CN104703611B - 用于生产免疫调节剂的多阶段方法 - Google Patents

用于生产免疫调节剂的多阶段方法 Download PDF

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Publication number
CN104703611B
CN104703611B CN201380035496.XA CN201380035496A CN104703611B CN 104703611 B CN104703611 B CN 104703611B CN 201380035496 A CN201380035496 A CN 201380035496A CN 104703611 B CN104703611 B CN 104703611B
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growth medium
euglena
method described
bioreactor
growth
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CN104703611A (zh
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罗伯特·伯纳德·莱文
杰弗里·理查德·勒布伦
杰弗里·保罗·霍斯特
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Jianming Michigan Co ltd
Kemin Industries Inc
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Ai Erge Scientific & Technical Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/60—Edible seaweed
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/10—Protozoa; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
CN201380035496.XA 2012-05-07 2013-05-07 用于生产免疫调节剂的多阶段方法 Active CN104703611B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261643572P 2012-05-07 2012-05-07
US61/643,572 2012-05-07
PCT/US2013/039939 WO2013169768A1 (en) 2012-05-07 2013-05-07 Multi-stage process for production of immune modulator

Publications (2)

Publication Number Publication Date
CN104703611A CN104703611A (zh) 2015-06-10
CN104703611B true CN104703611B (zh) 2018-05-18

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US (1) US9574217B2 (https=)
EP (1) EP2858652B1 (https=)
CN (1) CN104703611B (https=)
BR (1) BR112014027989A2 (https=)
CA (1) CA2873026C (https=)
ES (1) ES2743428T3 (https=)
IN (1) IN2014DN09956A (https=)
MX (1) MX362256B (https=)
PL (1) PL2858652T3 (https=)
WO (1) WO2013169768A1 (https=)

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MX363063B (es) 2013-03-14 2019-03-06 Algal Scient Corporation Modulacion de la funcion del sistema inmunitario de las plantas.
WO2015099817A1 (en) * 2013-12-26 2015-07-02 Algal Scientific Corporation Method for improving feed efficiency and increasing growth rates in animals
US10456433B2 (en) * 2015-04-08 2019-10-29 Euglena Co., Ltd. Suppressive agent for rheumatoid arthritis, prophylactic agent for rheumatoid arthritis, therapeutic agent for rheumatoid arthritis, and food for suppressing rheumatoid arthritis
WO2017075262A1 (en) 2015-10-28 2017-05-04 Algal Scientific Corporation Use of beta-1,3-glucan for modulating immune function and treating intestinal inflammation
US20170290853A1 (en) * 2016-04-12 2017-10-12 Kemin Industries, Inc. Methods to facilitate the solubilization of beta-1,3-glucan and enhance immune function and other related uses
CN105942310A (zh) * 2016-04-28 2016-09-21 北京珍生康业生物科技有限公司 一种破膜裸藻干粉的制备方法
US20180168190A1 (en) * 2016-06-09 2018-06-21 Algaeon, Inc. Euglena derived animal feed composition
US20180169161A1 (en) * 2016-06-09 2018-06-21 Algaeon, Inc. Euglena derived composition having immune response inducing components
JP2019523654A (ja) * 2016-06-09 2019-08-29 エフ３ プラットフォーム・バイオロジクス，インコーポレーテッド ユーグレナ溶解産物組成物ならびに該組成物および精製されたベータ−１，３−グルカンを生産するための方法
US9901606B2 (en) * 2016-06-09 2018-02-27 Algaeon, Inc. Euglena lysate composition
US20180280450A1 (en) * 2017-03-28 2018-10-04 Kemin Industries, Inc. Method of promoting immune health using the water-soluble component from genus euglena organism
US20190167738A1 (en) * 2017-12-01 2019-06-06 Kemin Industries, Inc. Compositions containing euglena gracilis for viral protection and related methods
WO2019160599A1 (en) * 2018-02-19 2019-08-22 F3 Platform Biologics, Inc. Euglena derived composition, including animal feed composition
EP3990619A4 (en) * 2019-06-28 2024-07-03 Noblegen Inc. Methods of optimized euglena fermentation using engineered tank design
KR102083165B1 (ko) * 2019-09-18 2020-03-02 대상 주식회사 베타-1,3-글루칸 생산능을 갖는 신규의 유글레나 속 균주 및 이를 이용한 베타-1,3-글루칸을 함유하는 유글레나 균체의 제조방법

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Publication number Publication date
PL2858652T3 (pl) 2020-01-31
MX362256B (es) 2019-01-09
US9574217B2 (en) 2017-02-21
US20130303752A1 (en) 2013-11-14
CA2873026A1 (en) 2013-11-14
MX2014013553A (es) 2015-07-14
EP2858652A4 (en) 2016-04-27
EP2858652A1 (en) 2015-04-15
CA2873026C (en) 2021-01-12
IN2014DN09956A (https=) 2015-08-14
WO2013169768A1 (en) 2013-11-14
BR112014027989A2 (pt) 2017-07-18
CN104703611A (zh) 2015-06-10
ES2743428T3 (es) 2020-02-19
EP2858652B1 (en) 2019-07-10

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