CN104872656B - A kind of composition with health care function and preparation method thereof - Google Patents
A kind of composition with health care function and preparation method thereof Download PDFInfo
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- CN104872656B CN104872656B CN201510237224.9A CN201510237224A CN104872656B CN 104872656 B CN104872656 B CN 104872656B CN 201510237224 A CN201510237224 A CN 201510237224A CN 104872656 B CN104872656 B CN 104872656B
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- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of compositions with health care function, it is characterised in that: it is including medicament made of the raw material of following weight proportion: 5-75 parts of maca, 1-45 parts of Cordyceps militaris, 1-45 parts of fructus lycii, 5-75 parts of arillus longan.Maca, Cordyceps militaris, fructus lycii and arillus longan are combined and composition are made by the present invention, are made medicament by ethyl alcohol leaching, no matter dosage height, all have that excellent enhancing is immune and anti-fatigue effect；The assembled alcoholic drinks manufacture craft made from the composition is simple, and product is natural, green, nutrition, health, with good healthcare function.
Description
Technical field
The invention belongs to field of food more particularly to a kind of composition with health care function and preparation method thereof.
Background technique
Maca (Maca) also known as maca, Peruvian ginseng, maka, maca, maino, ayak chichira,
Ayak willku etc. is a kind of plant for originating in South America.It has been investigated that maca, which has, improves fertility, improvement property function
Can, it adjust the effects of endocrine function.
Cordyceps militaris also known as northern Chinese caterpillar Fungus, pupa grass, Cordceps militaris, pupa grass bacterium etc., Cordyceps (Cordycps).It is sent out through research
It is existing, artery sclerosis is prevented in reducing blood lipid containing plurality of active ingredients such as cordycepin, cordycepic acid, polysaccharide, adenosines in Cordyceps militaris, is protected
Shield heart, brain tissue, tranquilizing soporific enhance the activity of macrophage, and anti-inflammatory, anticancer, antibacterial, anti-aging etc. have good function
Effect.
Fructus lycii is both traditional rare traditional Chinese medicine and a kind of tonic food.As traditional Chinese medicine, fructus lycii is sweet natured,
Have effects that nourishing liver and kidney, benefiting shrewd head, moistening lung.By chemical composition analysis, the fruit of fructus lycii detects rich in
The nutritional ingredients such as natural Beta-carotene, vitamin C, fructus lycii proteoglycan, glycine betaine, linoleic acid and iron, phosphorus, calcium, there is qi-restoratives peace
Mind, improving eyesight wind-dispelling, the effects of nourshing kidney moistening lung and protect liver is antitumor.
Arillus longan is also a kind of common Chinese medicine, has the effect of tonifying heart and spleen, nourishing blood and tranquilization, is usually used in qi and blood not
Foot, palpitation and severe palpitation, amnesia insomnia, blood deficiency chlorosis.
But maca, Cordyceps militaris, fructus lycii and arillus longan are not prepared as to the report of drug or health care product at present still.
Summary of the invention
The present invention provides a kind of composition with health care function and its assembled alcoholic drinks, a kind of the composition is additionally provided
Preparation method.
The present invention provides a kind of compositions with health care function, it is by including that the raw material of following weight proportion is made
Medicament:
5-75 parts of maca, 1-45 parts of Cordyceps militaris, 1-45 parts of fructus lycii, 5-75 parts of arillus longan.
It is further preferred that it is the medicament made of the raw material of following weight parts proportion:
5-75 parts of maca, 1-45 parts of Cordyceps militaris, 1-45 parts of fructus lycii, 5-75 parts of arillus longan.
It is further preferred that it is the medicament made of the raw material of following weight parts proportion:
10-43.5 parts of maca, 4.5-14.5 parts of Cordyceps militaris, 3-25 parts of fructus lycii, 7-18 parts of arillus longan.
It is further preferred that the sum of the maca, Cordyceps militaris, parts by weight of fructus lycii and arillus longan are 58 parts.
It is further preferred that it is the medicament made of the raw material of following weight parts proportion:
20 parts of maca, 10 parts of Cordyceps militaris, 20 parts of fructus lycii, 8 parts of arillus longan；
Or: 10 parts of maca, 20 parts of Cordyceps militaris, 20 parts of fructus lycii, 8 parts of arillus longan；
Or: 10 parts of maca, 15 parts of Cordyceps militaris, 20 parts of fructus lycii, 8 parts of arillus longan；
Or: 10 parts of maca, 10 parts of Cordyceps militaris, 25 parts of fructus lycii, 13 parts of arillus longan；
Or: 10 parts of maca, 13 parts of Cordyceps militaris, 23 parts of fructus lycii, 12 parts of arillus longan；
Or: 10 parts of maca, 10 parts of Cordyceps militaris, 20 parts of fructus lycii, 18 parts of arillus longan；
Or: 43.5 parts of maca, 4.5 parts of Cordyceps militaris, 3 parts of fructus lycii, 7 parts of arillus longan；
Or: 23.5 parts of maca, 14.5 parts of Cordyceps militaris, 8 parts of fructus lycii, 12 parts of arillus longan；
Or: 33.5 parts of maca, 10 parts of Cordyceps militaris, 7.5 parts of fructus lycii, 7 parts of arillus longan；
Or: 13.5 parts of maca, 14.5 parts of Cordyceps militaris, 18 parts of fructus lycii, 12 parts of arillus longan.
It is further preferred that the medicament is semisolid preparation or liquid preparation.The semisolid preparation includes liquid extract
Agent, extract etc.；Liquid preparation includes vina, decoction, tincture etc..
It is further preferred that it is the medicament being prepared by following step:
(1) raw material of following portions by weight is taken: 5-75 parts of maca, 1-45 parts of Cordyceps militaris, 1-45 parts of fructus lycii, arillus longan 5-
75 parts；
(2) ethyl alcohol that concentration is 50-70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate；
(3) gained filtrate in concentration step (2) to obtain the final product.
It is further preferred that be the reflux leaching at 80-100 DEG C when ethyl alcohol leaches in the step (2), leaching
Number is 1-2 times, and the ethanol consumption leached every time is 3-5 times of medicinal material amount, and the time leached every time is 1-3 hours.
It is further preferred that the concentration ratio in the step (3) is 15%.
The present invention also provides a kind of methods for preparing the composition, comprising the following steps:
(1) raw material of following portions by weight is taken: 5-75 parts of maca, 1-45 parts of Cordyceps militaris, 1-45 parts of fructus lycii, arillus longan 5-
75 parts；
(2) ethyl alcohol that concentration is 50-70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate；
(3) gained filtrate in concentration step (2) to obtain the final product.
It is further preferred that be the reflux leaching at 80-100 DEG C when ethyl alcohol leaches in the step (2), leaching
Number is 2 times, and the ethanol consumption leached every time is 3-5 times of medicinal material amount, and the time leached every time is 2 hours.
It is further preferred that the concentration ratio in the step (3) is 15%.
The present invention also provides the compositions in preparation treatment and/or to prevent to be immunized as caused by chemotherapy and/or radiotherapy
The drug of inhibition or the purposes in health care product.It is further preferred that the immunosupress is bone marrow suppression and/or immune organ weight
Amount is reduced.
The present invention also provides use of the composition in preparation enhancing immune and/or antifatigue drug or health care product
On the way.
The present invention also provides a kind of assembled alcoholic drinks, it is the assembled alcoholic drinks being prepared by following step: by the combination
Object is mixed according to the ratio and Spirit of 1:10-1:20, is filtered to obtain the final product.
It is further preferred that the Spirit is the bent wine that concentration is 30-60%.
Maca, Cordyceps militaris, fructus lycii and arillus longan are combined and composition are made by the present invention, and medicine is made by ethyl alcohol leaching
Agent, no matter dosage height, all have that excellent enhancing is immune and anti-fatigue effect；The assembled alcoholic drinks made from the composition makes work
Skill is simple, and product is natural, green, nutrition, health, with good healthcare function.
The present invention is described in further details below by specific embodiment, but is not to limit of the invention
System, above content according to the present invention, according to the ordinary technical knowledge and customary means of this field, not departing from, the present invention is above-mentioned
Under the premise of basic fundamental thought, the modification, replacement or change of other diversified forms can also be made.
Specific embodiment
Raw material used in following embodiment comes from Chengdu lotus pond medicinal material market.
Raw material pre-treatment: maca, Cordyceps militaris crushed 10 meshes.
The preparation of 1 present composition of embodiment
(1) raw material of following portions by weight: maca 20g, Cordyceps militaris 10g, fructus lycii 20g, arillus longan 8g are taken；
(2) ethyl alcohol that concentration is 50% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate and is concentrated back
Ethyl alcohol is received, leaching is the leaching that flows back at 80-100 DEG C, and the number of leaching is 2 times, and the ethanol consumption leached every time is
200mL, the time leached every time are 2 hours.
(3) in concentration step (2) gained filtrate to 30mL to obtain the final product.
The preparation of 2 present composition of embodiment
(1) raw material of following portions by weight: maca 20g, Cordyceps militaris 10g, fructus lycii 20g, arillus longan 8g are taken；
(2) ethyl alcohol that concentration is 60% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate, leaches
It is the leaching that flows back at 80-100 DEG C, the number of leaching is 2 times, and the ethanol consumption leached every time is 200mL, is leached every time
Time is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL to obtain the final product.
The preparation of 3 present composition of embodiment
(1) raw material of following portions by weight: maca 20g, Cordyceps militaris 10g, fructus lycii 20g, arillus longan 8g are taken；
(2) ethyl alcohol that concentration is 70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate, leaches
It is the leaching that flows back at 80-100 DEG C, the number of leaching is 1 time, and the ethanol consumption of leaching is 200mL, and leaching time is 3 small
When.
(3) in concentration step (2) gained filtrate to 30mL to obtain the final product.
The preparation of 4 present composition of embodiment
(1) raw material of following portions by weight: maca 20g, Cordyceps militaris 10g, fructus lycii 20g, arillus longan 8g are taken；
(2) ethyl alcohol that concentration is 70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate, leaches
It is the leaching that flows back at 80-100 DEG C, the number of leaching is 2 times, and the ethanol consumption leached every time is 200mL, is leached every time
Time is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL to obtain the final product.
The preparation of the pharmaceutical composition of the present invention of embodiment 5
(1) raw material of following portions by weight: maca 20g, Cordyceps militaris 10g, fructus lycii 20g, arillus longan 8g are taken；
(2) ethyl alcohol that concentration is 70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate, leaches
It is the leaching that flows back at 80-100 DEG C, the number of leaching is 2 times, and the ethanol consumption leached every time is 200mL, is leached every time
Time is 1 hour.
(3) in concentration step (2) gained filtrate to 30mL to obtain the final product.
The preparation of the pharmaceutical composition of the present invention of embodiment 6
(1) raw material of following portions by weight: maca 10g, Cordyceps militaris 20g, fructus lycii 20g, arillus longan 8g are taken；
(2) ethyl alcohol that concentration is 70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate, leaches
It is the leaching that flows back at 80-100 DEG C, the number of leaching is 2 times, and the ethanol consumption leached every time is 200mL, is leached every time
Time is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL to obtain the final product.
The preparation of the pharmaceutical composition of the present invention of embodiment 7
(1) raw material of following portions by weight: maca 10g, Cordyceps militaris 15g, fructus lycii 25g, arillus longan 8g are taken；
(2) ethyl alcohol that concentration is 70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate, leaches
It is the leaching that flows back at 80-100 DEG C, the number of leaching is 2 times, and the ethanol consumption leached every time is 200mL, is leached every time
Time is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL to obtain the final product.
The preparation of the pharmaceutical composition of the present invention of embodiment 8
(1) raw material of following portions by weight: maca 10g, Cordyceps militaris 10g, fructus lycii 25g, arillus longan 13g are taken；
(2) ethyl alcohol that concentration is 70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate, leaches
It is the leaching that flows back at 80-100 DEG C, the number of leaching is 2 times, and the ethanol consumption leached every time is 200mL, is leached every time
Time is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL to obtain the final product.
The preparation of the pharmaceutical composition of the present invention of embodiment 9
(1) raw material of following portions by weight: maca 10g, Cordyceps militaris 13g, fructus lycii 23g, arillus longan 12g are taken；
(2) ethyl alcohol that concentration is 70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate, leaches
It is the leaching that flows back at 80-100 DEG C, the number of leaching is 2 times, and the ethanol consumption leached every time is 200mL, is leached every time
Time is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL to obtain the final product.
The preparation of the pharmaceutical composition of the present invention of embodiment 10
(1) raw material of following portions by weight: maca 10g, Cordyceps militaris 10g, fructus lycii 20g, arillus longan 18g are taken；
(2) ethyl alcohol that concentration is 70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate, leaches
It is the leaching that flows back at 80-100 DEG C, the number of leaching is 2 times, and the ethanol consumption leached every time is 200mL, is leached every time
Time is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL to obtain the final product.
The preparation of the pharmaceutical composition of the present invention of embodiment 11
(1) raw material of following portions by weight: maca 43.5g, Cordyceps militaris 4.5g, fructus lycii 3g, arillus longan 7g are taken；
(2) ethyl alcohol that concentration is 70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate, leaches
It is the leaching that flows back at 80-100 DEG C, the number of leaching is 2 times, and the ethanol consumption leached every time is 200mL, is leached every time
Time is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL to obtain the final product.
The preparation of the pharmaceutical composition of the present invention of embodiment 12
(1) raw material of following portions by weight: maca 23.5g, Cordyceps militaris 14.5g, fructus lycii 8g, arillus longan 12g are taken；
(2) ethyl alcohol that concentration is 70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate, leaches
It is the leaching that flows back at 80-100 DEG C, the number of leaching is 2 times, and the ethanol consumption leached every time is 200mL, is leached every time
Time is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL to obtain the final product.
The preparation of the pharmaceutical composition of the present invention of embodiment 13
(1) raw material of following portions by weight: maca 33.5g, Cordyceps militaris 10g, fructus lycii 7.5g, arillus longan 7g are taken；
(2) ethyl alcohol that concentration is 70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate, leaches
It is the leaching that flows back at 80-100 DEG C, the number of leaching is 2 times, and the ethanol consumption leached every time is 200mL, is leached every time
Time is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL to obtain the final product.
The preparation of the pharmaceutical composition of the present invention of embodiment 14
(1) raw material of following portions by weight: maca 13.5g, Cordyceps militaris 14.5g, fructus lycii 18g, arillus longan 12g are taken；
(2) ethyl alcohol that concentration is 70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate, leaches
It is the leaching that flows back at 80-100 DEG C, the number of leaching is 2 times, and the ethanol consumption leached every time is 200mL, is leached every time
Time is 2 hours.
(3) in concentration step (2) gained filtrate to 30mL to obtain the final product.
The preparation of the assembled alcoholic drinks of the present invention of embodiment 15
4 gained pharmaceutical composition of embodiment is mixed according to the fragrant type brewing that the ratio and concentration of 1:10 are 30%, mistake
It filters to obtain the final product, which meets sensory evaluation criteria shown in table 1.
1 sensory evaluation of table
| Project | Sensory evaluation |
| Appearance | It is clear and transparent, no precipitating and suspended matter |
| Color | In faint yellow or brown color |
| Fragrance | It is all fragrant harmonious with corresponding plant perfume and aroma |
| Flavour | It is pure and mild, it relaxes along harmony, wine body is complete |
The preparation of the assembled alcoholic drinks of the present invention of embodiment 16
4 gained pharmaceutical composition of embodiment is mixed according to the fragrant type brewing that the ratio and concentration of 1:20 are 60%, mistake
It filters to obtain the final product, which meets sensory evaluation criteria shown in table 1.
In order to prove the beneficial effect of pharmaceutical composition of the present invention, following tests example is provided.
The immunosupress as caused by chemotherapy and/or radiotherapy of the medicine composite for curing of the present invention of test example 1 and/or prevention
1. material and instrument
1.1 drug
(1) composition of embodiment 1 is as dosage 1. group.
(2) composition of embodiment 2 is as dosage 2. group.
(3) composition of embodiment 3 is as dosage 3. group.
(4) composition of embodiment 4 is as dosage 4. group.
(5) composition of embodiment 5 is as dosage 5. group.
(6) composition of embodiment 6 is as dosage 6. group.
(7) composition of embodiment 7 is as dosage 7. group.
(8) composition of embodiment 8 is as dosage 8. group.
(9) composition of embodiment 9 is as dosage 9. group.
(10) composition of embodiment 10 is as dosage 10. group.
(11) composition of embodiment 11 is as dosageGroup.
(12) composition of embodiment 12 is as dosageGroup.
(13) composition of embodiment 13 is as dosageGroup.
(14) composition of embodiment 14 is as dosageGroup.
1.2 experimental animal
KM mouse, 18.5~22.5g of weight.
1.3 laboratory apparatus, reagent
(1) blood picture analyzer, electronic balance etc.；
(2) hemolytic agent, cleaning agent, dilution etc..
1.4 positive drug
SHENGMAI JIAONANG.
2. effect experiment
2.1 experimental method
All mouse adaptable feds are randomly divided into after 1 week by weight: normal group, model group, positive group (SHENGMAI JIAONANG
Group), dosage 1.~Group, every group 10.Each experimental group since the experimental day according to dosage, administration mode give relative medicine,
Wherein normal group and the isometric pure water of model group stomach-filling, continuous 10 days.Test the 4th day, except for the normal group, remaining each group mouse
By 60mgkg-1Dosage intraperitoneal injection of cyclophosphamide normal saline solution is continuous 4 days, normal to organize mouse peritoneal injection in equal volume
Physiological saline.It tests the 10th day, each experimental mice eye socket takes blood, is collected with the 1.5mLEP pipe equipped with sodium heparin anticoagulant, gently
It shakes, mixes.In taking each experimental mice spleen and thymus gland on aseptic working platform, physiological saline cleans bloodstain.
2.2 Testing index
(1) peripheral blood cells: using full-automatic blood counting instrument to each experimental mice peripheral white blood cells (WBC), red
Cell (RBC) and hemoglobin (HGB) quantity are counted.
(2) immune organ weight coefficient: weighing each experimental mice spleen and thymic weight, calculates organ coefficient [organ
Weight (mg)/weight (20g)].
2.3 experimental result
2.3.1 to the effect of bone marrow suppression
It the results are shown in Table 2.
Each experimental mice peripheral blood cells of table 2 accelerate ()
Note: compared with model group, P < 0.01 * P < 0.05, * *；Compared with positive group, P < 0.01 △ P < 0.05, △ △.
As shown in Table 2, compared with model group, each dosage group peripheral blood in mice leucocyte accelerates and has significant raising
(P < 0.05), 4. group has extremely significant raising (P < 0.01) to act on to dosage.Compared with positive group, dosage 4.-Group mouse peripheral blood
Liquid leucocyte, which is accelerated, significant raising (P < 0.05)；Compared with model group, each dosage group peripheral blood in mice red blood cell
Accelerating has significant raising (P < 0.05).Compared with positive group, dosage 4.-Group peripheral blood in mice red blood cell increases
Quantity has significant raising (P < 0.05)；Compared with model group, each dosage group peripheral blood in mice hemoglobin is accelerated
There is significant raising (P < 0.05).Compared with positive group, 4. dosage organizes peripheral blood in mice hemoglobin and accelerates significant liter
High (P < 0.05).
Therefore, compared with model group, no matter dosage height, each dosage group all has significant treatment and/or prevents by ring
The effect of bone marrow suppression caused by phosphamide, wherein it is particularly evident to the promotion effect of periphery white blood cell count, it is increased to
4.5-6.3 times of model group.Especially dosage 4. group increases from experimental animal peripheral white blood cells, red blood cell, hemoglobin is promoted
It is significantly better than positive group in terms of dosage, effect is best.
2.3.2 to the effect of immune organ weight reduction
It the results are shown in Table 3.
Each experimental mice immune organ weight coefficient of table 3 ()
Note: compared with model group, P < 0.01 * P < 0.05, * *；Compared with positive group, P < 0.01 △ P < 0.05, △ △.
As shown in Table 3, compared with model group, each dosage group to mouse spleen weight coefficient have significant raising (P <
0.05).Compared with positive group, 4. dosage organizes mouse spleen weight coefficient significant raising (P < 0.05).Compared with model group, respectively
Dosage group mouse thymus weight coefficient has significant raising (P < 0.05).Compared with positive group, dosage 3., 4. organize mouse thymus weight
Coefficient of discharge has significant raising (P < 0.05).
Therefore, compared with model group, no matter dosage height, each dosage group all has significant treatment and/or prevents by ring
The effect of immune organ weight reduction caused by phosphamide.Wherein with dosage, 4. group, promotion experimental animal spleen, thymus gland are dirty especially
The effect of device index is better than positive drug comprehensively, and effect is best.
To sum up, no matter dosage height, pharmaceutical composition of the present invention can treat effectively and/or prevent by chemotherapy and/or put
Immunosupress caused by treating has the function of that enhancing is immune.
Test example 2 is antifatigue with pharmaceutical composition of the present invention
1. material and instrument
1.1 drug
(1) composition of embodiment 1 is as dosage 1. group.
(2) composition of embodiment 2 is as dosage 2. group.
(3) composition of embodiment 3 is as dosage 3. group.
(4) composition of embodiment 4 is as dosage 4. group.
(5) composition of embodiment 5 is as dosage 5. group.
(6) composition of embodiment 6 is as dosage 6. group.
(7) composition of embodiment 7 is as dosage 7. group.
(8) composition of embodiment 8 is as dosage 8. group.
(9) composition of embodiment 9 is as dosage 9. group.
(10) composition of embodiment 10 is as dosage 10. group.
(11) composition of embodiment 11 is as dosageGroup.
(12) composition of embodiment 12 is as dosageGroup.
(13) composition of embodiment 13 is as dosageGroup.
(14) composition of embodiment 14 is as dosageGroup.
1.2 experimental animal
KM mouse, 18.5~22.5g of weight.
1.3 laboratory apparatus, reagent
(1) experimental animal behaviouristics swimming pool, Electric radiator etc.；
(2) stopwatch, iron wire etc..
1.4 positive drug
SHENGMAI JIAONANG.
2. effect experiment
2.1 experimental method
All mouse adaptable feds are randomly divided into after 1 week by weight: control group, positive group (SHENGMAI JIAONANG group), dosage
1.~Group, every group 10.Each experimental group since the experimental day according to dosage, administration mode give relative medicine, wherein normally
Group and the isometric pure water of model group stomach-filling, continuous 10 days.Test 2h after being administered, each experimental mice tail portion load the 10th day
The iron wire of 10% weight is swum (25 DEG C of water temperature, depth of water 20cm) into the water, and observation mouse swims to power and exhausts, and (10s is not under water
Can float), which is the swimming time of mouse.
2.2 Testing index
Each experimental mice swimming time.
2.3 experimental result
It the results are shown in Table 4.
Each experimental mice swimming time of table 4 ()
Note: compared with model group, P < 0.01 * P < 0.05, * *；Compared with positive group, P < 0.01 △ P < 0.05, △ △.
As shown in Table 4, compared with model group, each dosage group mouse swimming time has significant extension (P < 0.05), dosage
3.~Group has extremely significant extension (P < 0.01).Compared with positive group, dosage 4. organize mouse swimming time have significant extension (P <
0.05)。
Therefore, compared with model group or positive group, no matter dosage height, each dosage group can significantly improve mouse
Swimming time, there is significant antifatigue effect, wherein it is best 4. to organize effect with dosage especially.
In conclusion the present invention, which combines maca, Cordyceps militaris, fructus lycii and arillus longan, is made composition, soaked by ethyl alcohol
It takes and medicament is made, no matter the immunosupress as caused by chemotherapy and/or radiotherapy can effectively be treated and/or be prevented to dosage just, and
And have excellent enhancing immune and anti-fatigue effect；The assembled alcoholic drinks manufacture craft made from the composition is simple, product is natural,
Green, nutrition, health have good healthcare function.
Claims (13)
1. it is a kind of be used to prepare alleviate the immunosuppressive health care product as caused by chemotherapy composition, it is characterised in that: it be by
Medicament made of the raw material of following weight parts proportion:
20 parts of maca, 10 parts of Cordyceps militaris, 20 parts of fructus lycii, 8 parts of arillus longan.
2. according to claim 1 be used to prepare the composition for alleviating the immunosuppressive health care product as caused by chemotherapy,
Be characterized in that: the medicament is semisolid preparation or liquid preparation.
3. according to claim 1 be used to prepare the composition for alleviating the immunosuppressive health care product as caused by chemotherapy,
Be characterized in that: it is the medicament being prepared by following step:
(1) raw material of following portions by weight is taken: 20 parts of maca, 10 parts of Cordyceps militaris, 20 parts of fructus lycii, 8 parts of arillus longan；
(2) ethyl alcohol that concentration is 50-70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate；(3) dense
Filtrate obtained by contracting step (2) to obtain the final product.
4. composition according to claim 3, it is characterised in that: when ethyl alcohol leaches in the step (2), in 80-100
At DEG C reflux leaching, the number of leaching is 1-2 times, and the ethanol consumption leached every time is 3-5 times of medicinal material amount, leach every time when
Between be 1-3 hours.
5. composition according to claim 4, it is characterised in that: the concentration ratio in the step (3) is 15%.
6. it is a kind of prepare Claims 1 to 5 it is described in any item be used to prepare alleviate the immunosuppressive health care as caused by chemotherapy
The method of the composition of product, comprising the following steps:
(1) raw material of following portions by weight is taken: 20 parts of maca, 10 parts of Cordyceps militaris, 20 parts of fructus lycii, 8 parts of arillus longan；
(2) ethyl alcohol that concentration is 50-70% is added to raw material described in step (1) to leach, filtering leaching liquid obtains filtrate；
(3) gained filtrate in concentration step (2) to obtain the final product.
7. preparation method according to claim 6, it is characterised in that: when ethyl alcohol leaches in the step (2), in 80-
Reflux leaching at 100 DEG C, the number of leaching is 2 times, and the ethanol consumption leached every time is 3-5 times of medicinal material amount, is leached every time
Time is 2 hours.
8. preparation method according to claim 6, it is characterised in that: the concentration ratio in the step (3) is 15%.
9. the described in any item compositions of Claims 1 to 5 are in preparation treatment and/or prevent as caused by chemotherapy and/or radiotherapy
Purposes in immunosuppressive drug.
10. purposes according to claim 9, it is characterised in that: the immunosupress is bone marrow suppression and/or immune organ
Weight is reduced.
11. the described in any item compositions of the Claims 1 to 5 drug or health care product immune and/or antifatigue in preparation enhancing
In purposes.
12. a kind of assembled alcoholic drinks, it is characterised in that: it is the assembled alcoholic drinks being prepared by following step: Claims 1 to 5 is appointed
The ratio for alleviating the composition of the immunosuppressive health care product as caused by chemotherapy according to 1:10-1:20 is used to prepare described in one
It mixes, filters with Spirit to obtain the final product.
13. assembled alcoholic drinks according to claim 12, it is characterised in that: the Spirit is the bent wine that concentration is 30-60%.
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| CN106605901A (en) * | 2015-10-16 | 2017-05-03 | 镇江市天益生物科技有限公司 | Cordyceps militaris-Maca tablet production method |
| CN107772439A (en) * | 2016-08-24 | 2018-03-09 | 江苏康缘药业股份有限公司 | The Chinese medicine composition and its chewable tablets of a kind of longan containing maca |
| CN107142184B (en) * | 2017-06-30 | 2020-09-11 | 宁夏塞上无极生物产业有限公司 | Wolfberry polysaccharide health wine and preparation method thereof |
| CN109762707A (en) * | 2019-03-01 | 2019-05-17 | 湖北艾中艾健康酒业有限公司 | A kind of health liquor and preparation method thereof |
| CN113604321B (en) * | 2021-08-18 | 2023-05-05 | 陕西开元制药有限公司 | Cordyceps sinensis health wine and production process thereof |
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