB201101801D0 (en) * 2011-02-02 2011-03-16 Axis Shield Diagnostics Ltd Binding molecule and method for measuring
AU2012312907A1 (en) 2011-08-26 2014-03-13 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2759551B1 (en) 2011-09-21 2019-05-22 Fujirebio Inc. Antibodies binding to an affinity complex comprising 25oh vitamin d2 or d3 and an antibody thereto
US10983136B2 (en) * 2013-01-28 2021-04-20 Diasorin S.P.A. Use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker
EP2759550B1 (en) 2013-01-28 2018-08-15 DiaSorin S.p.A. Method and kit for detecting 1,25-dihydroxyvitamin D and related antibodies

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001631A1 (en) * 1987-08-14 1989-02-23 Wisconsin Alumni Research Foundation Assay for 1,25-dihydroxy vitamin d
EP0583945A2 (en) * 1992-08-14 1994-02-23 Wisconsin Alumni Research Foundation Assay for 1,25 Dihydroxy Vitamin D
CN102046812A (zh) * 2008-04-02 2011-05-04 赛特克罗公司 用于维生素d缺乏症和相关障碍的方法、组合物、用途和试剂盒

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A new enzyme-linked immunosorbant assay for the measurement of human vitamin D receptor;S. Swami et al.;《Bone》;20010331;第28卷(第3期);摘要，第320页左栏第3段-右栏第3段 *
Current Understanding of the molecular actions of vitamin D;Glenville Jones et al;《Physiological reviews》;19981031;第78卷(第４期);第1194页-1195页右栏第1段，第1198页左栏第3段-右栏2段，第1203页右栏第2段-第1207页右栏第2段，第1210页右栏最后1段-1211页左栏第2段，第1214页左栏最后１段-第1221页右栏第2段，表１ *
The nuclear receptor ligand-binding domain: structure and funtion;Dino Moras et al;《Current Opinion in Cell Biology》;19981231(第10期);第384-391页 *

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Publication number Publication date
AU2014209857A1 (en) 2015-08-13
PT2759550T (pt) 2018-11-16
DK2759550T3 (en) 2018-11-26
CA2899350C (en) 2023-01-10
ZA201505263B (en) 2016-06-29
EP2759550B1 (en) 2018-08-15
JP2016505634A (ja) 2016-02-25
WO2014114780A1 (en) 2014-07-31
ES2780823T3 (es) 2020-08-27
US20150361178A1 (en) 2015-12-17
KR102196924B1 (ko) 2020-12-31
DK2948474T3 (da) 2020-03-09
HK1218129A1 (en) 2017-02-03
PT2948474T (pt) 2020-03-05
EP2759550A1 (en) 2014-07-30
EP3650467A1 (en) 2020-05-13
CN104955841A (zh) 2015-09-30
KR20150110680A (ko) 2015-10-02
PL2948474T3 (pl) 2020-07-27
JP6471099B2 (ja) 2019-02-13
CA2899350A1 (en) 2014-07-31
AU2014209857B2 (en) 2018-10-04
EP2948474A1 (en) 2015-12-02
PL2759550T3 (pl) 2019-01-31
US10501548B2 (en) 2019-12-10
ES2696075T3 (es) 2019-01-14
US10196449B2 (en) 2019-02-05
EP2948474B1 (en) 2020-01-15
US20170267770A1 (en) 2017-09-21

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