A kind of agate coffee compound oral liquid and preparation method thereof
Technical field
The present invention relates to a kind of health products agate coffee compound oral liquid, belong to health products and manufacture field.
Background technology
The main purpose that South America locals plants agate coffee is to obtain edible, when agate coffee root using fresh herb, can fry edible together with meat or other vegetables, after drying water or milk to boil be edible, agate coffee root is squeezed into juice together with fruit with honey also very popular in locality as beverage, in addition agate coffee is immersed in wine and can obtains the Maca wine with tonic effect, and agate coffee leaf not only can be made tealeaves, fresh leaf is because its special flavour can also be used for salad. But more agate coffee is dried as the exchange of commodities or storage (can several years of storage), make bread and biscuit after can also being processed into agate coffee root powder. Because wherein fiber content is low, more crisp sweeter more eutrophy composition.
Think traditionally agate coffee except being rich in nutrition, a kind of aphrodisiac especially, its energy enhancement ability, also can strengthen fecundity, agate coffee is also declared can be applicable to the treatment of the illnesss such as rheumatism, respiratory disorder, depression, anemia, osteoporosis, cancer, female climacteric syndrome simultaneously. the local resident of long-term edible agate coffee is in vigorous health, strong to the withstand force of disease, has according to statistics 80% local resident not spend medical station throughout the year and cures the disease. nutritional labeling and the efficacy effects of people to agate coffee such as early stage Peru scientific researcher ChaconG carried out preliminary research, preliminary identification agate coffee improving mammal fertility, antifatigue, the aspects such as antidepression have certain effect, and from wherein having found to be named as 4 kinds of active alkaloids and the glucosinolate (glucosinolates) of " macaina ", but it is since the eighties in 20th century that agate coffee obtains international botanist and medical research person's generally attention, particularly the mid-90 Italian DiniA etc. has delivered after the component analysis of the dry root of agate coffee, along with modern analysis and pharmacological effect technology mouth benefit maturation, the Phytochemistry analysis of agate coffee, effect, toxicity and clinical research have had large development in late 1990s. in agate coffee, find the alkaloid of new plant chemical composition agate coffee acid amides (macamides) and agate coffee alkene (macaenes) and some structure uniquenesses, glucosinolate and isothiocyanic acid benzyl fat thereof are also by the analysis of system, thereby agate coffee is improving fertility, the efficacy study that promotes the aspects such as sexual desire and clinical research also constantly deeply. increasing agate coffee product is as MacaPure, Vimaca, IMPERIALGOLDMACA., SuMACATM etc. release one after another from the U.S., Peru, Kou Bendeng state, product function taking strengthen energy, improve sexual function and alleviate female dimacteric syndrome as main, agate coffee completed by traditional food to " health food " and transformation. and the form of agate coffee product also by early stage agate coffee dry powder, Maca wine, agate coffee beverage etc. to second generation agate coffee production developments such as agate coffee capsule, agate coffee tablet, agate coffee concentrated oral liquid, agate coffee complex health care products, agate coffee becomes rapidly a nova in international Medicines and Health Product market, is subject to especially extensively liking of mid-aged population, athletes, vigorous and graceful fan, female patient of climacteric syndrome of consumers in general. after beating powder with agate coffee root, conventional product great majority make agate coffee capsule, agate coffee tablet etc.
In sum, agate coffee have antifatigue, anti-oxidant, strengthen immunity, improve sexual function, regulate endocrine, improve fertility, the effect such as anti-anaemia, anticancer, anti-leukocythemia, treatment climacteric metancholia. Simultaneously agate coffee can match in excellence or beauty with ginseng aspect effect of nutritional labeling and enhancing energy, endurance.
Along with social development, people require also to improve constantly to the health care of health. Due to the increase of life stress, the speed-raising of rhythm of life, the factors such as the deterioration of living environment, cause the problems such as modern's fatiguability, easily aging, immunity reduction, endocrinopathy, memory and fecundity reduction. Therefore health products become the object that people pursue.
Granted publication number is CN102613555B, in the patent of invention that denomination of invention is " a kind of pueraria root powder ginseng composition and preparation method thereof ", a kind of pueraria root powder ginseng composition is disclosed, it is by 2.5 ~ 8.5 parts of ginseng extracts, 10 ~ 30 parts of gadol extracts, 10 ~ 30 parts of Shorthorned Epimedium P.Es, 6 ~ 18 parts of Fructus lycii P.Es, 75 ~ 250 parts of compositions of pueraria root powder, have the health-care efficacy that strengthens immunity, alleviating physical fatigue. The present invention on this basis, becomes component selections and proportioning to adjust to it, and the effect of its fatigue-relieving is more remarkable. And various components compatibilities are reasonable, play effect of mutual help.
Summary of the invention
The technical problem that the present invention mainly solves is given full play to effect of various compositions, and a kind of agate coffee compound oral liquid and preparation method thereof is provided, and wherein each composition and ratio are through long-term screening, and the oral liquid fatigue-relieving effect of making is remarkable.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is:
A kind of agate coffee compound oral liquid, is made up of the material composition of following weight portion: 100 ~ 150 parts of agate coffees, 10 ~ 20 parts of composite aminophenol powders, 50 ~ 70 parts of glossy ganodermas, 20 ~ 30 parts of flower of Panax ginseng, 1 ~ 3 part of stevioside, 2 ~ 5 parts of ethyl maltols, 80 ~ 100 parts, water.
A kind of agate coffee compound oral liquid, preferably, is grouped into by the one-tenth of following weight portion: 120 parts of agate coffees, 15 parts of composite aminophenol powders, 60 parts of glossy ganodermas, 25 parts of flower of Panax ginseng, 2 parts of steviosides, 3 parts of ethyl maltols, 90 parts, water.
The preparation method of above-mentioned agate coffee compound oral liquid, comprises the steps:
(1) preparation of agate coffee extract:
1. fresh agate coffee is dried, under 35 ~ 45 DEG C of conditions, dry, be ground into 60-120 object fine powder, add water boiling and extraction 1-2 time that 5-15 doubly measures, each 1-4 hour, filters, and while making filtrate be concentrated into 20 DEG C, relative density is 1.1 ~ 1.3, dry;
2. by step 1. the dry thing of gained extract under the condition of reflow treatment or the condition of ultrasonic wave processing with 75 ~ 85% ethanolic solutions, filter, after filtrate mode concentrated, spray-dried or drying under reduced pressure is dried and get final product;
(2) preparation of glossy ganoderma and flower of Panax ginseng extract
Glossy ganoderma and ginseng pollen are broken into 60-120 object fine powder, and with volume fraction 90-98% alcohol lixiviate 3-4 time, doubly, each extraction time is 20-25h to the 4-8 that each lixiviate alcohol used is raw material gross weight, and each extraction temperature is 40-60 DEG C; Dregs of a decoction boiling secondary, 1-5 hour for the first time, 1-3 hour for the second time, filters to get filtrate after collecting decoction and each lixiviate, is evaporated in concentrate alcohol-free at 55-65 DEG C;
(3) agate coffee extract, composite aminophenol powder, glossy ganoderma and flower of Panax ginseng extract, stevioside, ethyl maltol are mixed, mix after adding water, make agate coffee compound oral liquid.
Step (1) 2. described in hyperacoustic ultrasonic power be 350-400W/cm2, extraction time 20-40 minute; Filtrate is concentrated is Vacuum Concentration at the temperature of 60 ~ 70 DEG C, and its vacuum is-0.050 ± 0.01Mpa.
Usage and dosage: oral, every day 2-3 time; Each 10 ~ 20ml 30 days is a course for the treatment of.
Adaptation population: immunologic hypofunction, the diseases such as anti-fatigue ability is low, have a delicate constitution, insomnia.
Main effect of various active ingredients is as follows:
1, agate coffee major function and effect: improve sexual function, improve fecundity; Firm immune system, improves sub-health state; Anti-oxidant, reducing blood lipid, prevent artery sclerosis; Firm immune system, improves sub-health state; Enhance metabolism, liver protecting; Blood nourishing and calcium replenishing; Strengthen the locomitivity of muscle.
2, the major function of composite aminophenol powder and effect: strengthen immune function of human body, strengthen nutrition absorbability; Alleviate mental worker's the brainfag various ill symptomses that cause of not having enough sleep; Liver function, renal function, functions of intestines and stomach are all had to good improvement; Promote children intelligence development, strengthen memory.
3, the major function of glossy ganoderma and effect: there is invigorating qi for tranquilization, relieving cough and asthma effect, the sweet property of this taste is flat, enter the heart channel of Hang-Shaoyin, can bushing blood, the beneficial motive, tranquilizing mind, control the diseases such as insufficiency of vital energy and blood, the mind lose having no peace of mind due to supporting, insomnia, palpitation with fear, dreaminess, forgetful, the tired god of body is tired, food is few therefore available.
4, the major function of flower of Panax ginseng and effect: can supplement human body vigour, regain one's strength, strengthen body immunity.
Through a large amount of experiments, the dose of above every medicine is screened, compatibility is reasonable, and effect increases doubly, effectively fatigue-relieving.
The invention has the beneficial effects as follows:
The invention belongs to medicine-food two-purpose food, action temperature and, do not stimulate body, safety non-toxic, side effect is extremely low, has realized gentle conditioning.
Agate coffee oral liquid provided by the invention, raw material is natural, edible safety, effect is remarkable, proves to have the effect that strengthens immunity, alleviating physical fatigue through function test.
Agate coffee oral liquid provided by the invention, curative effect and definite ingredients, suitable crowd are wide, and the market space is very large, has a good application prospect.
The present invention, on the basis of former agate coffee ginseng composition, becomes component selections and proportioning to adjust to it, and the effect of its fatigue-relieving is more remarkable. And various components compatibilities are reasonable, play effect of mutual help.
Detailed description of the invention
Embodiment 1
A kind of agate coffee compound oral liquid, is made up of the material composition of following weight portion: 100 parts of agate coffees, 10 parts of composite aminophenol powders, 50 parts of glossy ganodermas, 20 parts of flower of Panax ginseng, 1 part of stevioside, 2 parts of ethyl maltols, 80 parts, water.
The preparation method of above-mentioned agate coffee compound oral liquid, comprises the steps:
(1) preparation of agate coffee extract:
1. fresh agate coffee is dried, under 35 DEG C of conditions, dry, be ground into 60 object fine powders, add the water boiling and extraction 2 times of 5 times of amounts, each 2 hours, filter, while making filtrate be concentrated into 20 DEG C, relative density is 1.1, dry;
2. by step 1. the dry thing of gained extract under the condition of reflow treatment with 75% ethanolic solution, 40 minutes extraction times; Filter, after the mode of concentrated, the spray-dried or drying under reduced pressure of filtrate is dried and get final product; Filtrate is concentrated is Vacuum Concentration at the temperature of 60 DEG C, and its vacuum is-0.04Mpa.
(2) preparation of glossy ganoderma and flower of Panax ginseng extract
Glossy ganoderma and ginseng pollen are broken into 60 object fine powders, and with volume fraction 90% alcohol lixiviate 3 times, each lixiviate alcohol used is 4 times of raw material gross weight, and each extraction time is 25h, and each extraction temperature is 40 DEG C; Dregs of a decoction boiling secondary, 2 hours for the first time, 3 hours for the second time, after collecting decoction and each lixiviate, filter to get filtrate, at 55 DEG C, be evaporated in concentrate alcohol-free;
(3) agate coffee extract, composite aminophenol powder, glossy ganoderma and flower of Panax ginseng extract, stevioside, ethyl maltol are proportionally mixed, mix after adding water, make agate coffee compound oral liquid.
Embodiment 2
A kind of agate coffee compound oral liquid, is made up of the material composition of following weight portion: 150 parts of agate coffees, 20 parts of composite aminophenol powders, 70 parts of glossy ganodermas, 30 parts of flower of Panax ginseng, 3 parts of steviosides, 5 parts of ethyl maltols, 100 parts, water.
The preparation method of above-mentioned agate coffee compound oral liquid, comprises the steps:
(1) preparation of agate coffee extract:
1. fresh agate coffee is dried, under 45 DEG C of conditions, dry, be ground into 120 object fine powders, add the water boiling and extraction 2 times of 15 times of amounts, each 2 hours, filter, while making filtrate be concentrated into 20 DEG C, relative density is 1.2, dry;
2. by step 1. the dry thing of gained extract under the condition of ultrasonic wave processing with 85% ethanolic solution, filter, after filtrate mode concentrated, spray-dried or drying under reduced pressure is dried and get final product; Described hyperacoustic ultrasonic power is 400W/cm2, 20 minutes extraction times; Filtrate is concentrated is Vacuum Concentration at the temperature of 70 DEG C, and its vacuum is-0.06Mpa.
(2) preparation of glossy ganoderma and flower of Panax ginseng extract
Glossy ganoderma and ginseng pollen are broken into 120 object fine powders, and with volume fraction 98% alcohol lixiviate 3 times, each lixiviate alcohol used is 8 times of raw material gross weight, and each extraction time is 25h, and each extraction temperature is 60 DEG C; Dregs of a decoction boiling secondary, for the first time hour, 1 hour for the second time, after collecting decoction and each lixiviate, filter to get filtrate, at 65 DEG C, be evaporated in concentrate alcohol-free;
(3) agate coffee extract, composite aminophenol powder, glossy ganoderma and flower of Panax ginseng extract, stevioside, ethyl maltol are proportionally mixed, mix after adding water, make agate coffee compound oral liquid.
Embodiment 3
A kind of agate coffee compound oral liquid, is grouped into by the one-tenth of following weight portion: 120 parts of agate coffees, 15 parts of composite aminophenol powders, 60 parts of glossy ganodermas, 25 parts of flower of Panax ginseng, 2 parts of steviosides, 3 parts of ethyl maltols, 90 parts, water.
The preparation method of above-mentioned agate coffee compound oral liquid, comprises the steps:
(1) preparation of agate coffee extract:
1. fresh agate coffee is dried, under 40 DEG C of conditions, dry, be ground into 80 object fine powders, add water boiling and extraction 1-2 time of 10 times of amounts, each 1-4 hour, filters, and while making filtrate be concentrated into 20 DEG C, relative density is 1.3, dry;
2. by step 1. the dry thing of gained extract under the condition of ultrasonic wave processing with 80% ethanolic solution, filter, after filtrate mode concentrated, spray-dried or drying under reduced pressure is dried and get final product; Described hyperacoustic ultrasonic power 370W/cm2, 30 minutes extraction times; Filtrate is concentrated is Vacuum Concentration at the temperature of 65 DEG C, and its vacuum is-0.050Mpa.
(2) preparation of glossy ganoderma and flower of Panax ginseng extract
Glossy ganoderma and ginseng pollen are broken into 0 object fine powder, and with volume fraction 95% alcohol lixiviate 3 times, each lixiviate alcohol used is 6 times of raw material gross weight, and each extraction time is 22h, and each extraction temperature is 50 DEG C; Dregs of a decoction boiling secondary, 3 hours for the first time, 2 hours for the second time, after collecting decoction and each lixiviate, filter to get filtrate, at 60 DEG C, be evaporated in concentrate alcohol-free;
(3) agate coffee extract, composite aminophenol powder, glossy ganoderma and flower of Panax ginseng extract, stevioside, ethyl maltol are proportionally mixed, mix after adding water, make agate coffee compound oral liquid.
The oral liquid of making is carried out to clinical testing.
Diagnostic criteria is:
Take nothing recurrence symptom after a year, belong to and curing.
After taking a course for the treatment of (within 30 days, being a course for the treatment of), there is obvious alleviation or remove the above person of symptom 70%, belonging to effective.
After taking 1-2 the course for the treatment of, there is alleviation or eliminate the above person of symptom 50%, belong to effectively.
A course for the treatment of is above without alleviating and eliminating symptom, invalid.
Clinical effectiveness statistics: at 100 lassitudes, in the crowd of be short of physical strength (" inferior health " state),
Cure rate: 76%; Efficient: 100%; Obvious effective rate: 5%.
Concrete case 1:
Certain female, 32 years old. Main suit: feel very much deficient in energyly, very tired, sit down and be just reluctant, often weak, insomnia, appetite is low, loose stool.
Have a medical check-up: arteries and veins: soft unable, thick libngual fur is greasy, and eye is without god. Examine: fire excess from yin deficiency, anti-fatigue ability is low, malnutritive, insufficiency of the spleen.
Treatment: take oral liquid of the present invention (embodiment 1), every day 2 ~ 3 times, each 10ml, effect: take medicine after the course for the treatment of, anti-fatigue ability strengthens, and feels that energy increases simultaneously, appetite is low, loose stool situation still exists.
Second course for the treatment of: for this patient's constitutive character, take oral liquid of the present invention (embodiment 1), every day 2 ~ 3 times, each 10ml, adds JIAWEI XIAOYAOWAN, every day twice, each 6g.
Take after two courses for the treatment of, anti-fatigue ability improves completely, and appetite is also improved, loose stool situation improves.
Illustrate that agate coffee compound oral liquid of the present invention has good anti-fatigue ability, and share without subtracting effect effect with other drug.
Concrete case 2
Certain man, 49 years old; Main suit: weak, go examination in hospital again without the case of a physically strong patient running a high fever.
Have a medical check-up: blood cell survey report shows: lymphocyte percentage is low more than 20%. Weak pulse, tongue fur look light are, fat large. Examine: qi-deficiency type immunologic hypofunction, belongs to " inferior health " state.
Treatment: take medicine of the present invention (embodiment 2), every day 2 ~ 3 times, each 10ml.
Effect: take after the course for the treatment of, symptom is obviously improved, took after two courses for the treatment of, and all symptoms all disappear, energetic, and immunologic function also gets a promotion a lot, had eliminated " inferior health " situation, fully recovered.
Illustrate that agate coffee compound oral liquid of the present invention has good anti-fatigue ability, and there is the immune function of certain lifting.
Concrete case 3
Certain female, 53 years old. Main suit: feel very much deficient in energyly, very tired, various minor illness is burdened with, insomnia and dreamful sleep, temperish, to life self-distrust.
Have a medical check-up: arteries and veins: soft unable, red tongue body, eye is without god. Examine: hot-tempered, anti-fatigue ability is low, climacteric.
Treatment: take oral liquid of the present invention (embodiment 1), every day 2 ~ 3 times, each 10ml, effect: take medicine after the course for the treatment of, anti-fatigue ability strengthens, and feels that energy increases simultaneously.
Second course for the treatment of: for this patient's constitutive character, take oral liquid of the present invention (embodiment 3), every day 2 ~ 3 times, each 10ml, adds soothing the liver gripe water, every day twice, each 6g.
Take after two courses for the treatment of, anti-fatigue ability improves completely, and tongue fur is improved, and temperish situation alleviates.
Illustrate that agate coffee compound oral liquid of the present invention has good anti-fatigue ability, and share without subtracting effect effect with other drug.