CN105056183A - Traditional Chinese medicine composition used for treating anxiety neurosis - Google Patents
Traditional Chinese medicine composition used for treating anxiety neurosis Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine, and more specifically provides a traditional Chinese medicine composition used for treating anxiety neurosis. The traditional Chinese medicine composition is prepared from, 25 parts of Lindera metcalfiana Allen var.dictyophylla(Allen)H.P.Tsui fruit, 18 parts of Diplazium donianum (Mett.) Tard.-Blot, 10 parts of radix astragali, 10 parts of rhizoma anemarrhenae, 10 parts of Salvia miltiorrhiza, 10 parts of radix paeoniae alba, 10 parts of rhizoma rehmanniae, 10 parts of cornus officinalis, 15 parts of radix achyranthis bidentatae, 15 parts of Herba Taxilli, 10 parts of codonopsis pilosula, 10 parts of radix ophiopogonis, 10 parts of fructus schisandrae chinensis, 10 parts of rhizoma curcumae, 15 parts of uncaria rhynchophylla, 10 parts of rhizoma curculiginis, 10 parts of herba epimedii, 10 parts of rhizoma cyperi, 10 parts of liquorice, 30 parts of magnetite, 10 parts of fructus gardeniae, 10 parts of radix scutellariae, 10 parts of radix bupleuri, 10 parts of Rhizoma Pinelliae, 5 parts of Mangnolia officinalis, 10 parts of pericarpium citri reticulatae, 30 parts of Fossilizid, 10 parts of radix aucklandiae, 10 parts of cuttle bone, 10 parts of Bulbus fritillariae cirrhosae, 6 parts of rhizoma zingiberis, and 6 parts of rhizoma coptidis. The traditional Chinese medicine composition can be used for treating anxiety neurosis.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine composition being used for the treatment of anxiety neurosis and its preparation method and application.
Background technology
Anxiety neurosis, is also called anxiety neurosis, is modal one in this large class disease of neurosis, with anxiety experience for principal character.Chronic anxiety (generalized anxiety disorder) and acute anxiety attack (panic disorder) two kinds of forms can be divided into.Main manifestations is: the anxiety without clear and definite objective objects is worried, is on tenterhooks, and also has vegetative nerve symptom (cardiopalmus, hand shaking, perspiration, frequent micturition etc.).Because sickness rate is high, for this reason, be bursting to and develop the needs that more medicines for the treatment of anxiety neurosis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of anxiety neurosis disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of Chinese medicine composition being used for the treatment of anxiety neurosis, active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Caulis et Folium Hyptidis suaveolentis fruit 25 parts, 18 parts, comb leaf, the Radix Astragali 10 parts, the Rhizoma Anemarrhenae 10 parts, Radix Salviae Miltiorrhizae 10 parts, the Radix Paeoniae Alba 10 parts, Radix Rehmanniae 10 parts, Fructus Corni 10 parts, Radix Achyranthis Bidentatae 15 parts, Herba Taxilli 15 parts, Radix Codonopsis 10 parts, Radix Ophiopogonis 10 parts, Fructus Schisandrae Chinensis 10 parts, Rhizoma Curcumae 10 parts, Ramulus Uncariae Cum Uncis 15 parts, Rhizoma Curculiginis 10 parts, Herba Epimedii 10 parts, Rhizoma Cyperi 10 parts, 10 parts, Radix Glycyrrhizae, Magnetitum 30 parts, Fructus Gardeniae 10 parts, Radix Scutellariae 10 parts, Radix Bupleuri 10 parts, the Rhizoma Pinelliae 10 parts, Cortex Magnoliae Officinalis 5 parts, Pericarpium Citri Reticulatae 10 parts, Os Draconis 30 parts, Radix Aucklandiae (Radix Vladimiriae) 10 parts, Os Sepiae 10 parts, Bulbus Fritillariae Uninbracteatae 10 parts, Rhizoma Zingiberis 6 parts, Rhizoma Coptidis 6 parts.
The described Chinese medicine composition being used for the treatment of anxiety neurosis, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described Chinese medicine composition being used for the treatment of anxiety neurosis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of Chinese medicine composition in preparation treatment anxiety neurosis medicine being used for the treatment of anxiety neurosis.
Caulis et Folium Hyptidis suaveolentis fruit is the fruit of canella net leaf Fructus Linderae Glaucae.Latin name: LinderametcalfianaAllenvar.dictyophylla (Allen) H.P.Tsui, invigorating the liver and kidney; Warm waist knee joint.Main chills and pain of the waist and kness; Aching and limp weak.
Comb leaf is the herb of Athyriaceae plant Diplazium donianum (Mett.) Tard. Blet..Latin name: Diplaziumdonianum (Mett.) Tard-Blot. [AspleniumdonianumMett.], clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body.Cure mainly jaundice due to damp-heat; Venom; Traumatic hemorrhage; Dysmenorrhea.All the other medical materials are pharmacopeia kind.
Beneficial effect: Chinese medicine traditional treatment theory is thought: " five ZAHG-organs producing the five QI in the body, to give birth to the sad melancholy of susceptible to anger probably ".Chinese medicine emphasizes the important function of emotional factors to physical disease when treating physical disease; The impact of the overall physiological function change of body on Neurotoxicity is paid attention to when emotion regulation illness; This psychosoma dependency by people directly applies to the psychosoma integration of guiding clinical treatment, pays close attention to the organic conception of social nature of man survival condition, is the theoretical basis place of being good at adjustment treatment spiritual neuropathy clinical advantage Chinese medicine thousands of year.Anxiety neurosis, according to its Clinical symptoms, belongs to strongly fragrant sick category in the discussion of Chinese medicine tradition.It is unsuccessful that the strongly fragrant cause of disease is common in feelings will, and the stagnation of QI presses down spleen, motive consumption wound, and blood damaged by excess of seven emotions and the serious disease prolonged illness such as not repose consumes caused by sad spleen.Anxiety neurosis, as feelings will obstacle, is lacked of proper care closely relevant with the physiological function of liver and gall especially, and its etiology and pathogenesis is many enters few sun, the liver failing to maintain the normal flow of QI, the secretory function imbalance of gallbladder because of heresy, and the stagnation of QI is lost and reached, strongly fragrant and heat-transformation, upsets the mind and occurs all diseases of anxiety.Can also play while heat-clearing and toxic substances removing, soothing the liver, the kidney invigorating, stomach invigorating, sharp lung and calm the nerves, QI and blood regulating, the effect of Yin Yang balancing.Caulis et Folium Hyptidis suaveolentis fruit of the present invention, comb leaf, the Radix Astragali, the Rhizoma Anemarrhenae, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Radix Rehmanniae, Fructus Corni, Radix Achyranthis Bidentatae heat-clearing and toxic substances removing, soothing the liver, the kidney invigorating are monarch drug, Herba Taxilli, Radix Codonopsis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Rhizoma Curcumae, Ramulus Uncariae Cum Uncis, Rhizoma Curculiginis, Herba Epimedii, Rhizoma Cyperi, Radix Glycyrrhizae, Magnetitum, Fructus Gardeniae are calmed the nerves, QI and blood regulating is ministerial drug, Radix Scutellariae, Radix Bupleuri, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Os Draconis, Radix Aucklandiae (Radix Vladimiriae), Os Sepiae, Bulbus Fritillariae Uninbracteatae, Rhizoma Zingiberis, Rhizoma Coptidis are adjuvant, full side's heat-clearing and toxic substances removing, tranquillizing and allaying excitement, depressed liver-energy dispersing and QI regulating, full side's compatibility, bring out the best in each other, treatment anxiety neurosis successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Caulis et Folium Hyptidis suaveolentis fruit 25g, comb leaf 18g, Radix Astragali 10g, Rhizoma Anemarrhenae 10g, Radix Salviae Miltiorrhizae 10g, Radix Paeoniae Alba 10g, Radix Rehmanniae 10g, Fructus Corni 10g, Radix Achyranthis Bidentatae 15g, Herba Taxilli 15g, Radix Codonopsis 10g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 10g, Rhizoma Curcumae 10g, Ramulus Uncariae Cum Uncis 15g, Rhizoma Curculiginis 10g, Herba Epimedii 10g, Rhizoma Cyperi 10g, Radix Glycyrrhizae 10g, Magnetitum 30g, Fructus Gardeniae 10g, Radix Scutellariae 10g, Radix Bupleuri 10g, Rhizoma Pinelliae 10g, Cortex Magnoliae Officinalis 5g, Pericarpium Citri Reticulatae 10g, Os Draconis 30g, Radix Aucklandiae (Radix Vladimiriae) 10g, Os Sepiae 10g, Bulbus Fritillariae Uninbracteatae 10g, Rhizoma Zingiberis 6g, Rhizoma Coptidis 6g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Caulis et Folium Hyptidis suaveolentis fruit 25g, comb leaf 18g, Radix Astragali 10g, Rhizoma Anemarrhenae 10g, Radix Salviae Miltiorrhizae 10g, Radix Paeoniae Alba 10g, Radix Rehmanniae 10g, Fructus Corni 10g, Radix Achyranthis Bidentatae 15g, Herba Taxilli 15g, Radix Codonopsis 10g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 10g, Rhizoma Curcumae 10g, Ramulus Uncariae Cum Uncis 15g, Rhizoma Curculiginis 10g, Herba Epimedii 10g, Rhizoma Cyperi 10g, Radix Glycyrrhizae 10g, Magnetitum 30g, Fructus Gardeniae 10g, Radix Scutellariae 10g, Radix Bupleuri 10g, Rhizoma Pinelliae 10g, Cortex Magnoliae Officinalis 5g, Pericarpium Citri Reticulatae 10g, Os Draconis 30g, Radix Aucklandiae (Radix Vladimiriae) 10g, Os Sepiae 10g, Bulbus Fritillariae Uninbracteatae 10g, Rhizoma Zingiberis 6g, Rhizoma Coptidis 6g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Caulis et Folium Hyptidis suaveolentis fruit 25g, comb leaf 18g, Radix Astragali 10g, Rhizoma Anemarrhenae 10g, Radix Salviae Miltiorrhizae 10g, Radix Paeoniae Alba 10g, Radix Rehmanniae 10g, Fructus Corni 10g, Radix Achyranthis Bidentatae 15g, Herba Taxilli 15g, Radix Codonopsis 10g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 10g, Rhizoma Curcumae 10g, Ramulus Uncariae Cum Uncis 15g, Rhizoma Curculiginis 10g, Herba Epimedii 10g, Rhizoma Cyperi 10g, Radix Glycyrrhizae 10g, Magnetitum 30g, Fructus Gardeniae 10g, Radix Scutellariae 10g, Radix Bupleuri 10g, Rhizoma Pinelliae 10g, Cortex Magnoliae Officinalis 5g, Pericarpium Citri Reticulatae 10g, Os Draconis 30g, Radix Aucklandiae (Radix Vladimiriae) 10g, Os Sepiae 10g, Bulbus Fritillariae Uninbracteatae 10g, Rhizoma Zingiberis 6g, Rhizoma Coptidis 6g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, traditional Chinese medicine composition for treating anxiety neurosis of the present invention clinical research
4.1 general data: this Chinese medicine composition is applied to clinical observation anxiety neurosis case 50 example, wherein man 20 example, female 30 example, 24 ~ 52 years old age.The shortest person of the course of disease 1 year, most elder reaches 3 years, average 1.6 years.
4.2 diagnostic criterias: clinical manifestation 1. mental maladjustment: subjective doubt, lather, responsive excitation, absent minded, terrified very much, dying sense.2. somatization: xerostomia, uncomfortable in chest, tachycardia, frequent micturition, diarrhoea, constipation, shake perspiration, cardiopalmus, dyspnea.3. motor symptoms: hand shaking, muscular tone, to walk up and down uneasily.4. typing: generalized anxiety disorder and panic attack is clinical acute and chronic two classes.Diagnosis basis: the 1. anxiety persistent period that generalized anxiety disorder (1) is undue is more than half a year; (2) accompany that vegetative nerve function is hyperfunction, mobility is uneasy and too vigilant; (3) do not meet the diagnostic criteria of obsession, phobia, depressive neurosis, and anxiety is not organic disease causes.2. panic attack (1) without obvious cause occur suddenly strong terrified, accompany dying sense or sense out of control; (2) with serious vegetative nerve symptom when showing effect; (3) each outbreak of short duration (being generally no more than 2 hours), outbreak obviously affects routine work; Within (4) 1 months, at least show effect 3 times; (5) to note especially getting rid of hyperthyroidism and the similar outbreak caused by adrenal gland's chromaffin cell tumor, cardiovascular diseases, spontaneous hypoglycemia, endocrinopathy, drug withdrawal reaction and temporal lobe epilepsy.(6) diagnostic criteria recalling disease and phobia is not met.(7) electroencephalogram shows that X activity reduces B activity and increases.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within three months, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule three months is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: (1) fully recovers: clinical symptom disappearance, can participate in normal work and work.(2) take a turn for the better: clinical symptom relief.(3) invalid: symptom is without improvement.。
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 25 | 10 | 8 | 7 | 72 |
| Blank group | 25 | 1 | 1 | 23 | 8 |
Visible, the medicine that the present invention obtains can safe and effective treatment anxiety neurosis, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the Chinese medicine composition of anxiety neurosis, it is characterized in that, active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Caulis et Folium Hyptidis suaveolentis fruit 25 parts, 18 parts, comb leaf, the Radix Astragali 10 parts, the Rhizoma Anemarrhenae 10 parts, Radix Salviae Miltiorrhizae 10 parts, the Radix Paeoniae Alba 10 parts, Radix Rehmanniae 10 parts, Fructus Corni 10 parts, Radix Achyranthis Bidentatae 15 parts, Herba Taxilli 15 parts, Radix Codonopsis 10 parts, Radix Ophiopogonis 10 parts, Fructus Schisandrae Chinensis 10 parts, Rhizoma Curcumae 10 parts, Ramulus Uncariae Cum Uncis 15 parts, Rhizoma Curculiginis 10 parts, Herba Epimedii 10 parts, Rhizoma Cyperi 10 parts, 10 parts, Radix Glycyrrhizae, Magnetitum 30 parts, Fructus Gardeniae 10 parts, Radix Scutellariae 10 parts, Radix Bupleuri 10 parts, the Rhizoma Pinelliae 10 parts, Cortex Magnoliae Officinalis 5 parts, Pericarpium Citri Reticulatae 10 parts, Os Draconis 30 parts, Radix Aucklandiae (Radix Vladimiriae) 10 parts, Os Sepiae 10 parts, Bulbus Fritillariae Uninbracteatae 10 parts, Rhizoma Zingiberis 6 parts, Rhizoma Coptidis 6 parts.
2. be used for the treatment of the Chinese medicine composition of anxiety neurosis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the Chinese medicine composition of anxiety neurosis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of Chinese medicine composition in treatment anxiety neurosis medicine of anxiety neurosis according to claim 1.
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| CN101496865A (en) * | 2009-03-19 | 2009-08-05 | 杨颖� | Chinese medicament preparation for treating depression and anxiety as well as preparation method thereof |
| CN101524519A (en) * | 2008-03-06 | 2009-09-09 | 北京中科仁和科技有限公司 | Chinese materia medica preparation for treating insomnia and preparation method thereof |
| CN104784662A (en) * | 2015-04-23 | 2015-07-22 | 臧孝国 | Traditional Chinese medicine composition for treating anxiety |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101524519A (en) * | 2008-03-06 | 2009-09-09 | 北京中科仁和科技有限公司 | Chinese materia medica preparation for treating insomnia and preparation method thereof |
| CN101496865A (en) * | 2009-03-19 | 2009-08-05 | 杨颖� | Chinese medicament preparation for treating depression and anxiety as well as preparation method thereof |
| CN104784662A (en) * | 2015-04-23 | 2015-07-22 | 臧孝国 | Traditional Chinese medicine composition for treating anxiety |
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