CA2824599C - Arginase inhibitors and methods of use thereof - Google Patents

Arginase inhibitors and methods of use thereof Download PDF

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CA2824599C
CA2824599C CA2824599A CA2824599A CA2824599C CA 2824599 C CA2824599 C CA 2824599C CA 2824599 A CA2824599 A CA 2824599A CA 2824599 A CA2824599 A CA 2824599A CA 2824599 C CA2824599 C CA 2824599C
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alkyl
amino
compound
aryl
borono
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French (fr)
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CA2824599A1 (en
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Bruce Edward Tomczuk
Gary Lee Olson
Richard Scott Pottorf
Jane Wang
Bhaskara Rao Nallaganchu
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AstraZeneca UK Ltd
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
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    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
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    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
CA2824599A 2010-12-31 2011-07-26 Arginase inhibitors and methods of use thereof Active CA2824599C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201061428894P 2010-12-31 2010-12-31
US61/428,894 2010-12-31
US201161450804P 2011-03-09 2011-03-09
US61/450,804 2011-03-09
PCT/US2011/045373 WO2012091757A1 (en) 2010-12-31 2011-07-26 Arginase inhibitors and methods of use thereof

Publications (2)

Publication Number Publication Date
CA2824599A1 CA2824599A1 (en) 2012-07-05
CA2824599C true CA2824599C (en) 2020-03-10

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Family Applications (1)

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CA2824599A Active CA2824599C (en) 2010-12-31 2011-07-26 Arginase inhibitors and methods of use thereof

Country Status (7)

Country Link
US (2) US8894970B2 (https=)
EP (1) EP2658580A4 (https=)
JP (4) JP2014506253A (https=)
CN (3) CN104857005B (https=)
CA (1) CA2824599C (https=)
RU (2) RU2695650C2 (https=)
WO (1) WO2012091757A1 (https=)

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JP6807322B2 (ja) * 2015-10-16 2021-01-06 武田薬品工業株式会社 複素環化合物の製造方法
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PL417066A1 (pl) 2016-05-04 2017-11-06 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Inhibitory arginazy oraz ich zastosowania terapeutyczne
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WO2019205979A1 (zh) * 2018-04-27 2019-10-31 四川科伦博泰生物医药股份有限公司 非天然氨基酸类衍生物、包含其的药物组合物及其制备方法和用途
EP3810615B1 (en) 2018-06-20 2026-01-28 Merck Sharp & Dohme LLC Arginase inhibitors and methods of use
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US12240867B2 (en) 2018-12-18 2025-03-04 Merck Sharp & Dohme Llc Arginase inhibitors and methods of use
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TW202228720A (zh) 2020-12-22 2022-08-01 波蘭商昂科艾倫迪治療法股份公司 精胺酸酶抑制劑及其使用方法
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US8894970B2 (en) 2014-11-25
JP2014506253A (ja) 2014-03-13
JP6724115B2 (ja) 2020-07-15
WO2012091757A1 (en) 2012-07-05
CN110123820B (zh) 2022-05-31
CN104857005B (zh) 2019-04-26
CN110123820A (zh) 2019-08-16
CN103402549A (zh) 2013-11-20
US9447122B2 (en) 2016-09-20
EP2658580A1 (en) 2013-11-06
RU2695650C2 (ru) 2019-07-25
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US20160039847A1 (en) 2016-02-11
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CA2824599A1 (en) 2012-07-05
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CN104857005A (zh) 2015-08-26
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