CN104225259A - Traditional Chinese medicine for treating stagnant heat type angiitis and preparation method thereof - Google Patents
Traditional Chinese medicine for treating stagnant heat type angiitis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating stagnant heat type angiitis and a preparation method thereof. The traditional Chinese medicine includes the following raw medicinal materials: halenia corni, parnassia palustris, intermediary magnoliavine herb, Chinese holly, ellpticleaf spurgentian root, creeping ceratostigma root, bloodred iris rhizoma and root, himalayan prinsepia leaf, tuniclike psammosilene root, aquatic malachium herb, hairy clovershrub root, david anemone rhizome or leaf, all-grass of ames vanda, smallflower beggarticks herb, Chinese siphonostiga herb, cleome viscose, ludwigia hyssopifolia and alysicarpus vaginalis. The traditional Chinese medicine has the advantages of clearing heat and toxic materials, invigorating blood circulation, removing stasis, inducing dieresis, relieving pain, removing the necrotic tissues, promoting granulation and being precise in treatment effect and small in side effects.
Description
Technical field
The present invention relates to pharmaceutical technology, particularly relate to one and treat the vasculitic Chinese medicine of stagnant heat type and preparation method.
Background technology
Thromboangiitis obliterans is called for short vasculitis.Refer to a kind of Chronic persistent, the progressive vascular inflammation pathological changes of peripheral vascular (in, small artery and vein), cause thrombosis to make lumen of vessels inaccessible.Pathological changes is mainly involved in distal limbs, small artery, and accompanying vein and Superficial veins also often involve, based on lower limb.Can be there is the ulcer that not easily heals and gangrene in severe patient acra, permanent disfunction or limbs may be caused to lose, even dead.
Western medical treatment vasculitis is mainly based on antiinflammatory, analgesic Western medicine, and Western medicine can improve the state of an illness really, but antiphlogistic effects is poor, and side effect is large, thoroughly can not cure vasculitis.
Thromboangiitis obliterans belongs to " necrosis " category of Chinese medicine, and its cause of disease is because temper is not good for, insufficiency of kidney-YANG, and add again outer catching cold and freeze, the heresy of cold-damp is invaded and falls ill.Temper is not good for, and changes raw not enough, deficiency of qi and blood, interiorly can not strengthen foster internal organs; Can not to supplement nutrition outward extremity.Spleen kidney yang QI-insufficiency, can not replenishing vital QI with drugs of warm nature extremity, and again by the heresy of cold-damp, then coagulation of QI-blood, meridians block, stagnation of QI and blood may bring about pain, and extremity QI and blood is not filled, and lose and support that then skin and flesh is withered in moistening, necrosis comes off.If cold-evil accumulates for a long time, then strongly fragrant and heat-transformation, damp and hot contamination, then suffer from toe (finger) redness and to burst pus.YIN damaged by pathogenic heat, disease can cause deficiency of YIN-blood for a long time, and podomere loses supports, withered atrophy.The generation of primary disease take deficiency of spleen and stomach as this, and cold-damp wound is mark, and coagulation of QI-blood, meridian and vessels obstruction are its main pathogenesis.Tcm syndrome differentiation and typing is cold stasis of blood type vasculitis and stagnant heat type vasculitis.Stagnant heat type vasculitis is mainly because of caused by damp and hot alluvial.
Summary of the invention
Technical problem to be solved by this invention is, provide one to treat the vasculitic Chinese medicine of stagnant heat type and preparation method, Effect of Chinese Medicine Qing thermal detoxification of the present invention, blood circulation promoting and blood stasis dispelling, dampness removing pain relieving, removing the necrotic tissue and promoting granulation, has determined curative effect, the advantage that side effect is little.
In order to solve the problems of the technologies described above, the invention provides one and treat the vasculitic Chinese medicine of stagnant heat type, its raw medicinal material comprises: Herba Haleniae Corniculatae, Herba parnassiae, Herba Schisandrae intermediae, Ilex purpurea Hassk.[I.chinensis Sims, Radix haleniae ellipticae, Radix Ceratostigmatis mini, Radix et Rhizoma Iridis Sanguineae, Folium Prinsepiae Utilis, Radix Psammosilenes, Herba malachii aquatici, Radix Campylotropis hirtellae, Rhizoma anemones davidii, Vanda amesiana Reichb. F, Herba bidentis parviflorae, Herba Siphonostegiae, smelly arrow dish, grass dragon and Canis familiaris L. ant grass.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Haleniae Corniculatae 30 ~ 40 parts, Herba parnassiae 10 ~ 20 parts, Herba Schisandrae intermediae 10 ~ 20 parts, Ilex purpurea Hassk.[I.chinensis Sims 20 ~ 30 parts, Radix haleniae ellipticae 10 ~ 20 parts, Radix Ceratostigmatis mini 5 ~ 15 parts, Radix et Rhizoma Iridis Sanguineae 30 ~ 40 parts, Folium Prinsepiae Utilis 20 ~ 30 parts, Radix Psammosilenes 5 ~ 15 parts, Herba malachii aquatici 15 ~ 25 parts, Radix Campylotropis hirtellae 5 ~ 15 parts, Rhizoma anemones davidii 15 ~ 25 parts, Vanda amesiana Reichb. F 10 ~ 20 parts, Herba bidentis parviflorae 5 ~ 15 parts, Herba Siphonostegiae 15 ~ 25 parts, smelly arrow dish 5 ~ 15 parts, grass dragon 5 ~ 15 parts and Canis familiaris L. ant grass 20 ~ 30 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Haleniae Corniculatae 30 ~ 35 parts, Herba parnassiae 10 ~ 15 parts, Herba Schisandrae intermediae 10 ~ 15 parts, Ilex purpurea Hassk.[I.chinensis Sims 20 ~ 25 parts, Radix haleniae ellipticae 10 ~ 15 parts, Radix Ceratostigmatis mini 5 ~ 10 parts, Radix et Rhizoma Iridis Sanguineae 30 ~ 35 parts, Folium Prinsepiae Utilis 20 ~ 25 parts, Radix Psammosilenes 5 ~ 10 parts, Herba malachii aquatici 15 ~ 20 parts, Radix Campylotropis hirtellae 5 ~ 10 parts, Rhizoma anemones davidii 15 ~ 20 parts, Vanda amesiana Reichb. F 10 ~ 15 parts, Herba bidentis parviflorae 5 ~ 10 parts, Herba Siphonostegiae 15 ~ 20 parts, smelly arrow dish 5 ~ 10 parts, grass dragon 5 ~ 10 parts and Canis familiaris L. ant grass 20 ~ 25 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Haleniae Corniculatae 31 parts, Herba parnassiae 11 parts, Herba Schisandrae intermediae 12 parts, Ilex purpurea Hassk.[I.chinensis Sims 24 parts, Radix haleniae ellipticae 13 parts, Radix Ceratostigmatis mini 6 parts, Radix et Rhizoma Iridis Sanguineae 34 parts, Folium Prinsepiae Utilis 22 parts, Radix Psammosilenes 8 parts, Herba malachii aquatici 16 parts, Radix Campylotropis hirtellae 7 parts, Rhizoma anemones davidii 16 parts, Vanda amesiana Reichb. F 11 parts, Herba bidentis parviflorae 8 parts, Herba Siphonostegiae 19 parts, smelly arrow dish 7 parts, grass dragon 6 parts and Canis familiaris L. ant grass 24 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Haleniae Corniculatae 34 parts, Herba parnassiae 14 parts, Herba Schisandrae intermediae 13 parts, Ilex purpurea Hassk.[I.chinensis Sims 21 parts, Radix haleniae ellipticae 12 parts, Radix Ceratostigmatis mini 8 parts, Radix et Rhizoma Iridis Sanguineae 31 parts, Folium Prinsepiae Utilis 24 parts, Radix Psammosilenes 6 parts, Herba malachii aquatici 19 parts, Radix Campylotropis hirtellae 9 parts, Rhizoma anemones davidii 18 parts, Vanda amesiana Reichb. F 14 parts, Herba bidentis parviflorae 6 parts, Herba Siphonostegiae 16 parts, smelly arrow dish 8 parts, grass dragon 7 parts and Canis familiaris L. ant grass 22 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the starch of 0.1 ~ 0.3 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 3 times is the ethanol of 75 ~ 85%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 75 ~ 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 200 order ~ 300 object micropowders;
3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.
Beneficial effect of the present invention: Effect of Chinese Medicine Qing thermal detoxification of the present invention, blood circulation promoting and blood stasis dispelling, dampness removing pain relieving, removing the necrotic tissue and promoting granulation, has determined curative effect, the advantage that side effect is little.
Detailed description of the invention
The invention provides one and treat the vasculitic Chinese medicine of stagnant heat type, its raw medicinal material comprises: Herba Haleniae Corniculatae, Herba parnassiae, Herba Schisandrae intermediae, Ilex purpurea Hassk.[I.chinensis Sims, Radix haleniae ellipticae, Radix Ceratostigmatis mini, Radix et Rhizoma Iridis Sanguineae, Folium Prinsepiae Utilis, Radix Psammosilenes, Herba malachii aquatici, Radix Campylotropis hirtellae, Rhizoma anemones davidii, Vanda amesiana Reichb. F, Herba bidentis parviflorae, Herba Siphonostegiae, smelly arrow dish, grass dragon and Canis familiaris L. ant grass.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Herba Haleniae Corniculatae: sweet is bitter, cold.GUIXIN, Liver Channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis.Treating the liver is scorching, vasculitis, and trauma infection contamination is had a fever, traumatic hemorrhage.
Herba parnassiae: bitter, cool.Return lung, liver, gallbladder meridian.Clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling, relieving cough and resolving phlegm.Main icterohepatitis, bacillary dysentery, laryngopharynx swelling and pain, vasculitis, sore and toxic; Cough ant phlegm.
Herba Schisandrae intermediae: puckery, micro-hardship, cold.Heat-clearing and toxic substances removing, relaxing muscles and tendons to promote blood circulation, reducing swelling and alleviating pain.Control influenza, poisonous snake, lyssodexis, rheumatic numbness, traumatic injury, menoxenia, carbuncle sore tumefacting virus.
Ilex purpurea Hassk.[I.chinensis Sims: bitter, puckery, cool.Heat-clearing and toxic substances removing, promoting tissue regeneration and ulcer healing, promoting blood circulation and hemostasis.Cough due to lung-heat, laryngopharynx swelling and pain, dysentery, diarrhoea, biliary tract infection, urinary tract infection, angina pectoris, burn and scald, pyretic toxicity carbuncle, ulcer of the lower limb, leprelcosis, eczema, chilblain, chaps, thromboangiitis obliterans, traumatic hemorrhage.
Radix haleniae ellipticae: bitter, cold in nature.Return lung meridian.Heat-clearing and toxic substances removing, depressed liver-energy dispersing and function of gallbladder promoting, dispelling wind and relieving.Main acute hepatitis, chronic hepatitis, cholecystitis, gastroenteritis, influenza, throat pain, toothache, vasculitis, trauma infection contamination generates heat, and heatstroke is suffered from abdominal pain, traumatic hemorrhage.
Radix Ceratostigmatis mini: pungent is bitter, warm in nature.Return spleen, heart channel.Wind-damp dispelling, the meridian dredging, pain relieving.Main rheumatic numbness, gastral cavity abdomen hypochondriac pain, traumatic injury, fracture, vasculitis, parotitis." Yunnan Chinese herbal medicine ": dredge the meridian passage, wind-damp dispelling.Dispelling the wind and dampness pathogens is numb, vasculitis.
Radix et Rhizoma Iridis Sanguineae: pungent, sweet, temperature.Promoting blood flow to regulate menstruation, eliminating stasis to stop pain, spleen invigorating removing food stagnancy.For menoxenia, dysmenorrhea, amenorrhea, thromboangiitis obliterans, treating swelling and pain by traumatic injury, lumbago, rheumatic ostalgia, infantile malnutrition, neurasthenia; External training the body is itched.
Folium Prinsepiae Utilis: bitter, pungent, cold.GUIXIN, liver, kidney channel.Heat-clearing and toxic substances removing, blood circulation promoting and dispersing pathogen accumulation.Main acute mastitis, mumps, hemorrhoid, scrofula, traumatic injury, menoxenia.
Radix Psammosilenes: bitter, pungent, temperature.Except rheumatism, analgesic therapy, hemostasis, blood stasis dispelling.Dispelling the wind and dampness pathogens arthralgia pain, stomachache, wound hemorrhage, traumatic injury.
Herba malachii aquatici: sweet, acid, property is put down.Return liver, stomach warp.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Main dyspnea and cough due to lung-heat, dysentery, carbuncle, hemorrhoid, toothache, menoxenia, infantile malnutrition.
Radix Campylotropis hirtellae: puckery, micro-hardship, tepor.Invigorate blood circulation, regulating menstruation, regulates the flow of vital energy, pain relieving.Control menoxenia, amenorrhea, dysmenorrhea, metrorrhagia, leucorrhea, stomachache, sprains, traumatic hemorrhage, scalds.
Rhizoma anemones davidii: bitter, temperature.Return lung, liver, spleen, kidney channel.Invigorate blood circulation, pain relieving, blood stasis dispelling.Main traumatic injury, rheumatalgia, lumbar muscle strain.
Vanda amesiana Reichb. F: sweet, light, property is put down.Return liver, kidney channel.Heat-clearing and toxic substances removing, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling.Main malaria, laryngopharynx swelling and pain, damp-heat gonorrhoea, rheumatic arthralgia, impairment caused by overstrain lumbago, menoxenia, traumatic injury, fracture.
Herba bidentis parviflorae: sweet, micro-hardship, cool.Heat-clearing and toxic substances removing, blood circulation and promoting silt.Cure cold heating, laryngalgia, enteritis, diarrhea, appendicitis, traumatic injury, carbuncle furuncle.
Herba Siphonostegiae: bitter, cool.Clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling.Harness the Yellow River subcutaneous ulcer, dysuria, edema abdominal distention, falls and damages stasis of blood pain, dysentery, stranguria with blood, leukorrhagia, menoxenia, lump in the abdomen, stops the stasis of blood stomachache puerperal.
Smelly arrow dish: bitter, pungent, temperature.Dissipating blood stasis for subsidence of swelling, removing the necrotic tissue and promoting granulation.Control treating swelling and pain by traumatic injury, impairment caused by overstrain lumbago.
Grass dragon: light, cool.Heat-clearing and toxic substances removing, removing the necrotic tissue and promoting granulation.For cold, fever, laryngopharynx swelling and pain, stomatitis, oral ulcer, carbuncle furuncle swells.
Canis familiaris L. ant grass: sweet is bitter, flat.Clearing away heat and eliminating dampness, refutes atrophic debility of bones and swells, removing the necrotic tissue and promoting granulation.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Haleniae Corniculatae 30 ~ 40 parts, Herba parnassiae 10 ~ 20 parts, Herba Schisandrae intermediae 10 ~ 20 parts, Ilex purpurea Hassk.[I.chinensis Sims 20 ~ 30 parts, Radix haleniae ellipticae 10 ~ 20 parts, Radix Ceratostigmatis mini 5 ~ 15 parts, Radix et Rhizoma Iridis Sanguineae 30 ~ 40 parts, Folium Prinsepiae Utilis 20 ~ 30 parts, Radix Psammosilenes 5 ~ 15 parts, Herba malachii aquatici 15 ~ 25 parts, Radix Campylotropis hirtellae 5 ~ 15 parts, Rhizoma anemones davidii 15 ~ 25 parts, Vanda amesiana Reichb. F 10 ~ 20 parts, Herba bidentis parviflorae 5 ~ 15 parts, Herba Siphonostegiae 15 ~ 25 parts, smelly arrow dish 5 ~ 15 parts, grass dragon 5 ~ 15 parts and Canis familiaris L. ant grass 20 ~ 30 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Haleniae Corniculatae 30 ~ 35 parts, Herba parnassiae 10 ~ 15 parts, Herba Schisandrae intermediae 10 ~ 15 parts, Ilex purpurea Hassk.[I.chinensis Sims 20 ~ 25 parts, Radix haleniae ellipticae 10 ~ 15 parts, Radix Ceratostigmatis mini 5 ~ 10 parts, Radix et Rhizoma Iridis Sanguineae 30 ~ 35 parts, Folium Prinsepiae Utilis 20 ~ 25 parts, Radix Psammosilenes 5 ~ 10 parts, Herba malachii aquatici 15 ~ 20 parts, Radix Campylotropis hirtellae 5 ~ 10 parts, Rhizoma anemones davidii 15 ~ 20 parts, Vanda amesiana Reichb. F 10 ~ 15 parts, Herba bidentis parviflorae 5 ~ 10 parts, Herba Siphonostegiae 15 ~ 20 parts, smelly arrow dish 5 ~ 10 parts, grass dragon 5 ~ 10 parts and Canis familiaris L. ant grass 20 ~ 25 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Haleniae Corniculatae 31 parts, Herba parnassiae 11 parts, Herba Schisandrae intermediae 12 parts, Ilex purpurea Hassk.[I.chinensis Sims 24 parts, Radix haleniae ellipticae 13 parts, Radix Ceratostigmatis mini 6 parts, Radix et Rhizoma Iridis Sanguineae 34 parts, Folium Prinsepiae Utilis 22 parts, Radix Psammosilenes 8 parts, Herba malachii aquatici 16 parts, Radix Campylotropis hirtellae 7 parts, Rhizoma anemones davidii 16 parts, Vanda amesiana Reichb. F 11 parts, Herba bidentis parviflorae 8 parts, Herba Siphonostegiae 19 parts, smelly arrow dish 7 parts, grass dragon 6 parts and Canis familiaris L. ant grass 24 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Haleniae Corniculatae 34 parts, Herba parnassiae 14 parts, Herba Schisandrae intermediae 13 parts, Ilex purpurea Hassk.[I.chinensis Sims 21 parts, Radix haleniae ellipticae 12 parts, Radix Ceratostigmatis mini 8 parts, Radix et Rhizoma Iridis Sanguineae 31 parts, Folium Prinsepiae Utilis 24 parts, Radix Psammosilenes 6 parts, Herba malachii aquatici 19 parts, Radix Campylotropis hirtellae 9 parts, Rhizoma anemones davidii 18 parts, Vanda amesiana Reichb. F 14 parts, Herba bidentis parviflorae 6 parts, Herba Siphonostegiae 16 parts, smelly arrow dish 8 parts, grass dragon 7 parts and Canis familiaris L. ant grass 22 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the starch of 0.1 ~ 0.3 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 3 times is the ethanol of 75 ~ 85%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 75 ~ 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 200 order ~ 300 object micropowders;
3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: capsule
Get Herba Haleniae Corniculatae 310g, Herba parnassiae 110g, Herba Schisandrae intermediae 120g, Ilex purpurea Hassk.[I.chinensis Sims 240g, Radix haleniae ellipticae 130g, Radix Ceratostigmatis mini 60g, Radix et Rhizoma Iridis Sanguineae 340g, Folium Prinsepiae Utilis 220g, Radix Psammosilenes 80g, Herba malachii aquatici 160g, Radix Campylotropis hirtellae 70g, Rhizoma anemones davidii 160g, Vanda amesiana Reichb. F 110g, Herba bidentis parviflorae 80g, Herba Siphonostegiae 190g, smelly arrow dish 70g, careless imperial 60g and Canis familiaris L. ant grass 240g;
Prepare according to the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 90%, reflux 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 times again, reflux 1 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 hours, pulverize and sieve acquisition 200 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.3 times, the starch of 0.3 times, the magnesium stearate of 0.03 times, carry out mixing process, namely obtain capsule 's content, described Capsule content is incapsulated in housing, namely obtain capsule finished product.
Embodiment 2: powder
Get Herba Haleniae Corniculatae 340g, Herba parnassiae 140g, Herba Schisandrae intermediae 130g, Ilex purpurea Hassk.[I.chinensis Sims 210g, Radix haleniae ellipticae 120g, Radix Ceratostigmatis mini 80g, Radix et Rhizoma Iridis Sanguineae 310g, Folium Prinsepiae Utilis 240g, Radix Psammosilenes 60g, Herba malachii aquatici 190g, Radix Campylotropis hirtellae 90g, Rhizoma anemones davidii 180g, Vanda amesiana Reichb. F 140g, Herba bidentis parviflorae 60g, Herba Siphonostegiae 160g, smelly arrow dish 80g, careless imperial 70g and Canis familiaris L. ant grass 220g;
Prepare according to the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 85%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 1 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 300 object micropowders;
3rd step: add the starch relative to its quality 3 times in the micropowders obtained by second step, mixing, obtains powder.
Toxicity test:
Acute toxicity testing: application mice 50, male and female half and half, body weight 20 ~ 26g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 1, (concentration is 8.34g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 41.7 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>41.7 crude drug/kg, every day, maximum dosage-feeding was 83.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 7.8g crude drug/day/people, adult body weight in 60KG, average dosage is 0.13g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 23g) oral administration gavage Chinese medicine of the present invention is 642 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: the capsule diluent of the embodiment of the present invention 1 presses 14.67,22.33 and 43.15g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 79 routine cases are my Out-patient Department patient in May, 2010 ~ in May, 2013.Patient is divided into treatment group and matched group at random, wherein treatment group 42 people, male 35 people, women 7 people, 25 ~ 59 years old age, average (36 ± 7.5) year, the course of disease 3 months ~ 8 years, on average (14.6 ± 5.8) individual month, site of pathological change: one-sided 36 examples, bilateral 6 example; Severity Scaling: I phase 7 example, II phase 22 example, III phase 13 example; Matched group 37 people, male 30 people, women 7 people, 27 ~ 58 years old age, average (35 ± 6.5) year, the course of disease 4 months ~ 8 years, average (13.5 ± 6.4) individual month, site of pathological change: one-sided 32 examples, bilateral 5 example; Severity Scaling: I phase 6 example, II phase 19 example, III phase 12 example.Two groups in age, the course of disease, symptom and coincident with severity degree of condition etc. through statistical analysis there was no significant difference (p>0.05).
Diagnostic criteria: common male is between twenty and fifty, has smoking history more or catches cold and freeze history or history of making moist.Acra is afraid of cold, numb, pain, and skin colour changes, intermittent claudication, limbs malnutrition.40 ~ 60% have migrans superficial thrombophlebitis medical history and sign.Suffering limb arteriopalmus obviously weakens or disappears.
Therapeutic Method:
Matched group: give low-dose urokinase 300,000 U and add normal saline 100ml iv drip, every day 1 time, intravenous applications antibiotic infection control.30 days courses for the treatment of.
Treatment group: take Chinese medicine embodiment 1 capsule of the present invention every day 3 times, each 4.It within 30 days, is a course for the treatment of.
Curative effect judging standard: cure: cardinal symptom disappears, and wound surface heals completely, pain disappears, and skin temperature and color and luster recover normal, and suffering limb disturbance of blood circulation obviously improves, and resumes work in 1 year without recurrence.Effective: clinical symptoms major part disappears or obviously alleviates, and pain disappears, and skin temperature and color and luster are clearly better, wound surface is close to healing, and blood circulation is slight obstacle, can work.Effective: condition of illness alleviates, wound surface comparatively before reduces, and suffering limb blood circulation makes moderate progress, and still can not be engaged in work.Invalid: clinical symptoms and sign are all without improvement.
Differentiation of symptoms and signs for classification of syndrome: stagnant heat type: card is shown in that suffering limb is dark red and swollen, toe-end forms ulcer, or blackout, gangrene, and have an intense pain, FU YANG pulse the pulse of anterior tibial artery is beaten disappearances, or with fever, loss of appetite, becomes thin weak, red tongue, yellow fur or yellow greasy, stringy and rolling pulse or slide number.
Therapeutic outcome: see the following form.
| Group | n | Cure | Effective | Effectively | Invalid | Effectively total |
| Treatment group | 42 | 18 | 12 | 8 | 4 | 38(90.48％) |
| Matched group | 37 | 8 | 9 | 12 | 8 | 29(78.38％) |
Concrete case: Zheng, male, 36 years old, suffering limb is dark red and swollen, and toe-end forms ulcer, gangrene, has an intense pain, FU YANG pulse the pulse of anterior tibial artery is beaten disappearance, red tongue, yellow and greasy fur, slippery and rapid pulse, be diagnosed as stagnant heat type vasculitis, take Chinese medicine embodiment 1 capsule 1 of the present invention course for the treatment of, symptom disappears completely, recovery from illness, follows up a case by regular visits to and does not recur for 1 year.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. treat the vasculitic Chinese medicine of stagnant heat type, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Herba Haleniae Corniculatae, Herba parnassiae, Herba Schisandrae intermediae, Ilex purpurea Hassk.[I.chinensis Sims, Radix haleniae ellipticae, Radix Ceratostigmatis mini, Radix et Rhizoma Iridis Sanguineae, Folium Prinsepiae Utilis, Radix Psammosilenes, Herba malachii aquatici, Radix Campylotropis hirtellae, Rhizoma anemones davidii, Vanda amesiana Reichb. F, Herba bidentis parviflorae, Herba Siphonostegiae, smelly arrow dish, grass dragon and Canis familiaris L. ant grass.
2. Chinese medicine as claimed in claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Haleniae Corniculatae 30 ~ 40 parts, Herba parnassiae 10 ~ 20 parts, Herba Schisandrae intermediae 10 ~ 20 parts, Ilex purpurea Hassk.[I.chinensis Sims 20 ~ 30 parts, Radix haleniae ellipticae 10 ~ 20 parts, Radix Ceratostigmatis mini 5 ~ 15 parts, Radix et Rhizoma Iridis Sanguineae 30 ~ 40 parts, Folium Prinsepiae Utilis 20 ~ 30 parts, Radix Psammosilenes 5 ~ 15 parts, Herba malachii aquatici 15 ~ 25 parts, Radix Campylotropis hirtellae 5 ~ 15 parts, Rhizoma anemones davidii 15 ~ 25 parts, Vanda amesiana Reichb. F 10 ~ 20 parts, Herba bidentis parviflorae 5 ~ 15 parts, Herba Siphonostegiae 15 ~ 25 parts, smelly arrow dish 5 ~ 15 parts, grass dragon 5 ~ 15 parts and Canis familiaris L. ant grass 20 ~ 30 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Haleniae Corniculatae 30 ~ 35 parts, Herba parnassiae 10 ~ 15 parts, Herba Schisandrae intermediae 10 ~ 15 parts, Ilex purpurea Hassk.[I.chinensis Sims 20 ~ 25 parts, Radix haleniae ellipticae 10 ~ 15 parts, Radix Ceratostigmatis mini 5 ~ 10 parts, Radix et Rhizoma Iridis Sanguineae 30 ~ 35 parts, Folium Prinsepiae Utilis 20 ~ 25 parts, Radix Psammosilenes 5 ~ 10 parts, Herba malachii aquatici 15 ~ 20 parts, Radix Campylotropis hirtellae 5 ~ 10 parts, Rhizoma anemones davidii 15 ~ 20 parts, Vanda amesiana Reichb. F 10 ~ 15 parts, Herba bidentis parviflorae 5 ~ 10 parts, Herba Siphonostegiae 15 ~ 20 parts, smelly arrow dish 5 ~ 10 parts, grass dragon 5 ~ 10 parts and Canis familiaris L. ant grass 20 ~ 25 parts.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Haleniae Corniculatae 31 parts, Herba parnassiae 11 parts, Herba Schisandrae intermediae 12 parts, Ilex purpurea Hassk.[I.chinensis Sims 24 parts, Radix haleniae ellipticae 13 parts, Radix Ceratostigmatis mini 6 parts, Radix et Rhizoma Iridis Sanguineae 34 parts, Folium Prinsepiae Utilis 22 parts, Radix Psammosilenes 8 parts, Herba malachii aquatici 16 parts, Radix Campylotropis hirtellae 7 parts, Rhizoma anemones davidii 16 parts, Vanda amesiana Reichb. F 11 parts, Herba bidentis parviflorae 8 parts, Herba Siphonostegiae 19 parts, smelly arrow dish 7 parts, grass dragon 6 parts and Canis familiaris L. ant grass 24 parts.
5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Haleniae Corniculatae 34 parts, Herba parnassiae 14 parts, Herba Schisandrae intermediae 13 parts, Ilex purpurea Hassk.[I.chinensis Sims 21 parts, Radix haleniae ellipticae 12 parts, Radix Ceratostigmatis mini 8 parts, Radix et Rhizoma Iridis Sanguineae 31 parts, Folium Prinsepiae Utilis 24 parts, Radix Psammosilenes 6 parts, Herba malachii aquatici 19 parts, Radix Campylotropis hirtellae 9 parts, Rhizoma anemones davidii 18 parts, Vanda amesiana Reichb. F 14 parts, Herba bidentis parviflorae 6 parts, Herba Siphonostegiae 16 parts, smelly arrow dish 8 parts, grass dragon 7 parts and Canis familiaris L. ant grass 22 parts.
6. the Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the starch of 0.1 ~ 0.3 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
7. the Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 3 times is the ethanol of 75 ~ 85%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 75 ~ 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 200 order ~ 300 object micropowders;
3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the starch of 0.1 ~ 0.3 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 3 times is the ethanol of 75 ~ 85%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 75 ~ 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 200 order ~ 300 object micropowders;
3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.
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| CN106334038A (en) * | 2016-08-24 | 2017-01-18 | 任永霞 | Traditional Chinese medicine preparation for treating lower extremity superficial thrombophlebitis |
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| CN104027641A (en) * | 2014-06-04 | 2014-09-10 | 烟台瑞智生物医药科技有限公司 | Traditional Chinese medicine for treating damp heat syndrome type angiitis |
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| CN103638156A (en) * | 2013-11-26 | 2014-03-19 | 宋爱民 | Traditional Chinese medicine preparation for treating blood stasis angiitis |
| CN103638367A (en) * | 2013-12-23 | 2014-03-19 | 陈红 | Traditional Chinese medicine preparation for treating migraine with obstruction of collaterals by blood stasis and preparation method thereof |
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Inventor after: Han Yanhua Inventor before: Luan Yingjie Inventor before: Gu Weile Inventor before: Zhang Xiaoyan Inventor before: Xu Meihua Inventor before: Xue Weiqiang Inventor before: Xue Jun Inventor before: Li Yanhong |
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Effective date of registration: 20160108 Address after: 276000 Department of general surgery, Feixian County TCM Hospital, middle of Xing Cheng Road, Feixian County County, Linyi, Shandong Applicant after: Han Yanhua Address before: 266599 Huangdao Hospital of Huangdao District, Hainan Island, Shandong, China, No. 158, Qingdao District, Qingdao Applicant before: Luan Yingjie |
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