CN104940503A

CN104940503A - Traditional Chinese medicine combination for treating itchy skins of patients undergoing hemodialysis

Info

Publication number: CN104940503A
Application number: CN201510300793.3A
Authority: CN
Inventors: 相丽; 郑世峰
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-05-31
Filing date: 2015-05-31
Publication date: 2015-09-30

Abstract

The invention discloses a traditional Chinese medicine combination for treating the itchy skins of patients undergoing hemodialysis. The itchy skin condition belongs to the field of pruritus cutanea or pruritus in traditional Chinese medicine. The pathogenesis of the pruritus cutanea mainly relates to blood deficiency, wind dry, toxin deposition and inner junction. That is, the spleen is the primary reason of the pruritus cutanea, while the damp toxin and the wind toxin are the secondary reasons of the pruritus cutanea. The damp toxin spills over the skin of a patient and the wind toxin spills over the fur. In this way, the patient feels itchy in skin. According to the invention, buttonbush root, maidenhair, spikenard, common achyranthes herb, amomum, piper betle l., cyperus rotundus, dunn antiotrema root, tanacetum variifolium and fivevein meconopsis herb are decocted in water to obtain a decoction. The results of clinical tests show that, the total effective rate of the traditional Chinese medicine combination is 95.0%, and is clearly superior to the total effective rate of a control group.

Description

A kind of Chinese medicine composition for the treatment of hemodialysis patients skin pruritus

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of hemodialysis patients skin pruritus.

Background technology

One of skin symptom common when skin pruritus is chronic renal failure, in Maintained on hemodialysis patient, sickness rate is about 67% to 86%, during hemodialysis of being everlasting or dialysis after symptom the most obvious.How to cause skin lesion because of serious pruritus, uneasy in either sitting or lying, even lie awake all night, have a strong impact on the life quality of hemodialysis patients.Current without specially good effect immunotherapy targeted autoantibody method, hemodiafiltration and hemoperfusion energy partial rcsponse clinical symptoms, but owing to requiring higher and expensive medical expense to technical equipment, make it extensively cannot promote the use of at basic medical unit, a kind of better Therapeutic Method is provided for giving all patients, we are through clinical practice for many years, applicant develop a kind of curative effect obviously, have no side effect, prepare simple, cheap, subtract

The Chinese medicine preparation of few complication, applicable life-time service.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of hemodialysis patients skin pruritus.Motherland's medical science has relevant record for this disease, is attributed to " pruritus caused by wind pathogen ", " pruritus " category.Because " all itching all belongs to wind, all belongs to empty ", therefore primary disease is the disease of deficiency in origin and excess in superficiality.Its pathogenesis is mainly blood-deficiency and wind-dry, and knot in poison becomes silted up, it is at spleen, and it is designated as and wets as poison is wind.The excessive skin of noxious dampness, ailment said due to cold or exposure is walked to alter fur, then see skin pruritus.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment hemodialysis patients skin pruritus is made up of the Chinese medicine of following weight portion: Radix Cephalanthi Occidentalis 10-20 part, Herba Adianti Flabellulati 5-15 part, Radix Et Rhizoma Nardostachyos 2-4 part, Radix achyranthis asperae (Herba Achyranthis Asperae) 8-12 part, Herba Violae mundae 9-15 part, medicine beans leaf 8-12 part, Herba Marisci compacti 10-20 part, Radix Antiotrematis dunniani 8-12 part, Herba Tanaceti variifolii 3-6 part, Herba Meconopsis Quintuplinerviae 3-6 part.

Preferred: Radix Cephalanthi Occidentalis 15 parts, Herba Adianti Flabellulati 13 parts, Radix Et Rhizoma Nardostachyos 3 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 10 parts, Herba Violae mundae 13 Fen, Folium piperis betlis 10 parts, Herba Marisci compacti 15 parts, Radix Antiotrematis dunniani 10 parts, Herba Tanaceti variifolii 4.5 parts, Herba Meconopsis Quintuplinerviae 4.5 parts.

Preparation method makes decoction by traditional method decocting.

Fang Zhong: Radix Cephalanthi Occidentalis, Herba Adianti Flabellulati clearing away heat and eliminating dampness, removing blood stasis to reduce swelling; Radix Et Rhizoma Nardostachyos regulating QI to relieve pain, activating spleen and strengthening stomach; Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior, diuresis, to invigorate blood circulation; Herba Violae mundae clearing away heat to dispel wind, subside a swelling soothing the liver; Medicine beans leaf dispeiling pathogenic wind and removing dampness, antipruritic, parasite killing; Herba Marisci compacti dispelling wind for relieving itching, resolving depression regulating menstruation; Radix Antiotrematis dunniani yin nourishing tonify deficiency, heat-clearing and toxic substances removing; Herba Tanaceti variifolii dispels the wind relieving convulsion, heat-clearing and toxic substances removing; Herba Meconopsis Quintuplinerviae spasmolytic relieves dizziness, high fever, infantile convulsions, epilepsy, etc., heat-clearing and toxic substances removing, Dingchuan.

Clinical data

1, physical data: get hemodialysis skin pruritus patient 80 example for the treatment of in my institute for 2011 01 month ~ 2012 09 month, be divided into treatment group and matched group.Patient all has skin pruritus symptom in various degree, and through more than 3 months base therapies, symptom was without alleviation, all adopted hemodialysis.Treatment group 40 example, man 20 example, female 20 example; 20 ~ 60 years old age, 40.5 years old mean age; Kidney protopathy 18 example, diabetic nephropathy 10 example, hypertensive nephropathy 10 example, metabolic arthritis nephropathy 2 example; Dialysis time 5 ~ 120 months, average 39 months; Matched group 80 example, man 19 example, female 21 example; 19 ~ 62 years old age, 41 years old mean age; Kidney protopathy 16 example, diabetic nephropathy 11 example, hypertensive nephropathy 10 example, metabolic arthritis nephropathy 3 example; Dialysis time 4 ~ 125 months, average 38 months.The differences such as 2 groups of sexes, age, the course of disease, the state of an illness, TCM Syndrome Type and clinical symptoms integrations are little.

2, Therapeutic Method: 2 groups all give rule hemodialysis, anemia, replenish the calcium and correct the treatments such as acidosis, on this basis, treatment group, take Radix Cephalanthi Occidentalis 15g, Herba Adianti Flabellulati 13g, Radix Et Rhizoma Nardostachyos 3g, Radix achyranthis asperae (Herba Achyranthis Asperae) 10g, Herba Violae mundae 13g, medicine beans leaf 10g, Herba Marisci compacti 15g, Radix Antiotrematis dunniani 10g, Herba Tanaceti variifolii 4.5g, Herba Meconopsis Quintuplinerviae 4.5g, be decocted in water for oral dose, every day 2 times, 16 weeks courses for the treatment of.Matched group adopts hot water 250ml fumigation and wash method, every day 2 times, 16 weeks courses for the treatment of.

3, skin pruritus deciding degree standard is: light-duty: pruritus is shown effect once in a while, or only occurs under night and quiet environment, and limit, mild degree, does not affect sleep; Medium-sized: pruritus frequently occurs, can occur many places, degree is heavier simultaneously, impact sleep; Heavy: pruritus continues outbreak, and in popularity, degree is heavier, has a strong impact on sleep, can with changes such as skin scratch, blood crusts, pigmentation, eczema, lichens.

4, criterion of therapeutical effect: recovery from illness: pruritis disappears without recurrence; Effective: pruritus degree alleviates 2 grades, and namely heavy type becomes light-duty; Effective: pruritus degree alleviates 1 grade, namely heavy type transfer to medium-sized or medium-sized transfer to light-duty; Invalid: pruritus degree is without alleviating or increasing the weight of.

5, therapeutic outcome: treatment group patient total effective rate is 95%, matched group 60.25%, and significant difference, has statistical significance.Following table is two groups of comparitive study before and after treatment.

Note: treatment group has significant difference compared with matched group, P < 0.05.

Detailed description of the invention

Embodiment one: take Radix Cephalanthi Occidentalis 15g, Herba Adianti Flabellulati 13g, Radix Et Rhizoma Nardostachyos 3g, Radix achyranthis asperae (Herba Achyranthis Asperae) 10g, Herba Violae mundae 13g, Folium piperis betlis 10g, Herba Marisci compacti 15g, Radix Antiotrematis dunniani 10g, Herba Tanaceti variifolii 4.5g, Herba Meconopsis Quintuplinerviae 4.5g, make decoction by traditional method decocting,

Embodiment two: take Radix Cephalanthi Occidentalis 20g, Herba Adianti Flabellulati 15g, Radix Et Rhizoma Nardostachyos 4g, Radix achyranthis asperae (Herba Achyranthis Asperae) 8g, Herba Violae mundae 15g, medicine beans leaf 8g, Herba Marisci compacti 10g, Radix Antiotrematis dunniani 12g, Herba Tanaceti variifolii 3g, Herba Meconopsis Quintuplinerviae 6g, make decoction by traditional method decocting,

Embodiment three: take Radix Cephalanthi Occidentalis 10g, Herba Adianti Flabellulati 5g, Radix Et Rhizoma Nardostachyos 2g, Radix achyranthis asperae (Herba Achyranthis Asperae) 12g, Herba Violae mundae 9g, Folium piperis betlis 12g, Herba Marisci compacti 20g, Radix Antiotrematis dunniani 8g, Herba Tanaceti variifolii 6g, Herba Meconopsis Quintuplinerviae 3g, make decoction by traditional method decocting.

Claims

1. treat a Chinese medicine composition for hemodialysis patients skin pruritus, it is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Radix Cephalanthi Occidentalis 10-20 part, Herba Adianti Flabellulati 5-15 part, Radix Et Rhizoma Nardostachyos 2-4 part, Radix achyranthis asperae (Herba Achyranthis Asperae) 8-12 part, Herba Violae mundae 9-15 part, medicine beans leaf 8-12 part, Herba Marisci compacti 10-20 part, Radix Antiotrematis dunniani 8-12 part, Herba Tanaceti variifolii 3-6 part, Herba Meconopsis Quintuplinerviae 3-6 part.

2. a kind of Chinese medicine composition for the treatment of hemodialysis patients skin pruritus as claimed in claim 1, is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Radix Cephalanthi Occidentalis 15 parts, Herba Adianti Flabellulati 13 parts, Radix Et Rhizoma Nardostachyos 3 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 10 parts, Herba Violae mundae 13 parts, 10 parts, medicine beans leaf, Herba Marisci compacti 15 parts, Radix Antiotrematis dunniani 10 parts, Herba Tanaceti variifolii 4.5 parts, Herba Meconopsis Quintuplinerviae 4.5 parts.