CN103751293B - A kind of Chinese medicine composition for the treatment of chronic nephritis - Google Patents
A kind of Chinese medicine composition for the treatment of chronic nephritis Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for the treatment of chronic nephritis.Primary disease belongs to Chinese medicine " edema, deficient, hematuria, edema due to wind pathogen " category, blood stasis due to qi deficiency is damp and hot is the basic pathogenesis of chronic nephritis, the present invention selects to have benefiting QI for activating blood circulation, the Chinese medicine Semen Stizolobii Cochinchinensis of Qingre Quyu, Herba Vaccinii Bracteati, Radix securidacae, Radix seu Caulis Embeliae Parviflorae, Cortex Gossampini, Radix Lamii barbati, Radix seu Folium Viciae Unijugae, Herba Carlinae biebersteinii, Rhizoma Polliae Japonicae, decoction is made by I institute Drug Manufacturing Room, test through clinical comparison, total effective rate reaches 92.5%, is obviously better than 67.5% of matched group, curative effect highly significant.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of chronic nephritis.
Background technology
The one group of immune disease being primary in glomerule that chronic glomerulonephritis (abbreviation chronic nephritis) is made up of many reasons, multiple histological type.Primary disease is often in slow progressivity, and treatment difficulty, prognosis is poor.The state of an illness is developed to chronic nephritis late period gradually, and because nephron is constantly damaged, remaining nephron is fewer and feweri, proliferation of fibrous tissue, and renal atrophy finally causes renal failure.In China, chronic nephritis is the Etiological causing chronic renal failure, accounts for 64.6%, has become the important diseases having a strong impact on people ' s health.Therefore, seek effectively to treat nephritis, the method for delaying chronic kidney hypofunction development process is imperative.At present, doctor trained in Western medicine there is no specific medicament to chronic nephritis, and be only only limitted to the treatment controlling blood pressure, anticoagulant and hormone, cytotoxic drug, less effective, to delaying the more weary good art of renal failure.So, have very great significance from the effective ways tool of Chinese Traditional Medicine aspect treatment chronic nephritis.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of chronic nephritis.Primary disease belongs to Chinese medicine " edema, deficient, hematuria, edema due to wind pathogen " category, and blood stasis due to qi deficiency is damp and hot is the basic pathogenesis of chronic nephritis, and the traditional Chinese medical science thinks that benefiting QI for activating blood circulation clearing away damp-heat method is the fundamentum for the treatment of chronic nephritis.
Treat chronic nephritis a Chinese medicine composition, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Semen Stizolobii Cochinchinensis 6-9 part, Herba Vaccinii Bracteati 4-6 part, Radix securidacae 13-15 part, Radix seu Caulis Embeliae Parviflorae 15-30 part, Cortex Gossampini 15-25 part, Radix Lamii barbati 9-15 part, Radix seu Folium Viciae Unijugae 9-12 part, Herba Carlinae biebersteinii 12-30 part, Rhizoma Polliae Japonicae 3-9 part.
Preferably, Semen Stizolobii Cochinchinensis 7 parts, Herba Vaccinii Bracteati 5 parts, Radix securidacae 14 parts, Radix seu Caulis Embeliae Parviflorae 22 parts, Cortex Gossampini 20 parts, Radix Lamii barbati 12 parts, Radix seu Folium Viciae Unijugae 11 parts, Herba Carlinae biebersteinii 21 parts, Rhizoma Polliae Japonicae 6 parts.
Preparation method: above Chinese medicine is made decoction by traditional preparation methods.
Fang Zhong: Semen Stizolobii Cochinchinensis warming middle-JIAO QI invigorating, the kidney invigorating, pain relieving; The strong muscle QI invigorating of Herba Vaccinii Bracteati, detumescence; Radix securidacae promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, clearing away heat and promoting diuresis; Radix seu Caulis Embeliae Parviflorae promoting blood circulation to remove blood stasis, replenishing kidney, strengthening waist; Cortex Gossampini clearing away heat-damp and promoting diuresis, invigorate blood circulation, subside a swelling; Radix Lamii barbati clearing away heat-damp and promoting diuresis, promoting blood circulation and detumescence; Radix seu Folium Viciae Unijugae tonify deficiency; Herba Carlinae biebersteinii strengthening by means of tonics taste, regulating menstruation and activating blood; Rhizoma Polliae Japonicae the kidney invigorating, regulating QI to relieve pain, dispelling wind and eliminating swelling.
Clinical data
1, case selected by physical data all come self-institute Urology Department be in hospital and nephropathy special outpatient clinic patient 80 example, be divided into treatment group and matched group at random.Wherein treatment group 40 example, man 18 example, female 22 example, matched group 40 example, man 14 example, female 26 example.Patient age is between 20-71 year, and treatment group is (51.32 ± 12.28) year, and matched group is (48.36 ± 17.64) year.Two groups of patient's courses of disease the shortest are 1 year, the longest more than ten years.Merge renal insufficiency person 25 example, complicated hypertension person 10 example.Wherein row pathological biopsy person 14 example, glomerular minimal change person 6 example, mesangial matrix * person 10 example, focal segmental hardening nephritis 11 example, proliferative glomerulonephritis 4 example in diffusivity blood capillary.The aspects such as two groups of sexes, age, the course of disease, complication compare there was no significant difference (P > 0.05).
2, diagnostic criteria is with reference to " guideline of clinical investigations of new Chinese medicine treatment chronic nephritis ".
3, Therapeutic Method treatment group and matched group all first give general process, comprise correction water and rock-soil coupling, infection control, have edema person to add diuretic oral.Treatment group patient takes Chinese medicine composition of the present invention, takes Semen Stizolobii Cochinchinensis 7g, Herba Vaccinii Bracteati 5g, Radix securidacae 14g, Radix seu Caulis Embeliae Parviflorae 22g, Cortex Gossampini 20g, Radix Lamii barbati 12g, Radix seu Folium Viciae Unijugae 11g, Herba Carlinae biebersteinii 21g, Rhizoma Polliae Japonicae 6g.Every day 1 dose, decocting, point 2 clothes.Matched group patient, on the basis of general treatment, gives paecilomyces hepiall chen oral, each 4, every day 3 times.Two groups equal two months is a course for the treatment of.
3, criterion of therapeutical effect criterion of therapeutical effect was with reference to the 7th national combination of Chinese and Western medicine nephropathy academic conference symposium " chronic glomerulonephritis efficacy assessment standard " in 2003.Complete incidence graph: the symptom such as edema, Renal hypertension, sign disappear completely, urine protein continues negative, and quantitative < 0.2g/24h, urine erythrocyte continues < 2/HP, normal renal function.Basic alleviation: symptom, sign disappear substantially, urine protein quantitation reduces by 50%, urine erythrocyte < 2/HP, normal renal function before comparatively treating.Effective: symptom, sign are clearly better, urine protein quantitation is more front than treatment reduces 25%, normal or more front than the treatment rising < 50% of serum creatinine (Scr).Invalid: not reach effective standard.
5, the rear comparitive study of therapeutic outcome two groups treatment is in table 1
Detailed description of the invention
Embodiment one: take Semen Stizolobii Cochinchinensis 7g, Herba Vaccinii Bracteati 5g, Radix securidacae 14g, Radix seu Caulis Embeliae Parviflorae 22g, Cortex Gossampini 20g, Radix Lamii barbati 12g, Radix seu Folium Viciae Unijugae 11g, Herba Carlinae biebersteinii 21g, Rhizoma Polliae Japonicae 6g, above Chinese medicine is traditionally made decoction.
Embodiment two: take Semen Stizolobii Cochinchinensis 6g, Herba Vaccinii Bracteati 6g, Radix securidacae 13g, Radix seu Caulis Embeliae Parviflorae 15g, Cortex Gossampini 25g, Radix Lamii barbati 9g, Radix seu Folium Viciae Unijugae 12g, Herba Carlinae biebersteinii 30g, Rhizoma Polliae Japonicae 3g, above Chinese medicine is traditionally made decoction.
Embodiment three: take Semen Stizolobii Cochinchinensis 9g, Herba Vaccinii Bracteati 4g, Radix securidacae 15g, Radix seu Caulis Embeliae Parviflorae 30g, Cortex Gossampini 15g, Radix Lamii barbati 15g, Radix seu Folium Viciae Unijugae 9g, Herba Carlinae biebersteinii 12g, Rhizoma Polliae Japonicae 9g, above Chinese medicine is traditionally made decoction.
Claims (2)
1. treat a Chinese medicine composition for chronic nephritis, it is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Semen Stizolobii Cochinchinensis 6-9 part, Herba Vaccinii Bracteati 4-6 part, Radix securidacae 13-15 part, Radix seu Caulis Embeliae Parviflorae 15-30 part, Cortex Gossampini 15-25 part, Radix Lamii barbati 9-15 part, Radix seu Folium Viciae Unijugae 9-12 part, Herba Carlinae biebersteinii 12-30 part, Rhizoma Polliae Japonicae 3-9 part.
2. a kind of Chinese medicine composition for the treatment of chronic nephritis as claimed in claim 1, is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Semen Stizolobii Cochinchinensis 7 parts, Herba Vaccinii Bracteati 5 parts, Radix securidacae 14 parts, Radix seu Caulis Embeliae Parviflorae 22 parts, Cortex Gossampini 20 parts, Radix Lamii barbati 12 parts, Radix seu Folium Viciae Unijugae 11 parts, Herba Carlinae biebersteinii 21 parts, Rhizoma Polliae Japonicae 6 parts.
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| CN104873718A (en) * | 2015-05-04 | 2015-09-02 | 乜红臻 | Traditional Chinese medicine preparation for treating simple glomerular hematuria of children |
| CN106138239A (en) * | 2016-07-30 | 2016-11-23 | 庄炎 | A kind of Chinese medicine preparation treating chronic glomerulonephritis |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1522743A (en) * | 2003-09-12 | 2004-08-25 | 群 顾 | Kidney disease therapeutic pharmaceutical |
| CN102114131A (en) * | 2010-12-13 | 2011-07-06 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating diabetic nephropathy |
| CN102451305A (en) * | 2010-10-27 | 2012-05-16 | 赵传利 | Chinese medicinal formula for treating chronic pyelonephritis |
| CN102614423A (en) * | 2012-04-09 | 2012-08-01 | 李香云 | Traditional Chinese medical decoction for treatment of chronic kidney disease |
| CN103041276A (en) * | 2013-01-11 | 2013-04-17 | 粘芙蓉 | Chinese medicament for treating Qi-blood insufficiency type prematurely grey-hair disease |
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| KR101440489B1 (en) * | 2011-06-29 | 2014-09-17 | 한국생명공학연구원 | A pharmaceutical composition comprising extract of Dipterocarpus obtusifolius Teijsm. Ex Miq. for prevention and treatment of inflammatory diseases or allergic disease |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1522743A (en) * | 2003-09-12 | 2004-08-25 | 群 顾 | Kidney disease therapeutic pharmaceutical |
| CN102451305A (en) * | 2010-10-27 | 2012-05-16 | 赵传利 | Chinese medicinal formula for treating chronic pyelonephritis |
| CN102114131A (en) * | 2010-12-13 | 2011-07-06 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating diabetic nephropathy |
| CN102614423A (en) * | 2012-04-09 | 2012-08-01 | 李香云 | Traditional Chinese medical decoction for treatment of chronic kidney disease |
| CN103041276A (en) * | 2013-01-11 | 2013-04-17 | 粘芙蓉 | Chinese medicament for treating Qi-blood insufficiency type prematurely grey-hair disease |
Non-Patent Citations (1)
| Title |
|---|
| 加味当归汤治疗慢性肾炎32例;房馨;《陕西中医》;20101231;第31卷(第8期);第952页 * |
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