CN105477556A - Medicine for treating myocardial infarction type coronary heart disease - Google Patents
Medicine for treating myocardial infarction type coronary heart disease Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a medicine for treating the myocardial infarction type coronary heart disease. The medicine is mainly prepared from, by weight, 8-12 parts of radix angelica sinensis, 10-15 parts of roots of common peony, 12-18 parts of roots of red-rooted salvia, 8-12 parts of flos carthami, 8-12 parts of peach kernels, 18-22 parts of hawthorn fruits, 12-18 parts of radix curcumae, 8-10 parts of rhizoma corydalis, 10-15 parts of rhizoma chuanxiong, 8-12 parts of rhizoma curcumae, 8-10 parts of semen aesculi, 8-10 parts of cortex magnoliae officinalis, 8-12 parts of fructus amomi, 5-7 parts of fructus aurantii and 8-10 parts of radix bupleuri. According to the medicine for treating the myocardial infarction type coronary heart disease, the 15 kinds of natural Chinese herbs are selected and are in scientific compatibility, the formula is simple, all the raw medicine materials are in synergism to achieve the effects of regulating vital energy and promoting blood flow, and activating meridians to stop pain, and the medicine is fast in effect taking, capable of treating both the symptoms and root causes of the disease, free of toxic or side effects, simple in preparing method, convenient to take and low in cost. The effective rate reaches 92% or above.
Description
Technical field
The present invention relates to Chinese medicine, specifically a kind of medicine being used for the treatment of myocardial infarction type coronary heart disease.
Background technology
Coronary heart disease is the common a kind of cardiovascular disease of middle-aged and elderly people, is uneven between coronary blood flow because the functional change of coronary artery or organic disease cause and myocardial demand and cardiac damage that is that cause.The basic lesion of primary disease be supply myocardial nutrition material blood vessel---coronary artery there occurs atherosis, therefore its full name is coronary atherosclerotic heart disease, referred to as coronary heart disease.Main manifestations is angina pectoris, arrhythmia, heart failure, may die suddenly.Electrocardiogram, myocardium enzyme mensuration, radio nuclide examination and coronarography can be clarified a diagnosis further.Control generation and development that blood pressure, blood fat, body weight and smoking cessation effectively can prevent coronary heart disease.
The risk factor of coronary heart disease comprises changeable risk factor and unmodifiable risk factor.Understand and intervene the control that risk factor contributes to coronary heart disease.Changeable risk factor has: hypertension, dyslipidemia (T-CHOL is too high or low-density lipoprotein cholesterol is too high, triglyceride is too high, HDL-C too low), overweight/obesity, hyperglycemia/diabetes, bad life style comprises smoking, unreasonable meals (higher fatty acid, hypercholesterolemia, high heat etc.), lacks physical exertion, excessive consumption of alcohol, and socio-psychological factors.Unmodifiable risk factor has: sex, age, family history.In addition, relevant with infection, as cytomegalovirus, Chlamydia pneumoniae, helicobacter pylori etc.The outbreak of coronary heart disease usually with seasonal variations, excited, physical exertion increases, be satiated with food, a large amount of smoking and to drink etc. relevant.
Present is main mainly with Western medicine and operative treatment, but side effect is comparatively large, and easily recurs, and can not effect a radical cure, cause certain burden to patient's economy and physiology.And the therapeutic efficiency of some current Chinese medicines is also not satisfactory, treatment cycle is long, and curative effect is not remarkable.
Summary of the invention
The object of this invention is to provide the medicine being used for the treatment of myocardial infarction type coronary heart disease that a kind of good effect, short treating period, cost are low, have no side effect.
The technical scheme realizing the object of the invention is:
Be used for the treatment of a medicine for myocardial infarction type coronary heart disease, the raw material primarily of following weight parts proportioning is made:
Radix Angelicae Sinensis 8-12 part, Radix Paeoniae Rubra 10-15 part, Radix Salviae Miltiorrhizae 12-18 part, Flos Carthami 8-12 part, Semen Persicae 8-12 part, Fructus Crataegi 18-22 part, RADIX CURCUMAE 12-18 part, Rhizoma Corydalis 8-10 part, Rhizoma Chuanxiong 10-15 part, Rhizoma Curcumae 8-12 part, Semen Aesculi 8-10 part, Cortex Magnoliae Officinalis 8-10 part, Fructus Amomi 8-12 part, Fructus Aurantii 5-7 part, Radix Bupleuri 8-10 part.
The above-mentioned medicine being used for the treatment of myocardial infarction type coronary heart disease, optimum weight part proportioning of each raw material is:
Radix Angelicae Sinensis 10 parts, Radix Paeoniae Rubra 12 parts, Radix Salviae Miltiorrhizae 15 parts, 10 parts, Flos Carthami, 10 parts, Semen Persicae, Fructus Crataegi 20 parts, RADIX CURCUMAE 15 parts, Rhizoma Corydalis 9 parts, Rhizoma Chuanxiong 12 parts, Rhizoma Curcumae 10 parts, Semen Aesculi 9 parts, Cortex Magnoliae Officinalis 9 parts, Fructus Amomi 10 parts, Fructus Aurantii 6 parts, Radix Bupleuri 9 parts.
Described raw medicinal material is in shop of Chinese medicines and commercially available.
The preparation method of medicine of the present invention is as follows: take each crude drug by weight ratio, add mixing and be placed in container, add material quantity weight 10-20 soak by water doubly 3 times again, each decoction 30-40min, merges decoction liquor, filter and remove residue, it is the extractum of 1.10-1.30 that filtrate is concentrated into relative density at 50-60 DEG C, add adjuvant, make corresponding dosage form, to obtain final product.
In the present invention, pharmacology, effect of each crude drug are as follows:
Radix Angelicae Sinensis: having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.Be usually used in blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.
Radix Paeoniae Rubra: clearing away heat and cooling blood, eliminating stasis to stop pain.For thermal man's nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, addiction abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.
Radix Salviae Miltiorrhizae: have blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, effect of removing heat from blood eliminating carbuncle.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, abdominal mass abdominal mass is gathered, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, and dysmenorrhea amenorrhea, skin infection swells and ache.
Flos Carthami: there is promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, injury from falling down, skin infection swells and ache.
Semen Persicae: there is blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, effect of relieving cough and asthma.For amenorrhea dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, lung abscess acute appendicitis, injury from falling down, dryness of the intestine constipation, cough and asthma.
Fructus Crataegi: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, changes turbid blood fat reducing.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, obstruction of qi in the chest and cardialgia, hernia pain, hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.
RADIX CURCUMAE: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clear away heart-fire removing heat from blood, promoting the function of the gallbladder to alleviate jaundice.
Rhizoma Corydalis: have promoting blood circulation to remove blood stasis, the function of regulating QI to relieve pain.For whole body each portion qi depression to blood stasis pain, dysmenorrhea, amenorrhea, lump in the abdomen, postpartum stagnation, injury from falling down, hernia is had a pain.
Rhizoma Chuanxiong: activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Rhizoma Curcumae: cure mainly coagulation of QI-blood, trusted subordinate's distending pain, lump in the abdomen, gathers, and dyspepsia does not disappear, and women's blood stasis amenorrhea, traumatic injury is had a pain.There are promoting QI circulation for relieving depression, removing blood stasis with potent drugs, the function of pain relieving.
Semen Aesculi: depressed liver-energy dispersing and QI regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, breast abdominal distention is vexed, gastralgia.
Cortex Magnoliae Officinalis: dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Fructus Amomi: have removing dampness to whet the appetite, warming spleen and stopping diarrha, antiabortive effect of regulating the flow of vital energy.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Fructus Aurantii: there is regulating the flow of QI to ease the stomach, effect of the stagnant relieving distension of row.Be usually used in the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention, visceroptosis.
Radix Bupleuri: have reconciling superficies and interior, effect of soothing the liver yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia.
The present invention is used for the treatment of the medicine of myocardial infarction type coronary heart disease, choose 15 kinds of natural Chinese medicine scientific compatibility, formula is simple, each crude drug synergism plays the effect of vital energy regualting and blood circulation-promoting, removing obstruction in the collateral to relieve pain, instant effect, treating both the principal and secondary aspects of a disease, has no side effect, and its preparation method is simple, taking convenience, cost is low.
Detailed description of the invention
Below in conjunction with embodiment, content of the present invention is further described, but is not limitation of the invention.
Embodiment 1
Be used for the treatment of a medicine for myocardial infarction type coronary heart disease, the raw material primarily of following weight parts proportioning is made:
Radix Angelicae Sinensis 8kg, Radix Paeoniae Rubra 10kg, Radix Salviae Miltiorrhizae 12kg, Flos Carthami 8kg, Semen Persicae 8kg, Fructus Crataegi 18kg part, RADIX CURCUMAE 12kg, Rhizoma Corydalis 8kg, Rhizoma Chuanxiong 10kg, Rhizoma Curcumae 8kg, Semen Aesculi 8kg, Cortex Magnoliae Officinalis 8kg, Fructus Amomi 8kg, Fructus Aurantii 5kg, Radix Bupleuri 8kg.
Preparation method is as follows: take the mixing of each crude drug be placed in container by above-mentioned, then add the soak by water 3 times of material quantity weight 10 times, decoct 30min at every turn, merge decoction liquor, filter and remove residue, it is the extractum of 1.10 that filtrate is concentrated into relative density at 50 DEG C, add adjuvant, make tablet, every sheet 0.1g.
Embodiment 2
Be used for the treatment of a medicine for myocardial infarction type coronary heart disease, the raw material primarily of following weight parts proportioning is made:
Radix Angelicae Sinensis 10kg, Radix Paeoniae Rubra 12kg, Radix Salviae Miltiorrhizae 15kg, Flos Carthami 10kg, Semen Persicae 10kg, Fructus Crataegi 20kg, RADIX CURCUMAE 15kg, Rhizoma Corydalis 9kg, Rhizoma Chuanxiong 12kg, Rhizoma Curcumae 10kg, Semen Aesculi 9kg, Cortex Magnoliae Officinalis 9kg, Fructus Amomi 10kg, Fructus Aurantii 6kg, Radix Bupleuri 9kg.
Preparation method is as follows: take the mixing of each crude drug be placed in container by above-mentioned, then add the soak by water 3 times of material quantity weight 15 times, decoct 34min at every turn, merge decoction liquor, filter and remove residue, it is the extractum of 1.20 that filtrate is concentrated into relative density at 54 DEG C, add adjuvant, make tablet, every sheet 0.2g.
Embodiment 3
Be used for the treatment of a medicine for myocardial infarction type coronary heart disease, the raw material primarily of following weight parts proportioning is made:
Radix Angelicae Sinensis 12kg, Radix Paeoniae Rubra 15kg, Radix Salviae Miltiorrhizae 18kg, Flos Carthami 12kg, Semen Persicae 12kg, Fructus Crataegi 22kg, RADIX CURCUMAE 18kg, Rhizoma Corydalis 10kg, Rhizoma Chuanxiong 15kg, Rhizoma Curcumae 12kg, Semen Aesculi 10kg, Cortex Magnoliae Officinalis 10kg, Fructus Amomi 12kg, Fructus Aurantii 7kg, Radix Bupleuri 10kg.
Preparation method is as follows: take the mixing of each crude drug be placed in container by above-mentioned, then add the soak by water 3 times of material quantity weight 18 times, decoct 37min at every turn, merge decoction liquor, filter and remove residue, it is the extractum of 1.30 that filtrate is concentrated into relative density at 58 DEG C, add adjuvant, make pill, every 0.4g.
Embodiment 4
Be used for the treatment of a medicine for myocardial infarction type coronary heart disease, the raw material primarily of following weight parts proportioning is made:
Radix Angelicae Sinensis 12kg, Radix Paeoniae Rubra 15kg, Radix Salviae Miltiorrhizae 18kg, Flos Carthami 12kg, Semen Persicae 12kg, Fructus Crataegi 22kg, RADIX CURCUMAE 18kg, Rhizoma Corydalis 10kg, Rhizoma Chuanxiong 15kg, Rhizoma Curcumae 12kg, Semen Aesculi 10kg, Cortex Magnoliae Officinalis 10kg, Fructus Amomi 12kg, Fructus Aurantii 7kg, Radix Bupleuri 10kg.
Preparation method is as follows: take the mixing of each crude drug be placed in container by above-mentioned, then add the soak by water 3 times of material quantity weight 20 times, decoct 40min at every turn, merge decoction liquor, filter and remove residue, it is the extractum of 1.30 that filtrate is concentrated into relative density at 60 DEG C, add adjuvant, make pill, every 0.5g.
In order to prove the clinical efficacy of Chinese medicine of the present invention further, selecting 100 examples of accepting for medical treatment in patient, clinical observation is carried out to the curative effect of medicine of the present invention.Age 50-70 year, be divided into 4 groups at random, often group be 25 example, be respectively experimental group 1-4 group.
Experimental group 1-4 group takes the medicine of embodiment 1-4 respectively, every day 2 times, each 5 slices/for oral administration, within 12 days, is a course for the treatment of, takes 1-2 the course for the treatment of continuously.Wherein effective 90 examples, effective 92 examples, cure 89 examples, invalid 8 examples, cure rate 89%, effective percentage 92%.
Claims (3)
1. be used for the treatment of a medicine for myocardial infarction type coronary heart disease, it is characterized in that: the raw material primarily of following weight parts proportioning is made:
Radix Angelicae Sinensis 8-12 part, Radix Paeoniae Rubra 10-15 part, Radix Salviae Miltiorrhizae 12-18 part, Flos Carthami 8-12 part, Semen Persicae 8-12 part, Fructus Crataegi 18-22 part, RADIX CURCUMAE 12-18 part, Rhizoma Corydalis 8-10 part, Rhizoma Chuanxiong 10-15 part, Rhizoma Curcumae 8-12 part, Semen Aesculi 8-10 part, Cortex Magnoliae Officinalis 8-10 part, Fructus Amomi 8-12 part, Fructus Aurantii 5-7 part, Radix Bupleuri 8-10 part.
2. the medicine being used for the treatment of myocardial infarction type coronary heart disease according to claim 1, is characterized in that: optimum weight part proportioning of each raw material is:
Radix Angelicae Sinensis 10 parts, Radix Paeoniae Rubra 12 parts, Radix Salviae Miltiorrhizae 15 parts, 10 parts, Flos Carthami, 10 parts, Semen Persicae, Fructus Crataegi 20 parts, RADIX CURCUMAE 15 parts, Rhizoma Corydalis 9 parts, Rhizoma Chuanxiong 12 parts, Rhizoma Curcumae 10 parts, Semen Aesculi 9 parts, Cortex Magnoliae Officinalis 9 parts, Fructus Amomi 10 parts, Fructus Aurantii 6 parts, Radix Bupleuri 9 parts.
3. the medicine being used for the treatment of myocardial infarction type coronary heart disease according to claim 1, is characterized in that:
Preparation method is as follows: take each crude drug by weight ratio, add mixing and be placed in container, add material quantity weight 10-20 soak by water doubly 3 times again, each decoction 30-40min, merges decoction liquor, filter and remove residue, it is the extractum of 1.10-1.30 that filtrate is concentrated into relative density at 50-60 DEG C, add adjuvant, make corresponding dosage form, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511021847.9A CN105477556A (en) | 2015-12-30 | 2015-12-30 | Medicine for treating myocardial infarction type coronary heart disease |
Applications Claiming Priority (1)
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| CN201511021847.9A CN105477556A (en) | 2015-12-30 | 2015-12-30 | Medicine for treating myocardial infarction type coronary heart disease |
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| CN109908301A (en) * | 2019-04-09 | 2019-06-21 | 河北鹿天力科技有限公司 | A kind of Chinese materia medica preparation for treating myocardial infarction |
| CN113577225A (en) * | 2021-08-26 | 2021-11-02 | 宋恩著 | Traditional Chinese medicine composition for treating myocardial infarction as well as preparation method and application thereof |
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| CN104138566A (en) * | 2013-05-10 | 2014-11-12 | 哈尔滨济博生物技术开发有限公司 | Medicine for treating angina pectoris heart blood stasis type coronary heart disease |
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| CN109908301A (en) * | 2019-04-09 | 2019-06-21 | 河北鹿天力科技有限公司 | A kind of Chinese materia medica preparation for treating myocardial infarction |
| CN113577225A (en) * | 2021-08-26 | 2021-11-02 | 宋恩著 | Traditional Chinese medicine composition for treating myocardial infarction as well as preparation method and application thereof |
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