CN104844623B - 一种7‑氨基‑3‑丙烯‑1‑基‑3‑头孢烯‑4‑羧酸的合成方法 - Google Patents
一种7‑氨基‑3‑丙烯‑1‑基‑3‑头孢烯‑4‑羧酸的合成方法 Download PDFInfo
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- CN104844623B CN104844623B CN201510268177.4A CN201510268177A CN104844623B CN 104844623 B CN104844623 B CN 104844623B CN 201510268177 A CN201510268177 A CN 201510268177A CN 104844623 B CN104844623 B CN 104844623B
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- 0 CC=CC(CS[C@@]1[C@]2N)=C(C(O)=O)N1C2=* Chemical compound CC=CC(CS[C@@]1[C@]2N)=C(C(O)=O)N1C2=* 0.000 description 2
- TWAHQTDAFGRKLL-CLZZGJSISA-N N[C@@H]([C@H]1SCC(C=O)=C(C(O)=O)N11)C1=O Chemical compound N[C@@H]([C@H]1SCC(C=O)=C(C(O)=O)N11)C1=O TWAHQTDAFGRKLL-CLZZGJSISA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
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CN201510268177.4A CN104844623B (zh) | 2015-05-22 | 2015-05-22 | 一种7‑氨基‑3‑丙烯‑1‑基‑3‑头孢烯‑4‑羧酸的合成方法 |
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CN201510268177.4A CN104844623B (zh) | 2015-05-22 | 2015-05-22 | 一种7‑氨基‑3‑丙烯‑1‑基‑3‑头孢烯‑4‑羧酸的合成方法 |
Publications (2)
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CN104844623A CN104844623A (zh) | 2015-08-19 |
CN104844623B true CN104844623B (zh) | 2017-03-15 |
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CN201510268177.4A Active CN104844623B (zh) | 2015-05-22 | 2015-05-22 | 一种7‑氨基‑3‑丙烯‑1‑基‑3‑头孢烯‑4‑羧酸的合成方法 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109232608B (zh) * | 2018-11-14 | 2020-04-28 | 湖北凌晟药业有限公司 | 一种头孢丙烯的制备方法 |
CN109180704B (zh) * | 2018-11-19 | 2020-06-05 | 齐鲁安替制药有限公司 | 一种头孢妥仑匹酯的合成方法 |
CN110590814A (zh) * | 2019-09-29 | 2019-12-20 | 天津力生制药股份有限公司 | 一种生产头孢唑林钠产生的二聚体杂质的合成方法 |
CN110950892A (zh) * | 2019-12-16 | 2020-04-03 | 山东金城柯瑞化学有限公司 | 一种头孢呋辛中间体(3-去氨甲酰基-头孢呋酸)优化除杂的方法 |
CN111592557A (zh) * | 2020-05-09 | 2020-08-28 | 河北合佳医药科技集团股份有限公司 | 一种7-氨基-3-乙烯基头孢烷酸的一步法环保制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6903211B2 (en) * | 2002-10-30 | 2005-06-07 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of 3-propenyl cephalosporin DMF solvate |
KR100576336B1 (ko) * | 2003-10-30 | 2006-05-03 | 씨제이 주식회사 | 세팔로스포린 유도체의 제조방법 |
CN101058584B (zh) * | 2007-05-23 | 2010-05-26 | 上海骏捷生化科技有限公司 | 一种制备头孢丙烯母核7-氨基-3-丙烯基头孢烷酸的方法 |
CN101906068B (zh) * | 2009-06-04 | 2013-01-02 | 浙江医药股份有限公司新昌制药厂 | 2-吡啶甲醛的制备方法 |
JP6090666B2 (ja) * | 2013-05-20 | 2017-03-08 | 国立大学法人富山大学 | インドール誘導体および血糖降下剤。 |
CN104480181B (zh) * | 2014-12-31 | 2018-07-20 | 华北制药河北莱欣药业有限公司 | 3-去乙酰基-7-氨基头孢烯酸的制备方法 |
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- 2015-05-22 CN CN201510268177.4A patent/CN104844623B/zh active Active
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Inventor after: Li Fengxia Inventor after: Yang Liyuan Inventor after: Hou Chuanshan Inventor after: Wang Xin Inventor after: Fu Jinglong Inventor after: Fan Meiju Inventor after: Wang Yongjin Inventor after: Shi Shaohua Inventor after: Zhang Liang Inventor after: Lin Jun Inventor before: Li Fengxia Inventor before: Wang Yongjin Inventor before: Wang Xin Inventor before: Fu Jinglong Inventor before: Fan Meiju Inventor before: Shi Shaohua Inventor before: Zhang Liang Inventor before: Lin Jun Inventor before: Yang Liyuan |
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