CN104768548B - 作为选择性bmp抑制剂的稠合杂环化合物 - Google Patents

作为选择性bmp抑制剂的稠合杂环化合物 Download PDF

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CN104768548B
CN104768548B CN201380058849.8A CN201380058849A CN104768548B CN 104768548 B CN104768548 B CN 104768548B CN 201380058849 A CN201380058849 A CN 201380058849A CN 104768548 B CN104768548 B CN 104768548B
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aryl
heteroaryl
alkyl
cycloalkyl
bmp
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CN104768548A (zh
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科里·R·霍普金
查尔斯·C·洪
克雷格·W·林斯利
达伦·W·恩格尔斯
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Vanderbilt University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Orthopedic Medicine & Surgery (AREA)
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  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201380058849.8A 2012-09-28 2013-03-15 作为选择性bmp抑制剂的稠合杂环化合物 Expired - Fee Related CN104768548B (zh)

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US201261707661P 2012-09-28 2012-09-28
US61/707,661 2012-09-28
PCT/US2013/032588 WO2014051698A1 (en) 2012-09-28 2013-03-15 Fused heterocyclic compounds as selective bmp inhibitors

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CN104768548A CN104768548A (zh) 2015-07-08
CN104768548B true CN104768548B (zh) 2018-08-10

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JP (1) JP6430383B2 (enExample)
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CN (1) CN104768548B (enExample)
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EP2900238B1 (en) 2017-12-06
US20160068525A1 (en) 2016-03-10
CA2886187A1 (en) 2014-04-03
DK2900238T3 (en) 2018-03-12
KR20150064137A (ko) 2015-06-10
US20170313701A1 (en) 2017-11-02
EP2900238A1 (en) 2015-08-05
HK1206278A1 (en) 2016-01-08
ES2660051T3 (es) 2018-03-20
JP2015531371A (ja) 2015-11-02
CA2886187C (en) 2020-04-14
US9738636B2 (en) 2017-08-22
AU2013324396B2 (en) 2018-10-04
BR112015007136A2 (pt) 2018-05-15
EP2900238A4 (en) 2016-04-06
US10196392B2 (en) 2019-02-05
SG11201503299YA (en) 2015-06-29
WO2014051698A1 (en) 2014-04-03
CN104768548A (zh) 2015-07-08
JP6430383B2 (ja) 2018-11-28

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