CA2873026C - Multi-stage process for production of immune modulator - Google Patents

Multi-stage process for production of immune modulator Download PDF

Info

Publication number
CA2873026C
CA2873026C CA2873026A CA2873026A CA2873026C CA 2873026 C CA2873026 C CA 2873026C CA 2873026 A CA2873026 A CA 2873026A CA 2873026 A CA2873026 A CA 2873026A CA 2873026 C CA2873026 C CA 2873026C
Authority
CA
Canada
Prior art keywords
euglena
beta glucan
growth medium
bioreactor
culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2873026A
Other languages
English (en)
French (fr)
Other versions
CA2873026A1 (en
Inventor
Robert Bernard Levine
Jeffrey Richard Lebrun
Geoffrey Paul Horst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kemin Industries Inc
Original Assignee
Kemin Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kemin Industries Inc filed Critical Kemin Industries Inc
Publication of CA2873026A1 publication Critical patent/CA2873026A1/en
Application granted granted Critical
Publication of CA2873026C publication Critical patent/CA2873026C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/60—Edible seaweed
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/10—Protozoa; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
CA2873026A 2012-05-07 2013-05-07 Multi-stage process for production of immune modulator Active CA2873026C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261643572P 2012-05-07 2012-05-07
US61/643,572 2012-05-07
PCT/US2013/039939 WO2013169768A1 (en) 2012-05-07 2013-05-07 Multi-stage process for production of immune modulator

Publications (2)

Publication Number Publication Date
CA2873026A1 CA2873026A1 (en) 2013-11-14
CA2873026C true CA2873026C (en) 2021-01-12

Family

ID=49549117

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2873026A Active CA2873026C (en) 2012-05-07 2013-05-07 Multi-stage process for production of immune modulator

Country Status (10)

Country Link
US (1) US9574217B2 (https=)
EP (1) EP2858652B1 (https=)
CN (1) CN104703611B (https=)
BR (1) BR112014027989A2 (https=)
CA (1) CA2873026C (https=)
ES (1) ES2743428T3 (https=)
IN (1) IN2014DN09956A (https=)
MX (1) MX362256B (https=)
PL (1) PL2858652T3 (https=)
WO (1) WO2013169768A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX363063B (es) 2013-03-14 2019-03-06 Algal Scient Corporation Modulacion de la funcion del sistema inmunitario de las plantas.
WO2015099817A1 (en) * 2013-12-26 2015-07-02 Algal Scientific Corporation Method for improving feed efficiency and increasing growth rates in animals
US10456433B2 (en) * 2015-04-08 2019-10-29 Euglena Co., Ltd. Suppressive agent for rheumatoid arthritis, prophylactic agent for rheumatoid arthritis, therapeutic agent for rheumatoid arthritis, and food for suppressing rheumatoid arthritis
WO2017075262A1 (en) 2015-10-28 2017-05-04 Algal Scientific Corporation Use of beta-1,3-glucan for modulating immune function and treating intestinal inflammation
US20170290853A1 (en) * 2016-04-12 2017-10-12 Kemin Industries, Inc. Methods to facilitate the solubilization of beta-1,3-glucan and enhance immune function and other related uses
CN105942310A (zh) * 2016-04-28 2016-09-21 北京珍生康业生物科技有限公司 一种破膜裸藻干粉的制备方法
US20180168190A1 (en) * 2016-06-09 2018-06-21 Algaeon, Inc. Euglena derived animal feed composition
US20180169161A1 (en) * 2016-06-09 2018-06-21 Algaeon, Inc. Euglena derived composition having immune response inducing components
JP2019523654A (ja) * 2016-06-09 2019-08-29 エフ３ プラットフォーム・バイオロジクス，インコーポレーテッド ユーグレナ溶解産物組成物ならびに該組成物および精製されたベータ−１，３−グルカンを生産するための方法
US9901606B2 (en) * 2016-06-09 2018-02-27 Algaeon, Inc. Euglena lysate composition
US20180280450A1 (en) * 2017-03-28 2018-10-04 Kemin Industries, Inc. Method of promoting immune health using the water-soluble component from genus euglena organism
US20190167738A1 (en) * 2017-12-01 2019-06-06 Kemin Industries, Inc. Compositions containing euglena gracilis for viral protection and related methods
WO2019160599A1 (en) * 2018-02-19 2019-08-22 F3 Platform Biologics, Inc. Euglena derived composition, including animal feed composition
EP3990619A4 (en) * 2019-06-28 2024-07-03 Noblegen Inc. Methods of optimized euglena fermentation using engineered tank design
KR102083165B1 (ko) * 2019-09-18 2020-03-02 대상 주식회사 베타-1,3-글루칸 생산능을 갖는 신규의 유글레나 속 균주 및 이를 이용한 베타-1,3-글루칸을 함유하는 유글레나 균체의 제조방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2725677A (en) 1952-01-16 1955-12-06 Carnegie Inst Of Washington Method of effectuating high density mass culture of algae or other microorganisms
JPH0671430B2 (ja) * 1986-09-11 1994-09-14 大阪瓦斯株式会社 ユ−グレナ細胞によるβ−１，３−グルカンの製造方法
JP2516031B2 (ja) * 1987-09-14 1996-07-10 ハリマ化成株式会社 稚仔魚用餌料
US5272261A (en) 1989-01-11 1993-12-21 Merrell Dow Pharmaceuticals Inc. Preparation of sulfated polysaccharide fractions
US5084386A (en) * 1989-03-31 1992-01-28 Sri International Production of beta-1,3-glucan in euglena
JP2777418B2 (ja) * 1989-09-13 1998-07-16 雪印乳業株式会社 ユーグレナの培養方法とその装置
US5385382A (en) 1993-10-06 1995-01-31 Ford Motor Company Combination seat frame and ventilation apparatus
EP1029892B1 (de) 1999-02-10 2002-06-05 Dr. Suwelack Skin & Health Care AG Beta-1,3-Glucan aus Euglena enthaltendes gefriergetrocknetes Erzeugnis, seine Herstellung und Verwendung
WO2004030613A2 (en) 2002-09-04 2004-04-15 University Of Louisville Research Foundation, Inc. Cancer therapy using beta glucan and antibodies
JP5731982B2 (ja) 2008-10-14 2015-06-10 ソラザイム, インコーポレイテッドSolazyme Inc 微細藻類バイオマスの食物組成物
US20100303989A1 (en) * 2008-10-14 2010-12-02 Solazyme, Inc. Microalgal Flour
CN101979498B (zh) * 2010-12-01 2016-05-04 华东理工大学 一种微藻高产率异养培养的方法

Also Published As

Publication number Publication date
PL2858652T3 (pl) 2020-01-31
MX362256B (es) 2019-01-09
US9574217B2 (en) 2017-02-21
US20130303752A1 (en) 2013-11-14
CA2873026A1 (en) 2013-11-14
MX2014013553A (es) 2015-07-14
CN104703611B (zh) 2018-05-18
EP2858652A4 (en) 2016-04-27
EP2858652A1 (en) 2015-04-15
IN2014DN09956A (https=) 2015-08-14
WO2013169768A1 (en) 2013-11-14
BR112014027989A2 (pt) 2017-07-18
CN104703611A (zh) 2015-06-10
ES2743428T3 (es) 2020-02-19
EP2858652B1 (en) 2019-07-10

Similar Documents

Publication Publication Date Title
CA2873026C (en) Multi-stage process for production of immune modulator
Grewe et al. The biotechnology of cyanobacteria
Priyadarshani et al. Bioactive compounds from microalgae and cyanobacteria: utility and applications
MX2011007550A (es) Composiciones de levadura entrelazadas con arcilla y metodos de utilizarlas.
CN106687605B (zh) 半连续培养方法
US20170290853A1 (en) Methods to facilitate the solubilization of beta-1,3-glucan and enhance immune function and other related uses
JP2020501547A (ja) バイオマス材料からの核酸及びそのフラグメントの除去
Mahdhi et al. Dietary administration effects of exopolysaccharide from potential probiotic strains on immune and antioxidant status and nutritional value of European sea bass (Dicentrarchus labrax L.)
US20240060112A1 (en) Repeated fed-batch culture methods
AU2017277413B2 (en) Euglena lysate composition and method for producing the composition and a purified beta-1,3-glucan
Kuntsova et al. Obtaining yeast mannoproteins with antimicrobial properties
CN106795539A (zh) 在微生物中产生油的方法
Yamgar et al. Therapeutics role of spirulina platensis in disease prevention and treatment
US20210381024A1 (en) Personalized System for Restoring the Gastrointestinal Tract Microbiome
US20170354699A1 (en) Euglena lysate composition
KR20130015037A (ko) 미세녹조류를 이용한 항염증 및 항여드름효능을 가지는 추출물 및 그의 제조방법
Dehghani et al. Selenium-Enriched Microalgae: A Novel Bioactive Strategy for Immune System Enhancement
CN1405294A (zh) 深海远古生物基因免疫调控酒及其生产方法
WO2025243068A1 (en) Biomass production
UA50555A (uk) Штам halobacterium halobium 353п - продуцент білково-вітамінної біомаси
Muhammad Saeed et al. Single cell proteins: a novel value added food product.
HK1158681B (en) Photosynthetic microorganisms enriched in selenium using selenohydroxy acid compounds, uses thereof in nutrition, cosmetics and pharmacy
CA3003330A1 (en) Use of beta-1,3-glucan for modulating immune function and treating intestinal inflammation

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180417

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 12TH ANNIV.) - STANDARD

Year of fee payment: 12

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250429

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250429

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 13TH ANNIV.) - STANDARD

Year of fee payment: 13

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20260414

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20260414