CN104740113A - Chinese medicament for treating trichomonas vaginitis and preparation method - Google Patents
Chinese medicament for treating trichomonas vaginitis and preparation method Download PDFInfo
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Abstract
The invention provides a Chinese medicament for treating trichomonas vaginitis and a preparation method. The Chinese medicament is prepared from the following raw materials: water spinach, ampelopsin grossedentata, haloragis micrantha, malabar spinach, silene gallica, root of pilular adina, ajuga taiwanensis, herb of prostrate euphorbia, willow root, common nandina leaf, wing nut leaf, david's buddleia, chenopodium album, sensitive joint vetch wood, hedyotis diffusa willd, adiantum davidii and pteridium revolutum. The Chinese medicament has an exact treatment effect on trichomonas vaginitis and low toxic or side effect, and avoids relapse.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of trichomonal vaginitis.
Background technology
Trichomonal vaginitis is per vaginam trichomonal a kind of vaginitis.The cystose leucorrhoea grow in quantity that patients symptomatic is mainly thin and pruritus vulvae, can with burn feeling, pain and sexual anhedonia.Doctor trained in Western medicine generally adopts first nitre to file treatment, but effect is not fine, and has certain side effect.
Trichomonal vaginitis belongs to the traditional Chinese medical science " pudendal pruritus ", " leukorrheal diseases " category.Chinese medicine think its cause of disease mainly damp for suffer from, pathogenesis is liver,spleen,kidney malfunction and to appoint band two arteries and veins to lose solid, in addition neglecting personal hygiene or occupy dark and damp ground for a long time or feelings will is smooth, overworks, anxiety and rage etc., cause liver spleen virtual loss, the liver losing its smoothly moving state, strongly fragrant fire-transformation of a specified duration, dysfunction of the spleen in transportation, long-pending humidogene heat, damp invasion of lower energizer, accumulates strongly fragrant infested and send out primary disease.
Summary of the invention
Technical problem to be solved by this invention is, provide a kind of Chinese medicine and preparation method for the treatment of trichomonal vaginitis, Chinese medicine of the present invention has definite curative effect to trichomonal vaginitis, and toxic and side effects is little, not easily recurs.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of trichomonal vaginitis, its raw medicinal material comprises: Caulis et Folium Ipomoeae aquaticae, Ampelopsis grossedentata, Herba Haloragidis Micranthae, Herba basellae rubrae, fly grass, the Radix Adinae Piluliferae, Herba boeae clarkeanae, Herba euphorbiae prostratae, Radix Salicis Babylonicae, Folium Nandinae domesticae, Folium pterocaryae stenopterae, Ramulus et folium buddlejae davidii, Herba chenopodii is real, Folium Aeschynomense indicae, Herba Linderniae anagallis, bristles just and Herba Fimbristylis dichotomae.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Caulis et Folium Ipomoeae aquaticae 30 ~ 40 parts, Ampelopsis grossedentata 10 ~ 20 parts, Herba Haloragidis Micranthae 15 ~ 25 parts, Herba basellae rubrae 5 ~ 15 parts, fly grass 30 ~ 40 parts, the Radix Adinae Piluliferae 15 ~ 25 parts, Herba boeae clarkeanae 5 ~ 15 parts, Herba euphorbiae prostratae 5 ~ 15 parts, Radix Salicis Babylonicae 10 ~ 20 parts, Folium Nandinae domesticae 10 ~ 20 parts, Folium pterocaryae stenopterae 40 ~ 50 parts, Ramulus et folium buddlejae davidii 5 ~ 15 parts, real 5 ~ 15 parts of Herba chenopodii, Folium Aeschynomense indicae 15 ~ 25 parts, Herba Linderniae anagallis 15 ~ 25 parts, bristles firm 10 ~ 20 parts and Herba Fimbristylis dichotomae 40 ~ 50 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Caulis et Folium Ipomoeae aquaticae 30 ~ 35 parts, Ampelopsis grossedentata 10 ~ 15 parts, Herba Haloragidis Micranthae 15 ~ 20 parts, Herba basellae rubrae 5 ~ 10 parts, fly grass 30 ~ 35 parts, the Radix Adinae Piluliferae 15 ~ 20 parts, Herba boeae clarkeanae 5 ~ 10 parts, Herba euphorbiae prostratae 5 ~ 10 parts, Radix Salicis Babylonicae 10 ~ 15 parts, Folium Nandinae domesticae 10 ~ 15 parts, Folium pterocaryae stenopterae 40 ~ 45 parts, Ramulus et folium buddlejae davidii 5 ~ 10 parts, real 5 ~ 10 parts of Herba chenopodii, Folium Aeschynomense indicae 15 ~ 20 parts, Herba Linderniae anagallis 15 ~ 20 parts, bristles firm 10 ~ 15 parts and Herba Fimbristylis dichotomae 40 ~ 45 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Caulis et Folium Ipomoeae aquaticae 33 parts, Ampelopsis grossedentata 14 parts, Herba Haloragidis Micranthae 18 parts, Herba basellae rubrae 6 parts, fly grass 31 parts, the Radix Adinae Piluliferae 16 parts, Herba boeae clarkeanae 8 parts, Herba euphorbiae prostratae 6 parts, Radix Salicis Babylonicae 12 parts, Folium Nandinae domesticae 13 parts, Folium pterocaryae stenopterae 44 parts, Ramulus et folium buddlejae davidii 9 parts, real 7 parts of Herba chenopodii, Folium Aeschynomense indicae 17 parts, Herba Linderniae anagallis 19 parts, bristles firm 13 parts and Herba Fimbristylis dichotomae 42 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Caulis et Folium Ipomoeae aquaticae 35 parts, Ampelopsis grossedentata 12 parts, Herba Haloragidis Micranthae 16 parts, Herba basellae rubrae 9 parts, fly grass 34 parts, the Radix Adinae Piluliferae 19 parts, Herba boeae clarkeanae 5 parts, Herba euphorbiae prostratae 8 parts, Radix Salicis Babylonicae 14 parts, Folium Nandinae domesticae 11 parts, Folium pterocaryae stenopterae 42 parts, Ramulus et folium buddlejae davidii 7 parts, real 8 parts of Herba chenopodii, Folium Aeschynomense indicae 19 parts, Herba Linderniae anagallis 16 parts, bristles firm 11 parts and Herba Fimbristylis dichotomae 45 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is suppository, and its preparation method comprises the following steps:
The first step: described raw material is soaked 45 minutes to 2 hours, heated and boiled 1 ~ 2 hour, filter, filtrate is for subsequent use; The second time that adds water filtering residue heats, and boils 30 ~ 60 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into pasty state, puts into after 75 DEG C, baking oven is dried and cools, grind to form fine powder.
Second step: to get in semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol and poloxamer poloxamer one or more as substrate; By described substrate heating and melting under temperature 65 DEG C ~ 75 DEG C conditions, add first step gained fine powder, stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described fine powder and substrate is 1: 4 ~ 1: 6; Described tampon is the tampon of afterbody with cotton thread.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:
The first step: by described starting material with water wash clean, pull out and dry; Be ground into smalls with pulverizer, sieve and make 90 ~ 110 object smalls;
Second step: decoct in described ratio and ceaselessly stir putting into the pot that vegetable oil is housed, its temperature is 280 ~ 330 DEG C, and the time is 35 ~ 50 minutes, afterwards after filtration medicine juice;
3rd step: heated by above-mentioned medicine juice, its temperature is 180 ~ 220 DEG C, ceaselessly stirs simultaneously, endures 2 ~ 3 hours to obtain ointment.
Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to trichomonal vaginitis, and toxic and side effects is little, not easily recurs.
Detailed description of the invention
The invention provides a kind of Chinese medicine for the treatment of trichomonal vaginitis, its raw medicinal material comprises: Caulis et Folium Ipomoeae aquaticae, Ampelopsis grossedentata, Herba Haloragidis Micranthae, Herba basellae rubrae, fly grass, the Radix Adinae Piluliferae, Herba boeae clarkeanae, Herba euphorbiae prostratae, Radix Salicis Babylonicae, Folium Nandinae domesticae, Folium pterocaryae stenopterae, Ramulus et folium buddlejae davidii, Herba chenopodii is real, Folium Aeschynomense indicae, Herba Linderniae anagallis, and bristles just and Herba Fimbristylis dichotomae.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Caulis et Folium Ipomoeae aquaticae: stem, leaf that [source] is convolvulaceous plant Caulis et Folium Ipomoeae aquaticae.[nature and flavor] are sweet, cold.[return through] returns intestinal, stomach warp.[function cures mainly] cooling blood for hemostasis, clearing away heat-damp and promoting diuresis.Main epistaxis, constipation, stranguria with turbid discharge, has blood in stool, hematuria, hemorrhoid, carbuncle, injured, snake bite and insect sting.
Ampelopsis grossedentata: [source] is the branch and leaf of vitaceae Cayratia japonica (Thunb.) Gagnep..[nature and flavor] are bitter, micro-puckery, cool.[function cures mainly] clearing away heat-damp and promoting diuresis, suppressing the hyperactive liver blood pressure lowering, promoting blood circulation to remove obstruction in the collateral.Main dysentery, has loose bowels, and urine leaching pain, hypertension, dizzy order is swollen, traumatic injury.
Herba Haloragidis Micranthae: [source] is the herb of Haloragaceae plant Herba Haloragidis Micranthae.[nature and flavor] bitter in the mouth is puckery, cool in nature.[return through] returns lung, large intestine, urinary bladder channel.[function cures mainly] relieving cough and asthma, clearing away heat-damp and promoting diuresis, regulating menstruation and activating blood.Main cough, asthma, pyretic stranguria, constipation, dysentery, menoxenia, fracture, furuncle, acute mastitis, scalds, venom.
Herba basellae rubrae: the leaf that [source] is Basellaceae plant Herba basellae rubrae or herb.[nature and flavor] are sweet, acid, cold in nature.The relieving constipation of [function cures mainly] laxation, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, invigorates blood circulation.Main constipation, oliguria is puckery, dysentery, pathopyretic ulcer, traumatic injury.
Fly grass: [source] is the dry whole herb with root of pinkwort fly grass.[nature and flavor] are pungent, puckery, cool in nature.[return through] returns large intestine, urinary bladder channel.[function cures mainly] clearing away heat-damp and promoting diuresis, promoting blood circulation and detoxication.Main dysentery, enteritis, pyretic stranguria, leukorrhagia, laryngopharynx swelling and pain, impairment caused by overstrain is generated heat, traumatic injury, venom.
The Radix Adinae Piluliferae: the root that [source] is Maguireothamnus speciosus Ramulus et Folium Adinae Piluliferae or skin.[nature and flavor] bitter in the mouth is puckery, cool in nature.[return through] returns lung, urinary bladder channel.[function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Main cold, fever, cough due to lung-heat, parotitis, hepatitis, rheumatic arthritis.
Herba boeae clarkeanae: [source] is the herb of Aspidiaceae plant Quercifilix zeylanica (Houtl) Copel. (Ophioglossum zeylanica Houtl).[nature and flavor] are bitter, cool.[return through] returns Liver Channel.[function cures mainly] clearing away heat-damp and promoting diuresis, cooling blood for hemostasis.Main dysentery, infantile diarrhea, stranguria with turbid discharge, has blood in stool, epistaxis.
Herba euphorbiae prostratae: [source] is the herb of euphorbia plant Herba euphorbiae prostratae.[nature and flavor] are lightly seasoned, cool in nature.[return through] returns Liver Channel.[function cures mainly] clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, lactogenic.Main dysentery, has loose bowels, diphtheria, and milk is rare, and bleeding from the gum, has blood in stool, nebulousurine, hematuria, herpes zoster, carbuncle furuncle, eczema.
Radix Salicis Babylonicae: the root that [source] is Salicaceous Plants Salix babylonica L. and root hair.[nature and flavor] are bitter, cold in nature.[function cures mainly] relieving stranguria by diuresis, dispels the wind except pain, eliminating fire and detoxication.Main stranguria, nebulousurine, edema, jaundice, dysentery, leucorrhea, rheumatalgia, impetigo, toothache, scalds, acute mastitis.
Folium Nandinae domesticae: [source] is the leaf of Berberidaceae plant Fructus Nandinae Domesticae.[nature and flavor] bitter in the mouth, cold in nature.[return through] returns lung, urinary bladder channel.[function cures mainly] clearing away heat-damp and promoting diuresis, eliminating fire and detoxication.Main cough due to lung-heat, pertussis, pyretic stranguria, hematuria, conjunctival congestion and swelling pain, carbuncle sore, scrofula.
Folium pterocaryae stenopterae: [source] is the leaf of juglandaceae plant Pterocarya Stenoptera.[nature and flavor] are pungent, bitter, warm in nature.[return through] returns lung, Liver Channel.[function cures mainly] wind-expelling pain-stopping, killing parasites for relieving itching, removing toxic substances sore.Main air pain of dampness syndrome, toothache, knee-joint pain, scabies, eczema, trichomonas vaginitis, scalds, wound, ulcer being unable to heal, schistosomicide, cough and asthma.
Ramulus et folium buddlejae davidii: branch and leaf, root bark that [source] is Buddlejaceae plant Buddleia davidii.[nature and flavor] are pungent, micro-hardship, warm in nature.[return through] heart, liver, relieving rheumatism and cold, invigorating blood circulation and stopping pains for kidney channel [function cures mainly], removing toxic substances parasite killing.Main cough due to wind and cold, arthralgia pain, traumatic injury, carbuncle furuncle, women's pudendal pruritus, leprosy, tinea pedis.
Herba chenopodii is real: [source] is the fruits and seeds of chenopod Herba chenopodii.[nature and flavor] are bitter, micro-sweet, cold in nature.[function cures mainly] clearing heat and expelling damp, killing parasites for relieving itching.Main dysuria, edema, skin eczema, head sore, deaf.
Folium Aeschynomense indicae: [source] is the xylem of leguminous plant Herba Aeschynonenes Indicae stem.[nature and flavor] are light, micro-hardship, cool, flat.[return through] returns liver, urinary bladder channel.[function cures mainly] heat clearing away, diuresis, lactogenesis, improving eyesight.Main pyretic stranguria, dysuria, edema, galactostasis, nyctalopia.
Herba Linderniae anagallis: [source] is the herb of the long capsule Herba Linderniae Crustaceae of goatweed.[nature and flavor] bitter in the mouth is cool.[function cures mainly] clearing heat for detumescence, relieving stranguria by diuresis.Control wind heat ophthalmalgia, swollen ulcer drug, leucorrhea, gonorrhea, dysentery, infantile diarrhea.
Bristles are firm: [source] is the herb of the white back iron Colysis ellipiica (Thunb.) Chingpolypodium ellipticum Thumb. of adiantaceae plant.[nature and flavor] micro-hardship, cool.[function cures mainly] heat-clearing and toxic substances removing, relieving stranguria by diuresis.Main dysentery, urinary tract infection, stranguria with blood, chyluria, orchitis, mastitis.
Herba Fimbristylis dichotomae: [source] is the rhizome of Pteridiaceae plant Pteridium revolutum (Bl.) Naka..[nature and flavor] are micro-puckery, sweet, cool.[function cures mainly] heat-clearing and toxic substances removing, expelling wind and removing dampness, relieving stranguria by diuresis, anthelmintic.Main pathopyretic ulcer, scalds, proctoptosis, rheumatic arthralgia, urine leaching pain, parasites disease.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Caulis et Folium Ipomoeae aquaticae 30 ~ 40 parts, Ampelopsis grossedentata 10 ~ 20 parts, Herba Haloragidis Micranthae 15 ~ 25 parts, Herba basellae rubrae 5 ~ 15 parts, fly grass 30 ~ 40 parts, the Radix Adinae Piluliferae 15 ~ 25 parts, Herba boeae clarkeanae 5 ~ 15 parts, Herba euphorbiae prostratae 5 ~ 15 parts, Radix Salicis Babylonicae 10 ~ 20 parts, Folium Nandinae domesticae 10 ~ 20 parts, Folium pterocaryae stenopterae 40 ~ 50 parts, Ramulus et folium buddlejae davidii 5 ~ 15 parts, real 5 ~ 15 parts of Herba chenopodii, Folium Aeschynomense indicae 15 ~ 25 parts, Herba Linderniae anagallis 15 ~ 25 parts, bristles firm 10 ~ 20 parts and Herba Fimbristylis dichotomae 40 ~ 50 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Caulis et Folium Ipomoeae aquaticae 30 ~ 35 parts, Ampelopsis grossedentata 10 ~ 15 parts, Herba Haloragidis Micranthae 15 ~ 20 parts, Herba basellae rubrae 5 ~ 10 parts, fly grass 30 ~ 35 parts, the Radix Adinae Piluliferae 15 ~ 20 parts, Herba boeae clarkeanae 5 ~ 10 parts, Herba euphorbiae prostratae 5 ~ 10 parts, Radix Salicis Babylonicae 10 ~ 15 parts, Folium Nandinae domesticae 10 ~ 15 parts, Folium pterocaryae stenopterae 40 ~ 45 parts, Ramulus et folium buddlejae davidii 5 ~ 10 parts, real 5 ~ 10 parts of Herba chenopodii, Folium Aeschynomense indicae 15 ~ 20 parts, Herba Linderniae anagallis 15 ~ 20 parts, bristles firm 10 ~ 15 parts and Herba Fimbristylis dichotomae 40 ~ 45 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Caulis et Folium Ipomoeae aquaticae 33 parts, Ampelopsis grossedentata 14 parts, Herba Haloragidis Micranthae 18 parts, Herba basellae rubrae 6 parts, fly grass 31 parts, the Radix Adinae Piluliferae 16 parts, Herba boeae clarkeanae 8 parts, Herba euphorbiae prostratae 6 parts, Radix Salicis Babylonicae 12 parts, Folium Nandinae domesticae 13 parts, Folium pterocaryae stenopterae 44 parts, Ramulus et folium buddlejae davidii 9 parts, real 7 parts of Herba chenopodii, Folium Aeschynomense indicae 17 parts, Herba Linderniae anagallis 19 parts, bristles firm 13 parts and Herba Fimbristylis dichotomae 42 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Caulis et Folium Ipomoeae aquaticae 35 parts, Ampelopsis grossedentata 12 parts, Herba Haloragidis Micranthae 16 parts, Herba basellae rubrae 9 parts, fly grass 34 parts, the Radix Adinae Piluliferae 19 parts, Herba boeae clarkeanae 5 parts, Herba euphorbiae prostratae 8 parts, Radix Salicis Babylonicae 14 parts, Folium Nandinae domesticae 11 parts, Folium pterocaryae stenopterae 42 parts, Ramulus et folium buddlejae davidii 7 parts, real 8 parts of Herba chenopodii, Folium Aeschynomense indicae 19 parts, Herba Linderniae anagallis 16 parts, bristles firm 11 parts and Herba Fimbristylis dichotomae 45 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is suppository, and its preparation method comprises the following steps:
The first step: described raw material is soaked 45 minutes to 2 hours, heated and boiled 1 ~ 2 hour, filter, filtrate is for subsequent use; The second time that adds water filtering residue heats, and boils 30 ~ 60 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into pasty state, puts into after 75 DEG C, baking oven is dried and cools, grind to form fine powder.
Second step: to get in semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol and poloxamer poloxamer one or more as substrate; By described substrate heating and melting under temperature 65 DEG C ~ 75 DEG C conditions, add first step gained fine powder, stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described fine powder and substrate is 1: 4 ~ 1: 6; Described tampon is the tampon of afterbody with cotton thread.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:
The first step: by described starting material with water wash clean, pull out and dry; Be ground into smalls with pulverizer, sieve and make 90 ~ 110 object smalls;
Second step: decoct in described ratio and ceaselessly stir putting into the pot that vegetable oil is housed, its temperature is 280 ~ 330 DEG C, and the time is 35 ~ 50 minutes, afterwards after filtration medicine juice;
3rd step: heated by above-mentioned medicine juice, its temperature is 180 ~ 220 DEG C, ceaselessly stirs simultaneously, endures 2 ~ 3 hours to obtain ointment.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1 suppository
The ratio of weight and number getting each raw medicinal material in described Chinese medicine also can be preferably: Caulis et Folium Ipomoeae aquaticae 330g, Ampelopsis grossedentata 140g, Herba Haloragidis Micranthae 180g, Herba basellae rubrae 60g, fly grass 310g, Radix Adinae Piluliferae 160g, Herba boeae clarkeanae 80g, Herba euphorbiae prostratae 60g, Radix Salicis Babylonicae 120g, Folium Nandinae domesticae 130g, Folium pterocaryae stenopterae 440g, Ramulus et folium buddlejae davidii 90g, the real 70g of Herba chenopodii, Folium Aeschynomense indicae 170g, Herba Linderniae anagallis 190g, bristles firm 130g and Herba Fimbristylis dichotomae 420g;
Prepare according to the following steps:
The first step: described raw material is soaked 2 hours, heated and boiled 1 hour, filter, filtrate is for subsequent use; The second time that adds water filtering residue heats, and boils 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 minutes, filters; Three filtrates be combined, heating is concentrated into pasty state, puts into after 75 DEG C, baking oven is dried and cools, grind to form fine powder.
Second step: get lanoline, Polyethylene Glycol and poloxamer poloxamer, by 2:1:2 mixing as substrate; By described substrate heating and melting under temperature 75 DEG C of conditions, add first step gained fine powder, stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described fine powder and substrate is 1: 6; Described tampon is the tampon of afterbody with cotton thread.
Embodiment 2 unguentum
Get Caulis et Folium Ipomoeae aquaticae 350g, Ampelopsis grossedentata 120g, Herba Haloragidis Micranthae 160g, Herba basellae rubrae 90g, fly grass 340g, Radix Adinae Piluliferae 190g, Herba boeae clarkeanae 50g, Herba euphorbiae prostratae 80g, Radix Salicis Babylonicae 140g, Folium Nandinae domesticae 110g, Folium pterocaryae stenopterae 420g, Ramulus et folium buddlejae davidii 70g, the real 80g of Herba chenopodii, Folium Aeschynomense indicae 190g, Herba Linderniae anagallis 160g, bristles firm 110g and Herba Fimbristylis dichotomae 450g.
Prepare according to the following steps:
The first step: by described starting material with water wash clean, pull out and dry; Be ground into smalls with pulverizer, sieve and make 100 object smalls;
Second step: decoct in described ratio and ceaselessly stir putting into the pot that vegetable oil is housed, its temperature is 330 DEG C, and the time is 50 minutes, afterwards after filtration medicine juice;
3rd step: heated by above-mentioned medicine juice, its temperature is 220 DEG C, ceaselessly stirs simultaneously, endures 2 hours to obtain ointment.
Toxicity test:
1, experimental technique: evenly coated by depilatory guinea pig back spinal column both sides, makes unhairing scope about 40 square centimeters.Clean depilatory returns cage to observe 24 hours, often organize Cavia porcellus and be coated with Chinese medicine preparation suppository distilled water diluting liquid 0.3,0.5 of the present invention and 0.8ml respectively, respectively containing crude drug 130mg, 217mg and 347mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment terminates, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin do pathological examination.
2, result: above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity are movable, histopathologic examination, the administration group heart, liver, kidney and depilation skin with contrast word more also no significant difference.
Result is pointed out, and Chinese medicine for external application of the present invention, without local irritant effect, also has no general toxicity performance.Show Chinese medicine for external application use safety of the present invention.
Clinical data:
Case selection: whole 95 routine cases are my Out-patient Department patient of in October, 2011 ~ 2014 year April.Patient is divided into treatment group and matched group at random, wherein treatment group 50 people, 20 ~ 49 years old age.Matched group 45 people, at 21 ~ 48 years old age, vaginal secretions laboratory microscopy is all shown in infusorian.Two groups in age, the course of disease, symptom, coincident with severity degree of condition and laboratory checking index etc. through statistical analysis there was no significant difference (p>0.05).
Diagnostic criteria: symptom: have contact bleeding, pruritus vulvae, causalgia or with urethral stimulant symptoms such as frequent micturition, urgent micturition, dysureas or with local excitation symptom.Gynecologial examination: cervix uteri and vaginal mucosa hyperemia, secretions is abnormal.Vaginal secretions is yellow foam.Lab testing: trichomonal vaginitis, finds infusorian under microscope in vaginal secretions; Vagina cleanness degree is more than II degree.Vaginal pH 5.5 ~ 6.
Therapeutic Method:
Matched group: Metronidazole Compound vaginal suppository (every containing metronidazole 0.45g, tetracycline 0.05g, nystatin 0.05g), lie on the back after cleaning pudendum just before going to bed every night, get one and fill in vagina depths, every day 1 time, being used in conjunction 10 days is a course for the treatment of.
Treatment group: after cleaning pudendum before sleeping, put Chinese medicine embodiment 1 suppository of the present invention in vagina depths, every day 1 time, being used in conjunction 10 days was 1 course for the treatment of.
Curative effect judging standard: recovery from illness: purulence or foam sample vaginal secretions disappear, and pruritus vulvae, frequent micturition dysurea disappear, congested without vulvovaginal, check vaginal secretions smear for microscopic examination infusorian and be feminine gender after continuous 3 menstruations; Effective: vaginal secretions reduces, pruritus vulvae, frequent micturition dysurea symptom take a turn for the better, and vulvovaginal is without hyperemia, and secretions smear for microscopic examination infusorian reduces debility; Invalid: clinical symptoms and sign are without change, and infusorian number is without change.Fully recover and always effectively add up to effectively
Therapeutic outcome: in table 1.
A table 1 liang group patient total effects compares
| Group | n | Recovery from illness | Effectively | Invalid | Effectively total |
| Treatment group | 50 | 42 | 7 | 1 | 49(98.00％) |
| Matched group | 45 | 23 | 16 | 6 | 39(86.67％) |
Note: two groups of total effective rates compare p<0.05, and treatment group curative effect is better than matched group.
Two groups of recovery from illness Patients on Recurrence rates compare: choose treatment group and matched group case of fully recovering and carry out relapse rate, matched group has 4 people to recur, and relapse rate is 17.39% (4/23); Treatment group has 1 people's recurrence, and relapse rate is 2.38% (1/42).Difference has statistical significance (p<0.05), and treatment group relapse rate is lower than matched group.
Concrete case: late certain, women, 30 years old.JIUYUE in 2013 15 days is gone to a doctor, with urethral stimulant symptoms such as frequent micturition, urgent micturition, dysureas because of pruritus vulvae, causalgia.Gynecologial examination: cervix uteri and vaginal mucosa hyperemia, secretions is abnormal.Vaginal secretions is yellow foam.Lab testing: find infusorian under microscope in vaginal secretions; Be diagnosed as trichomonal vaginitis.Give Chinese medicine embodiment 1 suppository of the present invention every day 1 time, be used in conjunction 10 days, recovery from illness, follows up a case by regular visits to and does not recur half a year.
Claims (8)
1. treat a Chinese medicine for trichomonal vaginitis, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Caulis et Folium Ipomoeae aquaticae, Ampelopsis grossedentata, Herba Haloragidis Micranthae, Herba basellae rubrae, fly grass, the Radix Adinae Piluliferae, Herba boeae clarkeanae, Herba euphorbiae prostratae, Radix Salicis Babylonicae, Folium Nandinae domesticae, Folium pterocaryae stenopterae, Ramulus et folium buddlejae davidii, Herba chenopodii is real, Folium Aeschynomense indicae, Herba Linderniae anagallis, bristles just and Herba Fimbristylis dichotomae.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Caulis et Folium Ipomoeae aquaticae 30 ~ 40 parts, Ampelopsis grossedentata 10 ~ 20 parts, Herba Haloragidis Micranthae 15 ~ 25 parts, Herba basellae rubrae 5 ~ 15 parts, fly grass 30 ~ 40 parts, the Radix Adinae Piluliferae 15 ~ 25 parts, Herba boeae clarkeanae 5 ~ 15 parts, Herba euphorbiae prostratae 5 ~ 15 parts, Radix Salicis Babylonicae 10 ~ 20 parts, Folium Nandinae domesticae 10 ~ 20 parts, Folium pterocaryae stenopterae 40 ~ 50 parts, Ramulus et folium buddlejae davidii 5 ~ 15 parts, real 5 ~ 15 parts of Herba chenopodii, Folium Aeschynomense indicae 15 ~ 25 parts, Herba Linderniae anagallis 15 ~ 25 parts, bristles firm 10 ~ 20 parts and Herba Fimbristylis dichotomae 40 ~ 50 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Caulis et Folium Ipomoeae aquaticae 30 ~ 35 parts, Ampelopsis grossedentata 10 ~ 15 parts, Herba Haloragidis Micranthae 15 ~ 20 parts, Herba basellae rubrae 5 ~ 10 parts, fly grass 30 ~ 35 parts, the Radix Adinae Piluliferae 15 ~ 20 parts, Herba boeae clarkeanae 5 ~ 10 parts, Herba euphorbiae prostratae 5 ~ 10 parts, Radix Salicis Babylonicae 10 ~ 15 parts, Folium Nandinae domesticae 10 ~ 15 parts, Folium pterocaryae stenopterae 40 ~ 45 parts, Ramulus et folium buddlejae davidii 5 ~ 10 parts, real 5 ~ 10 parts of Herba chenopodii, Folium Aeschynomense indicae 15 ~ 20 parts, Herba Linderniae anagallis 15 ~ 20 parts, bristles firm 10 ~ 15 parts and Herba Fimbristylis dichotomae 40 ~ 45 parts.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Caulis et Folium Ipomoeae aquaticae 33 parts, Ampelopsis grossedentata 14 parts, Herba Haloragidis Micranthae 18 parts, Herba basellae rubrae 6 parts, fly grass 31 parts, the Radix Adinae Piluliferae 16 parts, Herba boeae clarkeanae 8 parts, Herba euphorbiae prostratae 6 parts, Radix Salicis Babylonicae 12 parts, Folium Nandinae domesticae 13 parts, Folium pterocaryae stenopterae 44 parts, Ramulus et folium buddlejae davidii 9 parts, real 7 parts of Herba chenopodii, Folium Aeschynomense indicae 17 parts, Herba Linderniae anagallis 19 parts, bristles firm 13 parts and Herba Fimbristylis dichotomae 42 parts.
5. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is suppository, and its preparation method comprises the following steps:
The first step: described raw material is soaked 45 minutes to 2 hours, heated and boiled 1 ~ 2 hour, filter, filtrate is for subsequent use; The second time that adds water filtering residue heats, and boils 30 ~ 60 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into pasty state, puts into after 75 DEG C, baking oven is dried and cools, grind to form fine powder.
Second step: to get in semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol and poloxamer poloxamer one or more as substrate; By described substrate heating and melting under temperature 65 DEG C ~ 75 DEG C conditions, add first step gained fine powder, stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described fine powder and substrate is 1: 4 ~ 1: 6; Described tampon is the tampon of afterbody with cotton thread.
6. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:
The first step: by described starting material with water wash clean, pull out and dry; Be ground into smalls with pulverizer, sieve and make 90 ~ 110 object smalls;
Second step: decoct in described ratio and ceaselessly stir putting into the pot that vegetable oil is housed, its temperature is 280 ~ 330 DEG C, and the time is 35 ~ 50 minutes, afterwards after filtration medicine juice;
3rd step: heated by above-mentioned medicine juice, its temperature is 180 ~ 220 DEG C, ceaselessly stirs simultaneously, endures 2 ~ 3 hours to obtain ointment.
7. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is suppository, and its preparation method comprises the following steps:
The first step: described raw material is soaked 45 minutes to 2 hours, heated and boiled 1 ~ 2 hour, filter, filtrate is for subsequent use; The second time that adds water filtering residue heats, and boils 30 ~ 60 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into pasty state, puts into after 75 DEG C, baking oven is dried and cools, grind to form fine powder.
Second step: to get in semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol and poloxamer poloxamer one or more as substrate; By described substrate heating and melting under temperature 65 DEG C ~ 75 DEG C conditions, add first step gained fine powder, stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described fine powder and substrate is 1: 4 ~ 1: 6; Described tampon is the tampon of afterbody with cotton thread.
8. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:
The first step: by described starting material with water wash clean, pull out and dry; Be ground into smalls with pulverizer, sieve and make 90 ~ 110 object smalls;
Second step: decoct in described ratio and ceaselessly stir putting into the pot that vegetable oil is housed, its temperature is 280 ~ 330 DEG C, and the time is 35 ~ 50 minutes, afterwards after filtration medicine juice;
3rd step: heated by above-mentioned medicine juice, its temperature is 180 ~ 220 DEG C, ceaselessly stirs simultaneously, endures 2 ~ 3 hours to obtain ointment.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520593A (en) * | 2013-10-03 | 2014-01-22 | 侯萍 | Chinese herba preparation for treating trichomonas vaginitis and preparation method thereof |
| CN103536826A (en) * | 2013-10-18 | 2014-01-29 | 李佃场 | Traditional Chinese medicine composition for treating kysthitis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520593A (en) * | 2013-10-03 | 2014-01-22 | 侯萍 | Chinese herba preparation for treating trichomonas vaginitis and preparation method thereof |
| CN103536826A (en) * | 2013-10-18 | 2014-01-29 | 李佃场 | Traditional Chinese medicine composition for treating kysthitis and preparation method thereof |
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Inventor after: Jiang Yonghua Inventor after: Zong Xiuhong Inventor after: Feng Zuoji Inventor after: Yang Haixia Inventor after: Chu Jingping Inventor before: Xue Jianfang Inventor before: Zong Xiuhong Inventor before: Feng Zuoji Inventor before: Yang Haixia Inventor before: Chu Jingping |
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Effective date of registration: 20170213 Address after: 266599 Hainan Island Road, Huangdao District, Shandong, No. 158, No. Applicant after: Huangdao District, the Qingdao City hospital of traditional Chinese hospital Address before: 266599 Huangdao Hospital of Huangdao District, Hainan Island, Shandong, China, No. 158, Qingdao District, Qingdao Applicant before: Xue Jianfang |
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