CN104815328A - 抗菌的细胞外多糖溶剂化体系 - Google Patents
抗菌的细胞外多糖溶剂化体系 Download PDFInfo
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- CN104815328A CN104815328A CN201510116539.8A CN201510116539A CN104815328A CN 104815328 A CN104815328 A CN 104815328A CN 201510116539 A CN201510116539 A CN 201510116539A CN 104815328 A CN104815328 A CN 104815328A
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- acid
- metal ion
- biofilm
- ion chelation
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Classifications
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- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/431,495 | 2006-05-10 | ||
| US11/431,495 US20070264296A1 (en) | 2006-05-10 | 2006-05-10 | Biofilm extracellular polysachharide solvating system |
| US11/739,508 | 2007-04-24 | ||
| US11/739,508 US7976873B2 (en) | 2006-05-10 | 2007-04-24 | Extracellular polysaccharide solvating system for treatment of bacterial ear conditions |
| CNA2007800167949A CN101443079A (zh) | 2006-05-10 | 2007-05-08 | 抗菌的细胞外多糖溶剂化体系 |
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| EP (1) | EP2029232B1 (https=) |
| JP (2) | JP5912218B2 (https=) |
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| CN (1) | CN104815328A (https=) |
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| CA (1) | CA2651646C (https=) |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770999A (zh) * | 2016-03-03 | 2016-07-20 | 宁夏大学 | 一种消除细菌生物被膜的复合生物材料 |
| CN109310087A (zh) * | 2016-06-30 | 2019-02-05 | 贴近科学Ip控股私人有限公司 | 抗微生物的组合物和应用该组合物的方法 |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070231406A1 (en) * | 2006-01-30 | 2007-10-04 | Bucalo Louis R | Use of gallium to treat biofilm-associated infections |
| US7993675B2 (en) | 2006-05-10 | 2011-08-09 | Medtronic Xomed, Inc. | Solvating system and sealant for medical use in the sinuses and nasal passages |
| US20070264296A1 (en) | 2006-05-10 | 2007-11-15 | Myntti Matthew F | Biofilm extracellular polysachharide solvating system |
| US7976873B2 (en) | 2006-05-10 | 2011-07-12 | Medtronic Xomed, Inc. | Extracellular polysaccharide solvating system for treatment of bacterial ear conditions |
| US7959943B2 (en) | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
| US8088095B2 (en) | 2007-02-08 | 2012-01-03 | Medtronic Xomed, Inc. | Polymeric sealant for medical use |
| JP5548121B2 (ja) | 2007-05-14 | 2014-07-16 | リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク | バイオフィルム中の細菌細胞における生理学的分散応答の誘導 |
| US20090054881A1 (en) * | 2007-06-14 | 2009-02-26 | Yosef Krespi | Mammalian biofilm treatment processes and instruments |
| ES2759373T3 (es) * | 2008-06-12 | 2020-05-08 | Medtronic Xomed Inc | Producto para el tratamiento de heridas crónicas con un sistema extracelular de solvatación de sustancias poliméricas |
| WO2010042427A2 (en) * | 2008-10-06 | 2010-04-15 | Microbial Defense Systems, Llc | Antimicrobial composition and methods of making and using same |
| DE102008064481A1 (de) * | 2008-12-18 | 2010-08-12 | Bode Chemie Gmbh | Kombinierte Desinfektions- und Dekontaminationsmittel mit erhöhter Wirksamkeit |
| AU2012253476B2 (en) | 2011-05-10 | 2015-09-24 | Next Science IP Holdings Pty Ltd | Antimicrobial solid and methods of making and using same |
| HUE047099T2 (hu) | 2011-10-08 | 2020-04-28 | Next Science IP Holdings Pty Ltd | Antimikrobiális kompozíciók és eljárások alkalmazásukra |
| CA2856196C (en) | 2011-12-06 | 2020-09-01 | Masco Corporation Of Indiana | Ozone distribution in a faucet |
| US9707520B2 (en) | 2012-01-18 | 2017-07-18 | Nch Corporation | Composition, system, and method for treating water systems |
| EP2807323B1 (en) | 2012-01-18 | 2020-05-13 | NCH Corporation | Composition and method for treating water systems |
| US9716253B2 (en) * | 2012-03-23 | 2017-07-25 | Lg Chem, Ltd. | Battery case for secondary battery |
| CN103484392A (zh) * | 2012-06-13 | 2014-01-01 | 中国海洋大学 | 用Pseudomonas fluorescens PGM37菌株生产葡甘聚糖 |
| AU2014259670B2 (en) | 2013-05-02 | 2017-11-02 | Osartis Gmbh | High osmolarity antimicrobial composition containing one or more organic solvents |
| US9192574B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan paste wound dressing |
| US9192692B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan stenting paste |
| US9441190B2 (en) | 2013-11-06 | 2016-09-13 | Nch Corporation | Composition and method for treating water systems |
| US9506016B2 (en) | 2013-11-06 | 2016-11-29 | Nch Corporation | Composition and method for treating water systems |
| US9848604B2 (en) | 2014-07-11 | 2017-12-26 | Medtronic Xomed, Inc. | Antimicrobial wash |
| US9744192B2 (en) | 2015-03-16 | 2017-08-29 | Lee A. Flippin | Methods of treating chronic rhinosinusitis |
| BR112018001002B1 (pt) | 2015-07-17 | 2022-06-21 | Next Science IP Holdings Pty Ltd | Composição antimicrobiana com eficácia contra endósporos |
| HK1253404A1 (zh) | 2015-08-07 | 2019-06-14 | 贴近科学Ip控股私人有限公司 | 具有抗内生孢子功效的抗微生物组合物 |
| WO2017112795A1 (en) | 2015-12-21 | 2017-06-29 | Delta Faucet Company | Fluid delivery system including a disinfectant device |
| AU2018367660C1 (en) | 2017-11-19 | 2025-04-03 | Osartis Gmbh | Compositions and methods for treating intervertebral discs |
| WO2019213396A1 (en) * | 2018-05-03 | 2019-11-07 | Jaim Nulman | Formulations and delivery methods for reduction and elimination of pathogen induced inflammations in the human body |
| US11819229B2 (en) | 2019-06-19 | 2023-11-21 | Boston Scientific Scimed, Inc. | Balloon surface photoacoustic pressure wave generation to disrupt vascular lesions |
| US12402946B2 (en) | 2019-06-19 | 2025-09-02 | Boston Scientific Scimed, Inc. | Breakdown of laser pulse energy for breakup of vascular calcium |
| US11717139B2 (en) | 2019-06-19 | 2023-08-08 | Bolt Medical, Inc. | Plasma creation via nonaqueous optical breakdown of laser pulse energy for breakup of vascular calcium |
| US11660427B2 (en) | 2019-06-24 | 2023-05-30 | Boston Scientific Scimed, Inc. | Superheating system for inertial impulse generation to disrupt vascular lesions |
| US20200406010A1 (en) | 2019-06-26 | 2020-12-31 | Boston Scientific Scimed, Inc. | Side light direction plasma system to disrupt vascular lesions |
| US11583339B2 (en) | 2019-10-31 | 2023-02-21 | Bolt Medical, Inc. | Asymmetrical balloon for intravascular lithotripsy device and method |
| US12102384B2 (en) | 2019-11-13 | 2024-10-01 | Bolt Medical, Inc. | Dynamic intravascular lithotripsy device with movable energy guide |
| US12274497B2 (en) | 2019-12-18 | 2025-04-15 | Bolt Medical, Inc. | Multiplexer for laser-driven intravascular lithotripsy device |
| EP4093355B1 (en) * | 2020-01-24 | 2025-09-24 | Spiral Therapeutics Inc. | Systems for treating hearing loss |
| US12446961B2 (en) | 2020-02-10 | 2025-10-21 | Bolt Medical, Inc. | System and method for pressure monitoring within a catheter system |
| US11672599B2 (en) | 2020-03-09 | 2023-06-13 | Bolt Medical, Inc. | Acoustic performance monitoring system and method within intravascular lithotripsy device |
| US12611253B2 (en) | 2020-03-18 | 2026-04-28 | Boston Scientific Scimed, Inc. | Optical analyzer assembly and method for intravascular lithotripsy device |
| US11707323B2 (en) | 2020-04-03 | 2023-07-25 | Bolt Medical, Inc. | Electrical analyzer assembly for intravascular lithotripsy device |
| US20210353359A1 (en) | 2020-05-12 | 2021-11-18 | Bolt Medical, Inc. | Active alignment system and method for optimizing optical coupling of multiplexer for laser-driven intravascular lithotripsy device |
| US12295654B2 (en) | 2020-06-03 | 2025-05-13 | Boston Scientific Scimed, Inc. | System and method for maintaining balloon integrity within intravascular lithotripsy device with plasma generator |
| US12207870B2 (en) | 2020-06-15 | 2025-01-28 | Boston Scientific Scimed, Inc. | Spectroscopic tissue identification for balloon intravascular lithotripsy guidance |
| MX2023004219A (es) | 2020-10-14 | 2023-12-01 | Next Science IP Holdings Pty Ltd | Composicion desinfectante de superficies duras. |
| US12016610B2 (en) | 2020-12-11 | 2024-06-25 | Bolt Medical, Inc. | Catheter system for valvuloplasty procedure |
| US11672773B2 (en) | 2020-12-13 | 2023-06-13 | Next Science IP Holdings Pty Ltd | Methods for treating ciliated cavities |
| WO2022154954A1 (en) | 2021-01-12 | 2022-07-21 | Bolt Medical, Inc. | Balloon assembly for valvuloplasty catheter system |
| US11672585B2 (en) | 2021-01-12 | 2023-06-13 | Bolt Medical, Inc. | Balloon assembly for valvuloplasty catheter system |
| US11648057B2 (en) | 2021-05-10 | 2023-05-16 | Bolt Medical, Inc. | Optical analyzer assembly with safety shutdown system for intravascular lithotripsy device |
| US11806075B2 (en) | 2021-06-07 | 2023-11-07 | Bolt Medical, Inc. | Active alignment system and method for laser optical coupling |
| US11839391B2 (en) | 2021-12-14 | 2023-12-12 | Bolt Medical, Inc. | Optical emitter housing assembly for intravascular lithotripsy device |
| US12533184B2 (en) | 2022-04-02 | 2026-01-27 | Boston Scientific Scimed, Inc. | Optical connector assembly for intravascular lithotripsy device |
| US12059430B2 (en) | 2022-09-29 | 2024-08-13 | Adora Animal Health Corporation | Storage stable formulations of sulfated glycosaminoglycans and fragments derived therefrom for the treatment of pain and other medical conditions |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5480658A (en) * | 1993-07-23 | 1996-01-02 | Melman; Steven A. | Ear and skin cleanser |
| CN1174093A (zh) * | 1996-06-27 | 1998-02-25 | 千寿制药株式会社 | 降低表面活性剂刺激性方法和降低了刺激性的水性组合物 |
| US6855678B2 (en) * | 2000-07-21 | 2005-02-15 | Reginald Reith Whiteley | Medical residue treatment composition comprising a lithium salt |
Family Cites Families (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB983130A (en) | 1962-08-06 | 1965-02-10 | Mundipharma Ag | Improvements in preparations for the removal of wax from the ear |
| US4002775A (en) | 1973-07-09 | 1977-01-11 | Kabara Jon J | Fatty acids and derivatives of antimicrobial agents |
| CA1052273A (en) | 1975-12-18 | 1979-04-10 | Edwin B. Michaels | Antimicrobial compositions |
| SU1128917A1 (ru) | 1980-12-24 | 1984-12-15 | Кишиневский государственный медицинский институт | Способ лечени пародонтоза |
| US5166331A (en) | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
| US4851521A (en) | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| CA1302280C (en) * | 1986-04-21 | 1992-06-02 | Jon Joseph Kabara | Topical antimicrobial pharmaceutical compositions and methods |
| US5208257A (en) | 1986-04-21 | 1993-05-04 | Kabara Jon J | Topical antimicrobial pharmaceutical compositions and methods |
| US5017229A (en) | 1990-06-25 | 1991-05-21 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
| US5290552A (en) | 1988-05-02 | 1994-03-01 | Matrix Pharmaceutical, Inc./Project Hear | Surgical adhesive material |
| IT1219587B (it) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| US5575815A (en) | 1988-08-24 | 1996-11-19 | Endoluminal Therapeutics, Inc. | Local polymeric gel therapy |
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| SU1699430A1 (ru) | 1989-03-03 | 1991-12-23 | Кишиневский государственный медицинский институт | Способ лечени пародонтита |
| EP0466397A3 (en) | 1990-07-10 | 1992-05-06 | Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo | Treatment of inflammatory diseases with polyoxyethylenesorbitan mono-higher-fatty acid esters |
| JPH06506694A (ja) | 1991-04-10 | 1994-07-28 | カペリ，クリストフアー・シー | 医療用に有用な抗微生物組成物 |
| US5662913A (en) | 1991-04-10 | 1997-09-02 | Capelli; Christopher C. | Antimicrobial compositions useful for medical applications |
| GB9204175D0 (en) * | 1992-02-27 | 1992-04-08 | Unilever Plc | Cleansing composition |
| US5229103A (en) | 1992-04-30 | 1993-07-20 | Hydrodent Laboratories, Inc. | Antiplaque mouthwash concentrate |
| IT1260154B (it) | 1992-07-03 | 1996-03-28 | Lanfranco Callegaro | Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn) |
| CN1091315A (zh) | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
| US5336163A (en) | 1993-01-06 | 1994-08-09 | Smith & Nephew Richards, Inc. | Expandable nasal stent |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| FR2710529A1 (fr) | 1993-09-29 | 1995-04-07 | Zirinis Phedon | Gel aqueux à usage nasal, pellets, et leur procédé de préparation. |
| US6544761B2 (en) | 1994-12-13 | 2003-04-08 | Human Genome Sciences, Inc. | Human tissue inhibitor of metalloproteinase-4 |
| US6086921A (en) | 1995-04-25 | 2000-07-11 | Wintrop-University Hospital | Metal/thiol biocides |
| US5817303A (en) | 1995-05-05 | 1998-10-06 | Protein Polymer Technologies, Inc. | Bonding together tissue with adhesive containing polyfunctional crosslinking agent and protein polymer |
| US6129761A (en) | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
| US5968542A (en) | 1995-06-07 | 1999-10-19 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system as a device |
| CZ293968B6 (cs) | 1995-08-29 | 2004-08-18 | Fidiaáadvancedábiopolymersźásrl | Složený biomateriál pro zabránění chirurgických adhezí tkáněŹ jeho použití a způsob |
| US5601594A (en) | 1995-09-14 | 1997-02-11 | Best; Barry D. | Nasal stent |
| FI955389A0 (fi) | 1995-11-09 | 1995-11-09 | Antti Sakari Aaltonen | Tandskyddande profylaktisk preparat och administreringsmedlen emot mellanoerpatogener |
| US6423694B1 (en) | 1996-02-21 | 2002-07-23 | Inspire Pharmaceuticals, Inc. | Method of treating otitis media with uridine triphosphates and related compounds |
| US5693065A (en) | 1996-06-25 | 1997-12-02 | Rains, Iii; B. Manrin | Frontal sinus stent |
| US6541460B2 (en) | 1996-08-07 | 2003-04-01 | George D. Petito | Method for use of hyaluronic acid in wound management |
| US6063061A (en) | 1996-08-27 | 2000-05-16 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US6203822B1 (en) * | 1996-09-03 | 2001-03-20 | University Of Iowa Research Foundation | Gallium-containing compounds for the treatment of infections caused by intracellular pathogens and pathogens causing chronic pulmonary infection |
| CZ112499A3 (cs) | 1996-10-01 | 1999-08-11 | Smithkline Beecham Corporation | Použití mupirocinu k výrobě léčiva pro léčbu bakteriálních infekcí spojených s kolonizací nosohltanu patogenními organismy |
| CO4910145A1 (es) | 1996-10-01 | 2000-04-24 | Smithkline Beecham Corp | Uso |
| IT1287967B1 (it) | 1996-10-17 | 1998-09-10 | Fidia Spa In Amministrazione S | Preparazioni farmaceutiche per uso anestetico locale |
| ZA9710342B (en) | 1996-11-25 | 1998-06-10 | Alza Corp | Directional drug delivery stent and method of use. |
| US5709546A (en) | 1996-11-27 | 1998-01-20 | Waggoner; Mark B. | Water sanitizing system and process |
| FR2756739B1 (fr) | 1996-12-05 | 2000-04-28 | Astra Ab | Nouvelle formulation de budesonide |
| ES2229477T3 (es) | 1997-01-24 | 2005-04-16 | Berna Biotech Ag | Procedimiento nuevo para el aislamiento de polisacaridos. |
| US6869938B1 (en) | 1997-06-17 | 2005-03-22 | Fziomed, Inc. | Compositions of polyacids and polyethers and methods for their use in reducing adhesions |
| US5925334A (en) | 1997-08-27 | 1999-07-20 | Rubin; Bruce K. | Use of surface active agents to promote mucus clearance |
| US6638621B2 (en) | 2000-08-16 | 2003-10-28 | Lyotropic Therapeutics, Inc. | Coated particles, methods of making and using |
| DE69831421T2 (de) | 1997-12-02 | 2006-06-22 | Archimedes Development Ltd. | Zusammensetzungen zur nasalen verabreichung |
| US5895781A (en) | 1997-12-22 | 1999-04-20 | S. C. Johnson & Son, Inc. | Cleaning compositions for ceramic and porcelain surfaces and related methods |
| ATE232388T1 (de) | 1997-12-24 | 2003-02-15 | Britannia Pharmaceuticals Ltd | Verwendung eines oberflächenaktiven mittels zur herstellung eines arzneimittels zur behandlung von erkrankungen des mittelohrs |
| US6541116B2 (en) | 1998-01-30 | 2003-04-01 | Advanced Cardiovascular Systems, Inc. | Superoxide dismutase or superoxide dismutase mimic coating for an intracorporeal medical device |
| IL123143A (en) | 1998-02-02 | 2001-08-26 | Agis Ind 1983 Ltd | Pharmaceutical compositions containing mupirocin |
| US6623521B2 (en) | 1998-02-17 | 2003-09-23 | Md3, Inc. | Expandable stent with sliding and locking radial elements |
| US7691829B2 (en) | 1998-03-24 | 2010-04-06 | Petito George D | Composition and method for healing tissues |
| US6824793B1 (en) | 1998-06-01 | 2004-11-30 | Chiron Corporation | Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants |
| US20030079758A1 (en) | 1998-06-03 | 2003-05-01 | Siegel Phyllis B. | Process and composition for removing biofilm |
| US20020022588A1 (en) | 1998-06-23 | 2002-02-21 | James Wilkie | Methods and compositions for sealing tissue leaks |
| US6706290B1 (en) | 1998-07-06 | 2004-03-16 | Olvai E. Kajander | Methods for eradication of nanobacteria |
| US6632457B1 (en) | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
| US6395746B1 (en) | 1998-09-30 | 2002-05-28 | Alcon Manufacturing, Ltd. | Methods of treating ophthalmic, otic and nasal infections and attendant inflammation |
| GB9822170D0 (en) | 1998-10-13 | 1998-12-02 | Danbioyst Uk Ltd | Novel formulations of fexofenadine |
| JP2002529545A (ja) | 1998-11-06 | 2002-09-10 | ユニベルシテ ドゥ モントリオール | バイオフィルムを除去するための改良型の殺菌性及び非殺菌性溶液 |
| US8197461B1 (en) | 1998-12-04 | 2012-06-12 | Durect Corporation | Controlled release system for delivering therapeutic agents into the inner ear |
| US6375963B1 (en) | 1999-06-16 | 2002-04-23 | Michael A. Repka | Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof |
| US20020061281A1 (en) | 1999-07-06 | 2002-05-23 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| US6576224B1 (en) | 1999-07-06 | 2003-06-10 | Sinuspharma, Inc. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| CA2385150C (en) | 1999-09-15 | 2010-11-23 | Cryolife, Inc. | Vascular coating composition |
| JP2003510263A (ja) | 1999-09-24 | 2003-03-18 | アルコン，インコーポレイテッド | シプロフロキサシンおよびデキサメタゾンを含有する局所用懸濁処方物 |
| US6533749B1 (en) | 1999-09-24 | 2003-03-18 | Medtronic Xomed, Inc. | Angled rotary tissue cutting instrument with flexible inner member |
| US6156294A (en) | 1999-11-28 | 2000-12-05 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
| US6676930B2 (en) | 1999-11-28 | 2004-01-13 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
| GB0002229D0 (en) | 2000-02-01 | 2000-03-22 | Reckitt & Colman Inc | Improvements in or relating to organic compositions |
| DE60103023T2 (de) | 2000-02-28 | 2005-01-27 | The Procter & Gamble Company, Cincinnati | Saure antimikrobielle zusammensetzungen zur behandlung von lebensmitteln und lebensmittel-kontaktflächen und verfahren zu ihrer anwendung |
| US6379382B1 (en) | 2000-03-13 | 2002-04-30 | Jun Yang | Stent having cover with drug delivery capability |
| US20030009213A1 (en) | 2000-03-13 | 2003-01-09 | Jun Yang | Stent having cover with drug delivery capability |
| AU2001263437B2 (en) | 2000-06-05 | 2005-08-11 | S.C. Johnson & Son, Inc. | Biocidal cleaner composition |
| US20020029015A1 (en) | 2000-07-04 | 2002-03-07 | Edoardo Camenzind | Device for administering a composition in a duct of a human or animal body |
| US6953772B2 (en) | 2000-07-18 | 2005-10-11 | Lopes John A | Concentrated sanitizing compositions for cleaning food and food contact surfaces |
| US20030133883A1 (en) | 2001-06-14 | 2003-07-17 | Finnegan Mary Beth | Oral care compositions containing grapefruit seed extract |
| GB0100761D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
| US6623513B2 (en) | 2001-01-19 | 2003-09-23 | Advanced Photodynamic Technologies, Inc. | Apparatus and method of photodynamic eradication of organisms utilizing pyrrolnitrin |
| DE10105592A1 (de) | 2001-02-06 | 2002-08-08 | Achim Goepferich | Platzhalter zur Arzneistofffreigabe in der Stirnhöhle |
| KR100492644B1 (ko) * | 2001-02-26 | 2005-06-02 | 미쓰비시 지도샤 고교(주) | 배기 가스 정화용 촉매 |
| US6610314B2 (en) | 2001-03-12 | 2003-08-26 | Kimberly-Clark Worldwide, Inc. | Antimicrobial formulations |
| US6682695B2 (en) | 2001-03-23 | 2004-01-27 | Clearant, Inc. | Methods for sterilizing biological materials by multiple rates |
| US6962813B2 (en) | 2001-05-21 | 2005-11-08 | The Brigham And Women's Hospital, Inc. | P. aeruginosa mucoid exopolysaccharide specific binding peptides |
| ATE326553T1 (de) * | 2001-09-13 | 2006-06-15 | Ak Steel Properties Inc | Verfahren zum kontinuierlichen giessen von elektrostahlband mit kontrollierter sprühkühlung |
| CN1231218C (zh) | 2001-09-21 | 2005-12-14 | 爱尔康公司 | 药物组合物在制备用于治疗中耳感染的药物中的用途 |
| US20030064000A1 (en) | 2001-09-24 | 2003-04-03 | Wilson Burgess | Methods of sterilizing biological mixtures using stabilizer mixtures |
| WO2003061579A2 (en) | 2002-01-18 | 2003-07-31 | Emory University | Phthalocyanine and porphyrazine pharmaceutical compositions |
| US20050042240A1 (en) | 2002-01-28 | 2005-02-24 | Utterberg David S. | High viscosity antibacterials |
| US20030180181A1 (en) | 2002-02-01 | 2003-09-25 | Teri Greib | Methods for sterilizing tissue |
| RU2228203C2 (ru) | 2002-04-12 | 2004-05-10 | ООО "Наука-Сервис-Центр" | Ранозаживляющий материал |
| WO2003088914A2 (en) | 2002-04-18 | 2003-10-30 | The University Of Iowa Research Foundation | Methods of inhibiting and treating bacterial biofilms by metal chelators |
| US6919348B2 (en) | 2002-05-02 | 2005-07-19 | Edward T. Wei | Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith |
| EP1374856A1 (en) | 2002-06-18 | 2004-01-02 | Impetus AG | Oily thixotropic nasal spray |
| US7105175B2 (en) | 2002-06-19 | 2006-09-12 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled delivery of a therapeutic agent |
| US7714011B2 (en) | 2002-09-13 | 2010-05-11 | Zicam, Llc | Compositions to reduce congestion and methods for application thereof to the nasal membrane |
| US20050064508A1 (en) | 2003-09-22 | 2005-03-24 | Semzyme | Peptide mediated synthesis of metallic and magnetic materials |
| US7119217B2 (en) | 2002-09-23 | 2006-10-10 | Genta Incorporated | Tri(alkylcarboxylato)gallium (III) products and pharmaceutical compositions containing them |
| US6770729B2 (en) | 2002-09-30 | 2004-08-03 | Medtronic Minimed, Inc. | Polymer compositions containing bioactive agents and methods for their use |
| BR0314952A (pt) | 2002-09-30 | 2005-08-02 | Bausch & Lomb | Método para inibir a aderência de bactérias a uma superfìcie de um dispositivo biomédico |
| US20040110738A1 (en) | 2002-10-22 | 2004-06-10 | Gillis Scott H. | Prophylactic treatment methods |
| US20040101506A1 (en) * | 2002-11-25 | 2004-05-27 | Fust Charles A. | Composition for the prevention and treatment of inflammation of the ear |
| US7220431B2 (en) | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
| US7491234B2 (en) | 2002-12-03 | 2009-02-17 | Boston Scientific Scimed, Inc. | Medical devices for delivery of therapeutic agents |
| GB2397067B (en) | 2002-12-23 | 2005-05-11 | Destiny Pharma Ltd | Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation |
| CA2518960C (en) | 2003-03-14 | 2013-08-27 | Sinexus, Inc. | Sinus delivery of sustained release therapeutics |
| US20040214753A1 (en) | 2003-03-20 | 2004-10-28 | Britten Nancy Jean | Dispersible pharmaceutical composition for treatment of mastitis and otic disorders |
| US20040213758A1 (en) | 2003-04-23 | 2004-10-28 | Rimon Therapeutics Ltd. | Hydroxyamate-containing materials for the inhibition of matrix metalloproteinases |
| US7090882B2 (en) | 2003-06-12 | 2006-08-15 | Cargill, Incorporated | Antimicrobial salt solutions for food safety applications |
| US20050003007A1 (en) | 2003-07-02 | 2005-01-06 | Michele Boix | Method of sterilization of polymeric microparticles |
| US7341983B2 (en) | 2003-08-04 | 2008-03-11 | Ecolab Inc. | Antimicrobial compositions including carboxylic acids and alkoxylated amines |
| MXPA06001776A (es) | 2003-08-15 | 2007-09-07 | Qlt Usa Inc | Sistema de suministro de farmaco transmucosal biocorrosivo, adhesivo. |
| US20050080396A1 (en) | 2003-10-03 | 2005-04-14 | Michael Rontal | Method and apparatus for the ultrasonic cleaning of biofilm coated surfaces |
| DE10347994A1 (de) | 2003-10-15 | 2005-06-16 | Pari GmbH Spezialisten für effektive Inhalation | Wässrige Aerosol-Zubereitung |
| EP1691614B1 (en) | 2003-12-04 | 2013-02-13 | University Of Iowa Research Foundation | Gallium inhibits biofilm formation |
| WO2005058331A1 (en) | 2003-12-17 | 2005-06-30 | Titan Pharmaceuticals, Inc. | Use of gallium to treat inflammatory arthritis |
| AU2004313245B2 (en) | 2003-12-30 | 2011-04-14 | Durect Corporation | Polymeric implants, preferably containing a mixture of PEG and PLG, for controlled release of active agents, preferably a GNRH |
| US7541320B2 (en) * | 2004-01-23 | 2009-06-02 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Mild, viscous cleansing composition with versatile compatibility and enhanced conditioning |
| US20100016267A1 (en) | 2004-03-15 | 2010-01-21 | Felix Theeuwes | Pharmaceutical compositions for administraton to a sinus |
| EP1737378A2 (en) | 2004-04-02 | 2007-01-03 | Baylor College of Medicine | Novel modification of medical prostheses |
| US7410480B2 (en) | 2004-04-21 | 2008-08-12 | Acclarent, Inc. | Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders |
| US7803150B2 (en) | 2004-04-21 | 2010-09-28 | Acclarent, Inc. | Devices, systems and methods useable for treating sinusitis |
| US20050282722A1 (en) | 2004-06-16 | 2005-12-22 | Mcreynolds Kent B | Two part cleaning composition |
| US7494963B2 (en) | 2004-08-11 | 2009-02-24 | Delaval Holding Ab | Non-chlorinated concentrated all-in-one acid detergent and method for using the same |
| US20060045850A1 (en) * | 2004-08-30 | 2006-03-02 | Qpharma, Llc | Nasal delivery of cyclodextrin complexes of anti-inflammatory steroids |
| US9028852B2 (en) | 2004-09-07 | 2015-05-12 | 3M Innovative Properties Company | Cationic antiseptic compositions and methods of use |
| EP2258837A1 (en) | 2004-09-10 | 2010-12-08 | Novozymes North America, Inc. | Methods for preventing, removing, reducing, or disrupting biofilm |
| US20060079420A1 (en) * | 2004-10-08 | 2006-04-13 | Wagner Julie A | Multi-phase personal cleansing composition |
| WO2006099325A2 (en) * | 2005-03-10 | 2006-09-21 | 3M Innovative Properties Company | Methods of treating ear infections |
| US20100240770A1 (en) | 2005-03-11 | 2010-09-23 | Jifa Qi | Synthesis and use of colloidal III-V nanoparticles |
| US7959943B2 (en) | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
| US7976873B2 (en) | 2006-05-10 | 2011-07-12 | Medtronic Xomed, Inc. | Extracellular polysaccharide solvating system for treatment of bacterial ear conditions |
| US7993675B2 (en) | 2006-05-10 | 2011-08-09 | Medtronic Xomed, Inc. | Solvating system and sealant for medical use in the sinuses and nasal passages |
| US7998404B2 (en) | 2006-07-13 | 2011-08-16 | Advanced Cardiovascular Systems, Inc. | Reduced temperature sterilization of stents |
| AU2007346705B2 (en) | 2007-02-08 | 2014-01-09 | Medtronic Xomed, Inc. | Solvating system and sealant for medical use |
-
2007
- 2007-04-24 US US11/739,508 patent/US7976873B2/en active Active
- 2007-05-08 KR KR1020087027422A patent/KR101453011B1/ko not_active Expired - Fee Related
- 2007-05-08 AU AU2007249413A patent/AU2007249413B2/en not_active Ceased
- 2007-05-08 WO PCT/US2007/068477 patent/WO2007134055A1/en not_active Ceased
- 2007-05-08 JP JP2009510146A patent/JP5912218B2/ja not_active Expired - Fee Related
- 2007-05-08 CA CA2651646A patent/CA2651646C/en not_active Expired - Fee Related
- 2007-05-08 EP EP07762011.0A patent/EP2029232B1/en active Active
- 2007-05-08 ES ES07762011.0T patent/ES2650974T3/es active Active
- 2007-05-08 CN CN201510116539.8A patent/CN104815328A/zh active Pending
-
2014
- 2014-08-28 JP JP2014173789A patent/JP2014240419A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5480658A (en) * | 1993-07-23 | 1996-01-02 | Melman; Steven A. | Ear and skin cleanser |
| CN1174093A (zh) * | 1996-06-27 | 1998-02-25 | 千寿制药株式会社 | 降低表面活性剂刺激性方法和降低了刺激性的水性组合物 |
| US6855678B2 (en) * | 2000-07-21 | 2005-02-15 | Reginald Reith Whiteley | Medical residue treatment composition comprising a lithium salt |
Non-Patent Citations (1)
| Title |
|---|
| 赵克健: "《现代药学名词手册》", 31 October 2004, 中国医药科技出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770999A (zh) * | 2016-03-03 | 2016-07-20 | 宁夏大学 | 一种消除细菌生物被膜的复合生物材料 |
| CN105770999B (zh) * | 2016-03-03 | 2019-01-29 | 宁夏大学 | 一种消除细菌生物被膜的复合生物材料 |
| CN109310087A (zh) * | 2016-06-30 | 2019-02-05 | 贴近科学Ip控股私人有限公司 | 抗微生物的组合物和应用该组合物的方法 |
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| US20070264353A1 (en) | 2007-11-15 |
| EP2029232B1 (en) | 2017-09-20 |
| JP5912218B2 (ja) | 2016-04-27 |
| JP2009536666A (ja) | 2009-10-15 |
| JP2014240419A (ja) | 2014-12-25 |
| EP2029232A1 (en) | 2009-03-04 |
| US7976873B2 (en) | 2011-07-12 |
| AU2007249413B2 (en) | 2012-08-30 |
| AU2007249413A1 (en) | 2007-11-22 |
| WO2007134055A1 (en) | 2007-11-22 |
| KR101453011B1 (ko) | 2014-10-21 |
| CA2651646C (en) | 2015-01-27 |
| ES2650974T3 (es) | 2018-01-23 |
| CA2651646A1 (en) | 2007-11-22 |
| KR20090005162A (ko) | 2009-01-12 |
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