CN104768971B - 用于从乳纯化乳铁蛋白的改进方法及其产品 - Google Patents

用于从乳纯化乳铁蛋白的改进方法及其产品 Download PDF

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Publication number
CN104768971B
CN104768971B CN201380055328.7A CN201380055328A CN104768971B CN 104768971 B CN104768971 B CN 104768971B CN 201380055328 A CN201380055328 A CN 201380055328A CN 104768971 B CN104768971 B CN 104768971B
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China
Prior art keywords
lactoferrin
milk
membrane
salt
growth factors
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Expired - Fee Related
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CN201380055328.7A
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English (en)
Chinese (zh)
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CN104768971A (zh
Inventor
A·布朗
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Sapto Dairy Australia Ltd
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Murray Goulburn Co Opeartive Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nutrition Science (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
CN201380055328.7A 2012-10-08 2013-10-08 用于从乳纯化乳铁蛋白的改进方法及其产品 Expired - Fee Related CN104768971B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2012904391A AU2012904391A0 (en) 2012-10-08 Improved process for purifying milk proteins and products thereof
AU2012904391 2012-10-08
AU2013204858 2013-04-12
AU2013204858A AU2013204858B2 (en) 2012-10-08 2013-04-12 Improved process for purifying milk proteins and products thereof
PCT/AU2013/001152 WO2014056025A1 (en) 2012-10-08 2013-10-08 Improved process for purifying lactoferrin from milk and products thereof

Publications (2)

Publication Number Publication Date
CN104768971A CN104768971A (zh) 2015-07-08
CN104768971B true CN104768971B (zh) 2017-12-05

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CN201380055328.7A Expired - Fee Related CN104768971B (zh) 2012-10-08 2013-10-08 用于从乳纯化乳铁蛋白的改进方法及其产品

Country Status (12)

Country Link
US (1) US10016487B2 (https=)
EP (1) EP2904006A4 (https=)
JP (1) JP6475163B2 (https=)
KR (1) KR20150068404A (https=)
CN (1) CN104768971B (https=)
AU (1) AU2013204858B2 (https=)
BR (1) BR112015007674A2 (https=)
CA (1) CA2886892A1 (https=)
IN (1) IN2015DN02971A (https=)
NZ (1) NZ631826A (https=)
RU (1) RU2683228C2 (https=)
WO (1) WO2014056025A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013204858B2 (en) 2012-10-08 2015-06-25 Saputo Dairy Australia Pty Limited Improved process for purifying milk proteins and products thereof
CN106215174A (zh) * 2016-08-04 2016-12-14 无锡科捷诺生物科技有限责任公司 一种人乳铁蛋白的制剂化制备方法
CN112533494A (zh) 2018-06-22 2021-03-19 方塔拉合作集团有限公司 使用极性脂质治疗或预防妊娠期糖尿病
JP7370224B2 (ja) * 2019-11-08 2023-10-27 ライオン株式会社 ラクトフェリン含有腸溶製剤
FR3115037B1 (fr) * 2020-10-12 2025-02-21 Cie Laitiere Europeenne Procédé de purification de fraction de protéines cationiques et fraction ainsi obtenue
CN113278063A (zh) * 2021-05-13 2021-08-20 上海仁统生物科技中心 一种利用超滤法自初乳中获取乳铁蛋白的方法
IL311036A (en) * 2021-08-23 2024-04-01 Lactea Therapeutics Llc Lactoferrin compositions and methods of use
PL248495B1 (pl) * 2023-05-07 2025-12-22 Polmlek Spolka Z Ograniczona Odpowiedzialnoscia Sposób uzyskiwania laktoferyny w proszku z surowego mleka

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2179947A (en) * 1985-07-11 1987-03-18 Roussel Uclaf Process for the extraction of proteins from milk
CN101501059A (zh) * 2006-05-31 2009-08-05 Lfb生物科技公司 奶中一种或多种蛋白的提取方法
CN102348387A (zh) * 2009-01-28 2012-02-08 让-保罗·佩罗丹 生产乳转铁蛋白的方法

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US5221734A (en) 1987-10-01 1993-06-22 Ciba-Geigy Corporation Process for preparing a polypeptide growth factor for milk
GB8729031D0 (en) * 1987-12-11 1988-01-27 Express Foods Group Ltd Isolation of immunoglobulin rich fraction from whey
JP2686831B2 (ja) 1989-09-22 1997-12-08 雪印乳業株式会社 鉄結合性蛋白質を分離、精製し、採取する方法
ATE129125T1 (de) * 1992-01-15 1995-11-15 Campina Melkunie Bv Verfahren zur isolierung von lactoferrin und lactoperoxidase aus milch und milchprodukten.
JPH05202098A (ja) 1992-01-29 1993-08-10 Snow Brand Milk Prod Co Ltd 乳質原料から生理活性物質の製造法
US5756680A (en) * 1994-01-05 1998-05-26 Sepragen Corporation Sequential separation of whey proteins and formulations thereof
EP0744901B1 (en) * 1994-02-16 2001-12-05 Pharming Intellectual Property BV Isolation of lactoferrin from milk
NL1005677C2 (nl) * 1997-03-27 1998-09-29 Campina Melkunie Bv Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan.
CN1555384B (zh) * 2001-07-20 2010-05-26 坎皮纳公司 从乳制品获得具有低相互交叉污染的生长因子(TGF-β和IGF-1)、乳过氧化物酶和免疫球蛋白制剂的方法
US6875459B2 (en) 2001-09-10 2005-04-05 Henry B. Kopf Method and apparatus for separation of milk, colostrum, and whey
EP1480524B1 (en) * 2002-03-07 2013-04-17 Upfront Chromatography A/S A process of isolating lactoferrin
FR2841747B1 (fr) * 2002-07-02 2004-08-20 Cie Laitiere Europeenne Isolat de proteines de lait et procede pour sa preparation
GB0313892D0 (en) * 2003-06-16 2003-07-23 Hannah Res Inst Control of lactation
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WO2007028211A1 (en) * 2005-09-09 2007-03-15 Murray Goulburn Co-Operative Co Limited Composition of whey growth factor extract for reducing muscle inflammation
CA2702645C (en) * 2006-11-10 2018-01-02 Agriculture Victoria Services Pty Ltd Process for the preparation of angiogenin
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JPWO2012015037A1 (ja) 2010-07-30 2013-09-12 森永乳業株式会社 抗菌活性増強剤
AU2013204858B2 (en) 2012-10-08 2015-06-25 Saputo Dairy Australia Pty Limited Improved process for purifying milk proteins and products thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2179947A (en) * 1985-07-11 1987-03-18 Roussel Uclaf Process for the extraction of proteins from milk
CN101501059A (zh) * 2006-05-31 2009-08-05 Lfb生物科技公司 奶中一种或多种蛋白的提取方法
CN102348387A (zh) * 2009-01-28 2012-02-08 让-保罗·佩罗丹 生产乳转铁蛋白的方法

Also Published As

Publication number Publication date
US20150315264A1 (en) 2015-11-05
JP2015536905A (ja) 2015-12-24
WO2014056025A1 (en) 2014-04-17
US10016487B2 (en) 2018-07-10
IN2015DN02971A (https=) 2015-09-18
WO2014056025A8 (en) 2015-05-14
RU2683228C2 (ru) 2019-03-26
CA2886892A1 (en) 2014-04-17
AU2013204858B2 (en) 2015-06-25
CN104768971A (zh) 2015-07-08
AU2013204858A1 (en) 2014-04-24
JP6475163B2 (ja) 2019-02-27
EP2904006A1 (en) 2015-08-12
EP2904006A4 (en) 2016-04-06
KR20150068404A (ko) 2015-06-19
RU2015116933A (ru) 2016-11-27
BR112015007674A2 (pt) 2017-07-04
NZ631826A (en) 2017-08-25

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