CN102961612B - Traditional Chinese medicine capsule for treating ankylosing spondylitis - Google Patents
Traditional Chinese medicine capsule for treating ankylosing spondylitis Download PDFInfo
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- CN102961612B CN102961612B CN201210527591.9A CN201210527591A CN102961612B CN 102961612 B CN102961612 B CN 102961612B CN 201210527591 A CN201210527591 A CN 201210527591A CN 102961612 B CN102961612 B CN 102961612B
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Abstract
The invention discloses a traditional Chinese medicine capsule for treating ankylosing spondylitis. The traditional Chinese medicine believes in that the ankylosing spondylitis belongs to the filed of traditional Chinese medicine 'bi-syndrome', and is named as 'kyphosis rheumatism', 'bamboo joint rheumatism', 'bone impediment' and the like. Consequently, the traditional Chinese medicine capsule selects the traditional Chinese medicines such as vaccinium fragile franch., siegesbeckia pubescens mak., radix rubi obcordati, caulis piperis kadsurae, colla corni cervi, rhizoma gastrodiae, rhizoma cibotii, plastrum testudinis, radix rehmanniae preparata, ramulus cinnamomi, processed olibanum, radix cyathulae, radix angelicae pubescentis, typhonium giganteum engl and peristrophe japonica which activate blood, relieve blockage, dispel wind, resolve dampness, tonify kidney and strength bone to prepare the capsule. Through the clinical experiences, the total efficiency reaches 96.7%, the traditional Chinese medicine capsule is obviously better than a control group, particularly, the main symptom, sing and main laboratory indicator variations of patients are obviously better than the control group, and the traditional Chinese medicine capsule has small side effects and is worth being popularized and applied.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicinal capsule for the treatment of ankylosing spondylitis.
Background technology
Ankylosing spondylitis (AS) is a kind of chronic inflammatory disease, mainly invades sacroiliac joint, spinal column apophysis, the other soft tissue of spinal column and periphery joint, and the extra-articular manifestation that can occur together.Clinical main manifestations is waist, the back of the body, neck, buttocks, hip pain and arthralgia, and deformity of spine and ankylosis can occur severe patient.Its pathogenesis is relevant with factors such as heredity, antibacterial infection, crucial immunological abnormality.Doctor trained in Western medicine is emphasized antiinflammatory and immunosuppressant therapy at present, and sulfasalazine and methotrexate are current generally acknowledged conventional therapy medicines, but these medicine life-time service easily cause gastrointestinal tract, hematology and other system concurrency disease, and patient compliance is poor.By test in recent years, think that traditional Chinese medical science comprehensive adjustment effect in treatment is strong, play and regulate immunologic function, antiinflammatory, analgesic effect, curative effect is better, and side effect is little, is applicable to long term maintenance treatment.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicinal capsule for the treatment of ankylosing spondylitis.Motherland's medical science is thought forces spondylitis to belong to the traditional Chinese medical science " numbness is sick " category, and ancients claim " kyphosis wind ", " ring wind ", " rheumatism involving the bone " etc.This disease be take activating blood circulation and unblocking obstruction, the removing dampness of dispeling the wind, Bu Shen Zhuang and is superintended and directed as the rule for the treatment of in treatment.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicinal capsule of this treatment ankylosing spondylitis is made by the Chinese medicine of following weight portion: Folium Vaccinii Fragilis 18-20 Fen, Herba Siegesbeckiae 15-18 part, Radix Rubi obcordati 14-16 part, Caulis Piperis Kadsurae 13-15 part, Colla cornus cervi 9-11 part, Rhizoma Gastrodiae 8-10 part, Rhizoma Cibotii 11-13 part, Carapax et Plastrum Testudinis 9-11 part, Radix Rehmanniae Preparata 11-13 part, Ramulus Cinnamomi 8-11 part, Olibanum (processed) 7-9 part, Radix Cyathulae 9-11 part, Radix Angelicae Pubescentis 11-13 part, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 5-7 part, Herba Peristrophes 6-8 part.
Preferably, Folium Vaccinii Fragilis 19 18 parts of Fen, Herba Siegesbeckiaes, 17 parts of Radix Rubi obcordatis, 14 parts of Caulis Piperis Kadsuraes, 10 parts of Colla cornus cervis, 9 parts, Rhizoma Gastrodiae, 12 parts of Rhizoma Cibotii, 10 parts of Carapax et Plastrum Testudiniss, 12 parts of Radix Rehmanniae Preparata, 10 parts of Ramulus Cinnamomi, 8 parts of Olibanum (processed)s, 10 parts of Radix Cyathulaes, 12 parts of Radix Angelicae Pubescentiss, 6 parts of Rhizoma Typhonium Gigantei (Rhizoma Typhonii), 7 parts of Herba Peristrophess.
Preparation method: the above Chinese medicine is dried to pulverize, pack capsule into No. 1.
In side: the Folium Vaccinii Fragilis cold-damp of dispeling the wind, relaxing muscles and tendons to promote blood circulation, reducing swelling and alleviating pain, main anemofrigid-damp arthralgia, the stupid fiber crops of brothers; Herba Siegesbeckiae wind-damp dispelling, relieving rigidity of muscles and joints, controls quadriplegia; Radix Rubi obcordati dredging collateral, detumescence antidiarrheal, controls bones and muscles pain; Caulis Piperis Kadsurae wind-damp dispelling, the meridian dredging, stopping numbness pain.For anemofrigid-damp arthralgia, the contracture of muscle arteries and veins; Colla cornus cervi enrich and benefit essence and blood, antiabortive hemostasis; Rhizoma Gastrodiae endogenous wind stopping relieving convulsion, suppressing liver-YANG, dispelling wind and removing obstruction in the collateral; Rhizoma Cibotii invigorating the liver and kidney, except rheumatism, strong waist foot, sharp joint; Carapax et Plastrum Testudinis YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, strong bone; The Radix Rehmanniae Preparata YIN nourishing of enriching blood, beneficial essence is filled out marrow; Ramulus Cinnamomi diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI; The pain relieving of Olibanum (processed) blood-activating and qi-promoting, detumescence and promoting granulation; Radix Cyathulae blood circulation promoting and blood stasis dispelling , Qu Wind dampness removing; Radix Angelicae Pubescentis expelling wind and dampness, dispersing cold for relieving pain; The Rhizoma Typhonium Gigantei (Rhizoma Typhonii) expectorant that dispels the wind, dampness expectorant, relieving convulsion pain relieving, detoxicating and resolving stagnation of pathogens; Herba Peristrophes dispelling pathogenic wind and eliminating phlegm, heat-clearing and toxic substances removing.
Clinical data
1, physical data 120 examples are 2008 months June-2009 year Decembers the AS patient of the court's diagnosis and treatment, are divided at random two groups: treatment group 60 examples, male 10 examples, female's 50 examples, minimum 23 years old of age, maximum 65 years old, average (46 ± 10.5) year; The course of disease is the shortest 2 months, the longest 11 years, average (3.5 ± 2.9) year; Observation group's 60 examples, male 12 examples, female's 48 examples; Minimum 24 years old of age, maximum 63 years old, average (49 ± 11.2) year; The course of disease is the shortest 3 months, the longest 15 years, average (3.8 ± 3.1) year.Epidemiological Analysis by statistics, two groups of Genders, age and course of disease comparisons, difference not statistically significant (P > 0.05), has comparability.
2, Therapeutic Method treatment group is taken the above Chinese medicinal capsule, every day three times, each 5; Matched group: take Sai Laipubu, oral 1 of every day.
3, criterion of therapeutical effect: clinical remission: cardinal symptom disappears substantially, main lab index recovers normal; Effective: cardinal symptom takes a turn for the better, main lab index is tending towards normal; Effective: cardinal symptom makes moderate progress, main lab index declines to some extent; Invalid: not arrive effective standard, or increase the weight of.
4, therapeutic outcome
Treating curative effect after 2 months for (1) two group compares in Table 1.The routine patient's medication for the treatment of group 60 clinical remission 20 examples (33.3%) after 2 months, effective 25 examples (41.7%), effective 13 examples (21.7%), invalid 2 examples (3.3%); Total effective rate 96.70; Matched group clinical remission 13 examples (21.7%%), effective 15 examples (25.0%), effective 17 examples (28.3%), invalid 15 examples (25.0%); Total effective rate 75.0%.Through x2 check, two groups of Different therapeutical effects have significance (P < 0.01), and the treatment group matched group that is better than evident in efficacy is described.
Treat curative effect comparison sheet 1 example (%) after 2 months for two groups
Note: with matched group comparison, Δ Δ P < 0.01
(2) two groups of patient's cardinal symptoms and sign change relatively in Table 2.Two groups of patients are more all improved after the cardinal symptoms such as spinal column stiff time in morning, chest expanding degree, Schober test, arthralgia number, arthroncus number and sign treatment with before treatment, and difference all has significance (P < 0.01); With matched group comparison, treatment group is improved degree difference also significant (P < 0.05).
Cardinal symptom, sign comparison (x ± s) table 2 before and after two groups of treatments.
(3) two groups of patient's laboratory leading indicators change relatively in Table 3.After two groups of treatments, before ESR, CRP and treatment, comparing difference all has obvious significance (P < 0.01), and treatment group improvement degree is more obviously better than matched group (P < 0.01), the rear IgG for the treatment of group treatment improves degree and matched group compares significance (P < 0.05), and after two groups of treatments, IgA, IgM compare without significant; Treatment group C
3, improvement degree is compared with matched group significance (P < 0.05) relatively.
Two groups of patient's laboratory leading indicators change comparison sheet 3
5, two groups of adverse reactions of patients comparisons: the untoward reaction in treatment group is less, 3 examples of wherein suffering from abdominal pain, laxativeness 5 examples, dizzy 2 examples, because above-mentioned symptom is all slighter, do not do any processing, and after two weeks, symptom disappears automatically, adheres to continuing medication.Matched group untoward reaction is obviously more than treatment group, flatulence 12 examples wherein, headache 5 examples, vomiting 6 examples, bellyache and diarrhea 7 examples, edema 5 examples, hypertension 3 examples, glutamate pyruvate transaminase 8 examples that slightly raise.
The specific embodiment
Embodiment mono-: take Folium Vaccinii Fragilis 19g, Herba Siegesbeckiae 18g, Radix Rubi obcordati 17g, Caulis Piperis Kadsurae 14g, Colla cornus cervi 10g, Rhizoma Gastrodiae 9g, Rhizoma Cibotii 12g, Carapax et Plastrum Testudinis 10g, Radix Rehmanniae Preparata 12g, Ramulus Cinnamomi 10g, Olibanum (processed) 8g, Radix Cyathulae 10g, Radix Angelicae Pubescentis 12g, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 6g, Herba Peristrophes 7g.The above Chinese medicine is dried to pulverize, pack capsule into No. 1.
Embodiment bis-: take Folium Vaccinii Fragilis 18g, Herba Siegesbeckiae 15g, Radix Rubi obcordati 14g, Caulis Piperis Kadsurae 13g, Colla cornus cervi 9g, Rhizoma Gastrodiae 8g, Rhizoma Cibotii 11g, Carapax et Plastrum Testudinis 9g, Radix Rehmanniae Preparata 11g, Ramulus Cinnamomi 8g, Olibanum (processed) 7g, Radix Cyathulae 9g, Radix Angelicae Pubescentis 11g, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 5g, Herba Peristrophes 6g.The above Chinese medicine is dried to pulverize, pack capsule into No. 1.
Embodiment tri-: take Folium Vaccinii Fragilis 20g, Herba Siegesbeckiae 18g, Radix Rubi obcordati 16g, Caulis Piperis Kadsurae 15g, Colla cornus cervi 11g, Rhizoma Gastrodiae 10g, Rhizoma Cibotii 13g, Carapax et Plastrum Testudinis 11g, Radix Rehmanniae Preparata 13g, Ramulus Cinnamomi 11g, Olibanum (processed) 9g, Radix Cyathulae 11g, Radix Angelicae Pubescentis 13g, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 7g, Herba Peristrophes 8.The above Chinese medicine is dried to pulverize, pack capsule into No. 1.
Claims (2)
1. treat a Chinese medicinal capsule for ankylosing spondylitis, it is characterized in that the Chinese medicinal capsule of this treatment ankylosing spondylitis is made by the Chinese medicine of following weight portion: Folium Vaccinii Fragilis 18-20 part, Herba Siegesbeckiae 15-18 part, Radix Rubi obcordati 14-16 part, Caulis Piperis Kadsurae 13-15 part, Colla cornus cervi 9-11 part, Rhizoma Gastrodiae 8-10 part, Rhizoma Cibotii 11-13 part, Carapax et Plastrum Testudinis 9-11 part, Radix Rehmanniae Preparata 11-13 part, Ramulus Cinnamomi 8-11 part, Olibanum (processed) 7-9 part, Radix Cyathulae 9-11 part, Radix Angelicae Pubescentis 11-13 part, Rhizoma Typhonium Gigantei (Rhizoma Typhonii) 5-7 part, Herba Peristrophes 6-8 part.
2. a kind of Chinese medicinal capsule for the treatment of ankylosing spondylitis according to claim 1, is characterized in that the Chinese medicinal capsule of this treatment ankylosing spondylitis is made by the Chinese medicine of following weight portion: Folium Vaccinii Fragilis 19 18 parts of Fen, Herba Siegesbeckiaes, 17 parts of Radix Rubi obcordatis, 14 parts of Caulis Piperis Kadsuraes, 10 parts of Colla cornus cervis, 9 parts, Rhizoma Gastrodiae, 12 parts of Rhizoma Cibotii, 10 parts of Carapax et Plastrum Testudiniss, 12 parts of Radix Rehmanniae Preparata, 10 parts of Ramulus Cinnamomi, 8 parts of Olibanum (processed)s, 10 parts of Radix Cyathulaes, 12 parts of Radix Angelicae Pubescentiss, 6 parts of Rhizoma Typhonium Gigantei (Rhizoma Typhonii), 7 parts of Herba Peristrophess.
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CN1377683A (en) * | 2002-04-22 | 2002-11-06 | 马有道 | Medicinal formula for curing sciatic nerve disease and protrusion of lumbar intervertebral disc |
CN1146343C (en) * | 1997-02-14 | 2004-04-21 | Seb公司 | Electric appliance for grilling or heating flat slice of food |
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CN1146343C (en) * | 1997-02-14 | 2004-04-21 | Seb公司 | Electric appliance for grilling or heating flat slice of food |
CN1377683A (en) * | 2002-04-22 | 2002-11-06 | 马有道 | Medicinal formula for curing sciatic nerve disease and protrusion of lumbar intervertebral disc |
Non-Patent Citations (4)
Title |
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强直性脊柱炎的中药治疗近况;柴晟等;《广西中医学院学报》;20060930;第09卷(第03期);87-90 * |
柴晟等.强直性脊柱炎的中药治疗近况.《广西中医学院学报》.2006,第09卷(第03期),87-90. |
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赖祥林.活血化瘀法在骨科的临床应用新进展.《中国中医骨伤科杂志》.2005,第13卷(第02期),60-63. |
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