CN104826064B - A kind of Chinese medicine preparation for preventing duck plague and preparation method thereof - Google Patents
A kind of Chinese medicine preparation for preventing duck plague and preparation method thereof Download PDFInfo
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The present invention relates to a kind of Chinese medicine preparations for preventing duck plague and preparation method thereof, are made of the raw material of following parts by weight：35 parts of hawthorn, 56 parts of cassia bark, 8 12 parts of the Chinese bulbul, 79 parts of granatum, 0.5 1 parts of betel nut, 8 12 parts of Asiatic plantain, 15 18 parts of honeysuckle, 23 parts of realgar, 58 parts of fevervine, 46 parts of Radix Ophiopogonis, 8 10 parts of dandelion, 35 parts of folium isatidis, 26 parts of rhizoma zingiberis, 37 parts of Radix Glycyrrhizae, 800 1000 parts of rice；The Chinese medicine preparation of the prevention duck plague of the present invention is easy to use, effective, easily promotes, and has great market in rural area.
Description
Technical field
The invention belongs to field of veterinary, are related to a kind of Chinese medicine preparation for preventing duck plague and preparation method thereof.
Background technology
Checken pest, duck plague are frequently-occurring diseases common in poultry, and duck plague is a kind of acute septic infectious disease, often shows as keeping in dark place
Shed tears, eyelid swelled, hyperemia, two leg turning weak to stand, and crop is spoken in a low voice hollow empty, diarrhea, row's green or canescence loose stool, duck anus
There is yellow green pseudomembrane in door.Duck plague hair pest rate is high, and infectiousness is strong, and the death rate is up to more than 90%, often to chicken, duck raising family band
Carry out huge economic loss.Disease prevention is generally inoculated using Western medicine, and costly, heavy workload, therapeutic effect is poor, sometimes
Though the state of an illness is alleviated, cure rate, it easily recurs, has seriously affected the growth of chicken, duck, added the feeding cost of raiser
And risk, ducker is frequently with once duck disease occurs, duck group's death rate is high, and commodity rate is low, and ducker's economic benefit is low, very
To loss of capital.Effective therapy there is no thoroughly to cure duck plague at this stage, main means of prevention is vaccine inoculation and strengthens raising pipe
Reason, treatment means are single and have the hidden danger of immuning failure, so by carrying out rationally screening and prescription to traditional Chinese medicine, for controlling
Treating duck plague disease has very important production practices meaning.
In recent years, the Chinese medicine preparation of many treatment duck plagues has also been emerged in large numbers, for example, application for a patent for invention 201210042852.8
Disclosed 10-30 parts of baidu powder of use, 20-40 parts of neomycin, the raw material medicine ordinance of 10-30 parts of synergist form
Treatment checken pest, the medicament of duck plague；Disclosed in application for a patent for invention 201210218475.9 by the coptis, Cortex Phellodendri, rheum officinale, old
The Chinese medicine preparation that skin, Rhizoma Chuanxiong, Radix Codonopsis, Radix Isatidis, the Chinese bulbul and Radix Glycyrrhizae form, however, the dosage form in Yi Shang patent makes
With middle there are certain limitation, the duck group of particularly free-ranging, feeding etc. is all in open-air atmosphere, and the form of medicament is vast
Rural area is difficult to promote.In this regard, inventor also contributes the experience accumulated in practice to come, provide it is a kind of highly desirable,
And Chinese medicine preparation of prevention duck plague easy to use and preparation method thereof.
The content of the invention
Present invention seek to address that existing duck plague is difficult to effectively treatment and epidemic prevention, and the form of Chinese drug of existing treatment duck plague is difficult
The problem of to use, provides a kind of Chinese medicine preparation that can effectively prevent duck plague and conveniently promote the use of and preparation method thereof.
In order to solve the above technical problems, the present invention uses following technological means：
A kind of Chinese medicine preparation for preventing duck plague and preparation method thereof, which is characterized in that the Chinese medicine preparation of the prevention duck plague
It is made of the raw material of following parts by weight：3-5 parts of hawthorn, 5-6 parts of cassia bark, 8-12 parts of the Chinese bulbul, 7-9 parts of granatum, betel nut 0.5-1
Part, 8-12 parts of Asiatic plantain, 15-18 parts of honeysuckle, 2-3 parts of realgar, 5-8 parts of fevervine, Radix Ophiopogonis 4-6 part, 8-10 parts of dandelion, greatly
3-5 parts of leafiness, 2-6 parts of rhizoma zingiberis, 3-7 parts of Radix Glycyrrhizae, 800-1000 parts of rice.
The preparation method of the Chinese medicine preparation of the prevention duck plague includes the following steps：
(1) raw material is weighed by weight；
(2) hawthorn weighed, betel nut, Asiatic plantain, honeysuckle, fevervine, Radix Ophiopogonis, dandelion, folium isatidis and Radix Glycyrrhizae are mixed
It closes, adds in the water of 2-4 times of mixture quality, be heated to seething with excitement in closed container, and constantly boiling 30-50min, it is then natural
Cooling, liquid A is obtained using 6 layers of filtered through gauze；
(3) cassia bark weighed, the Chinese bulbul, granatum and realgar are mixed, the ethyl alcohol for adding in 2-4 times of mixture quality is molten
Liquid, be placed in closed container be heated to wherein fluid temperature be 50-65 DEG C, and keep the temperature at 50-65 DEG C of 1-2 it is small when, and
Postcooling obtains medical liquid B using 6 layers of filtered through gauze, wherein the ethanol solution is the ethanol solution that volumetric concentration is 75%；
(4) liquid A and medical liquid B are mixed, addition weighs rice and adsorbed, with 8-10 revs/min in adsorption process
Speed stirring rice, make its absorption uniform, then dry the Chinese medicine preparation for obtaining prevention duck plague of the present invention.
Preferably, the Chinese medicine preparation of prevention duck plague of the invention is made of the raw material of following parts by weight：4 parts of hawthorn, cassia bark 5
Part, 9 parts of the Chinese bulbul, 8 parts of granatum, 0.75 part of betel nut, 9 parts of Asiatic plantain, 16 parts of honeysuckle, 2.5 parts of realgar, 7 parts of fevervine, wheat
5 parts of winter, 9 parts of dandelion, 4 parts of folium isatidis, 4 parts of rhizoma zingiberis, 5 parts of Radix Glycyrrhizae, 900 parts of rice.
Can also preferably, the Chinese medicine preparation of prevention duck plague of the invention is made of the raw material of following parts by weight：Hawthorn 5
Part, 6 parts of cassia bark, 12 parts of the Chinese bulbul, 7 parts of granatum, 0.5 part of betel nut, 12 parts of Asiatic plantain, 15 parts of honeysuckle, 3 parts of realgar, chicken arrow
8 parts of rattan, 4 parts of Radix Ophiopogonis, 10 parts of dandelion, 5 parts of folium isatidis, 2 parts of rhizoma zingiberis, 6 parts of Radix Glycyrrhizae, 800 parts of rice.
Can also preferably, the Chinese medicine preparation of prevention duck plague of the invention is made of the raw material of following parts by weight：Hawthorn 3
Part, 5 parts of cassia bark, 8 parts of the Chinese bulbul, 9 parts of granatum, 1 part of betel nut, 8 parts of Asiatic plantain, 18 parts of honeysuckle, 3 parts of realgar, fevervine 5
Part, 6 parts of Radix Ophiopogonis, 8 parts of dandelion, 5 parts of folium isatidis, 6 parts of rhizoma zingiberis, 3 parts of Radix Glycyrrhizae, 1000 parts of rice.
The Chinese medicine preparation final form of prevention duck plague obtained by the present invention is to have adsorbed the rice of liquid, can be independent
Duck group is fed, it can also be with being fed after the conventional feed mix of duck, use is extremely convenient.
The invention has the advantages that and advantageous effect：
(1) inventor, with reference to China's traditional Chinese medicine theory, passes through proportioning repeatedly and experiment according to experience is cultivated for many years
The pharmaceutical formulation of the present invention is obtained, various drugs mutually cooperate in the formula, have reached the maximization of drug effect, can be effective
Ground prevention duck plague is broken out, while can maximumlly inhibit the diffusion of duck plague when duck plague is broken out, in practice process, invention
People is found surprisingly that, using betel nut as efficacy-enhancing ingredient, although its addition is atomic, drug is drastically increased after adding in
Drug effect.
(2) pharmaceutical preparation is made in the form of rice absorption in the present invention, efficiently solves traditional drug system
Agent is difficult to extend the shortcomings that using in rural area, and preparation of the invention only needs Direct-fed or and duck in use
Conventional feed mix after feed, will not be uneven because spice during feeding and effect be not achieved, will not be with spice
In the process plus water and be lost in, utilization rate is high, and effect is good, in free trial extension process, has also obtained fabulous evaluation.
(3) ingredient that the present invention selects is natural traditional Chinese medicine ingredient, safe to use harmless, can be met existing with long-time service
For the demand of agricultural development, pursuit of the people for healthy living is also complied with.
In conclusion the Chinese medicine preparation of the prevention duck plague of the present invention is easy to use, effective, easily promote, in rural area
With great market.
Specific embodiment
Embodiment 1：A kind of Chinese medicine preparation for preventing duck plague and preparation method thereof, which is characterized in that the prevention duck plague
Chinese medicine preparation is made of the raw material of following parts by weight：4 parts of hawthorn, 5 parts of cassia bark, 9 parts of the Chinese bulbul, 8 parts of granatum, betel nut 0.75
Part, 9 parts of Asiatic plantain, 16 parts of honeysuckle, 2.5 parts of realgar, 7 parts of fevervine, 5 parts of Radix Ophiopogonis, 9 parts of dandelion, 4 parts of folium isatidis, rhizoma zingiberis 4
Part, 5 parts of Radix Glycyrrhizae, 900 parts of rice.
The preparation method of the Chinese medicine preparation of the prevention duck plague includes the following steps：
(1) raw material is weighed by weight；
(2) hawthorn weighed, betel nut, Asiatic plantain, honeysuckle, fevervine, Radix Ophiopogonis, dandelion, folium isatidis and Radix Glycyrrhizae are mixed
It closes, adds in the water of 2-4 times of mixture quality, be heated to seething with excitement in closed container, and constantly boiling 30-50min, it is then natural
Cooling, liquid A is obtained using 6 layers of filtered through gauze；
(3) cassia bark weighed, the Chinese bulbul, granatum and realgar are mixed, the ethyl alcohol for adding in 2-4 times of mixture quality is molten
Liquid, be placed in closed container be heated to wherein fluid temperature be 50-65 DEG C, and keep the temperature at 50-65 DEG C of 1-2 it is small when, and
Postcooling obtains medical liquid B using 6 layers of filtered through gauze, wherein the ethanol solution is the ethanol solution that volumetric concentration is 75%；
(4) liquid A and medical liquid B are mixed, addition weighs rice and adsorbed, with 8-10 revs/min in adsorption process
Speed stirring rice, make its absorption uniform, then dry the Chinese medicine preparation for obtaining prevention duck plague of the present invention.
Embodiment 2：A kind of Chinese medicine preparation for preventing duck plague and preparation method thereof, which is characterized in that the prevention duck plague
Chinese medicine preparation is made of the raw material of following parts by weight：5 parts of hawthorn, 6 parts of cassia bark, 12 parts of the Chinese bulbul, 7 parts of granatum, betel nut 0.5
Part, 12 parts of Asiatic plantain, 15 parts of honeysuckle, 3 parts of realgar, 8 parts of fevervine, 4 parts of Radix Ophiopogonis, 10 parts of dandelion, 5 parts of folium isatidis, rhizoma zingiberis 2
Part, 6 parts of Radix Glycyrrhizae, 800 parts of rice.
The preparation method of the Chinese medicine preparation of the prevention duck plague includes the following steps：
(1) raw material is weighed by weight；
(2) hawthorn weighed, betel nut, Asiatic plantain, honeysuckle, fevervine, Radix Ophiopogonis, dandelion, folium isatidis and Radix Glycyrrhizae are mixed
It closes, adds in the water of 2-4 times of mixture quality, be heated to seething with excitement in closed container, and constantly boiling 30-50min, it is then natural
Cooling, liquid A is obtained using 6 layers of filtered through gauze；
(3) cassia bark weighed, the Chinese bulbul, granatum and realgar are mixed, the ethyl alcohol for adding in 2-4 times of mixture quality is molten
Liquid, be placed in closed container be heated to wherein fluid temperature be 50-65 DEG C, and keep the temperature at 50-65 DEG C of 1-2 it is small when, and
Postcooling obtains medical liquid B using 6 layers of filtered through gauze, wherein the ethanol solution is the ethanol solution that volumetric concentration is 75%；
(4) liquid A and medical liquid B are mixed, addition weighs rice and adsorbed, with 8-10 revs/min in adsorption process
Speed stirring rice, make its absorption uniform, then dry the Chinese medicine preparation for obtaining prevention duck plague of the present invention.
Embodiment 3：A kind of Chinese medicine preparation for preventing duck plague and preparation method thereof, which is characterized in that the prevention duck plague
Chinese medicine preparation is made of the raw material of following parts by weight：3 parts of hawthorn, 5 parts of cassia bark, 8 parts of the Chinese bulbul, 9 parts of granatum, 1 part of betel nut, vehicle
First careless 8 parts, 18 parts of honeysuckle, 3 parts of realgar, 5 parts of fevervine, 6 parts of Radix Ophiopogonis, 8 parts of dandelion, 5 parts of folium isatidis, 6 parts of rhizoma zingiberis, Radix Glycyrrhizae
3 parts, 1000 parts of rice.
The preparation method of the Chinese medicine preparation of the prevention duck plague includes the following steps：
(1) raw material is weighed by weight；
(2) hawthorn weighed, betel nut, Asiatic plantain, honeysuckle, fevervine, Radix Ophiopogonis, dandelion, folium isatidis and Radix Glycyrrhizae are mixed
It closes, adds in the water of 2-4 times of mixture quality, be heated to seething with excitement in closed container, and constantly boiling 30-50min, it is then natural
Cooling, liquid A is obtained using 6 layers of filtered through gauze；
(3) cassia bark weighed, the Chinese bulbul, granatum and realgar are mixed, the ethyl alcohol for adding in 2-4 times of mixture quality is molten
Liquid, be placed in closed container be heated to wherein fluid temperature be 50-65 DEG C, and keep the temperature at 50-65 DEG C of 1-2 it is small when, and
Postcooling obtains medical liquid B using 6 layers of filtered through gauze, wherein the ethanol solution is the ethanol solution that volumetric concentration is 75%；
(4) liquid A and medical liquid B are mixed, addition weighs rice and adsorbed, with 8-10 revs/min in adsorption process
Speed stirring rice, make its absorption uniform, then dry the Chinese medicine preparation for obtaining prevention duck plague of the present invention.
Embodiment 4：Safety testing
(1) acute toxicity test in mice：It is substituted using the preparation (rice for impregnating liquid) of the embodiment of the present invention 1,2,3 small
Mouse feed feeds mouse, is observed continuously 14 days, and dead and undue toxicity reaction, off-test, Dissection test are had no during experiment
Mouse, observation liver,kidney,spleen, stomach, the heart, lung and intestines, is showed no abnormal change.According to acute toxicity criteria, which belongs to
Nontoxic grade.
(2) chronic toxicity test：Mouse is substituted using the preparation (rice for impregnating liquid) of the embodiment of the present invention 1,2,3 to raise
Material feeding mouse, continuous feeding 90 days, the results show：The mouse fur of feeding invention formulation is smooth, and behavioral activity is normal, takes the photograph
Food drinking-water is normal, and Normal-weight increases, and blood parameters and hematology fluctuate in normal range (NR), and routine urinalysis and marrow refer to
Mark fluctuates in normal range (NR), organizes internal organs no abnormality seen, generally speaking has no that toxicity reacts.
(3) duck group feeding trial：Duckling 100 is chosen, 50% embodiment of the present invention 1,2 or 3 is added in its feed
Feed addictive, according to normal feeding and management method feed 240 days, herein feed during, the entire growth course of the duckling
In death does not occur, the abnormal symptoms such as also do not occur being poisoned, healthy growth；And after eliminating, slaughtering after its laying period, it is dirty
Device organizes also no abnormality seen.Therefore, it is also safe and non-toxic for duck group.
Embodiment 5：Animal experiment
Select the preferable formula drawn in R ＆ D of complex of the present invention test example as a comparison, it is specific set with
Lower two comparative experimental examples：
Comparative experimental example 1：Disclosed in patent of invention CN201210218475.9 embodiments 1 by the coptis, Cortex Phellodendri, rheum officinale,
The Chinese medicine preparation that dried orange peel, Rhizoma Chuanxiong, Radix Codonopsis, Radix Isatidis, the Chinese bulbul and Radix Glycyrrhizae form, i.e., by the coptis, Cortex Phellodendri, rheum officinale, dried orange peel, river |
Temple, Radix Codonopsis, Radix Isatidis, the Chinese bulbul and Radix Glycyrrhizae composition, wherein coptis 3kg, Cortex Phellodendri 3kg, rheum officinale 1kg, dried orange peel 1.5kg, Rhizoma Chuanxiong
1.5kg, Radix Codonopsis 1.5kg, Radix Isatidis 2kg, Chinese bulbul 1.5kg, Radix Glycyrrhizae 2kg.Preparation method is the method for wherein embodiment 1.
Comparative experimental example 2：A kind of Chinese medicine preparation is made of the raw material of following parts by weight：4 parts of hawthorn, 5 parts of cassia bark, hoary hair
9 parts of father-in-law, 8 parts of granatum, 9 parts of Asiatic plantain, 16 parts of honeysuckle, 7 parts of fevervine, 5 parts of Radix Ophiopogonis, 9 parts of dandelion, 4 parts of folium isatidis do
4 parts of ginger, 5 parts of Radix Glycyrrhizae, 900 parts of rice.Preparation method is the same as the embodiment of the present application 1.
1. test objective：Verify that the Chinese medicine preparation of prevention duck plague produced by the invention resists duck plague to duck group, inhibits duck plague
Diffusion improves the effect of duck group's survival rate.
2. test site：There is a farm that the past duck plague breaks out history in Zhejiang, and when village where the farm is 1 year nearly
It is interior to have breaking out for duck plague
3. experimental animal：The duck group of production is just opened
4. experiment：
Choose the duck group that duck plague breaks out early stage, randomly select 800 therein, be divided into 4 groups, cage respectively, in batches between
Every putting in a suitable place to breed, to avoid mixed group, wherein group 1 is western medicine group, the commercially available effective remedy for duck pest-" Yawenling recommended using village animal doctor (hair is herded in Shanghai,
Main component is lomefloxacin chlorhydric acid etc.) carry out prophylactic treatment；Group 2 is test group, using the Chinese medicine preparation of the embodiment of the present invention 1
It prevents and treats, daily every duck averagely feeds medicament 50g, normal to feed；Group 3 is contrast groups 1, according to patent of invention
Dosage recorded in CN201210218475.9 uses, normal to feed；Group 4 is control group 2, using comparative experimental example 2 of the present invention
Chinese medicine preparation prevent and treat, daily every duck averagely feeds medicament 50g, normal to feed；30 days are persistently fed to outer
It encloses epidemic situation to terminate, the survival condition of record duck group and course of disease variation in the process while select 20 from every group at random
Only, mark, record the variation of its forward backward averaging weight.Experimental result is shown in Table 1：
1 animal feeding trials result of table
Wherein front and rear body weight growth rate=and (after experiment-before experiment)/* 100% before testing.
The duck fed by more than results showed that using the Chinese medicine preparation of the prevention duck plague of the embodiment of the present invention 1
Group, survival rate is apparently higher than western medicine and other contrast test groups, and the speed of growth of duck is also faster than pair during this period
According to group and contrast test group, i.e. the disease resistance of duck group is greatly improved, and survival rate is carried compared to immediate comparative example 2
It is 6 percentage points high, 29 percentage points are improved compared to western medicine group, this has particularly important meaning for duck farmer
Justice belongs to unexpected technique effect.And treatment during this period will not cause the hysteresis that duck all living creatures grows, for raiser
Speech also has great importance.By the comparison tested above, just because of unique formula composition and proportioning of the invention
Relation so that the present invention achieves unexpected technique effect.
Embodiment 6：Culture experiment
Culture experiment is carried out in yueyang, hunan somewhere, the medicament Free distribution of the embodiment of the present invention 2 to duck farmer is used, is made
With 2 months, during this period, which did not use the raiser of medicament of the present invention that the duck that scale does not wait has occurred in 4-6 months
Pest, and the raiser of this product has been used not have that duck plague occurs substantially, the economic loss that duck plague is brought is avoided, is tested
The consistent favorable comment of peasant household.
The raw material of the present invention is commercially available.Only specific embodiments of the present invention, but this hair disclosed above
Bright to be not limited to this, the changes that any person skilled in the art can think of should all be fallen within the scope and spirit of the invention.
Claims (4)
1. a kind of Chinese medicine preparation for preventing duck plague, which is characterized in that the Chinese medicine preparation of the prevention duck plague is by following parts by weight
Raw material is made：3-5 parts of hawthorn, 5-6 parts of cassia bark, 8-12 parts of the Chinese bulbul, 7-9 parts of granatum, 0.5-1 parts of betel nut, Asiatic plantain 8-12
Part, 15-18 parts of honeysuckle, 2-3 parts of realgar, 5-8 parts of fevervine, Radix Ophiopogonis 4-6 part, 8-10 parts of dandelion, 3-5 parts of folium isatidis do
2-6 parts of ginger, 3-7 parts of Radix Glycyrrhizae, 800-1000 parts of rice.
2. the Chinese medicine preparation of prevention duck plague according to claim 1, which is characterized in that by the raw material system of following parts by weight
Into：4 parts of hawthorn, 5 parts of cassia bark, 9 parts of the Chinese bulbul, 8 parts of granatum, 0.75 part of betel nut, 9 parts of Asiatic plantain, 16 parts of honeysuckle, realgar
2.5 parts, 7 parts of fevervine, 5 parts of Radix Ophiopogonis, 9 parts of dandelion, 4 parts of folium isatidis, 4 parts of rhizoma zingiberis, 5 parts of Radix Glycyrrhizae, 900 parts of rice.
3. the Chinese medicine preparation of prevention duck plague according to claim 1, which is characterized in that by the raw material system of following parts by weight
Into：5 parts of hawthorn, 6 parts of cassia bark, 12 parts of the Chinese bulbul, 7 parts of granatum, 0.5 part of betel nut, 12 parts of Asiatic plantain, 15 parts of honeysuckle, realgar 3
Part, 8 parts of fevervine, 4 parts of Radix Ophiopogonis, 10 parts of dandelion, 5 parts of folium isatidis, 2 parts of rhizoma zingiberis, 6 parts of Radix Glycyrrhizae, 800 parts of rice.
4. the Chinese medicine preparation of prevention duck plague according to claim 1, which is characterized in that by the raw material system of following parts by weight
Into：3 parts of hawthorn, 5 parts of cassia bark, 8 parts of the Chinese bulbul, 9 parts of granatum, 1 part of betel nut, 8 parts of Asiatic plantain, 18 parts of honeysuckle, 3 parts of realgar,
5 parts of fevervine, 6 parts of Radix Ophiopogonis, 8 parts of dandelion, 5 parts of folium isatidis, 6 parts of rhizoma zingiberis, 3 parts of Radix Glycyrrhizae, 1000 parts of rice.
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