CN104906373A - Medicine for treating stenocardia type coronary heart disease and preparing method thereof - Google Patents
Medicine for treating stenocardia type coronary heart disease and preparing method thereof Download PDFInfo
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- CN104906373A CN104906373A CN201510295110.XA CN201510295110A CN104906373A CN 104906373 A CN104906373 A CN 104906373A CN 201510295110 A CN201510295110 A CN 201510295110A CN 104906373 A CN104906373 A CN 104906373A
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Abstract
The invention discloses medicine for treating the stenocardia type coronary heart disease. The raw materials of the medicine include, by weight, 4-6 parts of anoectochilus formosanus, 8-12 parts of cinnamon, 8-12 parts of salvia miltiorrhiza, 4-6 parts of polygonum cuspidatum, 6-8 parts of black blood wine, 4-6 parts of seabuckthorn, 4-6 parts of fructus aurantii immaturus, 15-24 parts of tartary buckwheat, 12-18 parts of hovenia dulcis thumb, 3-4 parts of pomegranate seed and 3-4 parts of chondroitin sulfate. According to the medicine for treating the stenocardia type coronary heart disease, all the ingredients are in cooperation to play the synergistic effect. The coronary artery can be expanded, the blood flow of the coronary artery can be increased, the myocardium oxygen consumption condition can be improved, stenocardia and the expanding or pressing feeling of the precordium can be obviously relieved or removed, arrhythmia is relieved or eliminated, and peripheral circulation is improved. The medicine has prominent effects on treating the stenocardia type coronary heart disease.
Description
Technical field
The invention belongs to medical art, be specially a kind of medicine for the treatment of angina pectoris coronary heart disease and preparation method thereof.
Background technology
Coronary atherosclerotic heart disease is coronary artery generation atherosclerotic lesion and causes lumen of vessels stenosis or occlusion, causes myocardial ischemia, anoxia or downright bad and heart disease that is that cause, is usually called as " coronary heart disease ".But the scope of coronary heart disease may be more extensive, also comprises inflammation, thromboembolism etc. and cause luminal stenosis or obturation.Coronary heart disease is divided into 5 large classes by World Health Organization (WHO): silent ischemia (latent coronary heart disease), angina pectoris, myocardial infarction, ischemic heart failure (ischemic heart desease) and sudden death 5 kinds of Clinical types.Stable coronary heart disease and acute coronary syndrome is usually divided in clinical.
Summary of the invention
The object of this invention is to provide a kind of medicine for the treatment of angina pectoris coronary heart disease and preparation method thereof.
The medicine for the treatment of angina pectoris coronary heart disease of the present invention; Be made up of the raw material of following parts by weight: Herba Anoectochili roxburghii 4 ~ 6 parts, Cortex Cinnamomi 8 ~ 12 parts, Radix Salviae Miltiorrhizae 8 ~ 12 parts, Rhizoma Polygoni Cuspidati 4 ~ 6 parts, Caulis mucunae Macrocarpae 6 ~ 8 parts,
Fructus Hippophae 4 ~ 6 parts, Fructus Aurantii Immaturus 4 ~ 6 parts, Radix Et Rhizoma Fagopyri Tatarici 15 ~ 24 parts, Semen Hoveniae (Fructus Hoveniae) 12 ~ 18 parts, Semen Granati 3 ~ 4 parts, chondroitin sulfate 3 ~ 4 parts.
As optimization, the medicine of this treatment angina pectoris coronary heart disease, is made up of the raw material of following parts by weight: Herba Anoectochili roxburghii 5 parts, Cortex Cinnamomi 11 parts, Radix Salviae Miltiorrhizae 11 parts, Rhizoma Polygoni Cuspidati 5 parts, Caulis mucunae Macrocarpae 7 parts, Fructus Hippophae 5.5 parts, Fructus Aurantii Immaturus 5 parts, Radix Et Rhizoma Fagopyri Tatarici 18 parts, Semen Hoveniae (Fructus Hoveniae) 13 parts, Semen Granati 3.5 parts, chondroitin sulfate 3.2 parts.
Prepare the method for this treatment angina pectoris coronary heart disease medicine, comprise the following steps:
A, by the Fructus Hippophae of described parts by weight, Fructus Aurantii Immaturus, Radix Et Rhizoma Fagopyri Tatarici, Semen Hoveniae (Fructus Hoveniae) mixing, add Chinese medicine grinder pulverize; According to solid-liquid ratio 1:8, add 60% ethanol, Extracting temperature 67 DEG C, supersonic frequency 40kHz ultrasonic power 80W, 4 hours extraction times, filter, obtain filtrate;
B, by the Herba Anoectochili roxburghii of described parts by weight, Cortex Cinnamomi, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Caulis mucunae Macrocarpae, make 200 order powder; According to solid-liquid ratio 1:9, decoct with water secondary, each 2 hours, filter, merging filtrate;
C, the filtrate in step a and the filtrate in step b to be merged, be condensed into the thick paste that relative density is 1.30 ~ 1.35 (20 DEG C);
D, by the Semen Granati of described parts by weight, chondroitin sulfate, make 400 order powder; With the thick paste mixing in step c, incapsulate after dry, pulverize.
In this medicament composing prescription, Herba Anoectochili roxburghii clearing away heat and cooling blood, removing dampness and detoxicating, Yin Yang balancing, strengthening the body resistance, the function that yin yang complementarity, skin care of promoting the production of body fluid, QI and blood regulating, the five internal organs, foster longevity prolong life.Cortex Cinnamomi complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Radix Salviae Miltiorrhizae has stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire, for menoxenia, and amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.Rhizoma Polygoni Cuspidati is used for jaundice due to damp-heat, and stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus, burn due to hot liquid or fire, amenorrhea, lump in the abdomen, instep plays damage, cough due to lung-heat.Fructus Hippophae sour-puckery flavor warm in nature, has promoting blood circulation to remove blood stasis, effect of the chest stuffiness relieving that reduces phlegm, promoting the production of body fluid to quench thirst, clearing away heat to stop diarrhea, cures mainly the diseases such as traumatic injury, lung abscess, cough with copious phlegm, dyspnea, dyspepsia, high thermal burn the moon, enteritis and dysentery, stomachache, amenorrhea.Caulis mucunae Macrocarpae is enriched blood and is invigorated blood circulation; Clearing away lung-heat and moistening for dryness; Dredge the meridian passage.Main anemia; Have through uncomfortable; Lung-heat type cough; Hemoptysis; Soreness of waist and knee joint; Rheumatic arthralgia; Numb hand and foot; Paralysis.Fructus Aurantii Immaturus dispelling the stagnated QI, loose painful abdominal mass, rushes down expectorant, removing food stagnancy; Control distension and fullness of the chest and abdomen, the thoracic obstruction, painful abdominal mass pain, accumulation of phlegm in the hypochondrium, edema, food stagnation, constipation, gastroptosis, uterine prolapse, proctoptosis.Semen Granati has antioxidation, strengthening blood vessel wall, reduces blood fat, anti-bacteria and growth of cancer cells and digestive function.Wind pain that Radix Et Rhizoma Fagopyri Tatarici can be calmed the nerves, the wide intestinal of lively atmosphere blood, sending down the abnormal ascending QI, heat clearing away are swollen, long-pendingization of dispelling are stagnant, bowel relieving, intestine moistening, relieving constipation, cough-relieving, relieving asthma, antiinflammatory, antiallergic, heart tonifying, fat-reducing, the effect such as beauty treatment.Semen Hoveniae (Fructus Hoveniae) clearing away heat and promoting diuresis, cough-relieving relieving restlessness, alcoholic intoxication.For calentura excessive thirst, singultus, vomiting, dysuria, alcoholism.Chondroitin sulfate can lipid and lipoprotein in purged body inner blood, removes the cholesterol of heart, prevents and treats atherosclerosis, and increases lipid and fatty acid at intracellular conversion ratio.
The present invention treats the medicine of angina pectoris coronary heart disease, is made by special process, has at utmost played the synergism of each component; Can effective coronary artery dilator, increase coronary artery blood flow, improve myocardial oxygen consumption situation, can obviously alleviate or eliminate angina pectoris and precordial fullness is swollen or sense of compression; Alleviate or eliminate arrhythmia; Improve peripheral circulation.For treatment angina pectoris coronary heart disease, there is outstanding curative effect.
Pertinent clinical data is as follows:
Physical data: male 53 example in 82 routine angina pectoris coronary heart disease patients, women 29 example, 32 ~ 65 years old age, average 50 years old.Wherein middle exertional angina pectoris is 42 examples, and spontaneous angina is 22 examples, and mixed type angina is 18 examples.82 routine angina pectoris coronary heart disease patients are divided into matched group and treatment group, often organize 41 people, the basic documents such as the age between two groups, sex and medical history.There is no significant difference (Pl<0.05).There is comparability.
Method: the oral sorbitrate tablet of matched group patient, every day 3 times, each 10mg.Treatment group takes each 3 of the embodiment of the present invention 1 Chinese medicine capsule, every day 3 times.Treat after one month, observe the therapeutic effect of two groups of patients.
Curative effect judging standard: 1. effective: angina pectoris disappears completely, blood pressure drops, heart rate decline, and apex is not heard and noise, the untoward reaction such as no headache, hypotension, tachycardia; 2. effective: angina pectoris attacks number of times reduces but do not disappear completely, and slight Hypertension, heart rate are fast, can tolerate drug-induced headache untoward reaction; 3. invalid: after medication, symptom, sign are without improvement, angina pectoris attacks number of times is without minimizing, and angina pectoris attacks number of times, pain degree, persistent period were higher than in the past.Efficacy result is in table 1.
Detailed description of the invention
The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.
Embodiment 1, a, by Fructus Hippophae 5.5 kilograms, Fructus Aurantii Immaturus 5 kilograms, Radix Et Rhizoma Fagopyri Tatarici 18 kilograms, Semen Hoveniae (Fructus Hoveniae) 13 kilograms mixing, add absolute sincerity medicine Wk-800A high speed disintegrator and pulverize; According to solid-liquid ratio 1:8, add 60% ethanol, Extracting temperature 67 DEG C, supersonic frequency 40kHz ultrasonic power 80W, 4 hours extraction times, filter, obtain filtrate;
B, by Herba Anoectochili roxburghii 5 kilograms, Cortex Cinnamomi 11 kilograms, Radix Salviae Miltiorrhizae 11 kilograms, Rhizoma Polygoni Cuspidati 5 kilograms, Caulis mucunae Macrocarpae 7 kilograms, make 200 order powder; According to solid-liquid ratio 1:9, decoct with water secondary, each 2 hours, filter, merging filtrate;
C, the filtrate in step a and the filtrate in step b to be merged, be condensed into the thick paste that relative density is 1.30 ~ 1.35 (20 DEG C);
D, by Semen Granati 3.5 kilograms, chondroitin sulfate 3.2 kilograms, make 400 order powder; With the thick paste mix homogeneously in step c, after dry, pulverize, incapsulate according to 0.62 gram one.
Embodiment 2, a, by Fructus Hippophae 4 kilograms, Fructus Aurantii Immaturus 4 kilograms, Radix Et Rhizoma Fagopyri Tatarici 15 kilograms, Semen Hoveniae (Fructus Hoveniae) 12 kilograms mixing, add absolute sincerity medicine Wk-800A high speed disintegrator and pulverize; According to solid-liquid ratio 1:8, add 60% ethanol, Extracting temperature 67 DEG C, supersonic frequency 40kHz ultrasonic power 80W, 4 hours extraction times, filter, obtain filtrate;
B, by Herba Anoectochili roxburghii 4 kilograms, Cortex Cinnamomi 8 kilograms, Radix Salviae Miltiorrhizae 8 kilograms, Rhizoma Polygoni Cuspidati 4 kilograms, Caulis mucunae Macrocarpae 6 kilograms, make 200 order powder; According to solid-liquid ratio 1:9, decoct with water secondary, each 2 hours, filter, merging filtrate;
C, the filtrate in step a and the filtrate in step b to be merged, be condensed into the thick paste that relative density is 1.30 ~ 1.35 (20 DEG C);
D, by Semen Granati 3 kilograms, chondroitin sulfate 3 kilograms, make 400 order powder; With the thick paste mixing in step c, after dry, pulverize, incapsulate according to 0.62 gram one.
Embodiment 3, a, by Fructus Hippophae 6 kilograms, Fructus Aurantii Immaturus 6 kilograms, Radix Et Rhizoma Fagopyri Tatarici 24 kilograms, Semen Hoveniae (Fructus Hoveniae) 18 kilograms mixing, add absolute sincerity medicine Wk-800A high speed disintegrator and pulverize; According to solid-liquid ratio 1:8, add 60% ethanol, Extracting temperature 67 DEG C, supersonic frequency 40kHz ultrasonic power 80W, 4 hours extraction times, filter, obtain filtrate;
B, by Herba Anoectochili roxburghii 6 kilograms, Cortex Cinnamomi 12 kilograms, Radix Salviae Miltiorrhizae 12 kilograms, Rhizoma Polygoni Cuspidati 6 kilograms, Caulis mucunae Macrocarpae 8 kilograms, make 200 order powder; According to solid-liquid ratio 1:9, decoct with water secondary, each 2 hours, filter, merging filtrate;
C, the filtrate in step a and the filtrate in step b to be merged, be condensed into the thick paste that relative density is 1.30 ~ 1.35 (20 DEG C);
D, by Semen Granati 4 kilograms, chondroitin sulfate 4 kilograms, make 400 order powder; With the thick paste mixing in step c, after dry, pulverize, incapsulate according to 0.62 gram one.
Claims (3)
1. treat the medicine of angina pectoris coronary heart disease for one kind; It is characterized in that being made up of the raw material of following parts by weight: Herba Anoectochili roxburghii 4 ~ 6 parts, Cortex Cinnamomi 8 ~ 12 parts, Radix Salviae Miltiorrhizae 8 ~ 12 parts, Rhizoma Polygoni Cuspidati 4 ~ 6 parts, Caulis mucunae Macrocarpae 6 ~ 8 parts, Fructus Hippophae 4 ~ 6 parts, Fructus Aurantii Immaturus 4 ~ 6 parts, Radix Et Rhizoma Fagopyri Tatarici 15 ~ 24 parts, Semen Hoveniae (Fructus Hoveniae) 12 ~ 18 parts, Semen Granati 3 ~ 4 parts, chondroitin sulfate 3 ~ 4.
2. treat the medicine of angina pectoris coronary heart disease according to claim 1, it is characterized in that being made up of the raw material of following parts by weight: Herba Anoectochili roxburghii 5 parts, Cortex Cinnamomi 11 parts, Radix Salviae Miltiorrhizae 11 parts, Rhizoma Polygoni Cuspidati 5 parts, Caulis mucunae Macrocarpae 7 parts, Fructus Hippophae 5.5 parts, Fructus Aurantii Immaturus 5 parts, Radix Et Rhizoma Fagopyri Tatarici 18 parts, Semen Hoveniae (Fructus Hoveniae) 13 parts, Semen Granati 3.5 parts, chondroitin sulfate 3.2 parts.
3. prepare a method for the treatment of angina pectoris coronary heart disease medicine described in claim 1, it is characterized in that comprising the following steps:
A, by the Fructus Hippophae of described parts by weight, Fructus Aurantii Immaturus, Radix Et Rhizoma Fagopyri Tatarici, Semen Hoveniae (Fructus Hoveniae) mixing, add Chinese medicine grinder pulverize; According to solid-liquid ratio 1:8, add 60% ethanol, Extracting temperature 67 DEG C, supersonic frequency 40kHz ultrasonic power 80W, 4 hours extraction times, filter, obtain filtrate;
B, by the Herba Anoectochili roxburghii of described parts by weight, Cortex Cinnamomi, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Caulis mucunae Macrocarpae, make 200 order powder; According to solid-liquid ratio 1:9, decoct with water secondary, each 2 hours, filter, merging filtrate;
C, the filtrate in step a and the filtrate in step b to be merged, be condensed into the thick paste that relative density is 1.30 ~ 1.35 (20 DEG C);
D, by the Semen Granati of described parts by weight, chondroitin sulfate, make 400 order powder; With the thick paste mixing in step c, dry.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105125857A (en) * | 2015-10-09 | 2015-12-09 | 宋振民 | Tablets for treating angina pectoris coronary disease and preparing method thereof |
| WO2020119453A1 (en) * | 2018-12-11 | 2020-06-18 | 山东理工大学 | Cardioprotective botanical herbal formulation for preventing and alleviating coronary disease |
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| CN100998859A (en) * | 2007-01-09 | 2007-07-18 | 侍界 | Chinese medicine for treating obstruction of qi in the chest and its preparation method |
| CN104474490A (en) * | 2014-11-07 | 2015-04-01 | 弋江涛 | Traditional Chinese medicine liquor for treating angina pectoris |
| CN104623589A (en) * | 2014-12-28 | 2015-05-20 | 张巧红 | Chinese medicinal spirit for treating angina pectoris |
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2015
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100998859A (en) * | 2007-01-09 | 2007-07-18 | 侍界 | Chinese medicine for treating obstruction of qi in the chest and its preparation method |
| CN104474490A (en) * | 2014-11-07 | 2015-04-01 | 弋江涛 | Traditional Chinese medicine liquor for treating angina pectoris |
| CN104623589A (en) * | 2014-12-28 | 2015-05-20 | 张巧红 | Chinese medicinal spirit for treating angina pectoris |
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| 王培利: "《冠心病自我调养》", 30 November 2009, 科学技术文献出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105125857A (en) * | 2015-10-09 | 2015-12-09 | 宋振民 | Tablets for treating angina pectoris coronary disease and preparing method thereof |
| WO2020119453A1 (en) * | 2018-12-11 | 2020-06-18 | 山东理工大学 | Cardioprotective botanical herbal formulation for preventing and alleviating coronary disease |
| CN111298074A (en) * | 2018-12-11 | 2020-06-19 | 山东理工大学 | A cardioprotective herbal preparation for preventing and improving coronary heart disease |
| US11077162B2 (en) | 2018-12-11 | 2021-08-03 | Shandong University Of Technology | Heart-protective plant preparation for preventing and improving coronary heart disease |
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Application publication date: 20150916 |
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