CN104918925B - 用于电化学分析的检测装置 - Google Patents

用于电化学分析的检测装置 Download PDF

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Publication number
CN104918925B
CN104918925B CN201380069068.9A CN201380069068A CN104918925B CN 104918925 B CN104918925 B CN 104918925B CN 201380069068 A CN201380069068 A CN 201380069068A CN 104918925 B CN104918925 B CN 104918925B
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conductive
oxidase
conductive polymer
poly
electrode
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Expired - Fee Related
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Chinese (zh)
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CN104918925A (zh
Inventor
罗柳·约瑟夫·丹尼森
默里·约翰·怀特
克里斯多夫·约翰·斯莱文
安东尼·博兰
大卫·威廉·泰勒
约翰·安东尼·博罗特
杰罗姆·麦卡利尔
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Alere Switzerland GmbH
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Alere Switzerland GmbH
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/36—[b, e]-condensed, at least one with a further condensed benzene ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G01N33/561—Immunoelectrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3273—Devices therefor, e.g. test element readers, circuitry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
    • Y02E60/30—Hydrogen technology
    • Y02E60/50—Fuel cells

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201380069068.9A 2012-12-21 2013-12-20 用于电化学分析的检测装置 Expired - Fee Related CN104918925B (zh)

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US201261745211P 2012-12-21 2012-12-21
US61/745,211 2012-12-21
GBGB1223166.8A GB201223166D0 (en) 2012-12-21 2012-12-21 Test strip
GB1223166.8 2012-12-21
US201361770233P 2013-02-27 2013-02-27
US61/770,233 2013-02-27
PCT/EP2013/077797 WO2014096407A1 (en) 2012-12-21 2013-12-20 Test device for electrochemical analysis

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US (1) US20150330935A1 (cg-RX-API-DMAC7.html)
EP (1) EP2938602A1 (cg-RX-API-DMAC7.html)
JP (1) JP2016500447A (cg-RX-API-DMAC7.html)
KR (1) KR20150097692A (cg-RX-API-DMAC7.html)
CN (2) CN104918925B (cg-RX-API-DMAC7.html)
AU (1) AU2013366464B2 (cg-RX-API-DMAC7.html)
GB (2) GB201223166D0 (cg-RX-API-DMAC7.html)
HK (2) HK1213568A1 (cg-RX-API-DMAC7.html)
WO (1) WO2014096407A1 (cg-RX-API-DMAC7.html)

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KR101740034B1 (ko) 2015-07-20 2017-06-08 주식회사 아이센스 베타-히드록시부틸레이트 검출을 위한 산화환원 시약 조성물, 및 상기시약 조성물을 포함하는 전기화학적 바이오센서
JP2017036951A (ja) * 2015-08-07 2017-02-16 ソニー株式会社 カートリッジ、検出装置及び検出方法
CN108463719B (zh) * 2015-12-28 2021-12-21 生命扫描苏格兰有限公司 具有电极电压感测连接件的基于电化学的分析测试条以及与其一起使用的手持式测试仪
KR102290253B1 (ko) 2016-07-11 2021-08-20 삼성전자주식회사 바이오 센서 및 그의 제작 방법
CN106596693B (zh) * 2016-11-30 2019-03-29 中国科学院上海应用物理研究所 一种用于肌氨酸的电化学检测方法
CN107478707A (zh) * 2017-07-13 2017-12-15 大连大学 一种用于血糖测定的新型电极及其测定方法
EP3480595A1 (en) * 2017-11-02 2019-05-08 Elisha Systems Ltd. Biosensor manufacture
CN109781821B (zh) * 2017-11-10 2023-10-24 上海瀚联医疗技术股份有限公司 一种血糖检测仪
CN109781804A (zh) * 2017-11-10 2019-05-21 上海瀚联医疗技术股份有限公司 一种血糖测试模块
CN109781989A (zh) * 2017-11-10 2019-05-21 上海瀚联医疗技术股份有限公司 血糖测试的方法及生物传感器
WO2019142146A1 (en) 2018-01-18 2019-07-25 King Abdullah University Of Science And Technology N-type polymer based electrochemical device for direct enzymatic metabolite sensing and methods of making and using
WO2019224628A1 (en) * 2018-05-21 2019-11-28 King Abdullah University Of Science And Technology Inkjet-printed electrochemical metabolite sensors
CN109507250A (zh) * 2019-01-16 2019-03-22 威海纽普生物技术有限公司 检测d二聚体的电化学试剂盒及其制备方法
US12292406B2 (en) 2019-08-03 2025-05-06 King Abdullah University Of Science And Technology Device for detecting analytes in a sample, and methods of use thereof
KR102248653B1 (ko) * 2020-02-24 2021-05-04 성균관대학교산학협력단 가변저항소자, 이의 제조 방법 및 이를 포함하는 수위센서
KR20210112137A (ko) * 2020-03-04 2021-09-14 동우 화인켐 주식회사 전기화학센서 및 이의 제조방법
KR20210116889A (ko) 2020-03-18 2021-09-28 동우 화인켐 주식회사 바이오센서
CN114632559B (zh) * 2022-01-26 2023-03-31 浙江大学 基于电阻抗检测的片上微槽阵列数字pcr芯片及制作方法

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Publication number Publication date
CN104918925A (zh) 2015-09-16
WO2014096407A1 (en) 2014-06-26
KR20150097692A (ko) 2015-08-26
CN107941865A (zh) 2018-04-20
HK1214360A1 (zh) 2016-07-22
JP2016500447A (ja) 2016-01-12
HK1213568A1 (zh) 2016-07-08
AU2013366464B2 (en) 2017-05-25
AU2013366464A1 (en) 2015-08-06
EP2938602A1 (en) 2015-11-04
GB2523419A (en) 2015-08-26
US20150330935A1 (en) 2015-11-19
GB201410773D0 (en) 2014-07-30
GB201223166D0 (en) 2013-02-06

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