CN104857005B - 精氨酸酶抑制剂及其使用方法 - Google Patents

精氨酸酶抑制剂及其使用方法 Download PDF

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Publication number
CN104857005B
CN104857005B CN201510164702.8A CN201510164702A CN104857005B CN 104857005 B CN104857005 B CN 104857005B CN 201510164702 A CN201510164702 A CN 201510164702A CN 104857005 B CN104857005 B CN 104857005B
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amino
compound
acid
alkyl
arginase
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CN104857005A (zh
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B·E·汤米克祖克
G·L·奥逊
R·S·波特夫
J·王
B·R·那拉干储
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AstraZeneca AB
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AstraZeneca AB
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CN201510164702.8A 2010-12-31 2011-07-26 精氨酸酶抑制剂及其使用方法 Expired - Fee Related CN104857005B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201061428894P 2010-12-31 2010-12-31
US61/428,894 2010-12-31
US201161450804P 2011-03-09 2011-03-09
US61/450,804 2011-03-09
CN201180068843XA CN103402549A (zh) 2010-12-31 2011-07-26 精氨酸酶抑制剂及其使用方法

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CN104857005A CN104857005A (zh) 2015-08-26
CN104857005B true CN104857005B (zh) 2019-04-26

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CN201510164702.8A Expired - Fee Related CN104857005B (zh) 2010-12-31 2011-07-26 精氨酸酶抑制剂及其使用方法
CN201180068843XA Pending CN103402549A (zh) 2010-12-31 2011-07-26 精氨酸酶抑制剂及其使用方法
CN201910260085.XA Expired - Fee Related CN110123820B (zh) 2010-12-31 2011-07-26 精氨酸酶抑制剂及其使用方法

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CN201910260085.XA Expired - Fee Related CN110123820B (zh) 2010-12-31 2011-07-26 精氨酸酶抑制剂及其使用方法

Country Status (7)

Country Link
US (2) US8894970B2 (https=)
EP (1) EP2658580A4 (https=)
JP (4) JP2014506253A (https=)
CN (3) CN104857005B (https=)
CA (1) CA2824599C (https=)
RU (2) RU2695650C2 (https=)
WO (1) WO2012091757A1 (https=)

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CN103068830B (zh) 2010-04-22 2016-06-29 马尔斯公司 精氨酸酶抑制剂及其治疗应用
DK2632927T3 (en) 2010-10-26 2016-04-11 Mars Inc Boronates AS ARGINSASEINHIBITORER
US9266908B2 (en) 2011-10-19 2016-02-23 Mars, Incorporated Inhibitors of arginase and their therapeutic applications
CA2944903A1 (en) 2014-04-24 2015-10-29 Dana-Farber Cancer Institute, Inc. Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response
PL410665A1 (pl) 2014-12-29 2016-07-04 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Inhibitory arginazy oraz ich zastosowania terapeutyczne
KR20180021117A (ko) 2015-06-23 2018-02-28 칼리테라 바이오사이언시즈, 인코포레이티드 아르기나제 활성 억제를 위한 조성물 및 방법
CN108601767A (zh) * 2015-10-05 2018-09-28 卡利泰拉生物科技公司 用谷氨酰胺酶抑制剂和免疫肿瘤学药剂的组合疗法
JP6807322B2 (ja) * 2015-10-16 2021-01-06 武田薬品工業株式会社 複素環化合物の製造方法
WO2017075363A1 (en) * 2015-10-30 2017-05-04 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
PL417066A1 (pl) 2016-05-04 2017-11-06 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Inhibitory arginazy oraz ich zastosowania terapeutyczne
EP3538111B1 (en) 2016-11-08 2022-01-19 Calithera Biosciences, Inc. Arginase inhibitor combination therapies
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WO2018209290A1 (en) 2017-05-12 2018-11-15 Calithera Biosciences, Inc. Method of preparing (3r,4s)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide
TWI803574B (zh) * 2018-02-17 2023-06-01 瑞典商阿斯特捷利康公司 精胺酸酶抑制劑及其使用方法
CN111818928A (zh) 2018-03-05 2020-10-23 艾库斯生物科学有限公司 精氨酸酶抑制剂
EP3765006A4 (en) 2018-03-13 2022-02-23 Merck Sharp & Dohme Corp. ARGINASE INHIBITORS AND METHODS OF USE
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WO2019205979A1 (zh) * 2018-04-27 2019-10-31 四川科伦博泰生物医药股份有限公司 非天然氨基酸类衍生物、包含其的药物组合物及其制备方法和用途
EP3810615B1 (en) 2018-06-20 2026-01-28 Merck Sharp & Dohme LLC Arginase inhibitors and methods of use
ES3034676T3 (en) 2018-11-16 2025-08-21 Arcus Biosciences Inc Inhibitors of arg1 and/or arg2
US12240867B2 (en) 2018-12-18 2025-03-04 Merck Sharp & Dohme Llc Arginase inhibitors and methods of use
CN119119095A (zh) * 2019-07-23 2024-12-13 阿斯利康(瑞典)有限公司 精氨酸酶抑制剂及其使用方法
CA3180529A1 (en) * 2020-04-17 2021-10-21 Bio-Cancer Treatment International Limited Methods of treating viral infections using arginase
TW202228720A (zh) 2020-12-22 2022-08-01 波蘭商昂科艾倫迪治療法股份公司 精胺酸酶抑制劑及其使用方法
WO2022272268A1 (en) * 2021-06-23 2022-12-29 Yale University Compounds for molecular imaging of collagen turnover and methods using same

Citations (1)

* Cited by examiner, † Cited by third party
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