CN104027465A - Traditional Chinese medicine for treating heat toxin-induced angiitis - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating heat toxin-induced angiitis. The traditional Chinese medicine is characterized by being prepared from the following medicinal materials in parts by weight: 4 parts of freeze-dried sea cucumber, 50 parts of radix scrophulariae, 25 parts of angelica sinensis, 25 parts of radix paeoniae alba, 20 parts of caulis spatholobi, 25 parts of radix achyranthis bidentatae, 12 parts of microlepia marginata, 15 parts of liquorice, 8 parts of all-grass of Khas Aletris, 20 parts of herb of common leibnitzia, 5 parts of alangium kurzii, 20 parts of gray polypody, 8 parts of luffa roots, 10 parts of lumbricus and 10 parts of zaocys dhumnade. The traditional Chinese medicine disclosed by the invention realizes the purpose of treating heat toxin-induced angiitis by improving blood circulation, dredging microcirculation disturbance, promoting establishment of collateral circulation of limbs, adjusting blood distribution, dredging blood vessels, improving anaerobic condition of local tissues and relieving vasospasm and dissolving thrombus. Over the years, use of the traditional Chinese medicine on 40 patients shows that the effective rate is 99%.

Description

One is treated the vasculitic Chinese medicine of pyretic toxicity pattern of syndrome

 

Technical field

The present invention relates to a kind of Chinese medicine, particularly one and treat the vasculitic Chinese medicine of pyretic toxicity pattern of syndrome.

Background technology

Vasculitis is a kind of with limbs meridians obstruction, coagulation of QI-blood, and blood vessel trip plug, causes limb toe to refer to that ischemic necrosis is the vascular conditions of basic feature, and the traditional Chinese medical science is referred to as necrosis.How, because of reasons such as ailment said due to cold or exposure, cold-damp, damp and hot and blood stasis, cause stasis blocking passages through which vital energy circulates, cause QI and blood and can not arrive acra, acra loses due to moistening of QI and blood support.Pathological changes process is slow, taking cold extremities, numbness, intermittent claudication, pain, acromelic gangrene etc. as cardinal symptom, and multiple male person between twenty and fifty, lower limb are common.Vasculitis is a kind of disease more common in daily life, sickness rate is to increase year by year in recent years, bring very large impact to people's life, state of an illness the lighter's inconvenience of living, severe patient can cause suffering limb ischemic necrosis, even disable, the painful and harm causing to patient is all very big, and its clinical treatment is more thorny.At present, treat vasculitic method and mainly contain western medicine therapy, the combined therapy of Chinese and Western medicine, operative therapy and herbal treatment, these therapies have certain curative effect, but overall therapeutic effect (comprising cure rate) still owes satisfied, easily recurrence, and the side reaction of some drugs is more.And also do not have at present one to be directed to the vasculitic special Chinese patent medicine for the treatment of pyretic toxicity pattern of syndrome.

Summary of the invention

Object of the present invention aims to provide one and treats the vasculitic Chinese medicine of pyretic toxicity pattern of syndrome, by selecting suitable medical material and proportioning thereof, reaches and cures safely and effectively the vasculitic object for the treatment of pyretic toxicity pattern of syndrome.

: one is treated the vasculitic Chinese medicine of pyretic toxicity pattern of syndrome to it is characterized in that being made by the medical material of following weight proportion for realizing the technical scheme that above-mentioned purpose of the present invention adopts:

4 parts of lyophilizing Stichopus japonicuss, 50 parts of Radix Scrophulariae, 25 parts of Radix Angelicae Sinensis, 25 parts of the Radix Paeoniae Albas, 20 parts of Caulis Spatholobis, 25 parts of Radix Achyranthis Bidentataes, 12 parts of Microlepia margihaea(Houee) C. Chr, 15 parts, Radix Glycyrrhizae, 8 parts of muntjac grass, 5 parts of 20 part, mao Radix Alangiis of leopard eyes fruit, 20 parts of Rhizoma Polypodiodis Nipponicaies, 8 parts of Radix Luffae, 10 parts of Pheretimas, 10 parts of Zaocyss.

The source of the various medical materials that adopt in formula and function cure mainly as follows:

Stichopus japonicus [source] is all of Stichopodidae animal Radix Morinae Bulleyanae or other kind of Stichopus japonicus.[nature and flavor] are salty, temperature.[return through] enters the heart, kidney two warps.[function cures mainly] the kidney invigorating and essence nourishing, nourishing blood, it is dry to wash in a pan.Control essence and blood loss, weak labor is timid, sexual impotence, and nocturnal emission, frequent micturition, dryness of the intestine is just difficult.

 

The root of Radix Scrophulariae [source] Scrophulariaceae herbaceos perennial Radix Scrophulariae.[nature and flavor] bitter in the mouth is salty, and cold nature is nontoxic.[return through] enters lung, stomach, kidney channel.[function cures mainly] removing heat from blood YIN nourishing, eliminating fire and detoxication, hard masses softening and resolving.Be used for the excessive thirst of having a fever, spontaneous sweating, constipation, haematemesis nose bleeding, pharyngolaryngitis, pulmonary tuberculosis, constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, Tianjin.

Radix Angelicae Sinensis [source] this product is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.[nature and flavor] sweet, acrid, warm.[return through] returns liver, the heart, spleen channel.[function cures mainly] enriched blood and invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

The Radix Paeoniae Alba [source] is the dry root of Paeoniaceae plant peony (cultivation product) and Peony.[nature and flavor] hardship; Acid; Be slightly cold.[return through] liver; Spleen channel.[function cures mainly] nourished blood and sought; Relieving spasm to stop pain; Yin fluid astringing suppressing the hyperactive liver.Main menoxenia; Abdominal pain during menstruation; Metrorrhagia; Spontaneous perspiration; Night sweat; Side of body rib epigastric pain; Limb pain twin; Headache; Dizzy.

Caulis Spatholobi [source] this product is the dry rattan of leguminous plant spatholobus suberectus (Caulis Sargentodoxae, Radix seu Caulis Verntilaginis Leiocarpae, SANYE Caulis Spatholobi, nine layers of wind) Spatholobus suberectus Dunn.[nature and flavor] are bitter, sweet, temperature.[return through] returns liver, kidney channel.[function cures mainly] enriches blood, invigorate blood circulation, and dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.

Radix Achyranthis Bidentatae [source] this product is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae Achyranthes bidentata Blume..[nature and flavor] are bitter, sour, flat.[return through] returns liver, kidney channel.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.

Radix Glycyrrhizae [source] this product is the dry root of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..[nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Microlepia margihaea(Houee) C. Chr [source] is the tender leaf of Dennstaedtia scabra (Wall.) Moore. section plant Microlepia margihaea(Houee) C. Chr.[nature and flavor] hardship; Cold.[return through] Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Dispelling, collateral-activating.Main carbuncle furuncle is swollen; Rheumatic arthralgia; Traumatic injury.

Muntjac grass [source] is the herb of Huperziaceae plant Phlegmariurus fordii (Bak) Ching-Bak.[nature and flavor] hardship; Cool.[function cures mainly] dispelling wind and removing obstruction in the collateral; Reducing swelling and alleviating pain; Heat-clearing and toxic substances removing.Main joint swells and ache; Numb limbs and tense tendons; Traumatic injury; Cough with asthma; Pyretic stranguria; Venom.

The root of Brachystemma calycina D. Don. [source] Caryophyllaceae Brachystemma calycina D. Don. platymiscium Brachystemma calycina D. Don. brachystemma calycinum d. don.[nature and flavor] are sweet, flat.[function cures mainly] heat-clearing and toxic substances removing, relaxing muscles and tendons and activating QI and blood in the collateral.For diphtheria, rheumatic arthralgia, traumatic injury, menoxenia, weak after being ill.

Leopard eyes fruits [source] are the root of Myrsinacea plant button fruit.[nature and flavor] hardship; Pungent; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Eliminating stasis to stop pain.Main cold, fever; Laryngopharynx swelling and pain; Toothache erosion of the oral mucosa; Rheumatism pyretic arthralgia; Stomachache; Infantile malnutrition; Treating swelling and pain by traumatic injury.

Hair Radix Alangii [source] is lateral root, the fibrous root of Alangiaceae vegetable hair Radix Alangii.[nature and flavor] acrid in the mouth; Warm in nature; Poisonous.[function cures mainly] relaxing muscles and tendons to promote blood circulation; Eliminating stasis to stop pain.Cure mainly traumatic injury congestive edema; Fracture.

Rhizoma Polypodiodis Nipponicae [source] is the rhizome of Plants of Polypodiaceae Rhizoma Polypodiodis Nipponicae.[nature and flavor] hardship; Cool.[return through] heart; Liver; Lung meridian.[function cures mainly] clearing away heat-damp and promoting diuresis; Promoting blood circulation to remove obstruction in the collateral.Cure mainly acute diseases such as cholera and sunstroke stranguria with turbid discharge; Have loose bowels; Rheumatic arthralgia; Traumatic injury.

Radix Luffae [source] is the root of calabash and plant Fructus Luffae or Fructus Luffae difficult to understand.[nature and flavor] sweet in the mouth; Micro-hardship; Cold in nature.[function cures mainly] promoting blood circulation to remove obstruction in the collateral; Heat-clearing and toxic substances removing.Cure mainly migraine; Lumbago; Arthromyodynia; Mastitis; Rhinitis; Sinusitis; Acute throat trouble swells and ache; Discharging fresh blood stool; Anal fistula.

Pheretima [source] this product is the dry body of the animal Pheretima aspergillum Pheretima aspergillum of Ju Yin section (E. Perrier), popular Pheretimatschiliensis Pheretima vulgaris Chen, William Pheretimatschiliensis Pheretima guillelmi (Michaelsen) or the blind Pheretimatschiliensis Pheretima of comb pectinifera Michaelsen.[nature and flavor] are salty, cold.[return through] returns liver, spleen, urinary bladder channel.[function cures mainly] heat clearing away arresting convulsion, dredging collateral, relievings asthma, diuresis.For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.

Zaocys [source] this product is the dry body of Colubridae animal Zaocys Zaocys dhumnades (Cantor).[nature and flavor] are sweet, flat [return through] returns Liver Channel.[function cures mainly] dispels the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.

The vasculitic clinical manifestation of pyretic toxicity pattern of syndrome: the scorching hot pain of suffering limb, flushing or dark red swelling, that touches is scorching hot, and heat increases the weight of.It is purple black that the colour of skin gradually becomes, and the withered muscle of meat withers gradually, the acra necrosis of festering, and pus is yellow and glue, breath malodor, tongue is dark red, and yellow and greasy fur or Huang are dry, deep and hesitant pulse or carefully puckery.Companion's fever with aversion to cold, xerostomia is thirsty, unhappiness.Light night on daytime is heavy, and limbs are local red and swollen, large dry stool.The present invention is taking heat-clearing and toxic substances removing, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain as Therapeutic Principle, by improving blood circulation, unimpeded microcirculation disturbance, promote limbs side Zhi Xunhuan to set up, adjusting blood distributes, and dredging vascellum, improves local tissue hypoxia's state, remove vasospasm and thrombus, reach and cure the vasculitic object of pyretic toxicity pattern of syndrome.For many years, by 40 patients' use is shown, effective percentage reaches 99%.

Below in conjunction with clinical experiment data declaration beneficial effect of the present invention:

1, physical data:

In June, 2009～2013 year June, collect altogether the 40 vasculitic patients of routine pyretic toxicity pattern of syndrome, wherein, and women's 6 examples, male's 34 examples, the age is at 26～53 years old, the state of an illness 3 months-4 years, wherein, right foot 20 examples, left foot 17 examples, left and right foot 3 examples.

2, test method:

The Chinese medicine that 2.1 oral the present invention make according to embodiment 1, early, middle and late respectively once, 60 days courses for the treatment of.

2.2 observation items: the priority for the treatment of suffering limb wound surface, blood circulation and physical recovery situation etc. changes.

3, criterion of therapeutical effect and therapeutic outcome

3.1 criterions of therapeutical effect and therapeutic outcome

Criterion of therapeutical effect: recovery from illness: clinical symptom disappearance, limbs skin ulcer face heals completely, and limbs peripheral blood circulation obviously changes, walking speed 100-120 step/point, can continue walking 1km left and right, can normally work, live; Effective: clinical symptoms is obviously improved, limbs wound healing or approaching healing, limbs peripheral blood circulation obstacle improves, walking speed 100-120 step/point, can continue, about walking 500m, can normally work, live; Take a turn for the better: clinical symptom relief, limbs wound surface approaches healing or dwindles, and limbs peripheral blood circulation is slightly improved, walking speed 100-120 step/point, can continue about walking 300m energy orthobiosis; Invalid: treat after the course for the treatment of, symptom and sign are without improving or state of an illness continuation development person.

3.2 pyretic toxicity pattern of syndrome vasculitis pathological changes are many develops into gradually bilateral from single lower limb, even involves upper limb.Be broadly divided into for three phases according to pathological development.

The first stage ischemia phase: suffering limb has scorching hot pain, flushing or dark red swelling, that touches is scorching hot, and heat increases the weight of.There is feeling of numbness, suffer from foot and shank and slightly ache.Walk stretch gaskin and ache, crick, forces patient to walk lamely or takes a load off one's feet, have a rest one after the meeting pain can disappear, then walk after one section and can show effect again, be i.e. " intermittent claudication ".Part patient has migration superficial phlebitis.

The second stage malnutrition phase: suffering limb pain aggravation, hot, thirsty, the constipation of occurring together, dark coloured urine, red tongue, yellowish fur, suffering limb distending pain, burns pain, and for very, have an intense pain night, forces patient not fall asleep, and knee sprung is embraced foot and is sat.There is flushing, livid purple and purpura in suffering limb skin.Xerosis cutis, toe (finger) first thickens embrittlement.Calf muscle atrophy.The disappearance of beating of Ipsilateral dorsal artery of foot, posterior tibial artery.

The third stage tissue necrosis phase: limb pain is more violent.It is purple black that the colour of skin gradually becomes, and the withered muscle of meat withers gradually, toe (finger) necrosis of festering, and pus is yellow and glue, and spreads to full toe (finger) gradually, even prolongs and ankle.

3.3 treatment statistical results see the following form

Visible, the medicine that the present invention makes can safe and effective treatment pyretic toxicity pattern of syndrome vasculitis.

 

?further illustrate effect of the present invention below in conjunction with concrete case.

Concrete case 1

Week certain, man, 53 years old, teacher, on November 5th, 2009 is medical.Its left lower limb is before 2 years, feels little legs after walking stretch, often there will be crick, walk after a period of time, because skelalgia need take a load off one's feet, have a rest one after the meeting pain can disappear, then walk after one section and can show effect again.Closely over the past half year, the aggravation of left skelalgia pain, has distending pain, burns the sensation of pain, and night, pain was heavier, usually can not fall asleep, and knee sprung is embraced foot and sat.Often can have a fever, thirsty, constipation, red urine.See its dimly red tongue, yellowish fur, deep and hesitant pulse, suffering limb cyanosis of the skin, has part purpura, xerosis cutis, the thick and embrittlement of fingernail, Calf muscle atrophy, the disappearance of beating of left side dorsal artery of foot, posterior tibial artery.Be diagnosed as the pyretic toxicity pattern of syndrome vasculitis II phase.The Chinese medicine that oral the present invention makes according to embodiment 1, early, middle and late respectively once clothes are during to 30 days, and all clinical symptoms are obviously improved, left lower limb skin recovers normal substantially, purpura is not obvious, and other symptoms are also obviously improved, while taking to 60 days, left lower limb recovers normal technical ability completely, walking is normal, without pain, and recovery from illness.Follow up a case by regular visits to and do not recur half a year.

Concrete case 2

Zhang, man, 48 years old, workman, on May 6th, 2010 is medical.When medical, its left lower limb cyanosis of the skin, has part purpura, xerosis cutis, the thick and embrittlement of fingernail, Calf muscle atrophy, the disappearance of beating of left side dorsal artery of foot, posterior tibial artery.Right lower limb skin is atropurpureus, two toes downright bad phenomenon that occurs festering, and pus is yellow and sticky, and its tongue is dark red, yellow and greasy fur, thready and hesitant pulse, can not orthobiosis.Be diagnosed as the pyretic toxicity pattern of syndrome vasculitis III phase.Take the Chinese medicine that the present invention makes according to embodiment 1, early, in, evening respectively once, while taking to 30 days, all clinical symptoms are obviously improved, left lower limb skin recovers normal substantially, purpura is not obvious, other symptoms are also obviously improved, the right lower limb colour of skin obviously shoals, two most of healings of the toe festering, and there is no a pus, while taking to 60 days, left lower limb recovers normal technical ability completely, walking is normal, without pain, recovery from illness, right lower limb also recovers normal technical ability completely, the toe skin ulcer face of right crus of diaphragm heals completely, walking speed 100-120 step/point, can continue walking 1km left and right, can normally work, life, recovery from illness.Follow up a case by regular visits to and do not recur half a year.

Concrete case 3

Lee, female, 48 years old, teacher, on July 8th, 2011 is medical.When medical, its left and right skelalgia pain, two lower limb distending pains, burn pain, night sharp ache, Chang Buneng falls asleep, knee sprung is embraced foot and is sat.Right lower limb erubescence, livid purple, left lower limb skin is livid purple purpura.Two lower limb xerosis cutiss, left foot toenail thickens embrittlement, the atrophy of left lower limb Calf muscle, the disappearance of beating of left dorsal artery of foot, posterior tibial artery.Often with fever, often thirsty, constipation, dark coloured urine, see its dimly red tongue, yellowish fur, thready and hesitant pulse.Be diagnosed as the pyretic toxicity pattern of syndrome vasculitis II phase.The Chinese medicine that oral the present invention makes according to embodiment 1, early, middle and late respectively once clothes are during to 30 days, and all clinical symptoms of both legs are obviously improved, it is normal that skin recovers substantially, left lower limb purpura is not obvious, and other symptoms are also obviously improved, while taking to 60 days, both legs recover normal technical ability completely, walking is normal, without pain, and recovery from illness.Follow up a case by regular visits to and do not recur half a year.

Detailed description of the invention

Below in conjunction with the concrete example of implementing, the present invention is done to further detailed description.

Specific embodiment 1:

Take 50 grams of Radix Scrophulariae, 25 grams of Radix Angelicae Sinensis, 25 grams of the Radix Paeoniae Albas, 20 grams of Caulis Spatholobis, 25 grams of Radix Achyranthis Bidentataes, 12 grams of Microlepia margihaea(Houee) C. Chr, 15 grams, Radix Glycyrrhizae, 8 grams of muntjac grass, 5 grams of 20 gram, mao Radix Alangiis of leopard eyes fruit, 20 grams of Rhizoma Polypodiodis Nipponicaies, 8 grams of Radix Luffae, 10 grams of Pheretimas, 10 grams of Zaocyss, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, after mixing homogeneously with 4 grams of lyophilizing Stichopus japonicuss, incapsulate shell, must meet the capsule of 1 day consumption of normal adult.

Be used for the treatment of pyretic toxicity pattern of syndrome vasculitis.Oral, every bu is taken for early, middle and late three times.

Specific embodiment 2:

Take 50 grams of Radix Scrophulariae, 25 grams of Radix Angelicae Sinensis, 25 grams of the Radix Paeoniae Albas, 20 grams of Caulis Spatholobis, 25 grams of Radix Achyranthis Bidentataes, 12 grams of Microlepia margihaea(Houee) C. Chr, 15 grams, Radix Glycyrrhizae, 8 grams of muntjac grass, 5 grams of 20 gram, mao Radix Alangiis of leopard eyes fruit, 20 grams of Rhizoma Polypodiodis Nipponicaies, 8 grams of Radix Luffae, 10 grams of Pheretimas, 10 grams of Zaocyss, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, after mixing homogeneously with 4 grams of lyophilizing Stichopus japonicuss, pack, must meet the powder of 1 day consumption of normal adult.

Be used for the treatment of pyretic toxicity pattern of syndrome vasculitis.Oral, every bu is taken for early, middle and late three times.

Specific embodiment 3:

Take 50 grams of Radix Scrophulariae, 25 grams of Radix Angelicae Sinensis, 25 grams of the Radix Paeoniae Albas, 20 grams of Caulis Spatholobis, 25 grams of Radix Achyranthis Bidentataes, 12 grams of Microlepia margihaea(Houee) C. Chr, 15 grams, Radix Glycyrrhizae, 8 grams of muntjac grass, 5 grams of 20 gram, mao Radix Alangiis of leopard eyes fruit, 20 grams of Rhizoma Polypodiodis Nipponicaies, 8 grams of Radix Luffae, 10 grams of Pheretimas, 10 grams of Zaocyss, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, after mixing homogeneously with 4 grams of lyophilizing Stichopus japonicuss, granulate according to this area common process, pack, must meet the granule of 1 day consumption of normal adult.

Be used for the treatment of pyretic toxicity pattern of syndrome vasculitis.Oral, every bu is taken for early, middle and late three times.

Claims (1)

1. a treatment pyretic toxicity pattern of syndrome vasculitic Chinese medicine, is characterized in that being made up of the medical material of following weight proportion:

4 parts of lyophilizing Stichopus japonicuss, 50 parts of Radix Scrophulariae, 25 parts of Radix Angelicae Sinensis, 25 parts of the Radix Paeoniae Albas, 20 parts of Caulis Spatholobis, 25 parts of Radix Achyranthis Bidentataes, 12 parts of Microlepia margihaea(Houee) C. Chr, 15 parts, Radix Glycyrrhizae, 8 parts of muntjac grass, 5 parts of 20 part, mao Radix Alangiis of leopard eyes fruit, 20 parts of Rhizoma Polypodiodis Nipponicaies, 8 parts of Radix Luffae, 10 parts of Pheretimas, 10 parts of Zaocyss.