CN104884069B - 新的黏膜佐剂和递送系统 - Google Patents

新的黏膜佐剂和递送系统 Download PDF

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Publication number
CN104884069B
CN104884069B CN201380068777.5A CN201380068777A CN104884069B CN 104884069 B CN104884069 B CN 104884069B CN 201380068777 A CN201380068777 A CN 201380068777A CN 104884069 B CN104884069 B CN 104884069B
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chitosan
vaccine
vaccine formulation
adjuvant
antigen
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CN104884069A (zh
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B·M·哈吉斯
N·R·普姆弗德
M·穆尔甘
S·西瓦拉尔玛艾哈
G·特列斯
A·沃尔芬登
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University of Arkansas at Little Rock
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University of Arkansas at Little Rock
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CN201380068777.5A 2012-10-29 2013-10-29 新的黏膜佐剂和递送系统 Active CN104884069B (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109364244A (zh) * 2012-10-29 2019-02-22 阿肯色大学评议会 新的黏膜佐剂和递送系统

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2214701T (pt) * 2007-11-01 2016-11-02 Univ Guelph Composições e métodos de potenciar respostas imunes a eimeria
EP2956165B1 (en) 2013-02-14 2019-09-11 The Board of Trustees of the University of Arkansas Compositions and methods of enhancing immune responses to eimeria or limiting eimeria infection
CN105142653B (zh) 2013-03-15 2019-11-15 阿肯色大学评议会 增强对肠病原体免疫应答的组合物和方法
ES2672045T3 (es) * 2014-07-25 2018-06-12 Biosynth S.R.L. Vacunas de productos glicoconjugados que comprenden unidades básicas de una construcción molecular que expresa múltiples epítopos incorporados para la formulación de una vacuna de amplio espectro contra infecciones debidas a bacterias enteropatógenas
GB201522541D0 (en) 2015-12-21 2016-02-03 Inst Research In Biomedicine Compositions
AR108688A1 (es) 2016-05-03 2018-09-19 Univ Arkansas Vector de vacuna de levadura que incluye polipéptidos inmunoestimuladores y antigénicos, métodos para su uso
JPWO2018225662A1 (ja) * 2017-06-07 2020-04-09 出光興産株式会社 自然免疫増強剤
CN111603566A (zh) * 2019-02-25 2020-09-01 河南农业大学 一种靶向呼吸道黏膜的递呈载体复合物及应用
US12605239B2 (en) 2020-07-29 2026-04-21 North Carolina State University Enhancement of hydration and improvement in gut health through cloacal delivery of products
WO2022256740A1 (en) 2021-06-04 2022-12-08 Curia Ip Holdings, Llc Polymeric fusion proteins and compositions for inducing an immune response against infection
CN114134167A (zh) * 2021-11-30 2022-03-04 山东邦盛达生物科技有限公司 具有粘膜免疫调节作用的重组枯草芽孢杆菌的制备方法及重组枯草芽孢杆菌和应用
CN114288401B (zh) * 2021-12-31 2023-10-03 四川农业大学 抗原蛋白的应用、引物组以及试剂盒
JP2025510729A (ja) * 2022-03-21 2025-04-15 ユニバーシティ オブ サザン カリフォルニア 三重ワクチンは、訓練免疫を介して細菌および真菌病原体に対して防御する
KR102743672B1 (ko) * 2022-09-27 2024-12-17 전북대학교산학협력단 점막에서 항원 특이적 면역 반응을 증진시키는 신규한 펩타이드 및 상기 펩타이드를 유효성분으로 포함하는 점막 백신 보조제

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3501770A (en) * 1967-04-13 1970-03-17 Lilly Co Eli Shipping fever vaccine
DE69032484D1 (de) * 1989-10-27 1998-08-20 Arch Dev Corp Zusammensetzungen und deren verwendung zur förderung der immunopotentiation
CA2215978A1 (en) * 1995-04-04 1996-10-10 Wound Healing Of Oklahoma Cancer treatment by photodynamic therapy, in combination with an immunoadjuvant
GB9725084D0 (en) * 1997-11-28 1998-01-28 Medeva Europ Ltd Vaccine compositions
AT410635B (de) * 2000-10-18 2003-06-25 Cistem Biotechnologies Gmbh Vakzin-zusammensetzung
FI20010118A7 (fi) * 2001-01-19 2002-07-20 Carbion Oy Uudet helicobacter pylori reseptorit ja niiden käyttö
NO317654B1 (no) * 2002-05-03 2004-11-29 Stiftelsen Biopolymer Formulering som inneholder en nukleinsyre og et kitosan, fremgangsmate for fremstilling av formuleringen, samt anvendelser derav.
ES2387850T3 (es) * 2004-02-11 2012-10-02 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L. Proteína de fusión al antígeno carcinoembrionario y sus usos
GB0405787D0 (en) * 2004-03-15 2004-04-21 Chiron Srl Low dose vaccines
UA5098U (uk) 2004-07-05 2005-02-15 Михайло Валерійович Бабкін Використання хітозану як ад'юванту
WO2006059237A1 (en) * 2004-08-30 2006-06-08 Lunamed, Inc. 4-phenylbutyric acid controlled-release formulations for therapeutic use
CN101056877B (zh) * 2004-09-14 2010-06-09 诺华疫苗和诊断公司 咪唑并喹啉化合物
US20090028932A1 (en) * 2005-04-15 2009-01-29 Wilson Mary E Vaccine formulations for leishmania
ES2377884T3 (es) * 2005-11-04 2012-04-02 Novartis Vaccines And Diagnostics S.R.L. Vacunas contra la gripe que incluyen combinaciones de adyuvantes particulados e inmunopotenciadores
CA2668693A1 (en) 2006-11-15 2008-05-22 David E. Anderson Therapeutic uses of tim-3 modulators
MX2010004836A (es) * 2007-10-30 2010-10-20 Viscogel Ab Composicion de quitosan.
US8778384B2 (en) * 2008-03-24 2014-07-15 Advanced Bionutrition Corporation Compositions and methods for encapsulating vaccines for the oral vaccination and boostering of fish and other animals
JP5339243B2 (ja) * 2008-04-24 2013-11-13 株式会社微生物化学研究所 ストレプトコッカス・スイス感染症予防用ワクチン
JP2010065027A (ja) * 2008-08-12 2010-03-25 Mie Univ 魚類のウイルス性出血性敗血症に対する不活化ワクチンとその処方
WO2010056896A1 (en) * 2008-11-12 2010-05-20 Synedgen, Inc. Chitosan derivatives to treat animals or optimize animal health
EP2196196A1 (en) * 2008-12-10 2010-06-16 Medipol S.A. Compound, medicament, vaccine composition and nanocapsules
JP5292141B2 (ja) * 2009-03-17 2013-09-18 シチズンマシナリーミヤノ株式会社 タレット刃物台のクーラント供給構造
US9234047B2 (en) * 2009-11-06 2016-01-12 Pharmasan Labs, Inc. Preparing hapten-specific antibodies and their application for immunodiagnostics and research
EP2508212A1 (en) * 2011-04-05 2012-10-10 Universitätsklinikum Freiburg Biocompatible and biodegradable gradient layer system for regenerative medicine and for tissue support
AU2013338153B2 (en) * 2012-10-29 2018-06-21 The Board Of Trustees Of The University Of Arkansas Novel mucosal adjuvants and delivery systems

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Controlled release of PEI/DNA complexes from mannose-bearing chitosan microspheres as a potent delivery system to enhance immune response to HBV DNA vaccine;Xianfeng Zhou等;《Journal of Controlled Release》;20070525;第121卷;200-207 *
Mannosylated chitosan-zinc sulphide nanocrystals as fluorescent bioprobes for targeted cancer imaging;Aswathy Jayasree等;《Carbogydrate Polymers》;20110128;第85卷;37-43 *
The potential of mannosylated chitosan microspheres to target macrophage mannose receptors in an adjuvant-delivery system for intranasal immunization;Hu-Lin Jiang等;《Biomaterials》;20080125;第29卷;1931-1939 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109364244A (zh) * 2012-10-29 2019-02-22 阿肯色大学评议会 新的黏膜佐剂和递送系统
CN109364244B (zh) * 2012-10-29 2022-04-29 阿肯色大学评议会 黏膜佐剂和递送系统

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