CN104288282A - Traditional Chinese medicinal composition for treating rheumatic arthritis and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating rheumatic arthritis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicinal composition for treating rheumatic arthritis and a preparation method thereof. The traditional Chinese medicinal composition consists of an internally-used medicine and an externally-used medicine, wherein the internally-used medicine comprises the following medicinal raw materials: hedyotis hedyotidea, schefflera arboricola hayata, pyrola, Ventilago leiocarpa Benth, radix cudramiae, passiflora wilsonii, corydalis amabilis, oriental bittersweet root, forrest silkvine stem or root, boea hygrometrica, umbrellaleaf and adiantum capillus-veneris; the externally-used medicine comprises the following medicinal raw materials: prepared monkshood, safflower, fructus psoraleae, frankincense, myrrh, phryma leptostachya, asarum, epimedium, rhizoma corydalis, lycopodium clavatum, large-leaved gentian, rhizoma atractylodis and liquorice. The traditional Chinese medicinal composition has the beneficial effects as follows: in combination of internal use and external use, the traditional Chinese medicinal composition has an accurate therapeutic effect on the rheumatic arthritis and has small toxic and side effects.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine composition for the treatment of rheumatic arthritis and preparation method thereof.
Background technology
Rheumatic arthritis is a kind of common acute or chronic ICT.Can recurrent exerbation involve heart.Clinical with joint and muscle migrans miserable, heavily work, pain is for feature.Belong to allergic disease.One of main manifestations of rheumatic fever, mainly with febris acuta and arthralgia onset.
Rheumatic arthritis is the one performance of rheumatic fever.Rheumatic fever is the whole body allergic disease caused by A group beta hemolytic streptococcus infects, and onset of disease has erysipelas etc. to infect medical history often.Rheumatic fever onset is anxious, and is more common in teenager.Rheumatic arthritis can invade heart, causes rheumatic heart disease, and has the performances such as heating, subcutaneous nodule and erythra.
Current western medical treatment rheumatic arthritis there is no good Therapeutic Method, just to ease the pain, symptom management progress is main purpose, clinically also without specific drug, medicine used mostly is nonsteroidal antiinflammatory drug, hormone, slow-acting drug etc., because medicine time is long, toxic and side effects is large, and patient is often difficult to accept.
The rheumatic arthritis book traditional Chinese medical science " arthromyodynia " category, the traditional Chinese medical science thinks that ferritic is weak, space between skin and muscles is not solid, feels wind-cold damp pathogen again, is stranded in meridians, joint.Cause QI-blood circulation smooth, numbness yang channel arteries and veins and produce pain.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of Chinese medicine composition for the treatment of rheumatic arthritis and preparation method thereof, and Chinese medicine composition of the present invention is for oral administration to combine with external, and have definite curative effect to rheumatic arthritis, toxic and side effects is little.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of rheumatic arthritis, described Chinese medicine composition is made up of endo-medicine and external used medicine, the each raw medicinal material of described endo-medicine comprises: Caulis et Folium hedyotis hedyotideae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Pyrolae, Radix seu Caulis Verntilaginis Leiocarpae, Radix Cudraniae, Herba Passiflorae Wilsonii, Rhizoma Corydalis Decumbentis, Radix Celastri Orbiculati, Caulis et Radix Periplocae Forrestii, the Herba Blumeae Laciniatae, unmrellaleaf and Herba Adianti; The each raw medicinal material of described external used medicine comprises: Radix Aconiti Preparata, Flos Carthami, Fructus Psoraleae, Olibanum, Myrrha, Herba speranskiae tuberculatae, Herba Asari, Herba Epimedii, Rhizoma Corydalis, Herba Lycopodii, Radix Gentianae Macrophyllae, Rhizoma Atractylodis and Radix Glycyrrhizae.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material of endo-medicine is as follows: Caulis et Folium hedyotis hedyotideae 10 ~ 20 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 20 ~ 30 parts, Herba Pyrolae 5 ~ 15 parts, Radix seu Caulis Verntilaginis Leiocarpae 15 ~ 25 parts, Radix Cudraniae 25 ~ 35 parts, Herba Passiflorae Wilsonii 15 ~ 30 parts, Rhizoma Corydalis Decumbentis 10 ~ 20 parts, Radix Celastri Orbiculati 20 ~ 30 parts, Caulis et Radix Periplocae Forrestii 15 ~ 25 parts, the Herba Blumeae Laciniatae 8 ~ 25 parts, unmrellaleaf 18 ~ 36 parts and Herba Adianti 5 ~ 15 parts; The ratio of weight and number of each raw medicinal material of described external used medicine is as follows: Radix Aconiti Preparata 5 ~ 15 parts, 20 ~ 30 parts, Flos Carthami, Fructus Psoraleae 10 ~ 20 parts, Olibanum 15 ~ 25 parts, Myrrha 15 ~ 25 parts, Herba speranskiae tuberculatae 25 ~ 35 parts, Herba Asari 20 ~ 30 parts, Herba Epimedii 15 ~ 25 parts, Rhizoma Corydalis 25 ~ 35 parts, Herba Lycopodii 10 ~ 20 parts, Radix Gentianae Macrophyllae 5 ~ 15 parts, Rhizoma Atractylodis 15 ~ 25 parts and 20 ~ 30 parts, Radix Glycyrrhizae.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material of endo-medicine is as follows: Caulis et Folium hedyotis hedyotideae 15 ~ 20 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 25 ~ 30 parts, Herba Pyrolae 5 ~ 10 parts, Radix seu Caulis Verntilaginis Leiocarpae 20 ~ 25 parts, Radix Cudraniae 30 ~ 35 parts, Herba Passiflorae Wilsonii 15 ~ 25 parts, Rhizoma Corydalis Decumbentis 10 ~ 15 parts, Radix Celastri Orbiculati 25 ~ 30 parts, Caulis et Radix Periplocae Forrestii 20 ~ 25 parts, the Herba Blumeae Laciniatae 8 ~ 16 parts, unmrellaleaf 22 ~ 30 parts and Herba Adianti 5 ~ 8 parts; The ratio of weight and number of each raw medicinal material of described external used medicine is as follows: Radix Aconiti Preparata 5 ~ 10 parts, 25 ~ 30 parts, Flos Carthami, Fructus Psoraleae 15 ~ 20 parts, Olibanum 20 ~ 25 parts, Myrrha 15 ~ 20 parts, Herba speranskiae tuberculatae 30 ~ 35 parts, Herba Asari 20 ~ 25 parts, Herba Epimedii 15 ~ 20 parts, Rhizoma Corydalis 30 ~ 35 parts, Herba Lycopodii 10 ~ 15 parts, Radix Gentianae Macrophyllae 5 ~ 10 parts, Rhizoma Atractylodis 15 ~ 20 parts and 25 ~ 30 parts, Radix Glycyrrhizae.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material of endo-medicine is as follows: Caulis et Folium hedyotis hedyotideae 16 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 28 parts, Herba Pyrolae 7 parts, Radix seu Caulis Verntilaginis Leiocarpae 20 parts, Radix Cudraniae 33 parts, Herba Passiflorae Wilsonii 21 parts, Rhizoma Corydalis Decumbentis 12 parts, Radix Celastri Orbiculati 28 parts, Caulis et Radix Periplocae Forrestii 22 parts, the Herba Blumeae Laciniatae 9 parts, unmrellaleaf 25 parts and Herba Adianti 6 parts; The ratio of weight and number of each raw medicinal material of described external used medicine is as follows: Radix Aconiti Preparata 7 parts, 28 parts, Flos Carthami, Fructus Psoraleae 18 parts, Olibanum 22 parts, Myrrha 17 parts, Herba speranskiae tuberculatae 30 parts, Herba Asari 23 parts, Herba Epimedii 18 parts, Rhizoma Corydalis 34 parts, Herba Lycopodii 12 parts, Radix Gentianae Macrophyllae 8 parts, Rhizoma Atractylodis 19 parts and 30 parts, Radix Glycyrrhizae.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material of endo-medicine is as follows: Caulis et Folium hedyotis hedyotideae 19 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 25 parts, Herba Pyrolae 8 parts, Radix seu Caulis Verntilaginis Leiocarpae 24 parts, Radix Cudraniae 31 parts, Herba Passiflorae Wilsonii 16 parts, Rhizoma Corydalis Decumbentis 13 parts, Radix Celastri Orbiculati 26 parts, Caulis et Radix Periplocae Forrestii 21 parts, the Herba Blumeae Laciniatae 13 parts, unmrellaleaf 23 parts and Herba Adianti 8 parts; The ratio of weight and number of each raw medicinal material of described external used medicine is as follows: Radix Aconiti Preparata 9 parts, 26 parts, Flos Carthami, Fructus Psoraleae 15 parts, Olibanum 25 parts, Myrrha 16 parts, Herba speranskiae tuberculatae 33 parts, Herba Asari 20 parts, Herba Epimedii 16 parts, Rhizoma Corydalis 31 parts, Herba Lycopodii 14 parts, Radix Gentianae Macrophyllae 10 parts, Rhizoma Atractylodis 15 parts and 26 parts, Radix Glycyrrhizae.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, wherein, the dosage form of described endo-medicine is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 1 ~ 2 hour, extract, filter acquisition first extracting solution, it is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 35 ~ 45 minutes, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the lactose of 0.05 ~ 0.15 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes;
The dosage form of described external used medicine is unguentum, and its preparation method comprises the following steps:
The first step: by described starting material with water wash clean, pull out and dry; Be ground into smalls with pulverizer, sieve and make 90 ~ 110 object smalls;
Second step: decoct in described ratio and ceaselessly stir putting into the pot that vegetable oil is housed, its temperature is 280 ~ 330 DEG C, and the time is 35 ~ 50 minutes, afterwards after filtration medicine juice;
3rd step: heated by above-mentioned medicine juice, its temperature is 180 ~ 220 DEG C, ceaselessly stirs simultaneously, endures 2 ~ 3 hours to obtain ointment.
Beneficial effect of the present invention: Chinese medicine composition of the present invention is for oral administration to combine with external, and have definite curative effect to rheumatic arthritis, toxic and side effects is little.
Detailed description of the invention
The invention provides a kind of Chinese medicine composition for the treatment of rheumatic arthritis, described Chinese medicine composition is made up of endo-medicine and external used medicine, and each raw medicinal material of described endo-medicine comprises: Caulis et Folium hedyotis hedyotideae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Pyrolae, Radix seu Caulis Verntilaginis Leiocarpae, Radix Cudraniae, Herba Passiflorae Wilsonii, Rhizoma Corydalis Decumbentis, Radix Celastri Orbiculati, Caulis et Radix Periplocae Forrestii, the Herba Blumeae Laciniatae, unmrellaleaf and Herba Adianti; The each raw medicinal material of described external used medicine comprises: Radix Aconiti Preparata, Flos Carthami, Fructus Psoraleae, Olibanum, Myrrha, Herba speranskiae tuberculatae, Herba Asari, Herba Epimedii, Rhizoma Corydalis, Herba Lycopodii, Radix Gentianae Macrophyllae, Rhizoma Atractylodis and Radix Glycyrrhizae.
In described Chinese medicine composition, the pharmacology of each raw medicinal material is as follows:
Caulis et Folium hedyotis hedyotideae: sweet, light; Cool.Return lung; Liver; Kidney channel.Heat-clearing and toxic substances removing.Main heatstroke; High heat; Intestinal is scorching; Skin eczema; Herpes zoster; Carbuncle pyogenic infections from tumour or sore." choosing of Simao, Yunnan Chinese herbal medicine ": detumescence dissipating blood stasis, dredge the meridian passage, connects muscle symplectic bone.Control the fracture injury of tendon and muscle, traumatic injury, rheumatic arthritis, lumbago and skelalgia.
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae): acrid in the mouth; Micro-hardship; Warm in nature.Wind-expelling pain-stopping; Promoting blood circulation and detumescence.Main air shows arthralgia pain; Headache; Toothache; Epigastric pain; Dysmenorrhea; Puerperal abdonimal pain; Treating swelling and pain by traumatic injury; Fracture; Skin ulcer swells." the practical Chinese herbal medicine in Guangxi newly selects ": promoting the circulation of QI to relieve pain, promoting blood circulation and detumescence, strengthening bone and muscle.Control acute rheumatic arthritis, stomachache, fracture, bruise, lumbago and skelalgia, paralysis.
Herba Pyrolae: sweet, bitter, temperature.Return liver, kidney channel.Wind-damp dispelling, bone and muscle strengthening, hemostasis.For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.
Radix seu Caulis Verntilaginis Leiocarpae: sweet; Temperature.Return lung; Spleen channel.Fill blood; Bone and muscle strengthening; Relax meridians.Main deficient qi and blood; Have through uncomfortable; Blood deficiency amenorrhea; Rheumatalgia; Traumatic injury; Lumbar muscle strain.
Radix Cudraniae: lightly seasoned; Micro-hardship; Cool in nature.Dispelling wind and removing obstruction in the collateral; Removing damp-heat; Removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome; Traumatic injury; Yellow cellulitis; Parotitis; Pulmonary tuberculosis; Gastric duodenal ulcer; Stranguria with turbid discharge; Distention of the abdomen caused by various parasites; Amenorrhea; Impairment caused by overstrain hemoptysis; Treatment carbuncle sore swells.
Herba Passiflorae Wilsonii: mildly bitter flavor; Warm in nature.Wind-damp dispelling; Invigorating the liver and kidney; Promoting blood flow to regulate menstruation, parasite killing preventing the attack (or recurrence) of malaria.The sliding pain of main air temperature; Sore waist and aching in the waist and the back; Hepatitis; Liver cirrhosis; Menoxenia; Traumatic injury; Fracture; Malaria; Ascariasis.
Rhizoma Corydalis Decumbentis: bitter; Pungent; Cool.Return liver; Kidney channel.Expelling wind and removing dampness; Relaxing muscles and tendons to promote blood circulation; Removing obstruction in the collateral to relieve pain; Blood pressure lowering.Main air wet arthritis; Apoplectic hemiplegia; Sciatica; Poliomyelitis sequela; Lumbar muscle strain; Injury from falling down; Hypertension.
Radix Celastri Orbiculati: pungent; Bitter; Flat.Return kidney; Bladder; Liver Channel.Expelling wind and removing dampness; Promoting blood circulation to restore menstrual flow; Subduing swelling and detoxicating.Main air pain of dampness syndrome; Treating swelling and pain by traumatic injury; Amenorrhea; Headache; Lumbago; Colicky; Dysentery; Discharging fresh blood stool; Swollen ulcer drug; Burn due to hot liquid or fire; Venom.
Caulis et Radix Periplocae Forrestii: sweet in the mouth; Pungent warm in nature; Mild toxicity.Expelling wind and removing dampness; To invigorate blood circulation eliminating carbuncle.Main traumatic injury; Rheumatic arthralgia; Amenorrhea; Acute mastitis; Fracture.
The Herba Blumeae Laciniatae: acrid in the mouth; Bitter; Slightly warm in nature.Expelling wind and removing dampness; Removing obstruction in the collateral to relieve pain.Main Common Cold; Wind syndrome of head is had a headache; Anemofrigid-damp arthralgia; Joint aches; Traumatic injury; Carbuncle furuncle; Eczema; Snakebite.
Unmrellaleaf: bitter, pungent, temperature.Poisonous.Blood circulation promoting and blood stasis dispelling, removing toxic substances and promoting subsidence of swelling.For traumatic injury, bones and muscles pain due to rheumatism, menoxenia, lower abdomen pain; Venom is controlled in external, carbuncle furuncle and phyma poison.
Herba Adianti: bitter; Cool; Nontoxic.Return liver; Kidney channel.Heat-clearing and toxic substances removing; Relieving stranguria by diuresis.Main cold, fever; Cough due to lung-heat; Diarrhea due to damp-heat; Dysentery; Stranguria with turbid discharge; Leukorrhagia; Acute mastitis; Scrofula; Furunculosis; Scald; Venom.
Radix Aconiti Preparata: pungent, bitter, heat; Poisonous.GUIXIN, liver,kidney,spleen warp.Expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Flos Carthami: pungent, temperature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
Fructus Psoraleae: pungent, bitter, temperature.Return kidney, spleen channel.Warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.
Olibanum: acrid in the mouth; Bitter; Tepor.GUIXIN; Liver; Spleen channel.Blood-activating and qi-promoting; Inducing menstruation to relieve menalgia; Detumescence and promoting granulation.Main trusted subordinate's pain; Rheumatic arthralgia; Amenorrhea dysmenorrhea; Traumatic injury stasis of blood pain; Swollen ulcer drug; Intestinal carbuncle; The sore being festered and unhealed.
Myrrha: bitter; Flat.Return liver; Spleen; The heart; Kidney channel.Promoting blood circulation and stopping pain; Detumescence and promoting granulation.Main breast abdomen stasis of blood pain; Dysmenorrhea; Amenorrhea; Lump in the abdomen; Traumatic injury; Carbuncle skin infection; Intestinal carbuncle; Conjunctival congestion and swelling pain.
Herba speranskiae tuberculatae: pungent; Warm in nature.Return lung; Liver Channel.Expelling wind and removing dampness; Relaxing muscles and tendons to promote blood circulation; Dissipating blood stasis for subsidence of swelling; Removing toxic substances ophthalmalgia.Main air pain of dampness syndrome; Muscles and bones contracture; The disturbance of lower legs due to pathogenic cold and dampness; Lumbar strain; Paralysis; Amenorrhea; Eczema scrotum; Furuncle toxic swelling.
Herba Asari: pungent, temperature.GUIXIN, lung, kidney channel.Expelling wind and cold, understand things pain-stopping, warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal obstruction nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
Herba Epimedii: acrid, sweet, warm.Return liver, kidney channel.Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
Rhizoma Corydalis: pungent, bitter, temperature.Return liver, spleen channel.Invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Herba Lycopodii: micro-hardship, pungent, temperature.Return liver,spleen,kidney warp.Expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.
Radix Gentianae Macrophyllae: pungent, bitter is flat.Return stomach, liver, gallbladder meridian.Wind-damp dispelling, clearing away damp-heat, stopping numbness pain.For rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, and infantile malnutrition generates heat.
Rhizoma Atractylodis: pungent, bitter, temperature.Return spleen, stomach, Liver Channel.Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material of endo-medicine is as follows: Caulis et Folium hedyotis hedyotideae 10 ~ 20 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 20 ~ 30 parts, Herba Pyrolae 5 ~ 15 parts, Radix seu Caulis Verntilaginis Leiocarpae 15 ~ 25 parts, Radix Cudraniae 25 ~ 35 parts, Herba Passiflorae Wilsonii 15 ~ 30 parts, Rhizoma Corydalis Decumbentis 10 ~ 20 parts, Radix Celastri Orbiculati 20 ~ 30 parts, Caulis et Radix Periplocae Forrestii 15 ~ 25 parts, the Herba Blumeae Laciniatae 8 ~ 25 parts, unmrellaleaf 18 ~ 36 parts and Herba Adianti 5 ~ 15 parts; The ratio of weight and number of each raw medicinal material of described external used medicine is as follows: Radix Aconiti Preparata 5 ~ 15 parts, 20 ~ 30 parts, Flos Carthami, Fructus Psoraleae 10 ~ 20 parts, Olibanum 15 ~ 25 parts, Myrrha 15 ~ 25 parts, Herba speranskiae tuberculatae 25 ~ 35 parts, Herba Asari 20 ~ 30 parts, Herba Epimedii 15 ~ 25 parts, Rhizoma Corydalis 25 ~ 35 parts, Herba Lycopodii 10 ~ 20 parts, Radix Gentianae Macrophyllae 5 ~ 15 parts, Rhizoma Atractylodis 15 ~ 25 parts and 20 ~ 30 parts, Radix Glycyrrhizae.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material of endo-medicine is as follows: Caulis et Folium hedyotis hedyotideae 15 ~ 20 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 25 ~ 30 parts, Herba Pyrolae 5 ~ 10 parts, Radix seu Caulis Verntilaginis Leiocarpae 20 ~ 25 parts, Radix Cudraniae 30 ~ 35 parts, Herba Passiflorae Wilsonii 15 ~ 25 parts, Rhizoma Corydalis Decumbentis 10 ~ 15 parts, Radix Celastri Orbiculati 25 ~ 30 parts, Caulis et Radix Periplocae Forrestii 20 ~ 25 parts, the Herba Blumeae Laciniatae 8 ~ 16 parts, unmrellaleaf 22 ~ 30 parts and Herba Adianti 5 ~ 8 parts; The ratio of weight and number of each raw medicinal material of described external used medicine is as follows: Radix Aconiti Preparata 5 ~ 10 parts, 25 ~ 30 parts, Flos Carthami, Fructus Psoraleae 15 ~ 20 parts, Olibanum 20 ~ 25 parts, Myrrha 15 ~ 20 parts, Herba speranskiae tuberculatae 30 ~ 35 parts, Herba Asari 20 ~ 25 parts, Herba Epimedii 15 ~ 20 parts, Rhizoma Corydalis 30 ~ 35 parts, Herba Lycopodii 10 ~ 15 parts, Radix Gentianae Macrophyllae 5 ~ 10 parts, Rhizoma Atractylodis 15 ~ 20 parts and 25 ~ 30 parts, Radix Glycyrrhizae.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material of endo-medicine is as follows: Caulis et Folium hedyotis hedyotideae 16 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 28 parts, Herba Pyrolae 7 parts, Radix seu Caulis Verntilaginis Leiocarpae 20 parts, Radix Cudraniae 33 parts, Herba Passiflorae Wilsonii 21 parts, Rhizoma Corydalis Decumbentis 12 parts, Radix Celastri Orbiculati 28 parts, Caulis et Radix Periplocae Forrestii 22 parts, the Herba Blumeae Laciniatae 9 parts, unmrellaleaf 25 parts and Herba Adianti 6 parts; The ratio of weight and number of each raw medicinal material of described external used medicine is as follows: Radix Aconiti Preparata 7 parts, 28 parts, Flos Carthami, Fructus Psoraleae 18 parts, Olibanum 22 parts, Myrrha 17 parts, Herba speranskiae tuberculatae 30 parts, Herba Asari 23 parts, Herba Epimedii 18 parts, Rhizoma Corydalis 34 parts, Herba Lycopodii 12 parts, Radix Gentianae Macrophyllae 8 parts, Rhizoma Atractylodis 19 parts and 30 parts, Radix Glycyrrhizae.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material of endo-medicine is as follows: Caulis et Folium hedyotis hedyotideae 19 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 25 parts, Herba Pyrolae 8 parts, Radix seu Caulis Verntilaginis Leiocarpae 24 parts, Radix Cudraniae 31 parts, Herba Passiflorae Wilsonii 16 parts, Rhizoma Corydalis Decumbentis 13 parts, Radix Celastri Orbiculati 26 parts, Caulis et Radix Periplocae Forrestii 21 parts, the Herba Blumeae Laciniatae 13 parts, unmrellaleaf 23 parts and Herba Adianti 8 parts; The ratio of weight and number of each raw medicinal material of described external used medicine is as follows: Radix Aconiti Preparata 9 parts, 26 parts, Flos Carthami, Fructus Psoraleae 15 parts, Olibanum 25 parts, Myrrha 16 parts, Herba speranskiae tuberculatae 33 parts, Herba Asari 20 parts, Herba Epimedii 16 parts, Rhizoma Corydalis 31 parts, Herba Lycopodii 14 parts, Radix Gentianae Macrophyllae 10 parts, Rhizoma Atractylodis 15 parts and 26 parts, Radix Glycyrrhizae.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, wherein, the dosage form of described endo-medicine is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 1 ~ 2 hour, extract, filter acquisition first extracting solution, it is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 35 ~ 45 minutes, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the lactose of 0.05 ~ 0.15 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes;
The dosage form of described external used medicine is unguentum, and its preparation method comprises the following steps:
The first step: by described starting material with water wash clean, pull out and dry; Be ground into smalls with pulverizer, sieve and make 90 ~ 110 object smalls;
Second step: decoct in described ratio and ceaselessly stir putting into the pot that vegetable oil is housed, its temperature is 280 ~ 330 DEG C, and the time is 35 ~ 50 minutes, afterwards after filtration medicine juice;
3rd step: heated by above-mentioned medicine juice, its temperature is 180 ~ 220 DEG C, ceaselessly stirs simultaneously, endures 2 ~ 3 hours to obtain ointment.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1 tablet (endo-medicine)
Get Caulis et Folium hedyotis hedyotideae 160g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 280g, Herba Pyrolae 70g, Radix seu Caulis Verntilaginis Leiocarpae 200g, Radix Cudraniae 330g, Herba Passiflorae Wilsonii 210g, Rhizoma Corydalis Decumbentis 120g, Radix Celastri Orbiculati 280g, Caulis et Radix Periplocae Forrestii 220g, Herba Blumeae Laciniatae 90g, unmrellaleaf 250g and Herba Adianti 60g;
Its preparation method comprises the following steps:
The first step: each for described Chinese medicine component is mixed in proportion, adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 85%, reflux 2 hours, extract, filter acquisition first extracting solution, it is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 times again, reflux 45 minutes, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 hours, pulverize and sieve acquisition 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.3 times, the lactose of 0.1 times, the starch of 0.15 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, dry, add the magnesium stearate relative to micropowders quality 0.02 times, granulate, tabletting, makes.
Embodiment 2 unguentum (external used medicine)
Get Radix Aconiti Preparata 70g, Flos Carthami 280g, Fructus Psoraleae 180g, Olibanum 220g, Myrrha 170g, Herba speranskiae tuberculatae 300g, Herba Asari 230g, Herba Epimedii 180g, Rhizoma Corydalis 340g, Herba Lycopodii 120g, Radix Gentianae Macrophyllae 80g, Rhizoma Atractylodis 190g and Radix Glycyrrhizae 300g;
Its preparation method comprises the following steps:
The first step: by described starting material with water wash clean, pull out and dry; Be ground into smalls with pulverizer, sieve and make 100 object smalls;
Second step: decoct in described ratio and ceaselessly stir putting into the pot that vegetable oil is housed, its temperature is 300 DEG C, and the time is 50 minutes, afterwards after filtration medicine juice;
3rd step: heated by above-mentioned medicine juice, its temperature is 190 DEG C, ceaselessly stirs simultaneously, endures 3 hours to obtain ointment.
Toxicity test:
Oral medicine acute toxicity testing: application mice 60, male and female half and half, body weight 28-38g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 7.64g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 38.2 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>38.2 crude drug/kg, every day, maximum dosage-feeding was 76.4 crude drugs/kg/ day.Chinese medicine composition clinical application amount of the present invention be 7.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.127g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 33g) oral administration gavage Chinese medicine composition of the present invention is 602 times of quantity.Therefore Chinese medicine composition acute toxicity of the present invention is extremely low, clinical drug safety.
Oral medicine long term toxicity test: Chinese medicine composition embodiment 1 tablet of the present invention presses 13.45,20.68 and 39.12g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine composition of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Medicine for external use toxicity test:
1, experimental technique
Depilatory is evenly coated by 4 groups of Cavia porcelluss (often organizing 15) spinal column both sides, back, makes unhairing scope about 40 square centimeters.Clean depilatory returns cage to observe 24 hours, wherein three groups, often organize Cavia porcellus and be coated with Chinese medicine preparation externally used paste 0.3,0.5 of the present invention and 0.8ml respectively, respectively containing crude drug 95mg, 188mg and 370mg, another group is coated with solvent 0.8ml, every twice-daily, continuous one week, after experiment terminates, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin do pathological examination.
2, result
Above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, matched group no significant difference, histopathologic examination, the medication group heart, liver, kidney and depilation skin and the matched group more also no significant difference such as extremity are movable.
Result is pointed out, and Chinese medicine for external application of the present invention, without local irritant effect, also has no general toxicity performance.Show Chinese medicine for external application use safety of the present invention.
Clinical data:
Case selection: whole 78 routine cases are my Out-patient Department patient of in October, 2010 ~ 2013 year August.Be divided into treatment group and matched group at random, wherein treatment group 40 people, male 15 people, women 25 people, 20 ~ 63 years old age; Matched group 38 people, male 16 people, women 22 people, 19 ~ 61 years old age.Two groups in age, sex, clinical manifestation etc. through statistical analysis there was no significant difference (p>0.05).
Diagnostic criteria: the standard formulated according to the academic conference of Society of Internal Medicine of Chinese Medical Association Second National rheumatism: 1, have hemolytic streptococcal infection history before disease more; 2, extremities joint wandering pain or swell and ache; 3, affected joints red and swollen heat pain, movable function is limited, and some cases can have low grade fever concurrently, erythema nodosum or erythema iris, cardiopulmonary pathological changes etc.; 4, lab testing: active stage erythrocyte sedimentation rate speed, how normal nonmobile phase is; 5, x-ray inspection: the rarely seen soft tissue swelling of affected joints, without bone lesion.
Therapeutic Method:
Treatment group: take the embodiment of the present invention 1 tablet every day 3 times, each 3; Smear the embodiment of the present invention 2 unguentum in affected part, once a day.15 days courses for the treatment of.
Matched group: oral western medicine ibuprofen 0.3g/ time, every day 3 times.15 days courses for the treatment of.
Curative effect judging standard: 1, clinical recovery: affected joints swells and ache disappearance, joint movement function recovers normal, erythrocyte sedimentation rate and anti-" O " continuous be for 3 times normal value (monthly 1 time); 2, effective: affected joints swells and ache and is clearly better, movable joint recovers normal substantially, and erythrocyte sedimentation rate and anti-" O " obviously decline; 3, effective: swelling and ache of affected joints is improved, affected joints movable violent after also some swells and ache, erythrocyte sedimentation rate and anti-" O " decline; 4, invalid: after two courses for the treatment of of taking medicine, affected joints swells and ache without obviously alleviating, and movable function is still limited, erythrocyte sedimentation rate is unchanged with anti-" O ".
Therapeutic outcome: after treating two courses for the treatment of, statistical result sees the following form.
| ? | n | Clinical recovery | Effective | Effectively | Invalid | Effectively total |
| Treatment group | 40 | 10 | 20 | 8 | 2 | 38(95.0％) |
| Matched group | 38 | 1 | 18 | 12 | 7 | 31(81.6％) |
Concrete case: Shao, women, 44 years old.Have and occupy wetland history for a long time, symptom: grade fever symptom, the gonalgia is red and swollen, recurrent exerbation.Be diagnosed as rheumatic arthritis.Take Chinese medicine preparation embodiment 1 tablet of the present invention every day 3 times, each 3, and be coated with the embodiment of the present invention 2 unguentum in knee affected part, every day 1 time, after treating for 1 course for the treatment of, clinically control recovery from illness, follow up a case by regular visits to and do not fall ill for 1 year.
Claims (8)
1. treat a Chinese medicine composition for rheumatic arthritis, it is characterized in that, described Chinese medicine composition is made up of endo-medicine and external used medicine, the each raw medicinal material of described endo-medicine comprises: Caulis et Folium hedyotis hedyotideae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Pyrolae, Radix seu Caulis Verntilaginis Leiocarpae, Radix Cudraniae, Herba Passiflorae Wilsonii, Rhizoma Corydalis Decumbentis, Radix Celastri Orbiculati, Caulis et Radix Periplocae Forrestii, the Herba Blumeae Laciniatae, unmrellaleaf and Herba Adianti; The each raw medicinal material of described external used medicine comprises: Radix Aconiti Preparata, Flos Carthami, Fructus Psoraleae, Olibanum, Myrrha, Herba speranskiae tuberculatae, Herba Asari, Herba Epimedii, Rhizoma Corydalis, Herba Lycopodii, Radix Gentianae Macrophyllae, Rhizoma Atractylodis and Radix Glycyrrhizae.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material of endo-medicine is as follows: Caulis et Folium hedyotis hedyotideae 10 ~ 20 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 20 ~ 30 parts, Herba Pyrolae 5 ~ 15 parts, Radix seu Caulis Verntilaginis Leiocarpae 15 ~ 25 parts, Radix Cudraniae 25 ~ 35 parts, Herba Passiflorae Wilsonii 15 ~ 30 parts, Rhizoma Corydalis Decumbentis 10 ~ 20 parts, Radix Celastri Orbiculati 20 ~ 30 parts, Caulis et Radix Periplocae Forrestii 15 ~ 25 parts, the Herba Blumeae Laciniatae 8 ~ 25 parts, unmrellaleaf 18 ~ 36 parts and Herba Adianti 5 ~ 15 parts; The ratio of weight and number of each raw medicinal material of described external used medicine is as follows: Radix Aconiti Preparata 5 ~ 15 parts, 20 ~ 30 parts, Flos Carthami, Fructus Psoraleae 10 ~ 20 parts, Olibanum 15 ~ 25 parts, Myrrha 15 ~ 25 parts, Herba speranskiae tuberculatae 25 ~ 35 parts, Herba Asari 20 ~ 30 parts, Herba Epimedii 15 ~ 25 parts, Rhizoma Corydalis 25 ~ 35 parts, Herba Lycopodii 10 ~ 20 parts, Radix Gentianae Macrophyllae 5 ~ 15 parts, Rhizoma Atractylodis 15 ~ 25 parts and 20 ~ 30 parts, Radix Glycyrrhizae.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material of endo-medicine is as follows: Caulis et Folium hedyotis hedyotideae 15 ~ 20 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 25 ~ 30 parts, Herba Pyrolae 5 ~ 10 parts, Radix seu Caulis Verntilaginis Leiocarpae 20 ~ 25 parts, Radix Cudraniae 30 ~ 35 parts, Herba Passiflorae Wilsonii 15 ~ 25 parts, Rhizoma Corydalis Decumbentis 10 ~ 15 parts, Radix Celastri Orbiculati 25 ~ 30 parts, Caulis et Radix Periplocae Forrestii 20 ~ 25 parts, the Herba Blumeae Laciniatae 8 ~ 16 parts, unmrellaleaf 22 ~ 30 parts and Herba Adianti 5 ~ 8 parts; The ratio of weight and number of each raw medicinal material of described external used medicine is as follows: Radix Aconiti Preparata 5 ~ 10 parts, 25 ~ 30 parts, Flos Carthami, Fructus Psoraleae 15 ~ 20 parts, Olibanum 20 ~ 25 parts, Myrrha 15 ~ 20 parts, Herba speranskiae tuberculatae 30 ~ 35 parts, Herba Asari 20 ~ 25 parts, Herba Epimedii 15 ~ 20 parts, Rhizoma Corydalis 30 ~ 35 parts, Herba Lycopodii 10 ~ 15 parts, Radix Gentianae Macrophyllae 5 ~ 10 parts, Rhizoma Atractylodis 15 ~ 20 parts and 25 ~ 30 parts, Radix Glycyrrhizae.
4. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material of endo-medicine is as follows: Caulis et Folium hedyotis hedyotideae 16 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 28 parts, Herba Pyrolae 7 parts, Radix seu Caulis Verntilaginis Leiocarpae 20 parts, Radix Cudraniae 33 parts, Herba Passiflorae Wilsonii 21 parts, Rhizoma Corydalis Decumbentis 12 parts, Radix Celastri Orbiculati 28 parts, Caulis et Radix Periplocae Forrestii 22 parts, the Herba Blumeae Laciniatae 9 parts, unmrellaleaf 25 parts and Herba Adianti 6 parts; The ratio of weight and number of each raw medicinal material of described external used medicine is as follows: Radix Aconiti Preparata 7 parts, 28 parts, Flos Carthami, Fructus Psoraleae 18 parts, Olibanum 22 parts, Myrrha 17 parts, Herba speranskiae tuberculatae 30 parts, Herba Asari 23 parts, Herba Epimedii 18 parts, Rhizoma Corydalis 34 parts, Herba Lycopodii 12 parts, Radix Gentianae Macrophyllae 8 parts, Rhizoma Atractylodis 19 parts and 30 parts, Radix Glycyrrhizae.
5. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material of endo-medicine is as follows: Caulis et Folium hedyotis hedyotideae 19 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 25 parts, Herba Pyrolae 8 parts, Radix seu Caulis Verntilaginis Leiocarpae 24 parts, Radix Cudraniae 31 parts, Herba Passiflorae Wilsonii 16 parts, Rhizoma Corydalis Decumbentis 13 parts, Radix Celastri Orbiculati 26 parts, Caulis et Radix Periplocae Forrestii 21 parts, the Herba Blumeae Laciniatae 13 parts, unmrellaleaf 23 parts and Herba Adianti 8 parts; The ratio of weight and number of each raw medicinal material of described external used medicine is as follows: Radix Aconiti Preparata 9 parts, 26 parts, Flos Carthami, Fructus Psoraleae 15 parts, Olibanum 25 parts, Myrrha 16 parts, Herba speranskiae tuberculatae 33 parts, Herba Asari 20 parts, Herba Epimedii 16 parts, Rhizoma Corydalis 31 parts, Herba Lycopodii 14 parts, Radix Gentianae Macrophyllae 10 parts, Rhizoma Atractylodis 15 parts and 26 parts, Radix Glycyrrhizae.
6. the Chinese medicine composition described in claim 1 to 5, is characterized in that, the dosage form of described endo-medicine is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 1 ~ 2 hour, extract, filter acquisition first extracting solution, it is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 35 ~ 45 minutes, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the lactose of 0.05 ~ 0.15 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.
7. the Chinese medicine composition described in claim 1 to 5, is characterized in that, the dosage form of described external used medicine is unguentum, and its preparation method comprises the following steps:
The first step: by described starting material with water wash clean, pull out and dry; Be ground into smalls with pulverizer, sieve and make 90 ~ 110 object smalls;
Second step: decoct in described ratio and ceaselessly stir putting into the pot that vegetable oil is housed, its temperature is 280 ~ 330 DEG C, and the time is 35 ~ 50 minutes, afterwards after filtration medicine juice;
3rd step: heated by above-mentioned medicine juice, its temperature is 180 ~ 220 DEG C, ceaselessly stirs simultaneously, endures 2 ~ 3 hours to obtain ointment.
8. a preparation method for the Chinese medicine composition described in claim 1 to 5, is characterized in that, the dosage form of described endo-medicine is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 1 ~ 2 hour, extract, filter acquisition first extracting solution, it is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 35 ~ 45 minutes, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the lactose of 0.05 ~ 0.15 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes;
The dosage form of described external used medicine is unguentum, and its preparation method comprises the following steps:
The first step: by described starting material with water wash clean, pull out and dry; Be ground into smalls with pulverizer, sieve and make 90 ~ 110 object smalls;
Second step: decoct in described ratio and ceaselessly stir putting into the pot that vegetable oil is housed, its temperature is 280 ~ 330 DEG C, and the time is 35 ~ 50 minutes, afterwards after filtration medicine juice;
3rd step: heated by above-mentioned medicine juice, its temperature is 180 ~ 220 DEG C, ceaselessly stirs simultaneously, endures 2 ~ 3 hours to obtain ointment.
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| CN111956773A (en) * | 2020-08-26 | 2020-11-20 | 周璇 | Moxibustion stick and preparation method thereof |
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Inventor after: Mou Jie Inventor after: Liu Jinlun Inventor before: Gu Weile Inventor before: Xue Weiqiang Inventor before: Xue Jun Inventor before: Luan Yingjie Inventor before: Zhang Xiaoyan Inventor before: Xu Meihua Inventor before: Tang Xiaochun Inventor before: Li Yan |
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Effective date of registration: 20151231 Address after: 276403 Second People's Hospital of Yishui County, 2 health Road, Ma Ma Town, Linyi, Shandong, Yishui Applicant after: Mou Jie Address before: 266599 Huangdao Hospital of Huangdao District, Hainan Island, Shandong, China, No. 158, Qingdao District, Qingdao Applicant before: Gu Weile |
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