CN102698081B - Medicinal liquor with treatment effect and health-care function and preparation method thereof - Google Patents
Medicinal liquor with treatment effect and health-care function and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicinal liquor with a treatment effect and a health-care function. The medicinal liquor comprises 75-85 parts of edible wine of 38-53 degrees, 1-3 parts of ginsengs, 0.5-1.5 parts of hairy deerhorn, 1-3 parts of barbary wolfberry fruit, 1-3 parts of cherokee rose fruit, 2-6 parts of astragalus, 1.5-4 parts of epimedium herb, 0.5-1.5 parts of saffron or stigma croci, 1-3 parts of cortex eucommiae, 1-3 parts of sealwort, 1-3 parts of gecko and 1-3 parts of royal jelly or honey. The medicinal liquor is prepared from a plurality of Chinese medicines and edible wine, has good treatment effects and health-care prevention functions on a part of diseases, has unique mouthfeel, strong Chinese medicinal faint scent and multiple flavors, and has the characteristics of spliced flavor, strong flavor and fruit flavor. Moreover, the medicinal liquor has the effect of treating and preventing cancer cells. Meanwhile, the medicinal liquor disclosed by the invention is a remarkable success commercially.
Description
Technical field
The present invention relates to a kind of medicine, particularly relate to a kind of medicated wine.
Background technology
Medicated wine is as important conventional dosage forms, be used for the treatment of and health care, it by Chinese medicine and wine " molten " in one, not only preparation is convenient, the property of medicine is stable, safe and effective, and because ethanol is a kind of good semi-polarity organic solvent, the various effective ingredient of Chinese medicine are all soluble in wherein, and wine assisting drug, wine help medicine gesture and gives full play to its effect, improve curative effect; Medicated wine has conveniently to be taken, applied range, is easy to preserve.And medicated wine has good preventive effect to some diseases.But, owing to having added a large amount of Chinese medicine in medicated wine, therefore can make the mouthfeel of wine and taste be affected.
Summary of the invention
Technical problem to be solved by this invention is: a kind of medicated wine with therapeutic effect and health care is provided, and it not only has good therapeutic effect and health care, also has extraordinary mouthfeel, and unique local flavor, to overcome the deficiencies in the prior art.
The medicated wine with therapeutic effect and health care, comprise: 75～85 parts of 38～53 ° of edible wines, 1～3 part of ginseng class, 0.5～1.5 part, Cornu Cervi Pantotrichum, 1～3 part of Fructus Lycii, 1～3 part of Fructus Rosae Laevigatae, 2～6 parts of the Radixs Astragali, 1.5～4 parts of Herba Epimedii, 0.5～1.5 part of Stigma Croci or Stigma Croci, 1～3 part of the Cortex Eucommiae, 1～3 part of Rhizoma Polygonati, 1～3 part of 1～3 part of Gecko and Lac regis apis or Mel.
Described ginseng class is Radix Ginseng, one or more in Radix Ginseng Rubra or Radix Codonopsis.
Also comprise 1～3 part of Radix Cynanchi Paniculati.
Described edible wine is grain wine.
The preparation method with the medicated wine of therapeutic effect and health care, will join class, Cornu Cervi Pantotrichum, Fructus Lycii, Fructus Rosae Laevigatae, the Radix Astragali, Herba Epimedii, Stigma Croci or Stigma Croci, the Cortex Eucommiae, Rhizoma Polygonati, Gecko and Lac regis apis or Mel directly add or pulverize after add in edible wine sealing to soak more than 3 months, process after filtration again, subpackage, after obtain finished product.
Product of the present invention is the famous product in Guizhou " wine to congradulate one's birthday longevity ", and product of the present invention has warming and recuperating the spleen and kidney, tonifying YANG replenishing essence, and cloudy emerging sun rises, eliminates disease and prolong life, relieving fatigue, promoting blood circulation to remove obstruction in the collateral, bone and muscle strengthening, prolongs defying age, and reinforcement is anti-.Be applicable to treat impotence in male, seminal emission, premature ejaculation, lumbago, insomnia and woman's menoxenia, leukorrhagia is rare clearly, infertility etc.Person in middle and old age often drink the beneficial brain of can refreshing oneself, bone and muscle strengthening, spleen benefiting and stimulating the appetite.
In order to verify therapeutic effect and the toxic and side effects of product of the present invention, first carried out zoopery: 1, sample (1) source: it is appropriate that sample of the present invention provides (2) test liquid to prepare sample thief by Guizhou Province Chuan Qianjie source technology development company, concentrated in water-bath Back stroke alcohol, make the concentrated solution of 0.74g/ml (calculating by crude drug in whole).
2,20 of 17-19 gram of Kunming kind healthy mices (male and female half and half, sub-cage rearing is observed) are got in experiment, with above-mentioned test liquid 0.6ml/ (25g crude drug/kg) gastric infusion, in one day, administration is 3 times, observation post administration 7 days, all animal subjects are strong depositing all, has no toxic reaction.
According to through Guizhou, the distributors of " wine to congradulate one's birthday longevity " carries out questionnaire survey to the user of 100 these products of life-time service, in receiving investigator, the user of 20～30 years old age brackets is 10 people, the user of 30～40 years old age brackets is 20 people, the user of 40～60 years old age brackets is 40 people, and all the other users are 60 years old above age bracket; Wherein male user is 82 people, and women user is 18 people.According to the survey result of user feedback, show, receive in the male user of investigation, there are 77 people to represent to take " wine to congradulate one's birthday longevity " after 3 months by the description of product, really in the problem of alleviating in varying degrees or eliminated sexual impotence, seminal emission, premature ejaculation, lumbago or insomnia, and all without the discomfort of finding to produce because taking this product; The reason of all the other 5 people's long term purchase " wine to congradulate one's birthday longevity " is owing to liking its taste, also without finding uncomfortable symptom.In receiving the women user of investigation, there are 14 people to represent to take " wine to congradulate one's birthday longevity " after 3 months by the description of product, alleviated the clear rare symptom of menoxenia and leukorrhagia, there is no discomfort; All the other represent that buying " wine to congradulate one's birthday longevity " is that other kinsfolks drink.
Product of the present invention is except having above-mentioned therapeutic effect and health care, also have good mouthfeel, product of the present invention is allocated by various Chinese medicine, except having dense Effect of Chinese Medicine Qing fragrance, the flavor taste that also has a wine multi-flavor, has beans perfume (or spice), giving off a strong fragrance and fruity.
In order further to verify the effect of product of the present invention, test at the anticancer research center of product of the present invention " wine to congradulate one's birthday longevity " being delivered to Xiamen University again, and its experiment thes contents are as follows: the main trace element analysis in 1-1 wine to congradulate one's birthday longevity: employing is derived from absorption spectrum microanalysis and carries out.
Table 1 wine to congradulate one's birthday longevity main trace element content unit: μ g/ml
foodstuff amino acid analysis in 1-2 wine to congradulate one's birthday longevity: adopt source high performance liquid chromatography to carry out.
Table 2 wine to congradulate one's birthday longevity foodstuff amino acid content unit: μ g/ml
1-3 spectrum experiment scanning analysis 1-3-1 spectrofluorimetry: FDAC 4110 fluorophotometric instrument are measured: contain Effective Component of Chinese Medicine fluorescence spectral characteristic longevity in wine to congradulate one's birthday, excitation wave honeybee value 391.4nm, transmitted wave peak value 460.2nm.1-3-2 ultraviolet and visible Spectra Analysis on Edge Recycling: German Beckman uv-spectrophotometric instrument is measured: in longevity wine to congradulate one's birthday, contained main Chinese medicine ingredients is in 320-450nm scope, absorption spectrum is shown in scintigram, ingredient is more complicated, and 38-wine Chinese medicine content joins readout instrument determination and analysis a little more than 45-1-3-3 M-3550 type enzyme: wavelength 405nm.Working sample: 38-wine to congradulate one's birthday longevity, the long-lived permanently happy wine of control sample: 55-, reference sample: 38-ethanol.Table 3 wine to congradulate one's birthday longevity is on the impact of Peritoneal Cells of Mice phagocytic function (X ± D)
the 2-3 mouse growth state observation of drinking: BALB/C mice 5,3 of Kunming mouses, observe after 23 days brief summary as follows: (1) food-intake increases, the food that happiness cuisine canon wine longevity soaks.(2) lubricated, the light of hair color, cold tolerance strengthen, well-grown under 16-20 ℃ of room temperature condition.(3) mice is active, full of vitality, is quick on the draw.The variation of 2-4 inoculation S180 tumor: observe three groups of inoculated tumour cell Hou Chengliu statistical table units of 39 tables 4 of mice: only
table 5 three forms tumor mouse tumor body volume ratio compared with list position: cm
2 according to above experiment, can find out, of the present invention have a good raising nonspecific immunity effect, strengthens the ability that abdominal cavity phagocytic is removed foreign body and senile cell, also the one-tenth tumor of S180 sarcoma had to impact, has certain anti-cancer effect.
Impact on the food of " wine to congradulate one's birthday longevity " immunology and tumor animal experiment study (1) feed " wine to congradulate one's birthday longevity " immersion on laboratory animal tumor 8-180 sarcoma, ehrlich ascites tumor.(2) take after " wine to congradulate one's birthday longevity ", on improving, promote the impact of laboratory animal hematopoietic function.(3) take this after drinking, impact on middle-aged and elderly people immune function, whether there is enhancing, whether the effect (4) " wine to congradulate one's birthday longevity " that regulates immune function has obvious 2. impacts on Healthy People immunologic function that affect to the stress ability of laboratory animal: 2.1 objects of observation: user in health, old people, without infection, tumor and other chronic disease history, male's 8 examples wherein, women's 4 examples, 51.5 years old mean age.2.2) instructions of taking: 6 times weekly, take continuously each 20ml 8 weeks, total amount is 860ml, 38 ℃ longevity wine to congradulate one's birthday lot number: 940828, respectively venous blood sampling, separated lymphocyte and serum before and after taking, measure following index according to clinical immunology inspection method.The variation that inspection was met in Table 6, table 7 table 6 Healthy People (12 example) is taken immune indexes after wine to congradulate one's birthday longevity
table 7 Healthy People is taken the inspection of wine to congradulate one's birthday longevity front and back liver function, tumor related marker material
3. laboratory animal part: 3.1 laboratory animals: BALB/C mice, Kunming mouse, by Kang Liu center, animal housing provides.Select body weight 17-18g to use.3.2 tumor cell lines: SARCOMA-180 tumor system, original cultivation are solid tumor strain, build up suspension growth cell line from 1978 Nian You Chinese Academy of Sciences animals, and Mice Inoculated intraperitoneal grows up to ascitic type neoplasm lines.3.3 raise and medication: feedstuff is purchased from Shanghai western pul Yi Bikai company.Feedstuff composition: Fructus Hordei Vulgaris, Semen Glycines powder, alfalfa meal, green vegetable powder, fish flour, bone meal and vitamin etc.Take feedstuff 100g, add medicated wine 20ml, room temperature was placed after 2 hours, phase feeding animal, and matched group adding distil water or Chinese liquor the same manner are processed, and by every 6g/ days feeding, it is 1ml that average every mice is taken in medicated wine amount.3.4 solid tumors and the curative effect of ascites tumor experimental result table 8 wine to congradulate one's birthday longevity to Sarcoma-180 solid tumor
table 9 second batch S180 solid tumor mouse experiment
note: this experiment is carried out under 23 ± 2 ℃ of constant temperature and humidity laminar-flow rack conditions.Table 10 is taken longevity wine to congradulate one's birthday to the effect of ehrlich ascites tumor (one)
table 11 is taken longevity wine to congradulate one's birthday to the effect of ehrlich ascites tumor (two)
table 12 is taken the effect of wine to congradulate one's birthday longevity to S180 ascites tumor
note: table 6 inoculation 600,000 cells/only/0.2ml; Use animal is BALB/C mice.Table 6 is depicted as an inoculation 100,000/ehrlich ascites tumor cell, and use animal is kunming mouse.3.5 take the impact of wine to congradulate one's birthday longevity on healthy mice and tumor-bearing mice hemopoietic function: select animal standard and raising, medication the same (3.1-3.3), after 14 days, cutting tail gets peripheral blood and measures following index: (1) hemoglobin (2) erythrocyte (3) leukocyte, all establish conventional food contrast and the contrast of jowar wine food for every group, laboratory examination the results are shown in Table 8-10.In following experimental result, can find out, longevity, wine to congradulate one's birthday was remarkable for improving laboratory animal hemoglobin and erythrocyte number effect, was respectively 12.2% and 15.5%.Especially strikingly the impact on tumor-bearing mice hemoglobin, inoculation S180 solid tumor mice (0.2ml/50 ten thousand cell), takes wine to congradulate one's birthday group longevity, is increased significantly hemoglobin effect, and malignant tumor can cause the reduction of anemia and hemoglobin, in Table 8-table 11.Longevity, wine to congradulate one's birthday had important value on the impact of tumor-bearing mice hemopoietic function in active Immunotherapy of Cancer Induced work.Table 13 is taken the impact of wine to congradulate one's birthday longevity on Mouse Blood Lactoferrin (Hb)
table 14 is taken the impact of wine to congradulate one's birthday longevity on mouse red blood cell (RBC)
table 15 is taken the impact of wine to congradulate one's birthday longevity on murine interleukin (WBC)
table 16 is taken the impact of wine to congradulate one's birthday longevity on tumor-bearing mice hemoglobin (Hb)
the observation of 3.6 pairs of laboratory animal anti-stress abilities; 3.6.1 select mice standard the same (3.5), male and female half and half, random packet, experimental group is for taking food and drink thing longevity, matched group gives standard food, and successive administration 14 days was put into each group mice separately calcium chloride 250ml wide mouthed bottle is housed respectively to the 15th day, bottle stopper scribbles vaseline jam-pack, timing observed and recorded anoxia in mice death time: the results are shown in Table 17: table 17 mice anoxia enduring experimental result
3.6.2 laboratory animal endurance test: select mice standard the same, grouping and administration condition are the same, the 15th day, all mice fasting are after 12 hours, every additional 10% load of mouse tail, puts into depth of water 30cm, forced swimming in water temperature 26-28 ℃ of bucket, record mice and continue swimming time, the results are shown in Table 18: the endurance experimental result of table 18 mice
3.6.3 the low temperature resistant experimental selection animal standard of mice is the same, 33 of Kunming mouses, are divided into three groups at random, 11 every group, feed medicated wine soaked food after 14 days, each group mice is not put into wire mesh cage, every cage 5 or 6, put into-10 ℃ of low-temp. refrigerators, every 20 minutes kinds, observe once, record dead mouse number and survival number, during Continuous Observation 3.5, result is as follows: the low temperature resistant experimental result of table 19
3.6.4 take Testudinis and make the impact of wine to congradulate one's birthday on Mouse Weight and growth promoter: select animal standard the same, each 30 of BALB/C mice and kunming mouses, random packet, the former (BALB/C) enters between Homoiotherm, and the administration of laminar flow gnotobasis is raised, observe 28 days, the latter's (kunming mouse) puts between common mouse test, and same administration is raised 40 days, calculates respectively weightening finish and changes, in Table 20, table 21; Select 30 of BALB/C mice, inoculate respectively S-180 solid tumor, observe medicated wine, jowar wine and the control animals body weight change under lotus warty state, the observation period is 35 days.Three groups of results are obviously different, in Table 22.Table 20 BALB/C mice body weight change table (isothermal experiments condition)
note: illustrate that longevity, wine rang not obviously to experimental animals ghost image, be unlikely and cause obesity, fatty liver etc.The impact (g) of table 21 wine to congradulate one's birthday longevity on kunming mouse growth body weight
table 22 wine to congradulate one's birthday longevity is on the impact of tumor-bearing mice body weight (g)
the zoopery of carrying out through the anticancer research center of Xiamen University proves, product of the present invention has resisting fatigue, defying age, anti-hypoxia and anti-cold-resistant effect, can there is very good effect to the adjustment balance of red white corpuscle, therefore the present invention is except above-mentioned curative effect, and treatment and the prevention of antagonism cancerous cell all have certain effect.
Product of the present invention was once used wine in nineteen ninety-five as entertaining of Great Hall of the People Diaoyutai State Guesthouse, and sent wine as the gift of the United Nations; The title that has obtained a plurality of awards of State Scientific and Technological Commission, Ministry of Public Health, the Ministry of Domestic Trade, Ministry of Foreign Trade and National Tourism Administration and authorized domestic unique " Chinese health promoting wine king "; In the U.S., the fair of international Darwin's medicine has obtained the highest international gold medal, also obtains a plurality of gold medals and the highest gold medal of the countries such as Singapore, Thailand, Ukraine.Product of the present invention has commercially been obtained significant success.
Owing to having adopted technique scheme, the present invention adopts plurality of Chinese and edible wine jointly to make Chinese medicinal liquor, prepared Chinese medicinal liquor has good therapeutic effect and health care prophylactic function to part disease, and mouthfeel is unique, except having dense Effect of Chinese Medicine Qing fragrance, the flavor taste that also has a wine multi-flavor, has the feature of beans perfume (or spice), giving off a strong fragrance and fruity.And the present invention also has effect altogether to the treatment of cancerous cell and prevention.Product of the present invention has commercially also obtained significant success simultaneously.
The specific embodiment
Embodiments of the invention 1: there is the preparation of the medicated wine of therapeutic effect and health care, comprising: 80 parts of 53 ° of jowar wines, 2 parts of Radix Ginsengs, 1 part, Cornu Cervi Pantotrichum, 2 parts of Fructus Lyciis, 2 parts of Fructus Rosae Laevigatae, 4 parts of the Radixs Astragali, 3 parts of Herba Epimedii, 1 part of Stigma Croci, 2 parts of the Cortexs Eucommiae, 2 parts of Rhizoma Polygonatis, 2 parts of 2 parts of Geckos and Mel; By Radix Ginseng, Cornu Cervi Pantotrichum, Fructus Lycii, Fructus Rosae Laevigatae, the Radix Astragali, Herba Epimedii, Stigma Croci, the Cortex Eucommiae, Rhizoma Polygonati, Gecko and Mel directly add in jowar wine sealing to soak more than 3 months, then process after filtration, subpackage, after obtain finished product.
Embodiments of the invention 2: there is the medicated wine of therapeutic effect and health care, comprising: 75 parts, 38 ° of rice wine, 1 part of Radix Ginseng Rubra, 0.5 part, Cornu Cervi Pantotrichum, 1 part of Fructus Lycii, 1 part of Fructus Rosae Laevigatae, 2 parts of the Radixs Astragali, 1.5 parts of Herba Epimedii, 0.5 part of Stigma Croci, 1 part of the Cortex Eucommiae, 1 part of Rhizoma Polygonati, 1 part of Gecko, 2 parts of 1 part of Lac regis apis and Radix Cynanchi Paniculatis; By Radix Ginseng Rubra, Cornu Cervi Pantotrichum, Fructus Lycii, Fructus Rosae Laevigatae, the Radix Astragali, Herba Epimedii, Stigma Croci, the Cortex Eucommiae, Rhizoma Polygonati, Gecko, Lac regis apis and Radix Cynanchi Paniculati add sealing in rice wine to soak more than 3 months after pulverizing, then process after filtration, subpackage, after obtain finished product.
Embodiments of the invention 3: there is the medicated wine of therapeutic effect and health care, comprising: 85 parts of 43 ° of corn wines, 3 parts of Radix Codonopsis, 1.5 parts, Cornu Cervi Pantotrichum, 3 parts of Fructus Lyciis, 3 parts of Fructus Rosae Laevigatae, 6 parts of the Radixs Astragali, 4 parts of Herba Epimedii, 1.5 parts of Stigma Crocis, 3 parts of the Cortexs Eucommiae, 3 parts of Rhizoma Polygonatis, 3 parts of 3 parts of Geckos, 3 parts of Mel and Radix Cynanchi Paniculatis; By Radix Codonopsis, Cornu Cervi Pantotrichum, Fructus Lycii, Fructus Rosae Laevigatae, the Radix Astragali, Herba Epimedii, Stigma Croci, the Cortex Eucommiae, Rhizoma Polygonati, Gecko, Mel and Radix Cynanchi Paniculati directly add in corn wine sealing to soak more than 3 months, then process after filtration, subpackage, after obtain finished product.
The instructions of taking of the preparation-obtained medicated wine of the present invention: respectively take 25～50ml oral, every day sooner or later.
Specification: 500ml/ bottle, 250ml/ bottle, 100ml/ bottle, 25ml/ bottle.
Claims (3)
1. a medicated wine with therapeutic effect and health care, is characterized in that: by 75～85 parts of 38～53 ° of edible wines, and 1～3 part of ginseng class, 0.5～1.5 part, Cornu Cervi Pantotrichum, 1～3 part of Fructus Lycii, 1～3 part of Fructus Rosae Laevigatae, 2～6 parts of the Radixs Astragali, 1.5～4 parts of Herba Epimedii, 0.5～1.5 part of Stigma Croci or Stigma Croci, 1～3 part of the Cortex Eucommiae, 1～3 part of Rhizoma Polygonati, 1～3 part of Gecko, 1～3 part of Lac regis apis or Mel, and 1～3 part of composition of Radix Cynanchi Paniculati; Described ginseng class is Radix Ginseng, one or more in Radix Ginseng Rubra or Radix Codonopsis.
2. the medicated wine with therapeutic effect and health care according to claim 1, is characterized in that: described edible wine is grain wine.
3. a preparation method with the medicated wine of therapeutic effect and health care as claimed in claim 1, is characterized in that: will join class, Cornu Cervi Pantotrichum, Fructus Lycii, Fructus Rosae Laevigatae, the Radix Astragali, Herba Epimedii, Stigma Croci or Stigma Croci, the Cortex Eucommiae, Rhizoma Polygonati, Gecko and Lac regis apis or Mel directly add or pulverize after add in edible wine sealing to soak more than 3 months, process after filtration again, subpackage, after obtain finished product; Described ginseng class is Radix Ginseng, one or more in Radix Ginseng Rubra or Radix Codonopsis.
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| CN103215167A (en) * | 2013-03-26 | 2013-07-24 | 无为县华运酒厂 | Kidney-invigorating and body-strengthening grain distilled spirit and brewing method thereof |
| CN103202941B (en) * | 2013-04-23 | 2014-11-05 | 山东上水农业发展股份有限公司 | Nourishing and body-building medicinal liquor |
| CN103666959A (en) * | 2013-11-28 | 2014-03-26 | 祝迈 | Health-care wine |
| CN103666960B (en) * | 2013-11-28 | 2015-05-13 | 祝迈 | Health preserving wine |
| CN104069344A (en) * | 2014-06-10 | 2014-10-01 | 于东旭 | Traditional Chinese medicine composition for treating cancer and preparation and preparation method thereof |
| CN104988020A (en) * | 2015-07-28 | 2015-10-21 | 常熟市玉液商贸有限公司 | Conditioning wine, and preparation method and drinking method thereof |
| CN104988019A (en) * | 2015-07-28 | 2015-10-21 | 常熟市玉液商贸有限公司 | Fruit wine and preparation method thereof |
| CN104988016A (en) * | 2015-07-28 | 2015-10-21 | 常熟市玉液商贸有限公司 | Health-care conditioning wine and preparation method thereof |
| CN104988017A (en) * | 2015-07-28 | 2015-10-21 | 常熟市玉液商贸有限公司 | Health-care fruit wine and preparation method thereof |
| CN104988018A (en) * | 2015-07-28 | 2015-10-21 | 常熟市玉液商贸有限公司 | Conditioning wine and preparation method thereof |
| CN105132260A (en) * | 2015-09-11 | 2015-12-09 | 佛山市秸和科技有限公司 | Health-care wine and preparation method thereof |
| TR2021015083A2 (en) * | 2021-09-27 | 2021-10-21 | Turgut Mahmut | NATURAL BLOOD AND CELL RENEWAL MIX |
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| CN101856430A (en) * | 2009-04-08 | 2010-10-13 | 周艳 | Green tonic lucid ganoderma (three immortals) cream for preventing sub-health and preparation method thereof |
| CN102443513A (en) * | 2011-11-04 | 2012-05-09 | 张建国 | Preparation method of male drinking jujube wine |
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| CN102443513A (en) * | 2011-11-04 | 2012-05-09 | 张建国 | Preparation method of male drinking jujube wine |
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