CN104703986A - 厄他培南中间体的制备 - Google Patents

厄他培南中间体的制备 Download PDF

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Publication number
CN104703986A
CN104703986A CN201380053067.5A CN201380053067A CN104703986A CN 104703986 A CN104703986 A CN 104703986A CN 201380053067 A CN201380053067 A CN 201380053067A CN 104703986 A CN104703986 A CN 104703986A
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CN
China
Prior art keywords
formula
compound
salt
solvate
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380053067.5A
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English (en)
Chinese (zh)
Inventor
H·伦加尔
B·恩德尔
W·费尔曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of CN104703986A publication Critical patent/CN104703986A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201380053067.5A 2012-10-12 2013-10-11 厄他培南中间体的制备 Pending CN104703986A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12188351 2012-10-12
EP12188351.6 2012-10-12
PCT/EP2013/071252 WO2014057079A1 (en) 2012-10-12 2013-10-11 Preparation of ertapenem intermediates

Publications (1)

Publication Number Publication Date
CN104703986A true CN104703986A (zh) 2015-06-10

Family

ID=47022553

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380053067.5A Pending CN104703986A (zh) 2012-10-12 2013-10-11 厄他培南中间体的制备

Country Status (9)

Country Link
US (2) US9546171B2 (enExample)
EP (1) EP2906561A1 (enExample)
JP (1) JP2015533142A (enExample)
KR (1) KR20150065176A (enExample)
CN (1) CN104703986A (enExample)
AU (1) AU2013328585A1 (enExample)
CA (1) CA2887098A1 (enExample)
IN (1) IN2015DN02513A (enExample)
WO (1) WO2014057079A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113880839A (zh) * 2021-11-01 2022-01-04 石药集团中诺药业（石家庄）有限公司 一种厄他培南钠粗品的合成新方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2906561A1 (en) * 2012-10-12 2015-08-19 Sandoz AG Preparation of ertapenem intermediates

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5872250A (en) * 1997-07-30 1999-02-16 Merck & Co., Inc. Process for synthesizing carbapenem antibiotics
CN101935321A (zh) * 2010-07-20 2011-01-05 深圳市海滨制药有限公司 1β甲基碳青霉烯类抗生素的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
AR008255A1 (es) 1996-07-12 1999-12-29 Merck & Co Inc Procedimiento para sintetizar antibioticos de carbapenem
CA2293835C (en) 1997-06-16 2003-09-16 John M. Williams Stabilized carbapenem intermediates and synthetic use
JP2005508321A (ja) 2001-09-26 2005-03-31 メルク　エンド　カムパニー　インコーポレーテッド 結晶形態のエルタペネムナトリウム
CN100457760C (zh) * 2005-10-20 2009-02-04 上海交通大学 尔他培南钠盐的制备方法
US8293894B2 (en) 2006-11-20 2012-10-23 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
RU2575979C2 (ru) * 2009-04-30 2016-02-27 СиЭсПиСи ЧЖУНЦИ ФАРМАСЬЮТИКАЛ ТЕКНОЛОДЖИ (ШИЦЗЯЧЖУАН)КО., ЛТД. Способ получения промежуточного соединения эртапенема
US20110288289A1 (en) * 2010-05-19 2011-11-24 Savior Lifetec Corporation Preparation of Carbapenem Intermediate and Their Use
US8729260B2 (en) * 2010-05-19 2014-05-20 Savior Lifetec Corporation Process for the preparation of carbapenem using cabapenem intermediates and recovery of cabapenem
KR20120007331A (ko) 2010-07-14 2012-01-20 주식회사 경보제약 카르바페넴계 화합물들의 개선된 제조방법
CN102731502B (zh) 2011-04-13 2016-08-03 石药集团中奇制药技术（石家庄）有限公司 一种碳青霉烯抗生素的制备方法
CN102351861A (zh) * 2011-08-16 2012-02-15 湖南欧亚生物有限公司 一种厄他培南的工业化制备方法
CN102432611B (zh) * 2011-11-09 2013-11-20 上海希迈医药科技有限公司 一种双保护厄他培南结晶体及其制备方法
CN102731508A (zh) * 2012-07-03 2012-10-17 浙江海翔川南药业有限公司 一种晶体形式的厄他培南中间体及其制备方法和应用
EP2906561A1 (en) * 2012-10-12 2015-08-19 Sandoz AG Preparation of ertapenem intermediates

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5872250A (en) * 1997-07-30 1999-02-16 Merck & Co., Inc. Process for synthesizing carbapenem antibiotics
CN101935321A (zh) * 2010-07-20 2011-01-05 深圳市海滨制药有限公司 1β甲基碳青霉烯类抗生素的合成方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张义凤等: "碳青霉烯类抗生素厄他培南的合成", 《中国药科大学学报》, vol. 38, no. 4, 31 December 2007 (2007-12-31), pages 305 - 310 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113880839A (zh) * 2021-11-01 2022-01-04 石药集团中诺药业（石家庄）有限公司 一种厄他培南钠粗品的合成新方法

Also Published As

Publication number Publication date
US20150274732A1 (en) 2015-10-01
IN2015DN02513A (enExample) 2015-09-11
US20170166570A1 (en) 2017-06-15
JP2015533142A (ja) 2015-11-19
EP2906561A1 (en) 2015-08-19
US9546171B2 (en) 2017-01-17
KR20150065176A (ko) 2015-06-12
WO2014057079A1 (en) 2014-04-17
CA2887098A1 (en) 2014-04-17
AU2013328585A1 (en) 2015-04-09

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Application publication date: 20150610