CN105125857A - Tablets for treating angina pectoris coronary disease and preparing method thereof - Google Patents
Tablets for treating angina pectoris coronary disease and preparing method thereof Download PDFInfo
- Publication number
- CN105125857A CN105125857A CN201510646741.1A CN201510646741A CN105125857A CN 105125857 A CN105125857 A CN 105125857A CN 201510646741 A CN201510646741 A CN 201510646741A CN 105125857 A CN105125857 A CN 105125857A
- Authority
- CN
- China
- Prior art keywords
- radix
- weight portion
- mastic
- herba
- ruscifoliae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses tablets for treating the angina pectoris coronary disease and a preparing method thereof. The tablets are prepared from nitroglycerin, aspirin, cynanchum mooreanum, rhizoma Tupistrae chinensis, ficus esquiroliana, roots of shrubberry rhodiola, Indian damnacanthus herbs, embelia parviflora, illicium verum, arisaema fargesii, dog penises, sealwort, pyrola, wedelia urticifolia DC, radix Cudramiae, fragrant sarcococca herbs, radix paeoniae alba and roots of three-nerved spicebush. The tablets have the advantages of being capable of tonifying qi, replenishing blood, warming yang, tonifying kidney and activating meridians to stop pain, capable of treating the angina pectoris coronary disease scientifically through traditional Chinese medicine and western medicine combination, good in treatment effect, and capable of becoming effective quickly, reducing the occurrence rate of relapse and reducing side effects greatly.
Description
Technical field
The present invention relates to medical art, particularly a kind of tablet for the treatment of angina pectoris coronary heart disease and preparation method thereof.
Background technology
Coronary heart disease, refers to because lipid metabolism is abnormal, and the lipid in blood is calm on the endarterium of otherwise smooth, piles up and forms white speckle, be called atherosclerotic lesion at the lipid material of some similar medicated porridge samples of endarterium.These specklees gradually increase and cause lumen of artery narrow, blood flow is obstructed, causes heart ischemia, produce angina pectoris.
Angina pectoris: on the basis of coronary stricture, the increase due to myocardial muscle load cause cardiac muscle sharply, the clinical syndrome of of short duration ischemia and anoxia.
Symptom: with ictal chest pain for main clinical manifestation.Classical angina outbreak has following characteristics: (1) outbreak inducement: the most common is physical work or movable excessive, and be secondly excited, smoking, heavy meal, cold also can be brought out.The outbreak of pain is in inducements such as labours at that time, but not after labour.(2) painful area: typical position be on breastbone, rear, stage casing, scope is about hand size, and boundary line is very unclear.Pain can be radiated to inside left shoulder, left upper extremity and reach little finger of toe and fourth finger, maybe can reach neck, lower jaw part.(3) characteristic of pain: be squeezing property, austerity, can with sensation of asphyxia or dying fear.(4) persistent period: the time remaining 3-5min of general angina pectoris attacks, rarely exceeds 15min.(5) sign: sign during angina pectoris attacks can have pale complexion, is in a cold sweat, blood pressure rising, increased heart rate, apical region of heart decreased loudness of first sound, or there is gallop rhythm etc.(6) mode is alleviated: after stopping action or having a rest, and sublingual administration nitroglycerin, pain can be alleviated rapidly in 1-3min.
Due to simple western medical treatment mode, the toxicity of chemicals is too large, thus causes certain secondary accumulation of irreversible poison to patient, and there is certain recurrent and ageing, can symptom management be reached in short time, cannot fundamentally alleviate and disease therapy.Therefore, how better treating angina pectoris coronary heart disease, is the problem to be solved in the present invention.
Summary of the invention
In order to achieve the above object, a kind of tablet for the treatment of angina pectoris coronary heart disease and preparation method thereof is provided.
In order to realize foregoing invention object, the invention provides a kind of tablet for the treatment of angina pectoris coronary heart disease, wherein, described tablet comprises following raw material: described tablet comprises following raw material: nitroglycerin, aspirin, Radix Tylophorae arenicolae, Rhizoma Tupistrae Chinensis, Ficus fulva Reinw., Radix Rhodiolae Dumulosae, Herba Damnacanthi, Radix seu Caulis Embeliae Parviflorae, Fructus Anisi Stellati, Eriocheir sinensis seven, Testis et Pentis Canis, Rhizoma Polygonati, Herba Pyrolae, root of bleeding, Radix Cudraniae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), the Radix Paeoniae Alba and the Radix Linderae.
Wherein, the ratio of weight and number of described raw material is: nitroglycerin 0.01-0.05 weight portion, aspirin 1-2 weight portion, Radix Tylophorae arenicolae 5-10 weight portion, Rhizoma Tupistrae Chinensis 10-15 weight portion, Ficus fulva Reinw. 4-8 weight portion, Radix Rhodiolae Dumulosae 10-15 weight portion, Herba Damnacanthi 5-9 weight portion, Radix seu Caulis Embeliae Parviflorae 10-15 weight portion, Fructus Anisi Stellati 5-8 weight portion, Eriocheir sinensis seven 10-15 weight portion, Testis et Pentis Canis 3-7 weight portion, Rhizoma Polygonati 8-14 weight portion, Herba Pyrolae 10-15 weight portion, to bleed root 5-10 weight portion, Radix Cudraniae 6-12 weight portion, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 10-15 weight portion, Radix Paeoniae Alba 6-15 weight portion and Radix Linderae 10-20 weight portion.
Wherein, the ratio of weight and number of described raw material is: nitroglycerin 0.03 weight portion, aspirin 1 weight portion, Radix Tylophorae arenicolae 8 weight portion, Rhizoma Tupistrae Chinensis 12 weight portion, Ficus fulva Reinw. 6 weight portion, Radix Rhodiolae Dumulosae 12 weight portion, Herba Damnacanthi 7 weight portion, Radix seu Caulis Embeliae Parviflorae 12 weight portion, Fructus Anisi Stellati 6 weight portion, Eriocheir sinensis 7 12 weight portion, Testis et Pentis Canis 5 weight portion, Rhizoma Polygonati 10 weight portion, Herba Pyrolae 12 weight portion, root 7 weight portion of bleeding, Radix Cudraniae 8 weight portion, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 12 weight portion, the Radix Paeoniae Alba 12 weight portion and the Radix Linderae 15 weight portion.
In order to achieve the above object, present invention also offers the preparation method of described tablet, wherein, its preparation method comprises the following steps:
The first step, Radix Tylophorae arenicolae, Rhizoma Tupistrae Chinensis and Ficus fulva Reinw. are mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, Radix Rhodiolae Dumulosae, Herba Damnacanthi, Radix seu Caulis Embeliae Parviflorae, Fructus Anisi Stellati, Eriocheir sinensis seven, Testis et Pentis Canis, Rhizoma Polygonati, Herba Pyrolae, root of bleeding, Radix Cudraniae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), the Radix Paeoniae Alba and the Radix Linderae are mixed in proportion, add relative to mixture 3 ~ 5 times of water gagings, boil 2 ~ 4 hours, filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, adds nitroglycerin, aspirin and starch and carries out mixing process, obtain mastic mixture by described dried cream powder; The addition of described starch is dried cream powder 0.1-0.5 times amount; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain tablet; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.
The invention has the beneficial effects as follows: this tablet has the effect of vigorate qi and replenish the blood, temperature male wind-supplying kidney, removing obstruction in the collateral to relieve pain, by Chinese and western medicine geometry, reach the object of Scientific Treatment angina pectoris coronary heart disease, therapeutic effect is good, instant effect, not easily recurs, and greatly reduces toxic and side effects.
Detailed description of the invention
In order to achieve the above object, the invention provides a kind of tablet for the treatment of angina pectoris coronary heart disease, wherein, following raw material is comprised: nitroglycerin, aspirin, Radix Tylophorae arenicolae, Rhizoma Tupistrae Chinensis, Ficus fulva Reinw., Radix Rhodiolae Dumulosae, Herba Damnacanthi, Radix seu Caulis Embeliae Parviflorae, Fructus Anisi Stellati, Eriocheir sinensis seven, Testis et Pentis Canis, Rhizoma Polygonati, Herba Pyrolae, root of bleeding, Radix Cudraniae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), the Radix Paeoniae Alba and the Radix Linderae.
Wherein, the main pharmacological of nitroglycerin is lax vascular smooth muscle.Nitroglycerin release nitrogen oxide (NO), NO is identical with endothelium relaxation, activates guanylate cyclase, smooth muscle and other in-house cyclic guanylic acids (cGMP) are increased, cause myosin light chain dephosphorylation, regulate smooth muscle contraction state, cause vasodilation.Nitroglycerin expansion artery and vein vascular bed, based on expansion of veins, its action intensity is dosage correlation.Peripheral vein is expanded, and makes blood retention in periphery, and returned blood volume reduces, and left ventricular end diastolic presssure (preload) reduces.Expansion artery makes Peripheral resistance (afterload) reduce.
Aspirin pharmaceutical efficacy kinetics: 1. analgesic activity: mainly by suppress prostaglandin and other the pain sensation can be made the synthesis of the material (as Kallidin I, histamine) of mechanicalness or chemical irritation sensitivity, belong to periphery property analgesic.But the probability of central analgesia (may hypothalamus be acted on) can not be got rid of; 2. antiinflammation; Definite mechanism it be unclear that, inflammatory tissue may be acted on due to these product, can cause the synthesis of the material (as histamine) of inflammatory reaction by suppression prostaglandin or other and play antiinflammation, the release of suppression lysosomal enzyme and leukocyte vigor etc. also may be relevant with it; 3. refrigeration function: peripheral blood vessel can be caused to expand by acting on hypothalamus thermotaxic centre, SkBF increases, perspire, heat radiation is increased and a refrigeration function, and this kind of central effect may be suppressed relevant in the synthesis of hypothalamus with prostaglandin; 4. anti rheumatism action: the antiheumatic mechanism of these product, except antipyretic, analgesic activity, is mainly antiinflammation; 5. to the inhibitory action of platelet aggregation: be by suppressing hematoblastic prostaglandin epoxidase thus preventing the generation of TXA2. and work (TXA2 can impel platelet aggregation).This act as irreversibility.
In addition, Radix Tylophorae arenicolae, Rhizoma Tupistrae Chinensis, Ficus fulva Reinw. QI invigorating; Radix Rhodiolae Dumulosae, Herba Damnacanthi, Radix seu Caulis Embeliae Parviflorae are enriched blood; Fructus Anisi Stellati, Eriocheir sinensis seven, Testis et Pentis Canis warming YANG; Rhizoma Polygonati, Herba Pyrolae the kidney invigorating; To bleed root, Radix Cudraniae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) dredging collateral; The Radix Paeoniae Alba, Radix Linderae pain relieving.Each taste raw material scientific matching, reaches the object for the treatment of angina pectoris coronary heart disease.
The pharmacology being respectively raw medicinal material is as follows:
Radix Tylophorae arenicolae: [nature and flavor] are pungent is flat.1. " vegetation is side just ": " pungent, temperature." 2. " Shaanxi Chinese herbal medicine ": " sweet in the mouth is micro-pungent, and property is put down." [function cures mainly] the kidney invigorating, spleen invigorating, removing toxic substances.Control chronic consumptive disease chronic cough, edema, leucorrhea, menoxenia, scrofula, skin ulcer scabies.1. " vegetation is side just ": " tonification reinforcing YIN-essence, removing toxic substances.The labor that cures the wound chronic cough, edema due to deficiency, infections labor, Serpentis, worm, mad dog wound." 2. " classifying herbal ": " pastes son of itching, loose poison, and logical hernia, only nose bleeding, control woman leucorrhea dizzy, is coated with scabies." 3. " conventional glossary of Herbs and Drugs among the people ": " relieves the pain, and detoxification, controls scrofula, stimulating milk secretion, cough-relieving." 4. " Shaanxi Chinese herbal medicine ": " enriching yin and nourishing kidney, invigorating the spleen and benefiting QI, regulating menstruation and activating blood.Control menoxenia, deficiency of YIN leucorrhea."
Rhizoma Tupistrae Chinensis: [nature and flavor] " Shaanxi Chinese herbal medicine ": " sweet and slightly bitter taste, cold in nature." [function cures mainly] nourishing yin and purging fire, promoting blood flow to regulate menstruation.Control consumptive fever cough, rheumatic arthralgia, menoxenia, traumatic injury.1. " Shaanxi Chinese herbal medicine ": " except rheumatism, clearing away heat-fire, pain easing and hemostasis, regulating menstruation and activating blood, YIN nourishing tonify deficiency.Treating rheumatic arthritis, lumbago and skelalgia, traumatic injury, impairment caused by overstrain, menoxenia, hectic fever due to YIN-deficiency consumptive fever." 2. " Chengdu Chinese herbal medicine ": " benefiting QI for activating blood circulation, lung heat clearing, removing toxic substances."
Ficus fulva Reinw.: [nature and flavor] are sweet is flat.[function cures mainly] invigorating the spleen and benefiting QI, promoting blood circulation by removing wind.Curing mainly deficient qi and blood, uterine prolapse, proctoptosis, edema, rheumatic arthralgia, has loose bowels in loose stool.
Radix Rhodiolae Dumulosae: [nature and flavor] sweet puckery micro-hardship, temperature.[function cures mainly] the kidney invigorating, tranquilizing by nourishing the heart, regulating menstruation and activating blood, improving eyesight.
Herba Damnacanthi: [nature and flavor] are sweet, bitter is flat.[function cures mainly] expelling wind and removing dampness, promoting blood circulation and stopping pain.For hepatitis, bones and muscles pain due to rheumatism, traumatic injury, caries pain.
Radix seu Caulis Embeliae Parviflorae: [nature and flavor] are pained, temperature.1. Guangzhou air force " conventional Chinese herbal medicine handbook ": " puckery micro-hardship, flat." 2. " choosing of Simao, Yunnan Chinese herbal medicine ": " is pained, temperature." [function cures mainly] promoting blood circulation to remove blood stasis, replenishing kidney, strengthening waist.Control menoxenia, amenorrhea, anemia, traumatic injury, fracture.
Anistree meat or fish is fragrant: [nature and flavor] are pungent, temperature.[return through] returns liver,kidney,spleen, stomach warp.[function cures mainly] warming YANG to expel cold, regulating QI to relieve pain.
Eriocheir sinensis seven: [nature and flavor] are sweet, temperature.[function cures mainly] temperature male wind-supplying kidney, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling.
Testis et Pentis Canis: [nature and flavor] sweet in the mouth; Salty; Warm in nature.[return through] kidney channel.[function cures mainly] the kidney invigorating warming YANG.
Rhizoma Polygonati: [nature and flavor] are sweet is flat.[return through] returns spleen, lung, kidney channel.[function cures mainly] boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.
Herba Pyrolae: [nature and flavor] sweetness and bitterness, temperature.[return through] " Zhiwu Mingshi Tukao ": " enter liver, kidney two warp." expelling wind and removing dampness, promoting blood flow to regulate menstruation, controls weak cough, over-strained hemoptysis, rheumatic arthritis, metrorrhagia, leucorrhea, traumatic hemorrhage for [function cures mainly] tonify deficiency, kidney tonifying.
To bleed root: [nature and flavor] are sweet, warm.[function cures mainly] warming the meridian, dredging collateral, nourishes blood, and invigorates blood circulation, the kidney invigorating.
Radix Cudraniae: [nature and flavor] are lightly seasoned; Micro-hardship; Cool in nature.[function cures mainly] dispelling wind and removing obstruction in the collateral; Removing damp-heat; Removing toxic substances and promoting subsidence of swelling.
Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae): [nature and flavor] work hard is flat.[function cures mainly] dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain.
The Radix Paeoniae Alba: [nature and flavor] are bitter, sour, are slightly cold.[return through] returns liver, spleen channel.The pain relieving of [function cures mainly] suppressing the hyperactive liver, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
The Radix Linderae: [nature and flavor] are pungent, temperature.[return through] returns lung, spleen, kidney, urinary bladder channel.[function cures mainly] pleasant pain relieving, warming kidney for dispelling cold.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1
Prescription: nitroglycerin 0.03g, aspirin 1g, Radix Tylophorae arenicolae 5g, Rhizoma Tupistrae Chinensis 10g, Ficus fulva Reinw. 4g, Radix Rhodiolae Dumulosae 10g, Herba Damnacanthi 5g, Radix seu Caulis Embeliae Parviflorae 10g, Fructus Anisi Stellati 5g, Eriocheir sinensis seven 10g, Testis et Pentis Canis 3g, Rhizoma Polygonati 8g, Herba Pyrolae 10g, the root 5g that bleeds, Radix Cudraniae 6g, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 10g, Radix Paeoniae Alba 6g and Radix Linderae 10g.
Its preparation process is:
The first step, mixes Radix Tylophorae arenicolae, Rhizoma Tupistrae Chinensis and Ficus fulva Reinw., add relative to mixture 3 times amount determining alcohol be 55% alcohol reflux 2 times, each 2 hours, filter, filtrate merges, and reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30, for subsequent use;
Second step, Radix Rhodiolae Dumulosae, Herba Damnacanthi, Radix seu Caulis Embeliae Parviflorae, Fructus Anisi Stellati, Eriocheir sinensis seven, Testis et Pentis Canis, Rhizoma Polygonati, Herba Pyrolae, root of bleeding, Radix Cudraniae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), the Radix Paeoniae Alba and the Radix Linderae are mixed in proportion, add relative to mixture 3 times of water gagings, boil 2 hours, filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, adds nitroglycerin, aspirin and starch and carries out mixing process, obtain mastic mixture by described dried cream powder; The addition of described starch is dried cream powder 0.1 times amount; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain tablet; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 1: 0.15.
Embodiment 2
Prescription: nitroglycerin 0.05g, aspirin 2g, Radix Tylophorae arenicolae 10g, Rhizoma Tupistrae Chinensis 15g, Ficus fulva Reinw. 8g, Radix Rhodiolae Dumulosae 15g, Herba Damnacanthi 9g, Radix seu Caulis Embeliae Parviflorae 15g, Fructus Anisi Stellati 8g, Eriocheir sinensis seven 15g, Testis et Pentis Canis 7g, Rhizoma Polygonati 14g, Herba Pyrolae 15g, the root 10g that bleeds, Radix Cudraniae 12g, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 15g, Radix Paeoniae Alba 15g and Radix Linderae 20g.
Its preparation process is:
The first step, mixes Radix Tylophorae arenicolae, Rhizoma Tupistrae Chinensis and Ficus fulva Reinw., add relative to mixture 3 times ~ 5 times amount determining alcohol be 65% alcohol reflux 4 times, each 3 hours, filter, filtrate merges, and reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, for subsequent use;
Second step, Radix Rhodiolae Dumulosae, Herba Damnacanthi, Radix seu Caulis Embeliae Parviflorae, Fructus Anisi Stellati, Eriocheir sinensis seven, Testis et Pentis Canis, Rhizoma Polygonati, Herba Pyrolae, root of bleeding, Radix Cudraniae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), the Radix Paeoniae Alba and the Radix Linderae are mixed in proportion, add relative to mixture 5 times of water gagings, boil 4 hours, filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 65 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, adds nitroglycerin, aspirin and starch and carries out mixing process, obtain mastic mixture by described dried cream powder; The addition of described starch is dried cream powder 0.5 times amount; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain tablet; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 3: 0.3.
Embodiment 3
Prescription: nitroglycerin 0.03g, aspirin 1g, Radix Tylophorae arenicolae 8g, Rhizoma Tupistrae Chinensis 12g, Ficus fulva Reinw. 6g, Radix Rhodiolae Dumulosae 12g, Herba Damnacanthi 7g, Radix seu Caulis Embeliae Parviflorae 12g, Fructus Anisi Stellati 6g, Eriocheir sinensis seven 12g, Testis et Pentis Canis 5g, Rhizoma Polygonati 10g, Herba Pyrolae 12g, the root 7g that bleeds, Radix Cudraniae 8g, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 12g, Radix Paeoniae Alba 12g and Radix Linderae 15g.
Its preparation process is:
The first step, mixes Radix Tylophorae arenicolae, Rhizoma Tupistrae Chinensis and Ficus fulva Reinw., add relative to mixture 4 times amount determining alcohol be 60% alcohol reflux 3 times, each 2 hours, filter, filtrate merges, and reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, for subsequent use;
Second step, Radix Rhodiolae Dumulosae, Herba Damnacanthi, Radix seu Caulis Embeliae Parviflorae, Fructus Anisi Stellati, Eriocheir sinensis seven, Testis et Pentis Canis, Rhizoma Polygonati, Herba Pyrolae, root of bleeding, Radix Cudraniae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), the Radix Paeoniae Alba and the Radix Linderae are mixed in proportion, add relative to mixture 4 times of water gagings, boil 3 hours, filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28;
3rd step, the mastic mixing that the first step, second step are obtained, 60 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, adds nitroglycerin, aspirin and starch and carries out mixing process, obtain mastic mixture by described dried cream powder; The addition of described starch is dried cream powder 0.3 times amount; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain tablet; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 2: 0.18.
Toxicity test
1. acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Being smashed to pieces tablet prepared by embodiments of the invention 1 is dissolved in water, (concentration is 8g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 40g crude drug/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>40 crude drug/kg of the present invention, every day, maximum dosage-feeding was 80 crude drugs/kg/ day.Clinical application amount of the present invention be 4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.067g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage tablet of the present invention is 597 times of quantity.Therefore tablet acute toxicity of the present invention is low, clinical drug safety.
2. cumulative toxicity test: test method: select 20 healthy mices, female, each 10 of hero, with the tablet of the embodiment of the present invention 2 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, the LD50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.Tablet of the present invention is described, does not there is cumulative toxicity.
Illustrate, tablet of the present invention, does not have toxicity, is free from side effects.
Clinical trial
Choose patient 200 example of angina pectoris coronary heart disease, age and the course of disease do not have statistical significance, do not affect the contrast of test.Now patient is divided into four groups, often organizes 50 people, embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group.
Test method
Embodiment 1 group: this group patient uses the tablet of embodiments of the invention 1 to treat.Every day 2 times, each 2, every sheet 2g, oral meal 2 months is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.
Embodiment 2 groups: patient uses the tablet of embodiments of the invention 2 to treat.Every day 2 times, each 2, every sheet 2g, oral meal 2 months is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.
Embodiment 3 groups: patient uses the tablet of embodiments of the invention 3 to treat.Every day 2 times, each 2, every sheet 2g, oral meal 2 months is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.
Matched group: patient uses clopidogrel bisulfate tablet to treat.Every day twice, each 2.Within 2 months, be a course for the treatment of, 2 courses for the treatment of are carried out in treatment.
Efficacy evaluation
Effective: angina pectoris symptom disappears.Improve: angina pectoris disappears substantially.Invalid: symptom is without improvement.Increase the weight of: panic attacks number of times, degree and persistent period increase the weight of, or angina pectoris upgrading.
Therapeutic outcome
Table 1 is the therapeutic outcome contrast of each group
| Group | Effective | Improve | Invalid | Increase the weight of |
| Embodiment 1 group | 49（98%） | 1（2%） | 0（0%） | 0（0%） |
| Embodiment 2 groups | 49（98%） | 1（2%） | 0（0%） | 0（0%） |
| Embodiment 3 groups | 49（98%） | 1（2%） | 0（0%） | 0（0%） |
| Matched group | 30（60%） | 10（20%） | 7（14%） | 3（6%） |
Can be learnt by table 1, the treatment situation of three treatment groups will be better than matched group far away.It can thus be appreciated that tablet of the present invention, treatment angina pectoris coronary heart disease, effective, curative effect is high.
Table 2 is effective recurrence contrast
| Group | Effective | Recurrence and relapse rate |
| Embodiment 1 group | 49 | 0（0%） |
| Embodiment 2 groups | 49 | 0（0%） |
| Embodiment 3 groups | 49 | 0（0%） |
| Matched group | 30 | 6（20%） |
Can be learnt by table 2, in the effective patient of three treatment groups, not occur recurrence.It can thus be appreciated that, tablet of the present invention, treatment angina pectoris coronary heart disease, effective, not easily recur.
In sum, tablet of the present invention, treatment angina pectoris coronary heart disease, therapeutic effect is good, and curative effect level is high, does not recur.
Typical case: grandson patient, man, 58 years old, suffers from angina pectoris coronary heart disease existing 2 years, takes other tablets invalid.Patient uses the tablet of embodiments of the invention 3 to treat.Every day 2 times, each 2, every sheet 2g, oral meal 2 months is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.Transference cure, in use procedure, there is not the side effect of any situation in patient, do not occur any allergic phenomena yet.Later stage follow-up is not recurred yet.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. treat the tablet of angina pectoris coronary heart disease for one kind, it is characterized in that, described tablet comprises following raw material: nitroglycerin, aspirin, Radix Tylophorae arenicolae, Rhizoma Tupistrae Chinensis, Ficus fulva Reinw., Radix Rhodiolae Dumulosae, Herba Damnacanthi, Radix seu Caulis Embeliae Parviflorae, Fructus Anisi Stellati, Eriocheir sinensis seven, Testis et Pentis Canis, Rhizoma Polygonati, Herba Pyrolae, root of bleeding, Radix Cudraniae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), the Radix Paeoniae Alba and the Radix Linderae.
2. tablet according to claim 1, it is characterized in that, the ratio of weight and number of described raw material is: nitroglycerin 0.01-0.05 weight portion, aspirin 1-2 weight portion, Radix Tylophorae arenicolae 5-10 weight portion, Rhizoma Tupistrae Chinensis 10-15 weight portion, Ficus fulva Reinw. 4-8 weight portion, Radix Rhodiolae Dumulosae 10-15 weight portion, Herba Damnacanthi 5-9 weight portion, Radix seu Caulis Embeliae Parviflorae 10-15 weight portion, Fructus Anisi Stellati 5-8 weight portion, Eriocheir sinensis seven 10-15 weight portion, Testis et Pentis Canis 3-7 weight portion, Rhizoma Polygonati 8-14 weight portion, Herba Pyrolae 10-15 weight portion, to bleed root 5-10 weight portion, Radix Cudraniae 6-12 weight portion, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 10-15 weight portion, Radix Paeoniae Alba 6-15 weight portion and Radix Linderae 10-20 weight portion.
3. tablet according to claim 1 and 2, it is characterized in that, the ratio of weight and number of described raw material is: nitroglycerin 0.03 weight portion, aspirin 1 weight portion, Radix Tylophorae arenicolae 8 weight portion, Rhizoma Tupistrae Chinensis 12 weight portion, Ficus fulva Reinw. 6 weight portion, Radix Rhodiolae Dumulosae 12 weight portion, Herba Damnacanthi 7 weight portion, Radix seu Caulis Embeliae Parviflorae 12 weight portion, Fructus Anisi Stellati 6 weight portion, Eriocheir sinensis 7 12 weight portion, Testis et Pentis Canis 5 weight portion, Rhizoma Polygonati 10 weight portion, Herba Pyrolae 12 weight portion, root 7 weight portion of bleeding, Radix Cudraniae 8 weight portion, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 12 weight portion, the Radix Paeoniae Alba 12 weight portion and the Radix Linderae 15 weight portion.
4. the tablet according to any one of claims 1 to 3, is characterized in that, its preparation method comprises the following steps:
The first step, Radix Tylophorae arenicolae, Rhizoma Tupistrae Chinensis and Ficus fulva Reinw. are mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, Radix Rhodiolae Dumulosae, Herba Damnacanthi, Radix seu Caulis Embeliae Parviflorae, Fructus Anisi Stellati, Eriocheir sinensis seven, Testis et Pentis Canis, Rhizoma Polygonati, Herba Pyrolae, root of bleeding, Radix Cudraniae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), the Radix Paeoniae Alba and the Radix Linderae are mixed in proportion, add relative to mixture 3 ~ 5 times of water gagings, boil 2 ~ 4 hours, filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, adds nitroglycerin, aspirin and starch and carries out mixing process, obtain mastic mixture by described dried cream powder; The addition of described starch is dried cream powder 0.1-0.5 times amount; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain tablet; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.
5. a preparation method for the tablet according to any one of Claims 1-4, is characterized in that, its preparation method comprises the following steps:
The first step, Radix Tylophorae arenicolae, Rhizoma Tupistrae Chinensis and Ficus fulva Reinw. are mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, Radix Rhodiolae Dumulosae, Herba Damnacanthi, Radix seu Caulis Embeliae Parviflorae, Fructus Anisi Stellati, Eriocheir sinensis seven, Testis et Pentis Canis, Rhizoma Polygonati, Herba Pyrolae, root of bleeding, Radix Cudraniae, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), the Radix Paeoniae Alba and the Radix Linderae are mixed in proportion, add relative to mixture 3 ~ 5 times of water gagings, boil 2 ~ 4 hours, filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, adds nitroglycerin, aspirin and starch and carries out mixing process, obtain mastic mixture by described dried cream powder; The addition of described starch is dried cream powder 0.1-0.5 times amount; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain tablet; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510646741.1A CN105125857A (en) | 2015-10-09 | 2015-10-09 | Tablets for treating angina pectoris coronary disease and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510646741.1A CN105125857A (en) | 2015-10-09 | 2015-10-09 | Tablets for treating angina pectoris coronary disease and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105125857A true CN105125857A (en) | 2015-12-09 |
Family
ID=54711670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510646741.1A Withdrawn CN105125857A (en) | 2015-10-09 | 2015-10-09 | Tablets for treating angina pectoris coronary disease and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105125857A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081890A (en) * | 1993-02-17 | 1994-02-16 | 中国人民解放军第二炮兵西安中医多学科研究所 | The prescription and the production method of treatment angina pectoris coronary heart disease medicine |
| CN1923260A (en) * | 2005-08-29 | 2007-03-07 | 孙思宏 | Medicine for treating coronary disease of stenocardia type and its preparation method |
| CN104138431A (en) * | 2013-05-07 | 2014-11-12 | 孙玉建 | Traditional Chinese medicine for treating angina pectoris type coronary heart disease |
| CN104906373A (en) * | 2015-06-03 | 2015-09-16 | 吴优 | Medicine for treating stenocardia type coronary heart disease and preparing method thereof |
-
2015
- 2015-10-09 CN CN201510646741.1A patent/CN105125857A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081890A (en) * | 1993-02-17 | 1994-02-16 | 中国人民解放军第二炮兵西安中医多学科研究所 | The prescription and the production method of treatment angina pectoris coronary heart disease medicine |
| CN1923260A (en) * | 2005-08-29 | 2007-03-07 | 孙思宏 | Medicine for treating coronary disease of stenocardia type and its preparation method |
| CN104138431A (en) * | 2013-05-07 | 2014-11-12 | 孙玉建 | Traditional Chinese medicine for treating angina pectoris type coronary heart disease |
| CN104906373A (en) * | 2015-06-03 | 2015-09-16 | 吴优 | Medicine for treating stenocardia type coronary heart disease and preparing method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105194565A (en) | Traditional Chinese medicine pills for treatment of cardiac neurosis and preparation method thereof | |
| CN103520572A (en) | Traditional Chinese composition used for treating atopic dermatitis as well as preparation method of composition | |
| CN102772712B (en) | Traditional Chinese medicine composition for treating heat-toxicity, flourishing and blood stasis type diabetic foot | |
| CN104147536B (en) | A kind of pharmaceutical composition treating hemorrhoid and preparation method thereof | |
| CN102218127B (en) | Traditional Chinese medicine composition for treating dysmenorrhea and preparation method thereof | |
| CN104324330A (en) | Traditional Chinese medicine composition for treating blood stasis accumulation type hysteromyoma and preparation method of the traditional Chinese medicine composition | |
| CN104043058A (en) | Traditional Chinese medicinal preparation for treating kidney deficiency type lumbar disc herniation and preparation method thereof | |
| CN103860773A (en) | Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof | |
| TWI721367B (en) | Composition for regulating endocrine, improving immunity, delaying aging and preventing or treating constipation, its application and preparation method thereof | |
| CN105106634A (en) | Traditional Chinese medicine preparation for treating acute appendicitis and application thereof | |
| CN105125857A (en) | Tablets for treating angina pectoris coronary disease and preparing method thereof | |
| CN104800524A (en) | Traditional Chinese medicine ointment for relieving muscular pain caused by anesthesia dissipation | |
| CN104352866A (en) | Traditional Chinese medicine preparation for treating fire-toxin fluid-impairment type burns and preparation method thereof | |
| CN103989969A (en) | Traditional Chinese medicament for treating wind-cold obstruction type cervical spondylotic radiculopathy and preparation method thereof | |
| CN109464565A (en) | A kind of Chinese medicine composition and its preparation for treating chest impediment and cardialgia | |
| CN104367896B (en) | A kind of pharmaceutical composition for treating Qi deficiency blood stasis type apoplexy and preparation method thereof | |
| CN103285360B (en) | Traditional Chinese medicinal preparation for treating thromboangiitis obliterans, and preparation method thereof | |
| CN107158313A (en) | A kind of medicine for preventing and treating cardiovascular and cerebrovascular and preparation method thereof | |
| CN105056073A (en) | Traditional Chinese medicine preparation for treating arrhythmia and preparing method thereof | |
| CN105362944A (en) | Traditional Chinese medicine ointment for treating orthopedics sprain and contusion | |
| CN104873858A (en) | Traditional Chinese medicine composition for treating functional dysmenorrheal | |
| CN104189195B (en) | The Traditional Chinese medicine medicated bath for the treatment of neurotic skin pruritus and preparation method | |
| CN104116882B (en) | Treat the preparation method of the medicine of hemorrhoid | |
| CN104873627A (en) | Traditional Chinese medicine for treating urticaria and preparation method thereof | |
| CN103989837A (en) | Traditional Chinese medicine composition for preventing and treating haemorrhoids and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20151209 |
|
| WW01 | Invention patent application withdrawn after publication |