CN104872656A - Composition with health function and preparation method thereof - Google Patents
Composition with health function and preparation method thereof Download PDFInfo
- Publication number
- CN104872656A CN104872656A CN201510237224.9A CN201510237224A CN104872656A CN 104872656 A CN104872656 A CN 104872656A CN 201510237224 A CN201510237224 A CN 201510237224A CN 104872656 A CN104872656 A CN 104872656A
- Authority
- CN
- China
- Prior art keywords
- parts
- leaching
- fruit
- cordyceps militaris
- chinese wolfberry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- KQLDDLUWUFBQHP-UHFFFAOYSA-N Cordycepin Natural products C1=NC=2C(N)=NC=NC=2N1C1OCC(CO)C1O KQLDDLUWUFBQHP-UHFFFAOYSA-N 0.000 description 1
- 241000190633 Cordyceps Species 0.000 description 1
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- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
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- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
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- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 description 1
- OFEZSBMBBKLLBJ-UHFFFAOYSA-N cordycepine Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)CC1O OFEZSBMBBKLLBJ-UHFFFAOYSA-N 0.000 description 1
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- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a composition with a health function. The composition is characterized in that the composition is a medicament prepared from the following raw materials in parts by weight: 5-75 parts of maca, 1-45 parts of cordyceps militaris, 1-45 parts of wolfberry fruits and 5-75 parts of longan aril. The composition is prepared by combining maca, cordyceps militaris, the wolfberry fruits and the longan aril; maca, cordyceps militaris, the wolfberry fruits and the longan aril are leached with ethanol to be prepared into a medicament, and the medicament has the excellent immunity enhancing and anti-fatigue functions no matter how much the dosage is; and wine prepared from the composition has a simple manufacturing process, and the product is natural, green, nutritional and healthy, and has the good health function.
Description
Technical field
The invention belongs to field of food, particularly relate to a kind of composition and method of making the same with health care.
Background technology
Agate coffee (Maca), having another name called agate coffee, Peruvian ginseng, maka, maca, maino, ayakchichira, ayak willku etc., is a kind of plant originating in South America.Find after deliberation, agate coffee has effects such as improving fertility, improvement function, adjustment endocrine function.
Cordyceps militaris, has another name called northern Chinese caterpillar Fungus, pupa grass, Cordceps militaris, pupa grass bacterium etc., Cordyceps (Cordycps).Find after deliberation, containing plurality of active ingredients such as cordycepin, cordycepic acid, polysaccharide, adenosines in Cordyceps militaris, in reducing blood lipid; prevent artery sclerosis, the protection heart, brain tissue, tranquilizing soporific; strengthen the activity of macrophage, there is good effects anti-inflammatory, anticancer, antibacterial, anti-ageing aspect of waiting for a long time.
Matrimony vine is traditional rare traditional Chinese medicine, is again a kind of tonic food.As traditional Chinese medicine, the flat taste of matrimony vine property is sweet, has effect of nourishing liver and kidney, benefiting shrewd head, moistening lung.Pass through chemical composition analysis, the fruit of matrimony vine detects containing nutritional labelings such as abundant natural Beta-carotene, vitamin C, matrimony vine proteoglycan, betaine, linoleic acid and iron, phosphorus, calcium, has qi-restoratives to calm the nerves, improving eyesight is dispeled the wind, nourshing kidney moistening lung and protect the effects such as liver is antitumor.
Arillus longan is also a kind of common Chinese medicine, has tonifying heart and spleen, and effect of nourishing blood and tranquilization, is usually used in insufficiency of vital energy and blood, palpitation and severe palpitation, and forgetful insomnia, the deficiency of blood is sallow.
But, still agate coffee, Cordyceps militaris, matrimony vine and arillus longan are not prepared as the report of medicine or health products at present.
Summary of the invention
The invention provides a kind of composition and the assembled alcoholic drinks thereof with health care, additionally provide a kind of preparation method of said composition.
The invention provides a kind of composition with health care, it is the medicament be made up of the raw material comprising following weight proportioning:
Agate coffee 5-75 part, Cordyceps militaris 1-45 part, fruit of Chinese wolfberry 1-45 part, arillus longan 5-75 part.
Further preferably, it is the medicament be made up of the raw material of following weight parts proportioning:
Agate coffee 5-75 part, Cordyceps militaris 1-45 part, fruit of Chinese wolfberry 1-45 part, arillus longan 5-75 part.
Further preferably, it is the medicament be made up of the raw material of following weight parts proportioning:
Agate coffee 10-43.5 part, Cordyceps militaris 4.5-14.5 part, fruit of Chinese wolfberry 3-25 part, arillus longan 7-18 part.
Further preferably, the parts by weight sum of described agate coffee, Cordyceps militaris, the fruit of Chinese wolfberry and arillus longan is 58 parts.
Further preferably, it is the medicament be made up of the raw material of following weight parts proportioning:
Agate coffee 20 parts, Cordyceps militaris 10 parts, the fruit of Chinese wolfberry 20 parts, arillus longan 8 parts;
Or: agate coffee 10 parts, Cordyceps militaris 20 parts, the fruit of Chinese wolfberry 20 parts, arillus longan 8 parts;
Or: agate coffee 10 parts, Cordyceps militaris 15 parts, the fruit of Chinese wolfberry 20 parts, arillus longan 8 parts;
Or: agate coffee 10 parts, Cordyceps militaris 10 parts, the fruit of Chinese wolfberry 25 parts, arillus longan 13 parts;
Or: agate coffee 10 parts, Cordyceps militaris 13 parts, the fruit of Chinese wolfberry 23 parts, arillus longan 12 parts;
Or: agate coffee 10 parts, Cordyceps militaris 10 parts, the fruit of Chinese wolfberry 20 parts, arillus longan 18 parts;
Or: agate coffee 43.5 parts, Cordyceps militaris 4.5 parts, the fruit of Chinese wolfberry 3 parts, arillus longan 7 parts;
Or: agate coffee 23.5 parts, Cordyceps militaris 14.5 parts, the fruit of Chinese wolfberry 8 parts, arillus longan 12 parts;
Or: agate coffee 33.5 parts, Cordyceps militaris 10 parts, the fruit of Chinese wolfberry 7.5 parts, arillus longan 7 parts;
Or: agate coffee 13.5 parts, Cordyceps militaris 14.5 parts, the fruit of Chinese wolfberry 18 parts, arillus longan 12 parts.
Further preferably, described medicament is semisolid preparation or liquid preparation.Described semisolid preparation comprises liquid extract, extract etc.; Liquid preparation comprises vina, decoction, tincture etc.
Further preferably, it is the medicament prepared by following step:
(1) raw material of following portions by weight is got: agate coffee 5-75 part, Cordyceps militaris 1-45 part, fruit of Chinese wolfberry 1-45 part, arillus longan 5-75 part;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 50-70%, filter leaching liquid and obtain filtrate;
(3) gained filtrate and get final product in concentration step (2).
Further preferably, in described step (2) during ethanol leaching, leach for refluxing at 80-100 DEG C, the number of times of leaching is 1-2 time, and the ethanol consumption of each leaching is 3-5 times of medicinal material amount, and each time leached is 1-3 hour.
Further preferably, the concentration ratio in described step (3) is 15%.
Present invention also offers a kind of method preparing described composition, comprise the following steps:
(1) raw material of following portions by weight is got: agate coffee 5-75 part, Cordyceps militaris 1-45 part, fruit of Chinese wolfberry 1-45 part, arillus longan 5-75 part;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 50-70%, filter leaching liquid and obtain filtrate;
(3) gained filtrate and get final product in concentration step (2).
Further preferably, in described step (2) during ethanol leaching, leach for refluxing at 80-100 DEG C, the number of times of leaching is 2 times, and the ethanol consumption of each leaching is 3-5 times of medicinal material amount, and each time leached is 2 hours.
Further preferably, the concentration ratio in described step (3) is 15%.
Present invention also offers described composition and prepare the purposes treated and/or prevented in the immunosuppressant medicine or health products caused by chemotherapy and/or radiotherapy.Further preferably, described immunosupress is that bone marrow suppression and/or immune organ weight reduce.
Present invention also offers described composition and prepare the purposes in the medicine or health products strengthening immunity and/or antifatigue.
Present invention also offers a kind of assembled alcoholic drinks, it is the assembled alcoholic drinks prepared by following step: mixed according to the ratio of 1:10-1:20 and Spirit by described composition, filter and get final product.
Further preferably, the bent wine of described Spirit to be concentration be 30-60%.
Agate coffee, Cordyceps militaris, the fruit of Chinese wolfberry and arillus longan are combined obtained composition by the present invention, make medicament by ethanol leaching, and no matter dosage just, all has excellent enhancing immunity and anti-fatigue effect; The assembled alcoholic drinks manufacture craft obtained by said composition is simple, product is natural, green, nutrition, health, there is good health care.
Below by detailed description of the invention, the present invention is described in further details, but be not limitation of the present invention, according to foregoing of the present invention, according to ordinary technical knowledge and the customary means of this area, not departing under the present invention's above-mentioned basic fundamental thought prerequisite, the amendment of other various ways, replacement or change can also be made.
Detailed description of the invention
Raw material used in following examples is from lotus pond medicinal material market, Chengdu.
Raw material pre-treatment: agate coffee, Cordyceps militaris pulverized 10 mesh sieves.
The preparation of embodiment 1 present composition
(1) raw material of following portions by weight is got: agate coffee 20g, Cordyceps militaris 10g, fruit of Chinese wolfberry 20g, arillus longan 8g;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 50%, filter leaching liquid and obtain filtrate concentration and recovery ethanol, leaching refluxes leaching at 80-100 DEG C, the number of times of leaching is 2 times, the ethanol consumption of each leaching is 200mL, and the time of each leaching is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL and get final product.
The preparation of embodiment 2 present composition
(1) raw material of following portions by weight is got: agate coffee 20g, Cordyceps militaris 10g, fruit of Chinese wolfberry 20g, arillus longan 8g;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 60%, filter leaching liquid and obtain filtrate, leaching refluxes leaching at 80-100 DEG C, and the number of times of leaching is 2 times, the ethanol consumption of each leaching is 200mL, and the time of each leaching is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL and get final product.
The preparation of embodiment 3 present composition
(1) raw material of following portions by weight is got: agate coffee 20g, Cordyceps militaris 10g, fruit of Chinese wolfberry 20g, arillus longan 8g;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 70%, filter leaching liquid and obtain filtrate, leaching refluxes leaching at 80-100 DEG C, and the number of times of leaching is 1 time, the ethanol consumption of leaching is 200mL, and leaching time is 3 hours.
(3) in concentration step (2) gained filtrate to 30mL and get final product.
The preparation of embodiment 4 present composition
(1) raw material of following portions by weight is got: agate coffee 20g, Cordyceps militaris 10g, fruit of Chinese wolfberry 20g, arillus longan 8g;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 70%, filter leaching liquid and obtain filtrate, leaching refluxes leaching at 80-100 DEG C, and the number of times of leaching is 2 times, the ethanol consumption of each leaching is 200mL, and the time of each leaching is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL and get final product.
The preparation of embodiment 5 pharmaceutical composition of the present invention
(1) raw material of following portions by weight is got: agate coffee 20g, Cordyceps militaris 10g, fruit of Chinese wolfberry 20g, arillus longan 8g;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 70%, filter leaching liquid and obtain filtrate, leaching refluxes leaching at 80-100 DEG C, and the number of times of leaching is 2 times, the ethanol consumption of each leaching is 200mL, and the time of each leaching is 1 hour.
(3) in concentration step (2) gained filtrate to 30mL and get final product.
The preparation of embodiment 6 pharmaceutical composition of the present invention
(1) raw material of following portions by weight is got: agate coffee 10g, Cordyceps militaris 20g, fruit of Chinese wolfberry 20g, arillus longan 8g;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 70%, filter leaching liquid and obtain filtrate, leaching refluxes leaching at 80-100 DEG C, and the number of times of leaching is 2 times, the ethanol consumption of each leaching is 200mL, and the time of each leaching is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL and get final product.
The preparation of embodiment 7 pharmaceutical composition of the present invention
(1) raw material of following portions by weight is got: agate coffee 10g, Cordyceps militaris 15g, fruit of Chinese wolfberry 25g, arillus longan 8g;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 70%, filter leaching liquid and obtain filtrate, leaching refluxes leaching at 80-100 DEG C, and the number of times of leaching is 2 times, the ethanol consumption of each leaching is 200mL, and the time of each leaching is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL and get final product.
The preparation of embodiment 8 pharmaceutical composition of the present invention
(1) raw material of following portions by weight is got: agate coffee 10g, Cordyceps militaris 10g, fruit of Chinese wolfberry 25g, arillus longan 13g;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 70%, filter leaching liquid and obtain filtrate, leaching refluxes leaching at 80-100 DEG C, and the number of times of leaching is 2 times, the ethanol consumption of each leaching is 200mL, and the time of each leaching is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL and get final product.
The preparation of embodiment 9 pharmaceutical composition of the present invention
(1) raw material of following portions by weight is got: agate coffee 10g, Cordyceps militaris 13g, fruit of Chinese wolfberry 23g, arillus longan 12g;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 70%, filter leaching liquid and obtain filtrate, leaching refluxes leaching at 80-100 DEG C, and the number of times of leaching is 2 times, the ethanol consumption of each leaching is 200mL, and the time of each leaching is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL and get final product.
The preparation of embodiment 10 pharmaceutical composition of the present invention
(1) raw material of following portions by weight is got: agate coffee 10g, Cordyceps militaris 10g, fruit of Chinese wolfberry 20g, arillus longan 18g;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 70%, filter leaching liquid and obtain filtrate, leaching refluxes leaching at 80-100 DEG C, and the number of times of leaching is 2 times, the ethanol consumption of each leaching is 200mL, and the time of each leaching is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL and get final product.
The preparation of embodiment 11 pharmaceutical composition of the present invention
(1) raw material of following portions by weight is got: agate coffee 43.5g, Cordyceps militaris 4.5g, fruit of Chinese wolfberry 3g, arillus longan 7g;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 70%, filter leaching liquid and obtain filtrate, leaching refluxes leaching at 80-100 DEG C, and the number of times of leaching is 2 times, the ethanol consumption of each leaching is 200mL, and the time of each leaching is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL and get final product.
The preparation of embodiment 12 pharmaceutical composition of the present invention
(1) raw material of following portions by weight is got: agate coffee 23.5g, Cordyceps militaris 14.5g, fruit of Chinese wolfberry 8g, arillus longan 12g;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 70%, filter leaching liquid and obtain filtrate, leaching refluxes leaching at 80-100 DEG C, and the number of times of leaching is 2 times, the ethanol consumption of each leaching is 200mL, and the time of each leaching is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL and get final product.
The preparation of embodiment 13 pharmaceutical composition of the present invention
(1) raw material of following portions by weight is got: agate coffee 33.5g, Cordyceps militaris 10g, fruit of Chinese wolfberry 7.5g, arillus longan 7g;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 70%, filter leaching liquid and obtain filtrate, leaching refluxes leaching at 80-100 DEG C, and the number of times of leaching is 2 times, the ethanol consumption of each leaching is 200mL, and the time of each leaching is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL and get final product.
The preparation of embodiment 14 pharmaceutical composition of the present invention
(1) raw material of following portions by weight is got: agate coffee 13.5g, Cordyceps militaris 14.5g, fruit of Chinese wolfberry 18g, arillus longan 12g;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 70%, filter leaching liquid and obtain filtrate, leaching refluxes leaching at 80-100 DEG C, and the number of times of leaching is 2 times, the ethanol consumption of each leaching is 200mL, and the time of each leaching is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL and get final product.
The preparation of embodiment 15 assembled alcoholic drinks of the present invention
Mixed according to the fragrant type brewing that the ratio of 1:10 and concentration are 30% by embodiment 4 gained pharmaceutical composition, filter and get final product, this assembled alcoholic drinks meets the sensory evaluation standard shown in table 1.
Table 1 sensory evaluation
| Project | Sensory evaluation |
| Outward appearance | Limpid transparent, without precipitation and suspension |
| Color and luster | In faint yellow or brown color |
| Fragrance | There is corresponding plant perfume and aroma, all fragrant harmonious |
| Flavour | Alcohol and, relax along harmony, wine body is complete |
The preparation of embodiment 16 assembled alcoholic drinks of the present invention
Mixed according to the fragrant type brewing that the ratio of 1:20 and concentration are 60% by embodiment 4 gained pharmaceutical composition, filter and get final product, this assembled alcoholic drinks meets the sensory evaluation standard shown in table 1.
In order to prove the beneficial effect of pharmaceutical composition of the present invention, provide following test example.
The immunosupress that test example 1 is caused by chemotherapy and/or radiotherapy with medicine composite for curing of the present invention and/or prevention
1. material and instrument
1.1 medicine
(1) composition of embodiment 1 is as dosage 1. group.
(2) composition of embodiment 2 is as dosage 2. group.
(3) composition of embodiment 3 is as dosage 3. group.
(4) composition of embodiment 4 is as dosage 4. group.
(5) composition of embodiment 5 is as dosage 5. group.
(6) composition of embodiment 6 is as dosage 6. group.
(7) composition of embodiment 7 is as dosage 7. group.
(8) composition of embodiment 8 is as dosage 8. group.
(9) composition of embodiment 9 is as dosage 9. group.
(10) composition of embodiment 10 is as dosage 10. group.
(11) composition of embodiment 11 is as dosage
group.
(12) composition of embodiment 12 is as dosage
group.
(13) composition of embodiment 13 is as dosage
group.
(14) composition of embodiment 14 is as dosage
group.
1.2 animal used as test
KM mouse, body weight 18.5 ~ 22.5g.
1.3 laboratory apparatus, reagent
(1) blood picture analyzer, electronic balance etc.;
(2) hemolytic agent, cleaning agent, dilution etc.
1.4 positive drug
SHENGMAI JIAONANG.
2. effect experiment
2.1 experimental technique
Be divided at random by body weight after all mouse adaptability feeds 1 week: normal group, model group, positive group (SHENGMAI JIAONANG group), dosage 1. ~
group, often organizes 10.Each experimental group starts according to dosage from experimental day, administering mode gives relative medicine, wherein normal group and model group gavage equal-volume pure water, continuous 10 days.Test the 4th day, except normal group, all the other respectively organize mouse by 60mgkg
-1dosage intraperitoneal injection of cyclophosphamide normal saline solution, continuous 4 days, normal group mouse peritoneal injection equal-volume physiological saline.Test the 10th day, each experimental mice eye socket gets blood, collects, jog, mixing with the 1.5mLEP pipe that sodium heparin anticoagulant is housed.On aseptic working platform, take each experimental mice spleen and thymus gland, bloodstain cleaned by physiological saline.
2.2 Testing index
(1) PBC: adopt full-automatic blood counting instrument to count each experimental mice PBL (WBC), red blood cell (RBC) and hemoglobin (HGB) quantity.
(2) immune organ weight coefficient: take each experimental mice spleen and thymic weight, calculates organ coefficient [organ weight (mg)/body weight (20g)].
2.3 experimental result
2.3.1 to myelosuppressive effect
The results are shown in Table 2.
The each experimental mice PBC of table 2 is accelerated (
)
Note: compare with model group, * P<0.05, * * P<0.01; Compare with positive group, △ P<0.05, △ △ P<0.01.
As shown in Table 2, compare with model group, each dosage group mouse peripheral blood liquid leucocyte is accelerated and is all had remarkable rising (P<0.05), and dosage 4. group has extremely significantly rising (P<0.01) effect.Compare with positive group, dosage 4.-
group mouse peripheral blood liquid leucocyte is accelerated and is all had remarkable rising (P<0.05); Compare with model group, each dosage group mouse peripheral blood liquid red blood cell is accelerated and is all had remarkable rising (P<0.05).Compare with positive group, dosage 4.-
group mouse peripheral blood liquid red blood cell is accelerated and is all had remarkable rising (P<0.05); Compare with model group, each dosage group mouse peripheral blood liquid hemoglobin is accelerated and is all had remarkable rising (P<0.05).Compare with positive group, 4. dosage organized mouse peripheral blood liquid hemoglobin and to have been accelerated remarkable rising (P<0.05).
Therefore, compare with model group, no matter dosage height, each dosage group all has the myelosuppressive effect treating and/or preventing significantly and caused by endoxan, wherein, particularly evident to the lifting effect of periphery white blood cell count, bring up to the 4.5-6.3 of model group doubly.Especially dosage 4. group, is all significantly better than positive group, best results from lifting animal used as test PBL, red blood cell, hemoglobin recruitment aspect.
2.3.2 to the effect that immune organ weight reduces
The results are shown in Table 3.
Table 3 each experimental mice immune organ weight coefficient (
)
Note: compare with model group, * P<0.05, * * P<0.01; Compare with positive group, △ P<0.05, △ △ P<0.01.
As shown in Table 3, compare with model group, each dosage group all has remarkable rising (P<0.05) to mouse spleen weight coefficient.Compare with positive group, 4. dosage organize mouse spleen weight coefficient remarkable rising (P<0.05).Compare with model group, each dosage group mouse thymus weight coefficient all has remarkable rising (P<0.05).Compare with positive group, 3., 4. dosage organize mouse thymus weight coefficient all remarkable rising (P<0.05).
Therefore, compare with model group, no matter dosage height, each dosage group all has the effect treating and/or preventing the immune organ weight that caused by endoxan significantly and reduce.Wherein especially with dosage 4. group, it promotes animal used as test spleen, the effect of thymus gland organ index is better than positive drug, best results comprehensively.
To sum up, no matter dosage height, pharmaceutical composition of the present invention all can effectively treat and/or prevent the immunosupress caused by chemotherapy and/or radiotherapy, has the function strengthening immunity.
Test example 2 pharmaceutical composition antifatigue of the present invention
1. material and instrument
1.1 medicine
(1) composition of embodiment 1 is as dosage 1. group.
(2) composition of embodiment 2 is as dosage 2. group.
(3) composition of embodiment 3 is as dosage 3. group.
(4) composition of embodiment 4 is as dosage 4. group.
(5) composition of embodiment 5 is as dosage 5. group.
(6) composition of embodiment 6 is as dosage 6. group.
(7) composition of embodiment 7 is as dosage 7. group.
(8) composition of embodiment 8 is as dosage 8. group.
(9) composition of embodiment 9 is as dosage 9. group.
(10) composition of embodiment 10 is as dosage 10. group.
(11) composition of embodiment 11 is as dosage
group.
(12) composition of embodiment 12 is as dosage
group.
(13) composition of embodiment 13 is as dosage
group.
(14) composition of embodiment 14 is as dosage
group.
1.2 animal used as test
KM mouse, body weight 18.5 ~ 22.5g.
1.3 laboratory apparatus, reagent
(1) animal used as test behaviouristics swimming pool, Electric radiator etc.;
(2) stopwatch, iron wire etc.
1.4 positive drug
SHENGMAI JIAONANG.
2. effect experiment
2.1 experimental technique
Be divided at random by body weight after all mouse adaptability feeds 1 week: control group, positive group (SHENGMAI JIAONANG group), dosage 1. ~
group, often organizes 10.Each experimental group starts according to dosage from experimental day, administering mode gives relative medicine, wherein normal group and model group gavage equal-volume pure water, continuous 10 days.Test 2h after administration in the 10th day, the iron wire of each experimental mice afterbody load 10% body weight, puts into water went swimming (water temperature 25 DEG C, depth of water 20cm), observe mouse swimming to exhaust (10s can not float under water) to power, this time is the swimming time of mouse.
2.2 Testing index
Each experimental mice swimming time.
2.3 experimental result
The results are shown in Table 4.
The each experimental mice swimming time of table 4 (
)
Note: compare with model group, * P<0.05, * * P<0.01; Compare with positive group, △ P<0.05, △ △ P<0.01.
As shown in Table 4, compare with model group, each dosage group mouse swimming time all has significant prolongation (P<0.05), dosage 3. ~
group has pole significant prolongation (P<0.01).Compare with positive group, 4. dosage organize mouse swimming time significant prolongation (P<0.05).
Therefore, compare with model group or positive group, no matter dosage height, each dosage group all can significantly improve the swimming time of mouse, has significant antifatigue effect, wherein especially 4. organizes best results with dosage.
In sum, agate coffee, Cordyceps militaris, the fruit of Chinese wolfberry and arillus longan are combined obtained composition by the present invention, medicament is made by ethanol leaching, no matter dosage height, all can effectively treat and/or prevent the immunosupress caused by chemotherapy and/or radiotherapy, and there is excellent enhancing immunity and anti-fatigue effect; The assembled alcoholic drinks manufacture craft obtained by said composition is simple, product is natural, green, nutrition, health, there is good health care.
Claims (17)
1. there is a composition for health care, it is characterized in that: it is the medicament be made up of the raw material comprising following weight proportioning:
Agate coffee 5-75 part, Cordyceps militaris 1-45 part, fruit of Chinese wolfberry 1-45 part, arillus longan 5-75 part.
2. composition according to claim 1, is characterized in that: it is the medicament be made up of the raw material of following weight parts proportioning:
Agate coffee 5-75 part, Cordyceps militaris 1-45 part, fruit of Chinese wolfberry 1-45 part, arillus longan 5-75 part.
3. composition according to claim 2, is characterized in that: it is the medicament be made up of the raw material of following weight parts proportioning:
Agate coffee 10-43.5 part, Cordyceps militaris 4.5-14.5 part, fruit of Chinese wolfberry 3-25 part, arillus longan 7-18 part.
4. composition according to claim 3, is characterized in that: the parts by weight sum of described agate coffee, Cordyceps militaris, the fruit of Chinese wolfberry and arillus longan is 58 parts.
5. composition according to claim 4, is characterized in that: it is the medicament be made up of the raw material of following weight parts proportioning:
Agate coffee 20 parts, Cordyceps militaris 10 parts, the fruit of Chinese wolfberry 20 parts, arillus longan 8 parts;
Or: agate coffee 10 parts, Cordyceps militaris 20 parts, the fruit of Chinese wolfberry 20 parts, arillus longan 8 parts;
Or: agate coffee 10 parts, Cordyceps militaris 15 parts, the fruit of Chinese wolfberry 20 parts, arillus longan 8 parts;
Or: agate coffee 10 parts, Cordyceps militaris 10 parts, the fruit of Chinese wolfberry 25 parts, arillus longan 13 parts;
Or: agate coffee 10 parts, Cordyceps militaris 13 parts, the fruit of Chinese wolfberry 23 parts, arillus longan 12 parts;
Or: agate coffee 10 parts, Cordyceps militaris 10 parts, the fruit of Chinese wolfberry 20 parts, arillus longan 18 parts;
Or: agate coffee 43.5 parts, Cordyceps militaris 4.5 parts, the fruit of Chinese wolfberry 3 parts, arillus longan 7 parts;
Or: agate coffee 23.5 parts, Cordyceps militaris 14.5 parts, the fruit of Chinese wolfberry 8 parts, arillus longan 12 parts;
Or: agate coffee 33.5 parts, Cordyceps militaris 10 parts, the fruit of Chinese wolfberry 7.5 parts, arillus longan 7 parts;
Or: agate coffee 13.5 parts, Cordyceps militaris 14.5 parts, the fruit of Chinese wolfberry 18 parts, arillus longan 12 parts.
6. the composition according to arbitrary one of claim 1-5, is characterized in that: described medicament is semisolid preparation or liquid preparation.
7. composition according to claim 1, is characterized in that: it is the medicament prepared by following step:
(1) raw material of following portions by weight is got: agate coffee 5-75 part, Cordyceps militaris 1-45 part, fruit of Chinese wolfberry 1-45 part, arillus longan 5-75 part;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 50-70%, filter leaching liquid and obtain filtrate;
(3) gained filtrate and get final product in concentration step (2).
8. composition according to claim 7, it is characterized in that: in described step (2) during ethanol leaching, leach for refluxing at 80-100 DEG C, the number of times of leaching is 1-2 time, the ethanol consumption of each leaching is 3-5 times of medicinal material amount, and the time of each leaching is 1-3 hour.
9. composition according to claim 8, is characterized in that: the concentration ratio in described step (3) is 15%.
10. prepare a method for the composition described in arbitrary one of claim 1-9, comprise the following steps:
(1) raw material of following portions by weight is got: agate coffee 5-75 part, Cordyceps militaris 1-45 part, fruit of Chinese wolfberry 1-45 part, arillus longan 5-75 part;
(2) add to raw material described in step (1) the ethanol leaching that concentration is 50-70%, filter leaching liquid and obtain filtrate;
(3) gained filtrate and get final product in concentration step (2).
11. preparation methods according to claim 10, it is characterized in that: in described step (2) during ethanol leaching, leach for refluxing at 80-100 DEG C, the number of times of leaching is 2 times, the ethanol consumption of each leaching is 3-5 times of medicinal material amount, and the time of each leaching is 2 hours.
12. preparation methods according to claim 11, is characterized in that: the concentration ratio in described step (3) is 15%.
Composition described in arbitrary one of 13. claim 1-9 is preparing the purposes treated and/or prevented in the immunosuppressant medicine or health products caused by chemotherapy and/or radiotherapy.
14. purposes according to claim 13, is characterized in that: described immunosupress is that bone marrow suppression and/or immune organ weight reduce.
Composition described in arbitrary one of 15. claim 1-9 is preparing the purposes in the medicine or health products strengthening immunity and/or antifatigue.
16. 1 kinds of assembled alcoholic drinks, is characterized in that: it is the assembled alcoholic drinks prepared by following step:
Composition described in arbitrary for claim 1-9 one is mixed according to the ratio of 1:10-1:20 and Spirit, filters and get final product.
17. assembled alcoholic drinks according to claim 16, is characterized in that: the bent wine of described Spirit to be concentration be 30-60%.
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