CN104784662A - Traditional Chinese medicine composition for treating anxiety - Google Patents
Traditional Chinese medicine composition for treating anxiety Download PDFInfo
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- CN104784662A CN104784662A CN201510194620.8A CN201510194620A CN104784662A CN 104784662 A CN104784662 A CN 104784662A CN 201510194620 A CN201510194620 A CN 201510194620A CN 104784662 A CN104784662 A CN 104784662A
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Abstract
The invention provides a traditional Chinese medicine composition for treating anxiety. The traditional Chinese medicine composition is prepared from the following raw materials: Monochasma savatieri Franch, amaranthus spinosus, fructus psoraleae, radix paeoniae alba and the like. The traditional Chinese medicine composition can be used for treating anxiety.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine composition being used for the treatment of anxiety neurosis and its preparation method and application.
Background technology
Anxiety neurosis, is also called anxiety neurosis, is modal one in this large class disease of neurosis, with anxiety experience for principal character.Chronic anxiety (generalized anxiety disorder) and acute anxiety attack (panic disorder) two kinds of forms can be divided into.Main manifestations is: the anxiety without clear and definite objective objects is worried, is on tenterhooks, and also has vegetative nerve symptom (cardiopalmus, hand shaking, perspiration, frequent micturition etc.).Because sickness rate is high, for this reason, be bursting to and develop the needs that more medicines for the treatment of anxiety neurosis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of anxiety neurosis disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of Chinese medicine composition being used for the treatment of anxiety neurosis, active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: white hair Herba monochasmatis 12 parts, Amaranthus spinosus L. 18 parts, Fructus Psoraleae 10 parts, the Radix Paeoniae Alba 10 parts, Magnetitum 30 parts, the Radix Aucklandiae 10 parts, Rhizoma Atractylodis 10 parts, Radix Rehmanniae Preparata 10 parts, Fructus Gardeniae 10 parts, Os Sepiae 10 parts, Rhizoma Zingiberis 10 parts, Fructus Corni 10 parts, Radix Scutellariae 10 parts, Bulbus Fritillariae Uninbracteatae 10 parts, the Radix Astragali 60 parts, Ramulus Uncariae Cum Uncis 15 parts, Radix Bupleuri 10 parts, Rhizoma Coptidis 6 parts, Radix Codonopsis 10 parts, Rhizoma Curculiginis 10 parts, the Rhizoma Pinelliae 10 parts, Radix Ophiopogonis 10 parts, Herba Epimedii 10 parts, Cortex Magnoliae Officinalis 6 parts, Fructus Schisandrae Chinensis 5 parts, Rhizoma Cyperi 10 parts, Pericarpium Citri Reticulatae 6 parts, Radix Salviae Miltiorrhizae 10 parts, 10 parts, Radix Glycyrrhizae, Os Draconis 30 parts.
The described Chinese medicine composition being used for the treatment of anxiety neurosis, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described Chinese medicine composition being used for the treatment of anxiety neurosis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of Chinese medicine composition in preparation treatment anxiety neurosis medicine being used for the treatment of anxiety neurosis.
White hair Herba monochasmatis is the herb of Scrophulariaceae Herba monochasmatis platymiscium white hair Herba monochasmatis Monochasma savatieri Franch..Summer, autumn gather, and clean using fresh herb or dry, heat-clearing and toxic substances removing, cooling blood for hemostasis.For infantile thrush, toothache, pneumonia, infantile hyperpyrexia, rheumatic arthritis, spits blood, has blood in stool; Mastitis are controlled in external, traumatic hemorrhage.Amaranthus spinosus L. is dry herb or the root of amaranthaceous plant Amaranthusspinosus L. Amaranthus spinosus L..Summer, autumn gather, and removing silt, dries or take advantage of fresh-cut section, dry.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, cooling blood for hemostasis.For dysentery, enteritis, taste-blindness rate is hemorrhage, hemorrhoidal hemorrhage; Venom is controlled in external, skin eczema, furuncle and phyma pus infections.The present invention is with all herbal medicine.All the other medical materials are pharmacopeia kind.
Beneficial effect: the white hair Herba monochasmatis of the present invention, Amaranthus spinosus L. heat-clearing and toxic substances removing are monarch drug, Fructus Psoraleae, the Radix Paeoniae Alba, Magnetitum, the Radix Aucklandiae, Rhizoma Atractylodis, Radix Rehmanniae Preparata, Fructus Gardeniae, Os Sepiae, Rhizoma Zingiberis, Fructus Corni, Radix Scutellariae, Bulbus Fritillariae Uninbracteatae, the Radix Astragali, Ramulus Uncariae Cum Uncis, Radix Bupleuri, Rhizoma Coptidis, Radix Codonopsis, Rhizoma Curculiginis, Rhizoma Pinelliae tranquillizing and allaying excitement, depressed liver-energy dispersing and QI regulating is ministerial drug, Radix Ophiopogonis, Herba Epimedii, Cortex Magnoliae Officinalis, Fructus Schisandrae Chinensis, Rhizoma Cyperi, Pericarpium Citri Reticulatae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Os Draconis are adjuvant, full side's compatibility, bring out the best in each other, treatment anxiety neurosis successful.The present invention actively can prevent and treat generation and the development of anxiety neurosis effectively, and this is for improving existence and the quality of life of broad masses, protecting the health of broad masses, and then raising productivity, significant and higher practical value.Because primary disease sickness rate is high, estimate, once marketing application, good Social benefit and economic benefit will be produced.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get white hair Herba monochasmatis 12g, Amaranthus spinosus L. 18g, Fructus Psoraleae 10g, Radix Paeoniae Alba 10g, Magnetitum 30g, Radix Aucklandiae 10g, Rhizoma Atractylodis 10g, Radix Rehmanniae Preparata 10g, Fructus Gardeniae 10g, Os Sepiae 10g, Rhizoma Zingiberis 10g, Fructus Corni 10g, Radix Scutellariae 10g, Bulbus Fritillariae Uninbracteatae 10g, Radix Astragali 60g, Ramulus Uncariae Cum Uncis 15g, Radix Bupleuri 10g, Rhizoma Coptidis 6g, Radix Codonopsis 10g, Rhizoma Curculiginis 10g, Rhizoma Pinelliae 10g, Radix Ophiopogonis 10g, Herba Epimedii 10g, Cortex Magnoliae Officinalis 6g, Fructus Schisandrae Chinensis 5g, Rhizoma Cyperi 10g, Pericarpium Citri Reticulatae 6g, Radix Salviae Miltiorrhizae 10g, Radix Glycyrrhizae 10g, Os Draconis 30g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get white hair Herba monochasmatis 12g, Amaranthus spinosus L. 18g, Fructus Psoraleae 10g, Radix Paeoniae Alba 10g, Magnetitum 30g, Radix Aucklandiae 10g, Rhizoma Atractylodis 10g, Radix Rehmanniae Preparata 10g, Fructus Gardeniae 10g, Os Sepiae 10g, Rhizoma Zingiberis 10g, Fructus Corni 10g, Radix Scutellariae 10g, Bulbus Fritillariae Uninbracteatae 10g, Radix Astragali 60g, Ramulus Uncariae Cum Uncis 15g, Radix Bupleuri 10g, Rhizoma Coptidis 6g, Radix Codonopsis 10g, Rhizoma Curculiginis 10g, Rhizoma Pinelliae 10g, Radix Ophiopogonis 10g, Herba Epimedii 10g, Cortex Magnoliae Officinalis 6g, Fructus Schisandrae Chinensis 5g, Rhizoma Cyperi 10g, Pericarpium Citri Reticulatae 6g, Radix Salviae Miltiorrhizae 10g, Radix Glycyrrhizae 10g, Os Draconis 30g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get white hair Herba monochasmatis 12g, Amaranthus spinosus L. 18g, Fructus Psoraleae 10g, Radix Paeoniae Alba 10g, Magnetitum 30g, Radix Aucklandiae 10g, Rhizoma Atractylodis 10g, Radix Rehmanniae Preparata 10g, Fructus Gardeniae 10g, Os Sepiae 10g, Rhizoma Zingiberis 10g, Fructus Corni 10g, Radix Scutellariae 10g, Bulbus Fritillariae Uninbracteatae 10g, Radix Astragali 60g, Ramulus Uncariae Cum Uncis 15g, Radix Bupleuri 10g, Rhizoma Coptidis 6g, Radix Codonopsis 10g, Rhizoma Curculiginis 10g, Rhizoma Pinelliae 10g, Radix Ophiopogonis 10g, Herba Epimedii 10g, Cortex Magnoliae Officinalis 6g, Fructus Schisandrae Chinensis 5g, Rhizoma Cyperi 10g, Pericarpium Citri Reticulatae 6g, Radix Salviae Miltiorrhizae 10g, Radix Glycyrrhizae 10g, Os Draconis 30g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, traditional Chinese medicine composition for treating anxiety neurosis of the present invention clinical research
4.1 general data: this Chinese medicine composition is applied to clinical observation anxiety neurosis case 40 example, wherein man 10 example, female 30 example, 23 ~ 53 years old age.The shortest person of the course of disease 2 years, most elder reaches 4 years, average 2.6 years.
4.2 diagnostic criterias: clinical manifestation 1. mental maladjustment: subjective doubt, lather, responsive excitation, absent minded, terrified very much, dying sense.2. somatization: xerostomia, uncomfortable in chest, tachycardia, frequent micturition, diarrhoea, constipation, shake perspiration, cardiopalmus, dyspnea.3. motor symptoms: hand shaking, muscular tone, to walk up and down uneasily.4. typing: generalized anxiety disorder and panic attack is clinical acute and chronic two classes.Diagnosis basis: the 1. anxiety persistent period that generalized anxiety disorder (1) is undue is more than half a year; (2) accompany that vegetative nerve function is hyperfunction, mobility is uneasy and too vigilant; (3) do not meet the diagnostic criteria of obsession, phobia, depressive neurosis, and anxiety is not organic disease causes.2. panic attack (1) without obvious cause occur suddenly strong terrified, accompany dying sense or sense out of control; (2) with serious vegetative nerve symptom when showing effect; (3) each outbreak of short duration (being generally no more than 2 hours), outbreak obviously affects routine work; Within (4) 1 months, at least show effect 3 times; (5) to note especially getting rid of hyperthyroidism and the similar outbreak caused by adrenal gland's chromaffin cell tumor, cardiovascular diseases, spontaneous hypoglycemia, endocrinopathy, drug withdrawal reaction and temporal lobe epilepsy.(6) diagnostic criteria recalling disease and phobia is not met.(7) electroencephalogram shows that X activity reduces B activity and increases.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within three months, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule three months is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: (1) fully recovers: clinical symptom disappearance, can participate in normal work and work.(2) take a turn for the better: clinical symptom relief.(3) invalid: symptom is without improvement.。
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 20 | 2 | 12 | 6 | 70 |
| Blank group | 20 | 3 | 2 | 15 | 25 |
Visible, the medicine that the present invention obtains can safe and effective treatment anxiety neurosis.
Claims (4)
1. one kind is used for the treatment of the Chinese medicine composition of anxiety neurosis, it is characterized in that, active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: white hair Herba monochasmatis 12 parts, Amaranthus spinosus L. 18 parts, Fructus Psoraleae 10 parts, the Radix Paeoniae Alba 10 parts, Magnetitum 30 parts, the Radix Aucklandiae 10 parts, Rhizoma Atractylodis 10 parts, Radix Rehmanniae Preparata 10 parts, Fructus Gardeniae 10 parts, Os Sepiae 10 parts, Rhizoma Zingiberis 10 parts, Fructus Corni 10 parts, Radix Scutellariae 10 parts, Bulbus Fritillariae Uninbracteatae 10 parts, the Radix Astragali 60 parts, Ramulus Uncariae Cum Uncis 15 parts, Radix Bupleuri 10 parts, Rhizoma Coptidis 6 parts, Radix Codonopsis 10 parts, Rhizoma Curculiginis 10 parts, the Rhizoma Pinelliae 10 parts, Radix Ophiopogonis 10 parts, Herba Epimedii 10 parts, Cortex Magnoliae Officinalis 6 parts, Fructus Schisandrae Chinensis 5 parts, Rhizoma Cyperi 10 parts, Pericarpium Citri Reticulatae 6 parts, Radix Salviae Miltiorrhizae 10 parts, 10 parts, Radix Glycyrrhizae, Os Draconis 30 parts.
2. be used for the treatment of the Chinese medicine composition of anxiety neurosis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the Chinese medicine composition of anxiety neurosis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of Chinese medicine composition in treatment anxiety neurosis medicine of anxiety neurosis according to claim 1.
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Application publication date: 20150722 |