CN104719828A - Sweetener composition and oral care composition composed of same, and application - Google Patents
Sweetener composition and oral care composition composed of same, and application Download PDFInfo
- Publication number
- CN104719828A CN104719828A CN201510145722.0A CN201510145722A CN104719828A CN 104719828 A CN104719828 A CN 104719828A CN 201510145722 A CN201510145722 A CN 201510145722A CN 104719828 A CN104719828 A CN 104719828A
- Authority
- CN
- China
- Prior art keywords
- weight
- percentage
- oral care
- agent
- sweetener
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a sweetener composition and an oral care composition composed of the same, and an application. The sweetener composition comprises sucralose, stevioside and a high polymer material, wherein the weight ratio of the sucralose to the stevioside is 1: (0.1 to 20); the weight ratio of the sucralose and the stevioside to the high polymer material is 1: (0.01 to 10). The oral care composition composed of the sweetener composition further contains one or more carrier materials acceptable in the stomatological department. The oral care composition prepared by the sweetener composition disclosed by the invention is capable of improving sweetness, low in cost, good in safety, excellent in taste, and good in stability.
Description
Technical field
The invention belongs to food additives field, be specifically related to oral care composition and the application of a kind of sweetener composition and composition thereof.
Background technology
The offending aftertaste that other compositions bring is covered in the effect of sweetener in toothpaste, and gives sweet sense.At present, the sweetener generally used in domestic toothpaste is saccharin sodium, but due to saccharin sodium weak flavor, have obviously bitter, and its security exists dispute always, constantly reduces in the use amount of American-European countries; Meanwhile, its less stable; The Chinese government also takes the policy reducing saccharin sodium consumption, and regulation does not allow to use in infant foods.In recent years, security of new generation is higher, the development of performance better high sweetener is very fast, and market has wide range of applications, as sweet in Sucralose, 3,4-Dihydro-6-methyl-1,2,3-oxathiazin-4-one 2,2-dioxide potassium salt, Aspartame, knob, steviol glycoside, glycyrrhizin etc.But single high sweetener is because of factors such as security, cost, sugariness, local flavor, stability, can not meet the sweet taste requirement of actual product completely, therefore be necessary sweetener to carry out composite.Partly other novel high-intensity sweetener is as Sucralose, Aspartame, although sugariness is higher, and sweet taste is pure, without bad aftertaste, because cost and stability factor cause its application limited.Composite sweetener refers to a class sweetener of two or more sweetener compound use, thus reaches the object strengthening sweet taste and local flavor, cover or make up the bad aftertaste of the other side, the mouthfeel of improving product while reducing costs.
Composite sweetener have easy to use, stability is high, sugariness is high, sweet taste is pure, heat is low, cost low (at least waiting under sugariness condition and can not exceed Price of Sugar), thus become sweetener exploitation, application an important directions.The overall mouthfeel of part composite sweetener and local flavor are all satisfied, but sugariness is not high, need increase the consumption of composite sweetener in formulation of tooth-paste, and high salinity will cause formula system to occur wild effect.Another part composite sweetener, although it can effectively improve sweet sense and local flavor, sugariness also significantly improves, and the sweet sense persistence of composite sweetener is not good, causes its mouthfeel full not.
Sweetener in oral care product requires that it is under the effect of essence, can feel pure sweet taste, and this sweetener can cover the taste of other compositions, the bitter taste of such as Chinese medicine.Therefore, if the short sweetness of sweetener own or local flavor are not suitable for, will the bitterness sense covering some toothpaste matrix compositions be unfavorable for, thus affect the mouthfeel of toothpaste.If the essence adopted in most of toothpaste is mint aroma or other feature odor types, there is perfume (or spice) sense to a certain degree and cool feeling, mask the mouthfeel of sweetener in a way, cause its sweet sense not send out in time.Even if if by the composite sugariness that effectively can solve sweetener, avoid mutual bad flavor, but the mouthfeel of sweetener is not good when practical application.So the impact of the sugariness of sweetener itself, local flavor and essence causes the sweet sense impression reduction of sweetener in oral care product, even affects the overall taste flavor of product.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, provide a kind of have improve sweet taste, cost is low, security good, mouthfeel is superior, the sweetener composition of good stability and the oral care composition of composition thereof, and is applied to the oral care product comprising toothpaste, mouthwash, powder, confectionery.Described oral care composition both ensure that sugariness and the local flavor of composite sweetener, masked again the bad flavor of other compositions in oral care composition, improved the taste characteristics of oral care product.
Object of the present invention is achieved through the following technical solutions:
A kind of sweetener composition, comprises Sucralose, steviol glycoside and macromolecular material.
Sucralose is a kind of high sweetener of Prof. Du Yucang, and its sweet taste is pure, and approximate sucrose, sugariness multiple is high, and noenergy, stability and security are good, are widely used.Steviol glycoside is a kind of natural high sweetener, is to extract from the feverfew Stevia leaves on the ground such as original South America Paraguay, Brazil, has the terpenes glycocide of strong sweet taste, is widely used in varieties of food items, beverage, daily chemical industry product.Steviol glycoside cool taste is sweet, security and good stability, and calorific value is low, is the wide new sugared source of development prospect.
Preferably, described macromolecular material has adhesion function, be selected from ethylene methacrylic ether-copolymer-maleic anhydride, acrylic homopolymer, acrylic copolymer, vinyl-based homopolymers, vinyl-based copolymer, cellulose family, cellulose ethers, gelatin, sodium alginate one or more.Ethylene methacrylic ether-copolymer-maleic anhydride is as Gantrez AN-119 etc., acrylic homopolymer and copolymer are as polyacrylic acid, carbopol etc., vinyl-based equal thing is as polyvinylpyrrolidone etc., and cellulose ethers is as hydroxypropyl cellulose, hydroxypropyl methylcellulose etc.
Preferably, described macromolecular material is selected from hydroxypropyl methylcellulose and polyvinylpyrrolidone, and this adhesion material molecular weight is large, can be trapped in mucous membrane of mouth place, extends functional component action time in the oral cavity, improves product efficacy.
After macromolecule adhesion material of the present invention and composite sweetener combine, effectively can control sweetener residence time in the oral cavity, thus the sweet sense sustained release making composite sweetener out, improve the sweet sense persistence of sweetener.This sweetener composition can improve the sweet sense of oral care product, keeps the pure sweet taste of sweetener itself, and effectively covers the bad bitterness sense of other compositions in oral care product, improves the mouthfeel plumpness of product.
Preferably, the weight ratio of described Sucralose and steviol glycoside is 1:(0.1-20); The weight ratio of described Sucralose and steviol glycoside and macromolecular material is 1:(0.01-10).
Preferably, the weight ratio of described Sucralose and steviol glycoside is 1:(0.2-10); The weight ratio of described Sucralose and steviol glycoside and macromolecular material is 1:(0.1-1).
The invention provides another technical scheme: a kind of oral care composition, comprise described sweetener composition, and the carrier material that one or more departments of stomatology accept.
Preferably, comprise and be selected from following oral care active: calculus dentalis inhibitor, anticorrisive agent, NMF, rubbing agent, blowing agent, adhesive, flavor enhancement, surface-active, abrasive material, essence, antiseptic, antitack agent, caries preventive agent, desensitizer, brightening agent, breath freshening controlling agent, water and their mixture.
Preferably, described oral care composition comprises the sweetener composition of 0.05%-5% percentage by weight; Comprise the calculus dentalis inhibitor of 0.05%-5% percentage by weight; The anticorrisive agent of 0.05%-5% percentage by weight; The NMF of 20-80% percentage by weight; The blowing agent of 0.5-10% percentage by weight; The rubbing agent of 10-60% percentage by weight; The adhesive of 0.1-5% percentage by weight; The flavor enhancement of 0.05%-5% percentage by weight; The water of 5%-50% percentage by weight.
Preferably, described oral care composition comprises the sweetener composition of 0.1%-3% percentage by weight; Comprise the calculus dentalis inhibitor of 0.1-2% percentage by weight; The anticorrisive agent of 0.1-2% percentage by weight; The NMF of 25-70% percentage by weight; The blowing agent of 1%-5% percentage by weight; The rubbing agent of 15-50% percentage by weight; The adhesive of 0.1-3% percentage by weight; The flavor enhancement of 0.5%-2% percentage by weight; The water of 10%-45% percentage by weight.
Preferably, described calculus dentalis inhibitor is selected from as one or more in sodium pyrophosphate decahydrate, anhydrous sodium pyrophosphate, six defocusing sodium phosphates, sodium phosphate trimer, zinc citrate; Anticorrisive agent is selected from one or more in Sodium Benzoate, oxybenzene ester class; NMF is selected from one or more in glycerine, PEG-4000, sorbierite, propane diols; Blowing agent is selected from one or more in lauryl sodium sulfate, sodium lauroyl sarcosine, Cocoamidopropyl betaine; Rubbing agent is selected from one or more in calcium carbonate, silica; Adhesive is selected from one or more in sodium carboxymethylcellulose, xanthans; Described flavor enhancement is selected from one or more in essence, Natural menthol, coolant agent.
The application of a kind of oral care composition provided by the invention in toothpaste, mouthwash, tooth powder, mouthwass, lozenge, chewing gum.Oral care composition provided by the invention is preferably applied to actinal surface regularly, and preferred every day uses, and continues many days at least once a day; Or can every two days or three days once.Most preferably, described oral care composition is applied to actinal surface 1-3 time every day, continues at least 2 thoughtful 8 weeks or longer.In addition, oral care composition is applied in oral care product, and the sweet sense of sweetener can be made to discharge effectively constantly, and sweet sense persistence gets a promotion, and mouthfeel is more full.Comprise the oral care product good stability of described sweetener composition, and the sweet sense of product and local flavor obviously promote, thus improve the overall mouthfeel effect of oral care product.
Sweetener composition provided by the present invention forms by two kinds of high sweeteners are composite, i.e. Sucralose and steviol glycoside.Synergistic function because of Sucralose and steviol glycoside can significantly improve sugariness and the local flavor of sweetener, said composition is applied in oral care product, can covers the bad aftertaste of other compositions; Simultaneously, have after the macromolecular material of adhesion function and sweetener composition combine, the oral care product sweet sense rate of release in the oral cavity comprising described sweetener composition can be controlled, thus keep the natural sweet sense feature of sweetener itself, improve overall mouthfeel and the local flavor of product; In addition, the cost of material of described sweetener composition is low, the cost under sugariness condition such as can to reduce; Finally comprise the oral care composition good stability of described sweetener composition, reliable in quality, security is high and be widely used.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with embodiment, the present invention is further elaborated, but the scope of protection of present invention is not limited to the scope that embodiment is expressed.
Embodiment 1
| Composition | Formula 1 | Formula 2 | Formula 3 |
| Sucralose | 0.1 | 0.05 | 0.1 |
| Steviol glycoside | 0.1 | 0.35 | 0.1 |
| Hydroxypropyl methylcellulose | 0.05 | 0.1 | — |
| Sodium pyrophosphate | 0.5 | 0.3 | 0.5 |
| Methyl hydroxybenzoate | 0.15 | 0.15 | 0.15 |
| Sorbierite | 20 | 20 | 20 |
| Glycerine | 3 | — | 3 |
| PEG-4000 | 3 | 3 | 3 |
| Lauryl sodium sulfate | 2.4 | 2.2 | 2.4 |
| Calcium carbonate | 45 | 47 | 45 |
| Silica | 3 | 3 | 3 |
| Sodium carboxymethylcellulose | 0.5 | 0.4 | 0.5 |
| Xanthans | 0.5 | 0.6 | 0.5 |
| Essence | 1.2 | 1.05 | 1.2 |
| Water | 20.5 | 21.8 | 20.55 |
MC calcium carbonate toothpaste is prepared respectively by the formula 1-3 (recipe ingredient is by weight percentage) in above form:
1. by Sucralose, steviol glycoside, hydroxypropyl methylcellulose, sodium pyrophosphate, be added to the water dissolving, then add sorbierite, glycerine;
2. methyl hydroxybenzoate is added PEG-4000 hot melt, then add in the aqueous phase of step 1.
3. calcium carbonate, silica, sodium carboxymethylcellulose, xanthans, lauryl sodium sulfate mixing are uniformly dispersed;
4. combine and vacuum high-speed stirred 10-20 minute by the component of above 3 steps preparation;
5. in the lotion of step 4 preparation, add essence, fully mix under vacuum, disperse 10-15 minute, obtain the calcium carbonate toothpaste containing sweetener composition, be labeled as MC calcium carbonate toothpaste 1, MC calcium carbonate toothpaste 2 and MC calcium carbonate toothpaste 3 respectively.
Embodiment 2
| Composition | Formula 4 | Formula 5 | Formula 6 |
| Sucralose | 0.1 | 0.05 | 0.1 |
| Steviol glycoside | 0.05 | 0.3 | 0.05 |
| Hydroxypropyl methylcellulose | 0.02 | 0.1 | — |
| Sodium Benzoate | 0.2 | 0.25 | 0.2 |
| Sodium pyrophosphate | 0.3 | 0.2 | 0.3 |
| Sorbierite | 65 | 64 | 65 |
| Glycerine | 2 | 2 | 2 |
| PEG-4000 | 2 | 2 | 2 |
| Sldium lauryl sulfate | 2.4 | 2.2 | 2.4 |
| Silica | 18 | 18 | 18 |
| Sodium carboxymethylcellulose | 0.7 | 0.4 | 0.7 |
| Xanthans | — | 0.7 | — |
| Essence | 1.4 | 1.0 | 1.4 |
| Water | 7.83 | 8.8 | 7.85 |
| Composition | Formula 4 | Formula 5 | Formula 6 |
MC silica toothpaste is prepared respectively by the formula 4-6 (recipe ingredient is by weight percentage) in above form:
1. Sucralose, steviol glycoside, hydroxypropyl methylcellulose, sodium pyrophosphate, Sodium Benzoate are added to the water dissolving, then add sorbierite, glycerine, PEG-4000;
2. silica, sodium carboxymethylcellulose, xanthans, sldium lauryl sulfate mixing are uniformly dispersed;
3. combine and vacuum high-speed stirred 10-20 minute by two components of step 1 and 2 preparations;
4. in the lotion of step 3 preparation, add essence, fully mix under vacuum, disperse 10-15 minute, obtain the silica toothpaste containing sweetener composition, be labeled as MC silica toothpaste 4, MC silica toothpaste 5 and MC silica toothpaste 6 respectively.
Embodiment 3
| Composition | Formula 7 | Formula 8 |
| Sorbierite | 5 | 5 |
| Glycerine | 15 | 15 |
| Ethanol | 8 | 8 |
| Poloxamer | 1.0 | 1.0 |
| Methyl hydroxybenzoate | 0.15 | — |
| Sodium Benzoate | — | 0.2 |
| Sucralose | 0.05 | 0.05 |
| Steviol glycoside | 0.1 | 0.1 |
| Hydroxypropyl methylcellulose | 0.01 | — |
| Essence | 0.2 | 0.2 |
| Pigment | 0.1 | 0.1 |
| Water | 70.39 | 70.35 |
Oral care mouthrinse 7 and oral care mouthrinse 8 is prepared respectively by the formula 7-8 (recipe ingredient by weight percentage) in above form.
Embodiment 4
The quality stability of the product prepared by test formulations 1-8, carried out the mouthwash at normal temperatures aging trimestral stability test of toothpaste under 45 DEG C of high temperature and prepared by embodiment 3 prepared by embodiment 1-2 respectively, stability result is as follows:
As can be seen from test result above, the oral-care toothpaste prepared by embodiment 1-2 was still stablized after 3 months; Oral care mouthrinse prepared by embodiment 3 is normal after 3 months on fragrance and color, clarity was still clarified at 3 months later, still stablized with rear stability at 3 months, the oral care composition good stability be made up of sweetener composition provided by the invention is described.
Embodiment 5
The toothpaste of embodiment 5 prepared by testing example 1-2 and the mouthwash prepared by embodiment 3 on the impact of the effect of the sweet sense and overall mouthfeel that improve oral care product, thus carry out mouthfeel investigation.
Sensory test object is 10 people groups, is used in a continuous manner evaluated after one week by panelists, and experimenter brushes teeth twice (morning 10:00, afternoon 15:00) every day, then fills in the sensory test questionnaire designed.Use about 1.0 grams of sample toothpaste or 10mL mouthwash and subject per brushes teeth.
Test result is as follows:
Above test result shows, be added with the oral care composition that the sweet sense of oral care composition (as filled a prescription 1, formula 2, formula 4, formula 5, formula 7) of the sweetener composition composition of macromolecular material and the effect entirety of overall mouthfeel are better than not being added with the sweetener composition composition of macromolecular material, namely only containing composite sweetener combination product (as filled a prescription 3, formula 6, formula 8).
The announcement of book and instruction according to the above description, those skilled in the art in the invention can also change above-mentioned embodiment and revise.Therefore, the present invention is not limited to detailed description of the invention disclosed and described above, also should fall in the protection domain of claim of the present invention modifications and changes more of the present invention.In addition, although employ some specific terms in this description, these terms just for convenience of description, do not form any restriction to the present invention.
Claims (10)
1. a sweetener composition, is characterized in that, comprises Sucralose, steviol glycoside and macromolecular material.
2. a kind of sweetener composition according to claim 1, it is characterized in that, described macromolecular material be selected from ethylene methacrylic ether-copolymer-maleic anhydride, acrylic homopolymer, acrylic copolymer, vinyl-based homopolymers, vinyl-based copolymer, cellulose family, cellulose ethers, gelatin, sodium alginate one or more.
3. a kind of sweetener composition according to any one of claim 1 or 2, is characterized in that, the weight ratio of described Sucralose and steviol glycoside is 1:(0.1-20); The weight ratio of described Sucralose and steviol glycoside and macromolecular material is 1:(0.01-10).
4. a kind of sweetener composition according to claim 3, is characterized in that, the weight ratio of described Sucralose and steviol glycoside is 1:(0.2-10); The weight ratio of described Sucralose and steviol glycoside and macromolecular material is 1:(0.1-1).
5. an oral care composition, is characterized in that, comprises the carrier material that the sweetener composition described in any one of claim 1-4 accepts with one or more departments of stomatology.
6. a kind of oral care composition according to claim 5, it is characterized in that, comprise and be selected from following oral care active: calculus dentalis inhibitor, anticorrisive agent, NMF, rubbing agent, blowing agent, adhesive, flavor enhancement, surface-active, abrasive material, essence, antiseptic, antitack agent, caries preventive agent, desensitizer, brightening agent, breath freshening controlling agent, water and their mixture.
7. a kind of oral care composition according to claim 6, is characterized in that, described oral care composition comprises the sweetener composition of 0.05%-5% percentage by weight; Comprise the calculus dentalis inhibitor of 0.05%-5% percentage by weight; The anticorrisive agent of 0.05%-5% percentage by weight; The NMF of 20-80% percentage by weight; The blowing agent of 0.5-10% percentage by weight; The rubbing agent of 10-60% percentage by weight; The adhesive of 0.1-5% percentage by weight; The flavor enhancement of 0.05%-5% percentage by weight; The water of 5%-50% percentage by weight.
8. a kind of oral care composition according to claim 7, is characterized in that, described oral care composition comprises the sweetener composition of 0.1%-3% percentage by weight; Comprise the calculus dentalis inhibitor of 0.1-2% percentage by weight; The anticorrisive agent of 0.1-2% percentage by weight; The NMF of 25-70% percentage by weight; The blowing agent of 1%-5% percentage by weight; The rubbing agent of 15-50% percentage by weight; The adhesive of 0.1-3% percentage by weight; The flavor enhancement of 0.5%-2% percentage by weight; The water of 10%-45% percentage by weight.
9. a kind of oral care composition according to any one of claim 6-8, is characterized in that, described calculus dentalis inhibitor is selected from as one or more in sodium pyrophosphate decahydrate, anhydrous sodium pyrophosphate, six defocusing sodium phosphates, sodium phosphate trimer, zinc citrate; Anticorrisive agent is selected from one or more in Sodium Benzoate, oxybenzene ester class; NMF is selected from one or more in glycerine, PEG-4000, sorbierite, propane diols; Blowing agent is selected from one or more in lauryl sodium sulfate, sodium lauroyl sarcosine, Cocoamidopropyl betaine; Rubbing agent be selected from calcium carbonate, silica one or more; Adhesive is selected from one or more in sodium carboxymethylcellulose, xanthans; Described flavor enhancement is selected from one or more in essence, Natural menthol, coolant agent.
10. the application of a kind of oral care composition in toothpaste, mouthwash, tooth powder, mouthwass, lozenge, chewing gum described in any one of claim 6-9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510145722.0A CN104719828A (en) | 2015-03-30 | 2015-03-30 | Sweetener composition and oral care composition composed of same, and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510145722.0A CN104719828A (en) | 2015-03-30 | 2015-03-30 | Sweetener composition and oral care composition composed of same, and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104719828A true CN104719828A (en) | 2015-06-24 |
Family
ID=53444691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510145722.0A Pending CN104719828A (en) | 2015-03-30 | 2015-03-30 | Sweetener composition and oral care composition composed of same, and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104719828A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021017137A1 (en) * | 2019-07-26 | 2021-02-04 | 深圳雾芯科技有限公司 | Chewing gum, e-liquid and use thereof |
| CN114010521A (en) * | 2021-11-17 | 2022-02-08 | 重庆登康口腔护理用品股份有限公司 | Antibacterial and antiseptic composition with good taste, oral care solution and preparation method thereof |
-
2015
- 2015-03-30 CN CN201510145722.0A patent/CN104719828A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021017137A1 (en) * | 2019-07-26 | 2021-02-04 | 深圳雾芯科技有限公司 | Chewing gum, e-liquid and use thereof |
| CN114010521A (en) * | 2021-11-17 | 2022-02-08 | 重庆登康口腔护理用品股份有限公司 | Antibacterial and antiseptic composition with good taste, oral care solution and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103140214B (en) | There is the oral care composition improving sweet taste | |
| US6169118B1 (en) | Flavor blend for masking unpleasant taste of zinc compounds | |
| JP5398102B2 (en) | Oral or throat bactericidal composition | |
| CN104719828A (en) | Sweetener composition and oral care composition composed of same, and application | |
| JP2011098916A (en) | Dentifrice composition | |
| JP5614020B2 (en) | Dentifrice composition | |
| JP5493732B2 (en) | Oral composition | |
| WO2018221621A1 (en) | Composition for use in oral cavity | |
| JP2002029952A (en) | Composition for dentifrice | |
| CN109350556A (en) | A kind of anti-caries toothpaste and preparation method thereof | |
| JP5570777B2 (en) | Oral composition | |
| JPH08175945A (en) | Composition for oral cavity | |
| CN101088397A (en) | Food sweetening agent | |
| JP2003026557A (en) | Composition for oral cavity | |
| JP2000302655A (en) | Composition for oral cavity | |
| JPH0772124B2 (en) | Oral composition | |
| JP2011073970A (en) | Composition for oral cavity or throat | |
| CN108685742B (en) | Low irritation oral compositions | |
| JP2020083833A (en) | Dentifrice composition | |
| WO2018221609A1 (en) | Dentifrice composition | |
| JP2018203734A (en) | Dentifrice composition and reducing agent of unpleasing taste | |
| KR20190035000A (en) | Flavoring composition in use of expressing corn flavor | |
| CN108354872A (en) | A kind of Chinese medicinal toothpaste and preparation method thereof | |
| CN112043618B (en) | Composite sweetener and application thereof in toothpaste | |
| CN111278408B (en) | Novel compositions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150624 |