CN102114131A - Traditional Chinese medicine for treating diabetic nephropathy - Google Patents

Abstract

The invention relates to a traditional Chinese medicine for treating diabetic nephropathy, which belongs to the field of traditional Chinese medicines for treating diseases of the urinary system, and has the purposes of good effect and quick effect. The traditional Chinese medicine is prepared from the raw materials of fructus kochiae, pseudo-ginseng, Chinese angelica, rehmannia, lucid ganoderma, barbary wolfberry fruits, gordon euryale seeds, and the like. The traditional Chinese medicine has the effects of strengthening the body resistance to consolidate the constitution, invigorating Qi and nourishing blood, nourishing yin and clearing away heat, clearing damp and promoting diuresis, and promoting blood circulation and removing blood stasis. The traditional Chinese medicine has the advantages of obvious effect, exact effect and quicker effect.

Description

A kind of Chinese medicine of treatment of diabetic nephropathy

Technical field

The invention belongs to the field of Chinese medicines of treatment diseases of urinary system.

Background technology

According to statistics, at present among the nephrotic of China, about 52% is diabetic nephropathy, is a sizable illness colony.Diabetic nephropathy is due to diabetes complicated glomerular microangiopathy becomes, to be one of lethal major reason of diabetes.Diabetics about 20% is died from this disease.Be intended to the field of Chinese medicines of treatment of diabetic nephropathy at present, have the shortcoming of two aspects: the one, effect is obvious inadequately; The 2nd, it is slower to take effect, and large quantities of diabetic nephropathy patient are owing to can not get the treatment of active drug, and nephropathy constantly develops, and constantly worsens, and becomes renal failure, threat to life.Patient and family members are very dissatisfied.

At problem set forth above, the invention provides a kind of Chinese medicine of treatment of diabetic nephropathy, it can solve, and this type of Chinese medicine effect was obvious inadequately in the past, the slower problem that takes effect, effective, instant effect, it is remarkable to have effect, drug effect is definite, the advantage of quick result.

Summary of the invention

The present invention is achieved through the following technical solutions:

1, a kind of Chinese medicine of treatment of diabetic nephropathy adopts the raw material of Chinese medicine preparation, and filling a prescription is (by weight):

The Fructus Kochiae 5---18 parts of 15 portions of Radix Notoginseng 3---9 parts of Radix Angelicae Sinensis 6---

Radix Rehmanniae 6---18 parts of 18 portions of Ganodermas 6---18 parts of Fructus Lycii 6---

Semen Euryales 6---18 parts

The Chinese medicine of this treatment of diabetic nephropathy is made by following method:

(1) by above-mentioned weight ratio, Ganoderma is extracted ganoderan with decoction and alcohol sedimentation technique, technological process is as follows: Ganoderma is broken into graininess, cross 40 mesh sieves →, concentrate → mixed, leave standstill 10-12 hour, centrifugal → as to add 75% ethanol with 95% ethanol of 3 times of volumes with 1: 20 hot water (95 ℃) lixiviate → lixiviating solution decompression, precipitate polysaccharide → dry the ganoderan extract fine powder;

(2) by above-mentioned weight ratio, the Fructus Kochiae, Radix Angelicae Sinensis, Radix Rehmanniae, Fructus Lycii, Semen Euryales are extracted through conventional water extraction process, make extract extractum fine powder;

(3) by above-mentioned weight ratio, Radix Notoginseng is ground into fine powder, mixes, stir, make Chinese medicine granules, capsule, tablet with above-mentioned (1), (2) two kinds of extract fine powders.

The present invention is according to the folk tradition prescription, and the theory according to traditional Chinese medical science the body resistance strengthening and constitution consolidating, blood circulation promoting and blood stasis dispelling develops meticulously.We think that the most hypoimmunities of diabetics are given birth in the deficiency-heat, consume the body fluid that burns in research, blood is hypercoagulability, and stickiness is bigger, and blood flow is slow, cause the kidney blood supply insufficiency, the nephridial tissue microcirculation is not smooth, and this is the basic reason of kidney of diabetic patients generation microangiopathies.So, attach most importance to set upright, benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, the damp eliminating diuretic should be the rule of treatment of treatment of diabetic nephropathy.Ganoderma, Fructus Lycii the body resistance strengthening and constitution consolidating in the side, benefiting QI and nourishing blood, tranquilizing by nourishing the heart, enhancing human body immunity power; Radix Angelicae Sinensis, pseudo-ginseng blood-circulation-invigovating blood stasis dispelling increase the kidney blood flow, improve renal microcirculation; Radix Rehmanniae property is sweet cold, is longer than nourishing YIN and clearing away heat, can separate due to quenching one's thirst scorching, again can be and blood stasis dispelling by arthralgia due to stagnation of blood; Be aided with Fructus Kochiae clearing away damp-heat, diuresis; The Semen Euryales the kidney invigorating and essence nourishing, spleen invigorating, damp eliminating.All medicine compatibilities bring out the best in each other, and play the body resistance strengthening and constitution consolidating altogether, benefiting QI and nourishing blood, and replenishing YIN and removing heat, promoting diuresis to eliminate damp pathogen, the merit of blood circulation promoting and blood stasis dispelling, effective, instant effect, it is remarkable to have effect, and drug effect is definite, the advantage of quick result.

The specific embodiment

By following embodiment the present invention is done and to specify:

1, get following prescription (weight is unit by gram):

The Fructus Kochiae 60 gram Radix Notoginseng 30 gram Radix Angelicae Sinensis 70 grams

Radix Rehmanniae 70 kairine sesames 70 gram Fructus Lycii 70 grams

Semen Euryales 70 grams

Weight is extracted Ganoderma with decoction and alcohol sedimentation technique in accordance with regulations; With conventional water extraction process the Fructus Kochiae, Radix Angelicae Sinensis, Radix Rehmanniae, Fructus Lycii, Semen Euryales are extracted, make extract fine powder 82 grams altogether, Radix Notoginseng is ground into fine powder, mix with said extracted thing fine powder, stir, make fine particle, the capsule of packing into No. 0, make 400 of Chinese medicinal capsules, every capsules includes Chinese medicine fine powder and extract 0.28 gram.

2, get following prescription (weight is unit by gram):

The Fructus Kochiae 100 gram Radix Notoginseng 60 gram Radix Angelicae Sinensis 120 grams

Radix Rehmanniae 120 kairine sesames 120 gram Fructus Lycii 120 grams

Semen Euryales 120 grams

By above-mentioned same method, make 714 of Chinese medicinal capsules, every capsules includes Chinese medicine fine powder and extract 0.28 gram.

3, get following prescription (weight is unit by gram):

The Fructus Kochiae 150 gram Radix Notoginseng 80 gram Radix Angelicae Sinensis 180 grams

Radix Rehmanniae 180 kairine sesames 180 gram Fructus Lycii 180 grams

Semen Euryales 180 grams

By above-mentioned same method, make 1035 of Chinese medicinal capsules, every capsules includes Chinese medicine fine powder and extract 0.28 gram.

4, get following prescription (by weight):

7 parts of 3 parts of Radix Angelicae Sinensis of 6 portions of Radix Notoginseng of the Fructus Kochiae

7 parts of 7 parts of Fructus Lycii of 7 portions of Ganodermas of Radix Rehmanniae

7 parts of Semen Euryaless

By above-mentioned same method, make Chinese medicinal capsule, every capsules includes Chinese medicine fine powder and extract 0.28 gram.

5, get following prescription (by weight):

16 parts of 7 parts of Radix Angelicae Sinensis of 12 portions of Radix Notoginseng of the Fructus Kochiae

16 parts of 16 parts of Fructus Lycii of 16 portions of Ganodermas of Radix Rehmanniae

16 parts of Semen Euryaless

By above-mentioned same method, make Chinese medicinal capsule, every capsules includes Chinese medicine fine powder and extract 0.28 gram.

Clinical data:

The present invention is an example with traditional Chinese medical science diabetic nephropathy, through 9 routine clinical observations.Selecting the tcm diagnosis diabetic nephropathy is standard: diabetics has thirsty, polydipsia, frequent micturition, urgent micturition, and spiritlessness and weakness, edema of lower limbs has albuminuria, serum creatinine (scr) 133～442 μ mol/L.As above symptom can be made a definite diagnosis.In making a definite diagnosis the object of observation, male's 5 examples, women's 4 examples do not have other serious disease, and the age is 44 years old-81 years old, 64.6 years old mean age.

Efficacy determination:

1, produce effects: body constitution strengthens, on one's body energetically; Polydipsia polyuria, urine urgency-frequency disappear; Edema of lower limbs is alleviated; Albuminuria obviously reduces, and serum creatinine descends more than 10%.

2, effective: the polydipsia polyuria reduces to some extent, and on one's body energetically, edema, albuminuria are alleviated to some extent.

3, invalid: the disease no change.

During clinical experiment, except that the antidiabetic drug that diabetics is necessary is taken (medicine is constant, amount is constant) as usual, withdraw other medicines and health nutrient.Taking Chinese medicinal capsule of the present invention, observed 6 months, is a course of treatment.Instructions of taking: every day 2 times, each 4 capsules, every capsules include Chinese medicine fine powder and extract 0.28 gram, warm water delivery service after meal, symptom promptly has alleviation after 1 month, take 6 months after, symptom is obviously improved.9 philtrums of clinical experiment, produce effects 4 people, effective 4 people, invalid 1 people, total effective rate 88.8%.

Claims (1)

1. the Chinese medicine of a treatment of diabetic nephropathy, it is characterized in that: it is to make with the component of following weight ratio: the Fructus Kochiae 5---15 parts, Radix Notoginseng 3---9 parts, Radix Angelicae Sinensis 6---18 parts, Radix Rehmanniae 6---18 parts, Ganoderma 6---18 parts, Fructus Lycii 6---18 parts, Semen Euryales 6---18 parts.