CN103041156A - Drug for treating elderly intractable insomnia and preparation method of drug - Google Patents
Drug for treating elderly intractable insomnia and preparation method of drug Download PDFInfo
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Abstract
The invention discloses a drug for treating elderly intractable insomnia and a preparation method of the drug. The drug is prepared by the following material medicines in parts by weight: 20-30 parts of radix salviae miltiorrhizae, 20-30 parts of Chinese angelica, 6-8 parts of coptidis rhizome, 15-20 parts of spina date seeds, 6-10 parts of cinnamons, 15-20 parts of white paeony roots, 10-12 parts of cortex lycii radicis, 10-15 parts of poria cocos, 6-10 parts of ligusticum wallichii, 15-20 parts of semen sojae praeparatum, 10-15 parts of radix ophiopogonis, 10-15 parts of beautiful sweetgum fruits, 20-30 parts of astragali radix, 15-20 parts of medicinal cyathula roots, 10-15 parts of lilies and 15-30 parts of honey-fried licorice roots. The drug disclosed by the invention can be prepared into capsules by the steps such as decocting, filtering, concentrating the filtrate, drying and the like. According to the drug disclosed by the invention, the etiology and pathogenesis of the elderly insomnia are analyzed clearly, the theories of the traditional Chinese medicine and the theories of modern Chinese medicine are combined to realize the organic combination of the theories, methods, prescriptions and drugs of the traditional Chinese medicine, so that the multiple medicines are applied in a combined manner, the curative effect is remarkable and the adverse reactions are avoided.
Description
Technical field
The present invention relates to treat the Chinese medicine of intractable insomnia, is a kind of Chinese medicine for the treatment of senile intractable insomnia specifically.
Background technology
Along with the fast development of China's economy, the quickening of people's rhythm of life, insomnia, neurastheniac increases rapidly, ubiquity chronic insomnia in community-based population especially, along with the change of aged tendency of population and spectrum of disease, the incidence rate of insomnia is obvious ascendant trend.Do not have enough sleep and sleep disorder also just becomes and has a strong impact on the able-bodied great illness of people, the result of domestic and international most of Epidemiological studys shows, annual have 33% people in various degree sleep disorder once to occur approximately, 17% Genus Homo serious insomnia is arranged, and insomnia has badly influenced people's life, work and physical and mental health.In addition, insomnia also usually affects normal physiological function and immune system, can cause the mental symptoms such as depression, anxiety, brings out cardiovascular and cerebrovascular disease.
Cure for insomnia is still take Drug therapy as main at present, and relatively medicine commonly used has sedative hypnotic, antidepressants, antihistaminic etc.Sedative hypnotic drug has the popularity inhibitory action to the central nervous system, and this type of medicine can cause serious liver, nephrotoxicity, and for a long time with also producing the side effect such as toleration and dependency.Use in recent years benzodiazepine still to have addiction, dependency and the hangover phenomenon etc. of medicine, can also cause memory impairment and with comparatively serious withdrawal reaction and insomnia rebound phenomenon.What is more important, although these medicines can prolong total length of one's sleep, two kinds of of paramount importance sleep compositions are S sleep (SWS) and rapid eye movement sleep (REMS) in the sleep procedure but but damaged, what they prolonged only is shallow sleep, and does not fundamentally play the effect that improves sleep quality.
Both at home and abroad pathogeny and the diagnosis aspect of having a sleepless night made great progress at present, but in treatment, still without breakthrough.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind for the treatment of old people intractable insomnia of the obvious patient's of improvement sleep quality.
Another object of the present invention provides a kind of preparation method of the old people's for the treatment of intractable insomnia medicine.
A kind of medicine for the treatment of old people's intractable insomnia, the medicament of being made by the raw material of following weight parts:
Radix Salviae Miltiorrhizae 20-30 part, Radix Angelicae Sinensis 20-30 part, Rhizoma Coptidis 6-8 part, Semen Ziziphi Spinosae 15-20 part, Cortex Cinnamomi 6-10 part, Radix Paeoniae Alba 15-20 part, Cortex Lycii 10-12 part, Poria 10-15 part, Rhizoma Chuanxiong 6-10 part, Semen Sojae Preparatum 15-20 part, Radix Ophiopogonis 10-15 part, Fructus Liquidambaris 10-15 part, Radix Astragali 20-30 part, Radix Cyathulae 15-20 part, Bulbus Lilii 10-15 part, Radix Glycyrrhizae Preparata 15-30 part.
A kind of preparation method for the treatment of the medicine of old people's intractable insomnia, it is prepared into capsule formulation by following steps:
(1) raw material weighing: the described medical material of claim 1 cleaned choose in proportion raw material: Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Coptidis, Semen Ziziphi Spinosae, Cortex Cinnamomi, the Radix Paeoniae Alba, Cortex Lycii, Poria, Rhizoma Chuanxiong, Semen Sojae Preparatum, Radix Ophiopogonis, Fructus Liquidambaris, Radix Astragali, Radix Cyathulae, Bulbus Lilii, Radix Glycyrrhizae Preparata;
(2) preparation method: after the crude drug mixing, decoct with water twice, add the water that medical material gross weight 2-3 doubly measures for the first time, decocted 2 hours, and added the water that medical material gross weight 1.5-2 doubly measures for the second time, decocted 1.5 hours, behind the collecting decoction sedimentation and filtration, the filtrate temperature is controlled at 60 ℃-80 ℃, is concentrated into relative density and is 1.12 thick paste, fully stir, in 1-5 ℃ of drying, make dry extract, add starch, granulate, pulverize and be fine powder, incapsulate.Usage and dosage: oral, each 3-4 grain, three times on the one.
Solution of the present invention is based on motherland's medical science to its pathogenetic understanding of old people's intractable insomnia, with reference to the modern pharmacological research achievement, by middle medical knowledge, method, side, medicine prescription, realizes intractable insomnia is treated.In the present invention prescription, Radix Salviae Miltiorrhizae, when being classified as monarch drug; Wherein Radix Salviae Miltiorrhizae nourshing blood and promoting blood circulation, relieving restlessness are calmed the nerves, and Chinese angelica blood supplementing is invigorated blood circulation, tranquilizing by nourishing the heart; Semen Ziziphi Spinosae, the Radix Astragali, the Radix Paeoniae Alba, Radix Ophiopogonis are ministerial drug, and principal drug assistance is invigorated blood circulation, nourished blood, the power of YIN nourishing; Radix Astragali replenishing qi and promoting blood flow; The Semen Ziziphi Spinosae (parched) tranquilizing by nourishing the heart is yin fluid astringing again; Radix Paeoniae Alba nourishing the blood and yin, easing the affected liver reinforcing the heart; Radix Ophiopogonis nourishing YIN and benefiting blood; Other medicines are adjuvant; Rhizoma Coptidis: eliminating heart-fire; Fructus Liquidambaris is active allays excitement Semen Sojae Preparatum: declare strongly fragrant relieving restlessness.River Radix Cyathulae nourishing the liver and kidney, blood circulation promoting and blood stasis dispelling, ignite descending; Cortex Cinnamomi: the kidney warming sun, guiding fire to origin; Cortex Lycii: removing heat from blood relieving restlessness; The Poria spleen invigorating is calmed the nerves again; Bulbus Lilii; Clearing away heart-fire for tranquillization, invigorating the spleen and replenishing QI; Rhizoma Chuanxiong is transferred the blood nourishing the liver; Radix Glycyrrhizae air making-up and spleen enlivening, coordinating the actions of various ingredients in a prescription, full side plays supplementing QI and nourishing YIN, the effect that blood circulation promoting and blood stasis dispelling is calmed the nerves altogether.
The emotion of insomniac's abnormal anxiety can cause cerebral cortex nervous, and sympathetic activation causes vasospasm. and make cerebral blood supply insufficiency, cause the brain cell energy metabolism impairment, the neuron paradoxical discharge, these can increase the weight of again insomnia, form a vicious cycle.Drug for invigorating blood circulation and eliminating stasis energy expansion of cerebral vascular of the present invention; increase cerebral blood flow, improve local circulation and cerebral ischemia and nutriture, the energy metabolism of increase brain, improve the neuronal cell vigor; the high irritability that suppresses nerve nucleus; the protection brain cell; thereby improve the effect of sleep; with preferably curative effect is arranged behind this Chinese medicine preparation, and toxic and side effects is little in the Insomnia therapy.The present invention can obviously improve patient's sleep quality, and have no adverse reaction mainly for the intractable insomnia due to a variety of causes.
Modern pharmacological research confirms that also Semen Ziziphi Spinosae has convulsion, calmness, anti-allergic effects, be conducive to patient sleeping accelerate, sleep intensification and time lengthening, and with multiple sedative hypnotic synergism is arranged, and alone Semen Ziziphi Spinosae Cure for insomnia also being arranged clinically and the responder. Poria has calm and digestion promoting effect; Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba have sedation to the central nervous system.Radix Rehmanniae has obvious inhibitory action to the central nervous system, and its sedation position is at reticular formation of brain stem ascending reticular activating system and cerebral cortex.Huoxue Herbs has the hemorheological property of improvement, reduces whole blood viscosity, reduces platelet aggregation. in sum, this medicine is thorough to the pathogenic analysis of insomnia of the old people, in conjunction with traditional Chinese medicine theory and modern pharmacological research, realized the combination of middle medical knowledge, method, side, medicine, the multi-medicament use in conjunction, evident in efficacy, and have no adverse reaction.
Often take decoction as main, inconvenience is carried in decoction in Chinese traditional treatment, and treatment is usually interrupted, and some Chinese patent medicines of market circulation often are the Chinese medicine and western medicine compound formulation.In order to apply, improve the compliance that the old people takes medicine, thereby improve clinical efficacy, more gerontal patient is benefited from it, the present invention is prepared into Chinese patent medicine preparation with medicine, can be applied to widely clinical.
The specific embodiment
Embodiment 1
(1) raw material weighing: Radix Salviae Miltiorrhizae 3kg, Radix Angelicae Sinensis 2.0kg, Rhizoma Coptidis 0.6, Semen Ziziphi Spinosae 2.0kg, Cortex Cinnamomi 1.0kg, Radix Paeoniae Alba 2.0kg, Cortex Lycii 1.2kg, Poria 1.5kg, Rhizoma Chuanxiong 1.0kg, Semen Sojae Preparatum 2.0kg, Radix Ophiopogonis 1.5kg, Fructus Liquidambaris 1.5kg, Radix Astragali 3.0kg, Radix Cyathulae 2.0kg, Bulbus Lilii 1.5kg and Radix Glycyrrhizae Preparata 3.0kg.
(2) with after the said medicine mixing, decoct with water twice, add the water of 3 times of amounts of medical material gross weight for the first time, decocted 2 hours, extracting juice 28-32kg, add the water of 2 times of amounts of medical material gross weight the second time, decocted extracting juice 1.5 hours, collecting decoction filters, and the filtrate temperature is controlled at 80 ℃, it is standby to be concentrated into relative density and to be 1.12 thick paste, fully stirs low temperature 1-5 ℃ drying, make dry extract 3.0kg, add starch 450g, granulate, pulverize as fine powder, incapsulate, be prepared into the described capsule of a kind of pharmaceutics.Every weight 0.3g, after product quality was qualified, the plastic bottle packing, was pasted label vanning warehouse-in up to specification by 200 every bottle.
Usage and dosage: oral, each 3-4 grain, three times on the one.
Points for attention: the careful usefulness of anemia of pregnant woman.
Storage practice: airtight, protection against the tide.
Embodiment 2
(1), raw material weighing: Radix Salviae Miltiorrhizae 2.5kg, Radix Angelicae Sinensis 2.5kg, Rhizoma Coptidis 0.7kg, Semen Ziziphi Spinosae 1.8kg, Cortex Cinnamomi 0.8kg, Radix Paeoniae Alba 1.8kg, Cortex Lycii 1.1kg, Poria 1.2kg, Rhizoma Chuanxiong 0.8kg, Semen Sojae Preparatum 1.5kg, Radix Ophiopogonis 1.2kg, Fructus Liquidambaris 1.2kg, Radix Astragali 2.5kg, Radix Cyathulae 1.5kg, Bulbus Lilii 1.2kg, Radix Glycyrrhizae Preparata 2.5kg.
(2) with after the said medicine mixing, decoct with water twice, add the water of 3 times of amounts of medical material gross weight for the first time, decocted 2 hours, extracting juice 25-28kg, add for the second time the water of 1.8 times of amounts of medical material gross weight, decocted extracting juice 1.5 hours, collecting decoction, filter, the filtrate temperature is controlled at 70 ℃, and it is standby to be concentrated into relative density and to be 1.12 thick paste, fully stir, low temperature 1-5 ℃ drying makes dry extract 2.8kg, adds starch 420g, granulate, pulverize as fine powder, incapsulate, be prepared into the described capsule of a kind of pharmaceutics.Every weight 0.3g, after product quality was qualified, the plastic bottle packing, was pasted label vanning warehouse-in up to specification by 200 every bottle.
Usage and dosage: oral, each 3-4 grain, three times on the one.
Points for attention: the careful usefulness of anemia of pregnant woman.
Storage practice: airtight, protection against the tide.
Embodiment 3
(1) raw material weighing: Radix Salviae Miltiorrhizae 2kg, Radix Angelicae Sinensis 1.5kg, Rhizoma Coptidis 0.6kg, Semen Ziziphi Spinosae 1.5kg, Cortex Cinnamomi 0.6kg, Radix Paeoniae Alba 1.5kg, Cortex Lycii 1.0kg, Poria 1.0kg, Rhizoma Chuanxiong 0.6kg, Semen Sojae Preparatum 1.5kg, Radix Ophiopogonis 1.0kg, Fructus Liquidambaris 1.0kg, Radix Astragali 2.0kg, Radix Cyathulae 1.5kg, Bulbus Lilii 1.0kg and Radix Glycyrrhizae Preparata 2.0.
(2) with after the said medicine mixing, decoct with water twice, add the water of 2.5 times of amounts of medical material gross weight for the first time, decocted 2 hours, extracting juice 22-25kg, add for the second time the water of 1.5 times of amounts of medical material gross weight, decocted extracting juice 1.5 hours, collecting decoction, filter, the filtrate temperature is controlled at 60 ℃, and it is for subsequent use to be concentrated into relative density and to be 1.12 thick paste, fully stir, in low temperature 1-5 ℃ of lower drying, make dry extract 2.5kg, add starch 375g, granulate, pulverize as fine powder, incapsulate, be prepared into the described capsule of a kind of pharmaceutics.Every weight 0.3g, after product quality was qualified, the plastic bottle packing, was pasted label vanning warehouse-in up to specification by 200 every bottle.
Usage and dosage: oral, each 3-4 grain, three times on the one.
Points for attention: the careful usefulness of anemia of pregnant woman.
Storage practice: airtight, protection against the tide.
The lanqin oral solutions experiment
One, patient's data:
Totally 84 routine patients, wherein qualified 84 routine patients are divided into treatment by Chinese herbs group 42 examples, matched group 42 examples at random according to single even numbers of medical order.Treatment by Chinese herbs group male 18 examples, women's 24 examples, 60 years old-83 years old age, 73 years old mean age, the course of disease 3 months-30 years, average 3.6 years.Matched group male 20 examples, women's 22 examples, 60 years old-84 years old age, 71 years old mean age, the course of disease 3 months-33 years, average 4 years.Two groups at aspects such as sex, age, the courses of disease, learns by statistics and processes there was no significant difference (P〉0.05), has comparability.
Two, diagnostic criteria:
Meet (CCMD-3) insomnia's (F51.0) diagnostic criteria of Chinese Spirit Obstacles classification and diagnostic criteria (the 3rd edition)
[3](1) time for falling asleep: difficulty falling asleep (〉 30 minutes); (2) sleep quality: dreaminess, easily awake (〉 2 times), early awakening, rear being difficult for of waking up sleep again; (3) total sleep time: do not have enough sleep every night 5 hours; Get rid of ethanol, coffee, tea or drug-induced insomnia and great organic disease and patient with phychlogical problems.
Three, Therapeutic Method
Matched group: oral estazolam 1-2mg, the front clothes of sleeping serve on 30 days.
Treatment group: the Traditional Chinese medicine preparation capsule that embodiment makes is oral, each 3-4 grain, three times on the one.All withdraw other calming soporific medicines during all patient's researchs and maybe may cause insomnia and the medicine with syngignoscism; Avoid strong tea, coffee, raw and cold maror.Serveing on 15 days is 1 course for the treatment of.Gradually drug withdrawal after ortho sleep recovers is treated continuously and is carried out efficacy evaluation 2 courses for the treatment of.
Four, observation index and curative effect judgment criteria
1. curative effect determinate standard is according to " new Chinese medicine guideline of clinical investigations " evaluation.Clinical cure: recover the length of one's sleep, or Nighttime sleep is more than 6h, sleep is dull, and is hale and hearty after waking up; Produce effects: sleep is clearly better, and increases the length of one's sleep more than the 3h, and Depth of sleep increases; Effectively: sx↓ increases not enough 3h before the sleep; Invalid: insomnia is without obviously improving or the anti-severe one that adds after the treatment.
2. sleep quality evaluation: with Pittsburgh's sleep index scale (PSQI) evaluation.Adopt PSQI evaluation sleep quality before treatment and after the treatment.The total score value of PSQI is higher, and the expression sleep quality is poorer, and the insomnia degree is heavier.
Five, Clinical efficacy comparison after the treatment
1. the treatment group effective percentage is 90.5%, and matched group is 64.3%, two group and compares that significant differences (P＜0.01) is arranged.See Table 1.
Table 1 liang group Clinical efficacy comparison (example)
2. two groups of patient's sleep qualities improve situation
(dividing) compared in the PSQI scoring before and after table 2 treatment of control group
The T check is compared after treating with before the treatment, P＜0.05,
(dividing) compared in the PSQI scoring before and after the treatment of table 3 treatment group
Through the t check, compare P＜0.01 after treating with before the treatment;
PSQI total points comparison before and after the table 4 liang group patient treatment (x ± s)
Through the variance analysis of SPSS11.0 software to repeated measure two factor design data, P1〉0.05, P2＜0.05 P3＜0.01 P4＜0.01
The result shows that two groups of patient's sleep qualities all have some improvement, treatment group patient's sleep quality is better than matched group (P＜0.01), and rare untoward reaction, finish the course for the treatment of of taking medicine, and the patient not only sleeps and improves, and by integrally-regulated, the body general status also improves, and points out this Chinese medicine preparation treatment curative effect of being insomnia to determine, and can improve old people's sleep quality, follow up a case by regular visits to after March not recur and have some superiority, worth further further investigation and clinical application.
Six, clinical efficacy model case
1, huge so-and-so, the male, 67 years old, patient medical history numbers 495644, intractable insomnia more than 5 years, patient's worry of working hard, the mind is handed over overworked, of a specified duration leads to insomnia, often all night can not be closed order.The readme dysphoria and insomnia is difficult for falling asleep, dreaming often and waking easily, and palpitation and amnesia, the companion has a dizzy spell, the extremity asthenia, lustreless complexion, dark tongue quality has petechia, thready pulse without strength.Oral estazolam 2mg, 1 time every night, oryzanol 20mg, every day 3 times, 1 bag of acanthopanax root granule, every day 3 times, the state of an illness has no and is clearly better, in case drug withdrawal, easily recurrence.Get rid of organic disease through coherence check, meet the diagnostic criteria of insomnia, differential diagnosis in tcm is for being insomnia, the heart temper Yin bivacuity blood stasis type person that holds concurrently, with supplementing QI and nourishing YIN, activating blood circulation to dissipate blood stasis is calmed the nerves and is the main rule for the treatment of, 3 of the capsules of sleeping again of invigorating blood circulation, every day 3 times, oral, treated 15 days, remission continues above-mentioned treatment, clinical symptom disappearance after January, check Liver and kidney merit shows no obvious abnormalities, and clinical cure is followed up a case by regular visits to not recurrence after March.
Lee so-and-so, 62 years old, patient medical history numbers 495648, intractable insomnia, more than 8 years, patient's excessive thinking, lack of preservation of spirit of a specified duration leads to insomnia, often all night can not be closed order.The readme dysphoria and insomnia is difficult for falling asleep, dreaming often and waking easily, and palpitation and amnesia, difficult sleeping after waking up, accompany dizziness and tinnitus, soreness of the waist and knees, the extremity asthenia, weak, lustreless complexion, the few tongue of red tongue has petechia, deep,thready and forceless pulse.Oral estazolam 2mg, 1 time every night, behind the oryzanol 20mg, every days 3 inferior nutrition cranial nerve medicines, the state of an illness has no and is clearly better, in case drug withdrawal, easily recurrence.Get rid of organic disease through coherence check, meet the diagnostic criteria of insomnia, differential diagnosis in tcm is for being insomnia, the heart kidney qi Yin bivacuity blood stasis type person that holds concurrently, activating blood circulation to dissipate blood stasis, supplementing QI and nourishing YIN are the main rule for the treatment of, the capsule 3-4 grain of sleeping again of invigorating blood circulation, every day 3 times, oral, treated 15 days, remission continues above-mentioned treatment, clinical symptom disappearance after January, check Liver and kidney merit shows no obvious abnormalities, and follows up a case by regular visits to not recurrence after March, clinical cure.
Guo so-and-so, the women, 68 years old, patient medical history numbers 323754, intractable insomnia more than 10 years, the patient overworks, lack of preservation of spirit of a specified duration leads to insomnia, often all night can not be closed order.The readme dysphoria and insomnia is difficult for falling asleep, dreaming often and waking easily, and palpitation and amnesia, the companion has a dizzy spell, and is nose heave, the nausea belch, lustreless complexion, dark tongue quality has petechia, and slippery and rapid pulse is unable.Oral estazolam 2mg, 1 time every night, oryzanol 20mg, every day 3 times, after the Drug therapys such as vitamin B, the state of an illness has no and is clearly better, in case drug withdrawal, easily recurrence.Get rid of organic disease through coherence check, differential diagnosis in tcm is for being insomnia, the type of phlegm-heat attacking the heart blood stasis type person that holds concurrently, with activating blood circulation to dissipate blood stasis, reduce phlegm and calm the nerves, be the main rule for the treatment of, the capsule 3-4 grain of sleeping again of invigorating blood circulation, every day 3 times, oral, treated 15 days, remission continues above-mentioned treatment, clinical symptom disappearance after January, check Liver and kidney merit shows no obvious abnormalities, and follows up a case by regular visits to not recurrence after March, clinical cure.
The king so-and-so, the women, 72 years old, patient medical history numbers 323754, intractable insomnia more than 9 years, patient's fidgets due to deficiency is insomnia, lack of preservation of spirit of a specified duration leads to insomnia, often all night can not be closed order.The readme dysphoria and insomnia is difficult for falling asleep, dreaming often and waking easily, and palpitation and amnesia, tactile thing is easily frightened, and timidity and palpitation is accompanied the spontaneous perspiration of breathing hard, fatigue and weakness, lustreless complexion, dimly pale tongue has petechia, thready and rapid pulse without strength.Oral estazolam 2mg, 1 time every night, oryzanol 20mg, every day 3 times, after the Drug therapys such as vitamin B, the state of an illness has no and is clearly better, in case drug withdrawal, easily recurrence.Get rid of organic disease through coherence check, differential diagnosis in tcm is for being insomnia, the type of phlegm-heat attacking the heart blood stasis type person that holds concurrently, with activating blood circulation to dissipate blood stasis, and in calm the nerves, be the main rule for the treatment of, the capsule 3-4 grain of sleeping again of invigorating blood circulation, every day 3 times, oral, treated 15 days, remission continues above-mentioned treatment, clinical symptom disappearance after January, check Liver and kidney merit shows no obvious abnormalities, and follows up a case by regular visits to not recurrence after March, clinical cure
Section so-and-so, the women, 76 years old, patient medical history numbers 323894, intractable insomnia more than 15 years, patient's fidgets due to deficiency is insomnia, lack of preservation of spirit of a specified duration leads to insomnia, often all night can not be closed order.The readme dysphoria and insomnia is difficult for falling asleep, dreaming often and waking easily, and palpitation and amnesia, mental fatigue with loss of appetite, the spontaneous perspiration of breathing hard is accompanied in the abdominal distention loose stool, fatigue and weakness, lustreless complexion, dimly pale tongue has petechia, deep,thready and forceless pulse.Oral estazolam 2mg, 1 time every night, oryzanol 20mg, every day 3 times, after the Drug therapys such as tranquillizing and allaying excitement, the state of an illness has no and is clearly better, in case drug withdrawal, easily recurrence.Get rid of organic disease through coherence check, differential diagnosis in tcm is for being insomnia the heart spleen yang-energy two empty blood stasis type persons that hold concurrently, with activating blood circulation to dissipate blood stasis, the spleen invigorating invigorating QI and tranquilization is the main rule for the treatment of, the capsule 3-4 grain of sleeping again of invigorating blood circulation, every day 3 times, oral, treated 15 days, remission, continue above-mentioned treatment, clinical symptom disappearance after January, check Liver and kidney merit shows no obvious abnormalities, follow up a case by regular visits to not recurrence after March, clinical cure.
Claims (2)
1. medicine for the treatment of old people's intractable insomnia is characterized in that it is the medicament of being made by the raw material of following weight parts:
Radix Salviae Miltiorrhizae 20-30 part, Radix Angelicae Sinensis 20-30 part, Rhizoma Coptidis 6-8 part, Semen Ziziphi Spinosae 15-20 part, Cortex Cinnamomi 6-10 part, Radix Paeoniae Alba 15-20 part, Cortex Lycii 10-12 part, Poria 10-15 part, Rhizoma Chuanxiong 6-10 part, Semen Sojae Preparatum 15-20 part, Radix Ophiopogonis 10-15 part, Fructus Liquidambaris 10-15 part, Radix Astragali 20-30 part, Radix Cyathulae 15-20 part, Bulbus Lilii 10-15 part, Radix Glycyrrhizae Preparata 15-30 part.
2. the preparation method of the medicine of described treatment old people intractable insomnia according to claim 1 is characterized in that it is prepared into capsule formulation by following steps:
(1) raw material weighing: the described medical material of claim 1 cleaned choose in proportion raw material: Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Coptidis, Semen Ziziphi Spinosae, Cortex Cinnamomi, the Radix Paeoniae Alba, Cortex Lycii, Poria, Rhizoma Chuanxiong, Semen Sojae Preparatum, Radix Ophiopogonis, Fructus Liquidambaris, Radix Astragali, Radix Cyathulae, Bulbus Lilii, Radix Glycyrrhizae Preparata;
(2) preparation method: after the crude drug mixing, decoct with water twice, add the water that medical material gross weight 2-3 doubly measures for the first time, decocted 2 hours, and added the water that medical material gross weight 1.5-2 doubly measures for the second time, decocted 1.5 hours, behind the collecting decoction sedimentation and filtration, the filtrate temperature is controlled at 60 ℃-80 ℃, is concentrated into relative density and is 1.12 thick paste, fully stir, in 1-5 ℃ of drying, make dry extract, add starch, granulate, pulverize and be fine powder, incapsulate.
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| ES2472345A1 (en) * | 2013-06-20 | 2014-06-30 | José María NAVA ALEVIA | Procedure for obtaining a syrup for the treatment of nerves and other pathologies (Machine-translation by Google Translate, not legally binding) |
| CN104667185A (en) * | 2015-03-04 | 2015-06-03 | 济南高达信息技术有限公司 | Traditional Chinese medicine tablet for treating refractory insomnia |
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| CN1557384A (en) * | 2004-02-10 | 2004-12-29 | 波 赵 | Chinese medicine contained honey for treating insomnia and hypertension and its application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2472345A1 (en) * | 2013-06-20 | 2014-06-30 | José María NAVA ALEVIA | Procedure for obtaining a syrup for the treatment of nerves and other pathologies (Machine-translation by Google Translate, not legally binding) |
| CN104667185A (en) * | 2015-03-04 | 2015-06-03 | 济南高达信息技术有限公司 | Traditional Chinese medicine tablet for treating refractory insomnia |
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