CN105213669A - A kind of Chinese medicine and preparation method for the treatment of nodular vasculitis - Google Patents

Abstract

The invention provides a kind of Chinese medicine and preparation method for the treatment of nodular vasculitis, each raw medicinal material of Chinese medicine comprises: the Herba Blumeae Laciniatae, Radix Rubi reflexi, Herba Sambuci Adnatae, Os Draconis wind, Herba Senecionis Dianthui, Radix campsis, crosses mountain breeze, Radix Parthenocissi Heterophyllae, Radix Caulophylli, muntjac grass, Herba Clinopodii, Radix seu caulis epipremni pinnati, Herba Farfugii japonici, Herba Adianti Flabellulati and Drymoglossum Herba Drymoglossi.Chinese medicine of the present invention has definite curative effect to nodular vasculitis, and toxic and side effects is little.

Description

A kind of Chinese medicine and preparation method for the treatment of nodular vasculitis

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of nodular vasculitis.

Background technology

Nodular vasculitis is a kind of corium and subcutaneous tissue vasculitis, nodular lesions of lasting or recurrent exerbation, primary disease is apt to occur in female middle-aged, lower limb are more common in sick position, clinical manifestation is skin redness or the aubergine tuberosity of unsymmetry, tuberosity exceeds surface, differ in size, can merge by several tuberosity, skin lesion boundary is obvious.

Nodular vasculitis is a kind of disease of involving skin and subcutaneus adipose tissue thin vessels, and often with blood capillary, small artery, venular official jargon obturation, tube wall thickening, around cell infiltration is the clinical pathology process of feature.

Nodular vasculitis belongs to Chinese medicine " vasuclitis nodularis " category.Its pathogenesis is mostly wind heat, heat in blood, damp and hot heresy enter network for suffering from, and evil Sheng causes the stasis of blood, finally causes blood network impaired, and venation numbness hinders, qi depression to blood stasis and cause various vasculitis symptom.

Summary of the invention

Technical problem to be solved by this invention is, provide a kind of Chinese medicine and preparation method for the treatment of nodular vasculitis, Chinese medicine of the present invention has definite curative effect to nodular vasculitis, and toxic and side effects is little.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of nodular vasculitis, its raw medicinal material comprises: the Herba Blumeae Laciniatae, Radix Rubi reflexi, Herba Sambuci Adnatae, Os Draconis wind, Herba Senecionis Dianthui, Radix campsis, crosses mountain breeze, Radix Parthenocissi Heterophyllae, Radix Caulophylli, muntjac grass, Herba Clinopodii, Radix seu caulis epipremni pinnati, Herba Farfugii japonici, Herba Adianti Flabellulati and Drymoglossum Herba Drymoglossi.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: the Herba Blumeae Laciniatae 10 ~ 20 parts, Radix Rubi reflexi 30 ~ 40 parts, Herba Sambuci Adnatae 10 ~ 20 parts, Os Draconis wind 5 ~ 15 parts, Herba Senecionis Dianthui 5 ~ 15 parts, Radix campsis 15 ~ 25 parts, cross mountain breeze 10 ~ 20 parts, Radix Parthenocissi Heterophyllae 30 ~ 40 parts, Radix Caulophylli 15 ~ 25 parts, muntjac grass 30 ~ 40 parts, Herba Clinopodii 5 ~ 15 parts, Radix seu caulis epipremni pinnati 50 ~ 60 parts, Herba Farfugii japonici 15 ~ 25 parts, Herba Adianti Flabellulati 5 ~ 15 parts and Drymoglossum Herba Drymoglossi 10 ~ 20 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: the Herba Blumeae Laciniatae 10 ~ 15 parts, Radix Rubi reflexi 30 ~ 35 parts, Herba Sambuci Adnatae 10 ~ 15 parts, Os Draconis wind 5 ~ 10 parts, Herba Senecionis Dianthui 5 ~ 10 parts, Radix campsis 15 ~ 20 parts, cross mountain breeze 10 ~ 15 parts, Radix Parthenocissi Heterophyllae 30 ~ 35 parts, Radix Caulophylli 15 ~ 20 parts, muntjac grass 30 ~ 35 parts, Herba Clinopodii 5 ~ 10 parts, Radix seu caulis epipremni pinnati 50 ~ 55 parts, Herba Farfugii japonici 15 ~ 20 parts, Herba Adianti Flabellulati 5 ~ 10 parts and Drymoglossum Herba Drymoglossi 10 ~ 15 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: the Herba Blumeae Laciniatae 11 parts, Radix Rubi reflexi 33 parts, Herba Sambuci Adnatae 13 parts, Os Draconis wind 6 parts, Herba Senecionis Dianthui 8 parts, Radix campsis 17 parts, cross mountain breeze 12 parts, Radix Parthenocissi Heterophyllae 32 parts, Radix Caulophylli 16 parts, muntjac grass 34 parts, Herba Clinopodii 7 parts, Radix seu caulis epipremni pinnati 53 parts, Herba Farfugii japonici 16 parts, Herba Adianti Flabellulati 6 parts and Drymoglossum Herba Drymoglossi 14 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 60 ~ 70%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 60 ~ 70% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 150 ~ 250 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.3 ~ 0.5 times, the lactose of 0.03 ~ 0.3 times, the starch of 0.3 ~ 0.5 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.003 ~ 0.03 times, granulate, tabletting, makes.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 70 ~ 80%, be heated to boiling reflux 2 ~ 3 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 70 ~ 80 DEG C subsequently under vacuum 0.01 ~ 0.05Mpa, relative density is the mastic of 1.03 ~ 1.05, spraying dry, the inlet temperature of spray dryer 165 ~ 185 DEG C, leaving air temp 65 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.4 ~ 0.6 times and 0.4 ~ 0.6 times in the dried cream powder obtained, makes granule, in 65 ~ 75 DEG C of dryings, obtains granule.

Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to nodular vasculitis, and toxic and side effects is little.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of nodular vasculitis, its raw medicinal material comprises: the Herba Blumeae Laciniatae, Radix Rubi reflexi, Herba Sambuci Adnatae, Os Draconis wind, Herba Senecionis Dianthui, Radix campsis, crosses mountain breeze, Radix Parthenocissi Heterophyllae, Radix Caulophylli, muntjac grass, Herba Clinopodii, Radix seu caulis epipremni pinnati, Herba Farfugii japonici, Herba Adianti Flabellulati and Drymoglossum Herba Drymoglossi.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

The Herba Blumeae Laciniatae: [source] is the herb of feverfew six ear bell.[nature and flavor] acrid in the mouth, bitter, slightly warm in nature.[function cures mainly] expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.Main Common Cold, wind syndrome of head is had a headache, anemofrigid-damp arthralgia, joint aches, traumatic injury, carbuncle furuncle, eczema, snakebite.

Radix Rubi reflexi: [source] is the root of rosaceous plant Radix Rubi reflexi.[nature and flavor] are bitter, puckery, acid, flat.[return through] returns lung, Liver Channel.[function cures mainly] expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral.Main anemofrigid-damp arthralgia, membra arthralgia, apoplectic hemiplegia, numb limbs and tense tendons, moving obstacle.

Herba Sambuci Adnatae: the herb that [source] is caprifoliaceae plant Red Hill flower and root.[nature and flavor] are pungent, sweet, temperature.[function cures mainly] dispels the wind diuretic, dissipating blood stasis dredging collateral.Main acute and chronic nephritis, rheumatalgia, rubella pruritus, poliomyelitis sequela, sprains, fracture.

Os Draconis wind: [source] is the stem of Cyatheaceae plant Caulis cyatheae spinulosae.[nature and flavor] micro-hardship, flat.[return through] returns kidney, stomach, lung meridian.[function cures mainly] expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, relieving cough and asthma, heat-clearing and toxic substances removing, parasite killing.Main air pain of dampness syndrome, lumbago due to renal deficiency, traumatic injury, hernia, acute toothache, cough, asthma, scabies, ascariasis, enterobiasis and flu-prevention.

Herba Senecionis Dianthui: [source] is the herb of feverfew Senecio dianthus.[nature and flavor] bitter in the mouth, cold in nature.[function cures mainly] heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral.Main acute conjunctivitis, furuncle, dermatitis, rheumatic ostalgia, traumatic injury.

Radix campsis: [source] is the root that Bignoniaceae plant is reached the clouds or reach the clouds in America.[nature and flavor] sweet in the mouth, pungent, cold in nature.[return through] returns liver, spleen, kidney channel.[function cures mainly] cooling blood, expelling wind, promoting blood circulation to remove obstruction in the collateral.Main blood hot air wind producing, itching over the body, rubella, waist foot is unsuccessful, gout, rheumatic arthralgia, traumatic injury.

Cross mountain breeze: root, leaf, bark that [source] is canella wheel blade Fructus Litseae pungentis.[nature and flavor] are pungent, temperature.[function cures mainly] dispelling wind and removing obstruction in the collateral, promoting blood circulation and detumescence, pain relieving.Main air wet arthritis, lumbago and skelalgia, quadriplegia, dysmenorrhea, treating swelling and pain by traumatic injury.

Radix Parthenocissi Heterophyllae: the root that [source] is vitaceae great Ye parthenocissus or stem.[nature and flavor] are bitter, temperature.[function cures mainly] expelling wind and removing dampness, dredging collateral, hemostasis, removing toxic substances.Main air pain of dampness syndrome, migraine, rheumatism sore, fracture.

Radix Caulophylli: [source] is the root welding technology of Berberidaceae plant Radix Caulophylli.[nature and flavor] are pungent, bitter, temperature.[return through] returns liver, stomach warp.[function cures mainly] promoting blood circulation to remove blood stasis, expelling wind and removing dampness, promoting the circulation of QI to relieve pain.Main menoxenia, dysmenorrhea, puerperal abdominal pain due to blood stasis, the cold pain of gastral cavity abdomen, traumatic injury, rheumatic arthralgia.

Muntjac grass: [source] is the herb of Huperziaceae plant Phlegmariurus fordii (Bak) Ching-Bak.[nature and flavor] are bitter, cool.[function cures mainly] dispelling wind and removing obstruction in the collateral, reducing swelling and alleviating pain, heat-clearing and toxic substances removing.Main joint swells and ache, numb limbs and tense tendons, traumatic injury, cough with asthma, pyretic stranguria, venom.

Herba Clinopodii: [source] is the herb of labiate Fructus Seu Herba Pubescentis.[nature and flavor] acrid in the mouth is bitter, cool in nature.[function cures mainly] heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation.Main anemopyretic cold, cough, conjunctival congestion and swelling pain, laryngopharynx swelling and pain, diphtheria, stomachache, dysentery, spits blood, spitting of blood, hematuria, metrorrhagia, traumatic hemorrhage, hepatitis, cholecystitis, narrow rib, stomachache, arthralgia, and skin infection swells, venom, eczema, hemorrhoid, treating swelling and pain by traumatic injury.

Radix seu caulis epipremni pinnati: the stem and leaf that [source] is aroid kylin leaf or root.[nature and flavor] bitter in the mouth, micro-pungent, property is put down.[return through] returns liver, lung meridian.[function cures mainly] clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, removing toxic substances and promoting subsidence of swelling.Main cold, fever, epistaxis, conjunctival congestion and swelling pain, pertussis, traumatic injury, fracture, rheumatic arthralgia, phlegm-fire scrofula, carbuncle furuncle, venom.

Herba Farfugii japonici: [source] is the herb of feverfew Farfugium japonicum.[nature and flavor] acrid in the mouth, sweet, micro-hardship, cool in nature.[function cures mainly] heat-clearing and toxic substances removing, cooling blood for hemostasis, dispersing swelling and dissipating binds.Main flu, laryngopharynx swelling and pain, cough spitting of blood, has blood in stool, hematuria, menoxenia, mastitis, scrofula, carbuncle furuncle and phyma poison, carbuncle skin ulcer eczema, traumatic injury, venom.

Herba Adianti Flabellulati: the herb that [source] is adiantaceae plant flabellum venushair fern or root.[nature and flavor] are bitter, pungent, cool.[return through] returns liver, bladder, large intestine channel.[function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances, eliminating stagnation.Main flow sense is generated heat, and has loose bowels, dysentery, jaundice, stranguria caused by urinary stone, carbuncle, scrofula, snake bite and insect sting, treating swelling and pain by traumatic injury.

Drymoglossum Herba Drymoglossi: [source] is the herb of Plants of Polypodiaceae Drymoglossum Herba Drymoglossi.[nature and flavor] are sweet, light, micro-cool.[return through] returns liver, lung meridian.[function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, hemostasis.Main jaundice due to damp-heat, conjunctival congestion and swelling pain, suppurative otitis media, parotitis, lymphadenitis, mange, traumatic injury.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: the Herba Blumeae Laciniatae 10 ~ 20 parts, Radix Rubi reflexi 30 ~ 40 parts, Herba Sambuci Adnatae 10 ~ 20 parts, Os Draconis wind 5 ~ 15 parts, Herba Senecionis Dianthui 5 ~ 15 parts, Radix campsis 15 ~ 25 parts, cross mountain breeze 10 ~ 20 parts, Radix Parthenocissi Heterophyllae 30 ~ 40 parts, Radix Caulophylli 15 ~ 25 parts, muntjac grass 30 ~ 40 parts, Herba Clinopodii 5 ~ 15 parts, Radix seu caulis epipremni pinnati 50 ~ 60 parts, Herba Farfugii japonici 15 ~ 25 parts, Herba Adianti Flabellulati 5 ~ 15 parts and Drymoglossum Herba Drymoglossi 10 ~ 20 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: the Herba Blumeae Laciniatae 10 ~ 15 parts, Radix Rubi reflexi 30 ~ 35 parts, Herba Sambuci Adnatae 10 ~ 15 parts, Os Draconis wind 5 ~ 10 parts, Herba Senecionis Dianthui 5 ~ 10 parts, Radix campsis 15 ~ 20 parts, cross mountain breeze 10 ~ 15 parts, Radix Parthenocissi Heterophyllae 30 ~ 35 parts, Radix Caulophylli 15 ~ 20 parts, muntjac grass 30 ~ 35 parts, Herba Clinopodii 5 ~ 10 parts, Radix seu caulis epipremni pinnati 50 ~ 55 parts, Herba Farfugii japonici 15 ~ 20 parts, Herba Adianti Flabellulati 5 ~ 10 parts and Drymoglossum Herba Drymoglossi 10 ~ 15 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: the Herba Blumeae Laciniatae 11 parts, Radix Rubi reflexi 33 parts, Herba Sambuci Adnatae 13 parts, Os Draconis wind 6 parts, Herba Senecionis Dianthui 8 parts, Radix campsis 17 parts, cross mountain breeze 12 parts, Radix Parthenocissi Heterophyllae 32 parts, Radix Caulophylli 16 parts, muntjac grass 34 parts, Herba Clinopodii 7 parts, Radix seu caulis epipremni pinnati 53 parts, Herba Farfugii japonici 16 parts, Herba Adianti Flabellulati 6 parts and Drymoglossum Herba Drymoglossi 14 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 60 ~ 70%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 60 ~ 70% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 150 ~ 250 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.3 ~ 0.5 times, the lactose of 0.03 ~ 0.3 times, the starch of 0.3 ~ 0.5 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.003 ~ 0.03 times, granulate, tabletting, makes.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 times, mixture is the ethanol of 70%, be heated to boiling reflux 2 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with per minute 1 speed slowly percolation, collect percolate, when being evaporated to 80 DEG C subsequently under vacuum 0.03Mpa, relative density is the mastic of 1.03, spraying dry, the inlet temperature 185 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.4 times and 0.4 times in the dried cream powder obtained, makes granule, in 75 DEG C of dryings, obtains granule.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1: tablet

Get Herba Blumeae Laciniatae 110g, Radix Rubi reflexi 330g, Herba Sambuci Adnatae 130g, Os Draconis wind 60g, Herba Senecionis Dianthui 80g, Radix campsis 170g, crosses mountain breeze 120g, Radix Parthenocissi Heterophyllae 320g, Radix Caulophylli 160g, muntjac grass 340g, Herba Clinopodii 70g, Radix seu caulis epipremni pinnati 530g, Herba Farfugii japonici 160g, Herba Adianti Flabellulati 60g and Drymoglossum Herba Drymoglossi 140g;

Prepare according to the following steps:

The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 70%, reflux 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 70% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 3 times again, reflux 1 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 hour, pulverize and sieve acquisition 200 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.3, the lactose of 0.05 times, the starch of 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, dry, add the magnesium stearate relative to micropowders quality 0.005 times, granulate, tabletting, makes.

Embodiment 2: granule

Get Herba Blumeae Laciniatae 130g, Radix Rubi reflexi 320g, Herba Sambuci Adnatae 110g, Os Draconis wind 90g, Herba Senecionis Dianthui 60g, Radix campsis 190g, crosses mountain breeze 110g, Radix Parthenocissi Heterophyllae 340g, Radix Caulophylli 180g, muntjac grass 320g, Herba Clinopodii 60g, Radix seu caulis epipremni pinnati 510g, Herba Farfugii japonici 190g, Herba Adianti Flabellulati 80g and Drymoglossum Herba Drymoglossi 120g;

Prepare according to the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 times, mixture is the ethanol of 90%, be heated to boiling reflux 2 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 75 DEG C subsequently under vacuum 0.01Mpa, relative density is the mastic of 1.05, spraying dry, the inlet temperature 180 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;

Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.5 times and 0.5 times in the dried cream powder obtained, makes granule, in 70 DEG C of dryings, obtains granule.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 22-36g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 8.48g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.4 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>42.4 crude drug/kg of the present invention, every day, maximum dosage-feeding was 84.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.14g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 29g) oral administration gavage Chinese medicine of the present invention is 606 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention to three groups of mices (often organize 20) by 13.88,22.32 and 43.56g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 110 routine cases are my Out-patient Department patient of in July, 2011 ~ 2014 year June.Patient is divided into treatment group and matched group at random, and all patients are diagnosed as nodular vasculitis.Wherein treatment group 60 people, male 7 people, women 53 people, 24 ~ 58 years old age, average (36.2 ± 8.6) year, the course of disease: 1 month ~ 3 years, site of pathological change: upper limb 6 example, lower limb 54 example, node number 1 ~ 9, average 4.2; Matched group 50 people, male 5 people, women 45 people, 25 ~ 60 years old age, average (37.5 ± 7.3) year, the course of disease: 1 month ~ 3 years, site of pathological change: upper limb 4 example, lower limb 46 example, node number 1 ~ 9, average 3.7.Two groups in age, sex, the course of disease, symptom and coincident with severity degree of condition etc. through statistical analysis there was no significant difference (p>0.05).

Diagnostic criteria: diagnosis is mainly diagnosed according to clinical manifestation and histological characteristic.

Clinical manifestation: skin lesion is the infiltration block that subcutaneous nodule is extremely larger, is apt to occur in lower limb, is more common in medial leg, common asymmetric; Tuberosity is small circular or larger wellability speckle, moves towards arrangement along blood vessel, and some tuberosity arrangements are in wire; Surface skin flushing, has pain or tenderness, and skin lesion is generally not broken to move back, and disappear through 2 ~ 3 weeks posterior tubercles, there is pigmentation local, or leaves over fibrous tuberosity, then disappear very slow; Accidental tuberosity ulceration, forms ulcer, stays cicatrix more afterwards; Sometimes can with arthralgia and lower limb aching and limp unable, the chronic course of disease, tuberosity recurrent exerbation.

Tissue pathology checking: endarterium thickens, tube chamber thrombosis, inaccessible in various degree, blood vessel peripheral lymphoid tissues is that sleeve-like infiltrates, later stage fibrosis.

Therapeutic Method:

Matched group: treat based on hormone.Prednisolone acetate 30 ~ 50mg/d, reduces to 5 ~ 15mg/d after Morbidity control gradually, Glucosidorum Tripterygll Totorum 1 ~ 1.5mg/kg, and points 3 times oral.The obvious person of inflammation selects the antibiotic such as intravenous drip penicillin, ceftazidime 1 week.

Treatment group: oral Chinese medicine embodiment 1 tablet of the present invention, each 3, every day 3 times.

Within 30 days, be 1 course for the treatment of, treat 2 courses for the treatment of altogether.

Curative effect judging standard: cure: transference cure, skin lesion all disappears, and does not recur within 1 year.Effective: symptom is obviously improved, skin lesion disappears substantially, does not recur within half a year.Effective: symptom is improved, and skin lesion disappears more than 1/2.Invalid: symptom and skin lesion all do not improve or increase the weight of.

Therapeutic outcome: see the following form.

Group	n	Cure	Effective	Effectively	Invalid	Effectively total
							Treatment group	60	35	13	8	4	56(93.33％)
Matched group	50	17	10	10	13	37(74.00％)

Treatment group compares with matched group, and treatment group curative effect is better than matched group, and two groups of Different therapeutical effects have statistical significance (P<0.05).

Concrete case: Tan, women, 40 years old.There is nodular vasculitis medical history more than 1 year.Skin lesion is positioned at right lower extremity medial leg, conscious pain, and toothache obviously.Give Chinese medicine embodiment 1 tablet of the present invention, each 3, every day 3 times, treat healing in 45 days.Follow up a case by regular visits to and do not recur for 1 year.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. treat a Chinese medicine for nodular vasculitis, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: the Herba Blumeae Laciniatae, Radix Rubi reflexi, Herba Sambuci Adnatae, Os Draconis wind, Herba Senecionis Dianthui, Radix campsis, crosses mountain breeze, Radix Parthenocissi Heterophyllae, Radix Caulophylli, muntjac grass, Herba Clinopodii, Radix seu caulis epipremni pinnati, Herba Farfugii japonici, Herba Adianti Flabellulati and Drymoglossum Herba Drymoglossi.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: the Herba Blumeae Laciniatae 10 ~ 20 parts, Radix Rubi reflexi 30 ~ 40 parts, Herba Sambuci Adnatae 10 ~ 20 parts, Os Draconis wind 5 ~ 15 parts, Herba Senecionis Dianthui 5 ~ 15 parts, Radix campsis 15 ~ 25 parts, crosses mountain breeze 10 ~ 20 parts, Radix Parthenocissi Heterophyllae 30 ~ 40 parts, Radix Caulophylli 15 ~ 25 parts, muntjac grass 30 ~ 40 parts, Herba Clinopodii 5 ~ 15 parts, Radix seu caulis epipremni pinnati 50 ~ 60 parts, Herba Farfugii japonici 15 ~ 25 parts, Herba Adianti Flabellulati 5 ~ 15 parts and Drymoglossum Herba Drymoglossi 10 ~ 20 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: the Herba Blumeae Laciniatae 10 ~ 15 parts, Radix Rubi reflexi 30 ~ 35 parts, Herba Sambuci Adnatae 10 ~ 15 parts, Os Draconis wind 5 ~ 10 parts, Herba Senecionis Dianthui 5 ~ 10 parts, Radix campsis 15 ~ 20 parts, crosses mountain breeze 10 ~ 15 parts, Radix Parthenocissi Heterophyllae 30 ~ 35 parts, Radix Caulophylli 15 ~ 20 parts, muntjac grass 30 ~ 35 parts, Herba Clinopodii 5 ~ 10 parts, Radix seu caulis epipremni pinnati 50 ~ 55 parts, Herba Farfugii japonici 15 ~ 20 parts, Herba Adianti Flabellulati 5 ~ 10 parts and Drymoglossum Herba Drymoglossi 10 ~ 15 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: the Herba Blumeae Laciniatae 11 parts, Radix Rubi reflexi 33 parts, Herba Sambuci Adnatae 13 parts, Os Draconis wind 6 parts, Herba Senecionis Dianthui 8 parts, Radix campsis 17 parts, crosses mountain breeze 12 parts, Radix Parthenocissi Heterophyllae 32 parts, Radix Caulophylli 16 parts, muntjac grass 34 parts, Herba Clinopodii 7 parts, Radix seu caulis epipremni pinnati 53 parts, Herba Farfugii japonici 16 parts, Herba Adianti Flabellulati 6 parts and Drymoglossum Herba Drymoglossi 14 parts.

5. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 60 ~ 70%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 60 ~ 70% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 150 ~ 250 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.3 ~ 0.5 times, the lactose of 0.03 ~ 0.3 times, the starch of 0.3 ~ 0.5 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.003 ~ 0.03 times, granulate, tabletting, makes.

6. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 70 ~ 80%, be heated to boiling reflux 2 ~ 3 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 70 ~ 80 DEG C subsequently under vacuum 0.01 ~ 0.05Mpa, relative density is the mastic of 1.03 ~ 1.05, spraying dry, the inlet temperature of spray dryer 165 ~ 185 DEG C, leaving air temp 65 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.4 ~ 0.6 times and 0.4 ~ 0.6 times in the dried cream powder obtained, makes granule, in 65 ~ 75 DEG C of dryings, obtains granule.

7. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 60 ~ 70%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 60 ~ 70% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 150 ~ 250 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.3 ~ 0.5 times, the lactose of 0.03 ~ 0.3 times, the starch of 0.3 ~ 0.5 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.003 ~ 0.03 times, granulate, tabletting, makes.

8. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 70 ~ 80%, be heated to boiling reflux 2 ~ 3 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 70 ~ 80 DEG C subsequently under vacuum 0.01 ~ 0.05Mpa, relative density is the mastic of 1.03 ~ 1.05, spraying dry, the inlet temperature of spray dryer 165 ~ 185 DEG C, leaving air temp 65 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.4 ~ 0.6 times and 0.4 ~ 0.6 times in the dried cream powder obtained, makes granule, in 65 ~ 75 DEG C of dryings, obtains granule.